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Nigel S. SCRUTTON
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Articles

Flavin oxidation state impacts on nitrofuran antibiotic binding orientation in nitroreductases

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Helen S. Toogood, Nigel S. Scrutton
Journal: Biochemical Journal
Biochem J (2021) 478 (18): 3423–3428.
https://doi.org/10.1042/BCJ20210489
Published: 23 September 2021
View articletitled, Flavin oxidation state impacts on nitrofuran antibiotic binding orientation in nitroreductases
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Articles

Characterization of coenzyme binding and selectivity determinants in Mycobacterium tuberculosis flavoprotein reductase A: analysis of Arg 199 and Arg 200 mutants at the NADP(H) 2′-phosphate binding site

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Muna Sabri, Adrian J. Dunford, Kirsty J. McLean, Rajasekhar Neeli, Nigel S. Scrutton, David Leys, Andrew W. Munro
Journal: Biochemical Journal
Biochem J (2009) 417 (1): 103–114.
https://doi.org/10.1042/BJ20080466
Published: 12 December 2008
View articletitled, Characterization of coenzyme binding and selectivity determinants in Mycobacterium tuberculosis flavoprotein reductase A: analysis of Arg 199 and Arg 200 mutants at the NADP(H) 2′-phosphate binding site
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Includes: Supplementary data
Articles

Trp 359 regulates flavin thermodynamics and coenzyme selectivity in Mycobacterium tuberculosis FprA

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Rajasekhar Neeli, Muna Sabri, Kirsty J. McLean, Adrian J. Dunford, Nigel S. Scrutton, David Leys, Andrew W. Munro
Journal: Biochemical Journal
Biochem J (2008) 411 (3): 563–570.
https://doi.org/10.1042/BJ20071298
Published: 14 April 2008
View articletitled, Trp 359 regulates flavin thermodynamics and coenzyme selectivity in Mycobacterium tuberculosis FprA
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Includes: Supplementary data
Articles

Kinetic isotope effects and ligand binding in PQQ-dependent methanol dehydrogenase

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Parvinder HOTHI, Michael J. SUTCLIFFE, Nigel S. SCRUTTON
Journal: Biochemical Journal
Biochem J (2005) 388 (1): 123–133.
https://doi.org/10.1042/BJ20041731
Published: 10 May 2005
View articletitled, Kinetic isotope effects and ligand binding in PQQ-dependent methanol dehydrogenase
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Includes: Supplementary data
Articles

Kinetic, spectroscopic and thermodynamic characterization of the Mycobacterium tuberculosis adrenodoxin reductase homologue FprA

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Kirsty J. McLEAN, Nigel S. SCRUTTON, Andrew W. MUNRO
Journal: Biochemical Journal
Biochem J (2003) 372 (2): 317–327.
https://doi.org/10.1042/bj20021692
Published: 01 June 2003
View articletitled, Kinetic, spectroscopic and thermodynamic characterization of the Mycobacterium tuberculosis adrenodoxin reductase homologue FprA
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Articles

Stopped-flow kinetic studies of electron transfer in the reductase domain of neuronal nitric oxide synthase: re-evaluation of the kinetic mechanism reveals new enzyme intermediates and variation with cytochrome P450 reductase

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Kirsty KNIGHT, Nigel S. SCRUTTON
Journal: Biochemical Journal
Biochem J (2002) 367 (1): 19–30.
https://doi.org/10.1042/bj20020667
Published: 01 October 2002
View articletitled, Stopped-flow kinetic studies of electron transfer in the reductase domain of neuronal nitric oxide synthase: re-evaluation of the kinetic mechanism reveals new enzyme intermediates and variation with cytochrome P450 reductase
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Articles

Effects of environment on flavin reactivity in morphinone reductase: analysis of enzymes displaying differential charge near the N-1 atom and C-2 carbonyl region of the active-site flavin

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Daniel H. CRAIG, Terez BARNA, Peter C. E. MOODY, Neil C. BRUCE, Stephen K. CHAPMAN, Andrew W. MUNRO, Nigel S. SCRUTTON
Journal: Biochemical Journal
Biochem J (2001) 359 (2): 315–323.
https://doi.org/10.1042/bj3590315
Published: 08 October 2001
View articletitled, Effects of environment on flavin reactivity in morphinone reductase: analysis of enzymes displaying differential charge near the N-1 atom and C-2 carbonyl region of the active-site flavin
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Articles

