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Nick MORRICE
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Articles

PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the COR B GTPase domain

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Asad U. Malik, Athanasios Karapetsas, Raja S. Nirujogi, Deep Chatterjee, Toan K. Phung, Melanie Wightman, Robert Gourlay, Nick Morrice, Sebastian Mathea, Stefan Knapp, Dario R. Alessi
Journal: Biochemical Journal
Biochem J (2022) 479 (18): 1941–1965.
https://doi.org/10.1042/BCJ20220308
Published: 23 September 2022
View articletitled, PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the COR B GTPase domain
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Articles

Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazole

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Tamás Zeke, Nick Morrice, Cristina Vázquez-Martin, Patricia T. W. Cohen
Journal: Biochemical Journal
Biochem J (2021) 478 (22): 4025.
https://doi.org/10.1042/BJ20040690_EOC
Published: 23 November 2021
View articletitled, Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazole
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Articles

The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys 63 -linked polyubiquitination of IRAK1

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Alban Ordureau, Hilary Smith, Mark Windheim, Mark Peggie, Emma Carrick, Nick Morrice, Philip Cohen
Journal: Biochemical Journal
Biochem J (2008) 409 (1): 43–52.
https://doi.org/10.1042/BJ20071365
Published: 11 December 2007
View articletitled, The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys 63 -linked polyubiquitination of IRAK1
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Articles

dDYRK2 and Minibrain interact with the chromatin remodelling factors SNR1 and TRX

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Ross Kinstrie, Pamela A. Lochhead, Gary Sibbet, Nick Morrice, Vaughn Cleghon
Journal: Biochemical Journal
Biochem J (2006) 398 (1): 45–54.
https://doi.org/10.1042/BJ20060159
Published: 27 July 2006
View articletitled, dDYRK2 and Minibrain interact with the chromatin remodelling factors SNR1 and TRX
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Articles

Identification of calcium-regulated heat-stable protein of 24 kDa (CRHSP24) as a physiological substrate for PKB and RSK using KESTREL

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Gillian C. Auld, David G. Campbell, Nick Morrice, Philip Cohen
Journal: Biochemical Journal
Biochem J (2005) 389 (3): 775–783.
https://doi.org/10.1042/BJ20050733
Published: 26 July 2005
View articletitled, Identification of calcium-regulated heat-stable protein of 24 kDa (CRHSP24) as a physiological substrate for PKB and RSK using KESTREL
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Articles

The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ

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Claire E. EYERS, Helen McNEILL, Axel KNEBEL, Nick MORRICE, Simon J. C. ARTHUR, Ana CUENDA, Philip COHEN
Journal: Biochemical Journal
Biochem J (2005) 389 (1): 127–135.
https://doi.org/10.1042/BJ20050387
Published: 21 June 2005
View articletitled, The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ
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Articles

Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazole

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Tamás ZEKE, Nick MORRICE, Cristina VÁZQUEZ-MARTIN, Patricia T. W. COHEN
Journal: Biochemical Journal
Biochem J (2005) 385 (1): 45–56.
https://doi.org/10.1042/BJ20040690
Published: 14 December 2004
View articletitled, Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazole
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Articles

14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking

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Mercedes POZUELO RUBIO, Kathryn M. GERAGHTY, Barry H. C. WONG, Nicola T. WOOD, David G. CAMPBELL, Nick MORRICE, Carol MACKINTOSH
Journal: Biochemical Journal
Biochem J (2004) 379 (2): 395–408.
https://doi.org/10.1042/bj20031797
Published: 15 April 2004
View articletitled, 14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking
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Articles

WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate

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Alberto C. VITARI, Maria DEAK, Barry J. COLLINS, Nick MORRICE, Alan R. PRESCOTT, Anne PHELAN, Sian HUMPHREYS, Dario R. ALESSI
Journal: Biochemical Journal
Biochem J (2004) 378 (1): 257–268.
https://doi.org/10.1042/bj20031692
Published: 15 February 2004
View articletitled, WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate
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Articles

Modulation of human insulin receptor substrate-1 tyrosine phosphorylation by protein kinase Cdelta

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Michael W. GREENE, Nick MORRICE, Robert S. GAROFALO, Richard A. ROTH
Journal: Biochemical Journal
Biochem J (2004) 378 (1): 105–116.
https://doi.org/10.1042/bj20031493
Published: 15 February 2004
View articletitled, Modulation of human insulin receptor substrate-1 tyrosine phosphorylation by protein kinase Cdelta
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Articles

An analysis of the phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (ERK5) by mitogen-activated protein kinase kinase 5 (MKK5) in vitro

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Nimesh MODY, David G. CAMPBELL, Nick MORRICE, Mark PEGGIE, Philip COHEN
Journal: Biochemical Journal
Biochem J (2003) 372 (2): 567–575.
https://doi.org/10.1042/bj20030193
Published: 01 June 2003
View articletitled, An analysis of the phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (ERK5) by mitogen-activated protein kinase kinase 5 (MKK5) in vitro
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Articles

Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366

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Gopal P. SAPKOTA, Maria DEAK, Agnieszka KIELOCH, Nick MORRICE, Aaron A. GOODARZI, Carl SMYTHE, Yosef SHILOH, Susan P. LEES-MILLER, Dario R. ALESSI
Journal: Biochemical Journal
Biochem J (2002) 368 (2): 507–516.
https://doi.org/10.1042/bj20021284
Published: 01 December 2002
View articletitled, Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366
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Articles

Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase

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Pauline DOUGLAS, Gopal P. SAPKOTA, Nick MORRICE, Yaping YU, Aaron A. GOODARZI, Dennis MERKLE, Katheryn MEEK, Dario R. ALESSI, Susan P. LEES-MILLER
Journal: Biochemical Journal
Biochem J (2002) 368 (1): 243–251.
https://doi.org/10.1042/bj20020973
Published: 15 November 2002
View articletitled, Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase
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Articles

Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and −insensitive pathways

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Axel KNEBEL, Claire E. HAYDON, Nick MORRICE, Philip COHEN
Journal: Biochemical Journal
Biochem J (2002) 367 (2): 525–532.
https://doi.org/10.1042/bj20020916
Published: 15 October 2002
View articletitled, Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and −insensitive pathways
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Articles

Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz–Jeghers cancer syndrome

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Gopal P. SAPKOTA, Jérôme BOUDEAU, Maria DEAK, Agnieszka KIELOCH, Nick MORRICE, Dario R. ALESSI
Journal: Biochemical Journal
Biochem J (2002) 362 (2): 481–490.
https://doi.org/10.1042/bj3620481
Published: 22 February 2002
View articletitled, Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz–Jeghers cancer syndrome
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Articles

The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site

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Yvonne L. WOODS, Graham RENA, Nick MORRICE, Andreas BARTHEL, Walter BECKER, Shaodong GUO, Terry G. UNTERMAN, Philip COHEN
Journal: Biochemical Journal
Biochem J (2001) 355 (3): 597–607.
https://doi.org/10.1042/bj3550597
Published: 24 April 2001
View articletitled, The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site
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Articles

Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7

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Yvonne FLEMING, Christopher G. ARMSTRONG, Nick MORRICE, Andrew PATERSON, Michel GOEDERT, Philip COHEN
Journal: Biochemical Journal
Biochem J (2000) 352 (1): 145–154.
https://doi.org/10.1042/bj3520145
Published: 07 November 2000
View articletitled, Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7
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Articles

Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155

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Jose M. LIZCANO, Nick MORRICE, Philip COHEN
Journal: Biochemical Journal
Biochem J (2000) 349 (2): 547–557.
https://doi.org/10.1042/bj3490547
Published: 10 July 2000
View articletitled, Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155
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Articles

Phosphoinositide 3-kinase-dependent phosphorylation of the dual adaptor for phosphotyrosine and 3-phosphoinositides by the Src family of tyrosine kinase

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Simon DOWLER, Leire MONTALVO, Doreen CANTRELL, Nick MORRICE, Dario R. ALESSI
Journal: Biochemical Journal
Biochem J (2000) 349 (2): 605–610.
https://doi.org/10.1042/bj3490605
Published: 10 July 2000
View articletitled, Phosphoinositide 3-kinase-dependent phosphorylation of the dual adaptor for phosphotyrosine and 3-phosphoinositides by the Src family of tyrosine kinase
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Articles

A novel 50 kDa protein forms complexes with protein phosphatase 4 and is located at centrosomal microtubule organizing centres

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C. James HASTIE, Graeme K. CARNEGIE, Nick MORRICE, Patricia T. W. COHEN
Journal: Biochemical Journal
Biochem J (2000) 347 (3): 845–855.
https://doi.org/10.1042/bj3470845
Published: 25 April 2000
View articletitled, A novel 50 kDa protein forms complexes with protein phosphatase 4 and is located at centrosomal microtubule organizing centres
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Articles

Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase

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Takayasu KOBAYASHI, Maria DEAK, Nick MORRICE, Philip COHEN
Journal: Biochemical Journal
Biochem J (1999) 344 (1): 189–197.
https://doi.org/10.1042/bj3440189
Published: 08 November 1999
View articletitled, Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase
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