Kinetics of CO binding to the haem domain of murine inducible nitric oxide synthase: differential effects of haem domain ligands

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Thirza H. STEVENSON, Aldo F. GUTIERREZ, Wendy K. ALDERTON, Lu-yun LIAN, Nigel S. SCRUTTON
Journal: Biochemical Journal
Biochem J (2001) 358 (1): 201–208.
https://doi.org/10.1042/bj3580201
Published: 08 August 2001
View articletitled, Kinetics of CO binding to the haem domain of murine inducible nitric oxide synthase: differential effects of haem domain ligands
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Articles

Kinetics of CO binding and CO photodissociation in Pseudomonas stutzeri cd1 nitrite reductase: probing the role of extended N-termini in fast structural relaxation upon CO photodissociation

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Emma K. WILSON, Andrea BELLELLI, Francesca CUTRUZZOLÀ, Walter G. ZUMFT, Aldo GUTIERREZ, Nigel S. SCRUTTON
Journal: Biochemical Journal
Biochem J (2001) 355 (1): 39–43.
https://doi.org/10.1042/bj3550039
Published: 26 February 2001
View articletitled, Kinetics of CO binding and CO photodissociation in Pseudomonas stutzeri cd1 nitrite reductase: probing the role of extended N-termini in fast structural relaxation upon CO photodissociation
Open the PDF for Kinetics of CO binding and CO photodissociation in Pseudomonas stutzeri cd1 nitrite reductase: probing the role of extended N-termini in fast structural relaxation upon CO photodissociation in another window
Articles

Two-iron rubredoxin of Pseudomonas oleovorans: production, stability and characterization of the individual iron-binding domains by optical, CD and NMR spectroscopies

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Ashlee PERRY, Lu-Yun LIAN, Nigel S. SCRUTTON
Journal: Biochemical Journal
Biochem J (2001) 354 (1): 89–98.
https://doi.org/10.1042/bj3540089
Published: 08 February 2001
View articletitled, Two-iron rubredoxin of Pseudomonas oleovorans: production, stability and characterization of the individual iron-binding domains by optical, CD and NMR spectroscopies
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Articles

Reductive half-reaction of the H172Q mutant of trimethylamine dehydrogenase: evidence against a carbanion mechanism and assignment of kinetically influential ionizations in the enzyme–substrate complex

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Jaswir BASRAN, Michael J. SUTCLIFFE, Russ HILLE, Nigel S. SCRUTTON
Journal: Biochemical Journal
Biochem J (1999) 341 (2): 307–314.
https://doi.org/10.1042/bj3410307
Published: 08 July 1999
View articletitled, Reductive half-reaction of the H172Q mutant of trimethylamine dehydrogenase: evidence against a carbanion mechanism and assignment of kinetically influential ionizations in the enzyme–substrate complex
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Articles

Cation-π bonding and amino-aromatic interactions in the biomolecular recognition of substituted ammonium ligands

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Nigel S. SCRUTTON, Andrew R.C. RAINE
Journal: Biochemical Journal
Biochem J (1996) 319 (1): 1–8.
https://doi.org/10.1042/bj3190001
Published: 01 October 1996
View articletitled, Cation-π bonding and amino-aromatic interactions in the biomolecular recognition of substituted ammonium ligands
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Articles

Flavinylation in wild-type trimethylamine dehydrogenase and differentially charged mutant enzymes: a study of the protein environment around the N1 of the flavin isoalloxazine

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Martin MEWIES, Leonard C. PACKMAN, F. Scott MATHEWS, Nigel S. SCRUTTON
Journal: Biochemical Journal
Biochem J (1996) 317 (1): 267–272.
https://doi.org/10.1042/bj3170267
Published: 01 July 1996
View articletitled, Flavinylation in wild-type trimethylamine dehydrogenase and differentially charged mutant enzymes: a study of the protein environment around the N1 of the flavin isoalloxazine
Open the PDF for Flavinylation in wild-type trimethylamine dehydrogenase and differentially charged mutant enzymes: a study of the protein environment around the N1 of the flavin isoalloxazine in another window