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Articles

Ligand-induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg1433 and Tyr1349

Ralf Fliegert, Joanna M. Watt, Anja Schöbel, Monika D. Rozewitz, Christelle Moreau, Tanja Kirchberger, Mark P. Thomas, Wiebke Sick, Andrea C. Araujo, Angelika Harneit, Barry V.L. Potter, Andreas H. Guse

Biochem J (2017) 474 (13): 2159–2175.

https://doi.org/10.1042/BCJ20170091

Published: 16 June 2017

View articletitled, Ligand-induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg1433 and Tyr1349

Includes: Supplementary data

Articles

Thrombin-activated human platelets acutely generate oxidized docosahexaenoic-acid-containing phospholipids via 12-lipoxygenase

Lloyd T. Morgan, Christopher P. Thomas, Hartmut Kühn, Valerie B. O'Donnell

Biochem J (2010) 431 (1): 141–148.

https://doi.org/10.1042/BJ20100415

Published: 14 September 2010

View articletitled, Thrombin-activated human platelets acutely generate oxidized docosahexaenoic-acid-containing phospholipids via 12-lipoxygenase

Articles

Regulation of the cardiac L-type calcium channel in L6 cells by arginine-vasopressin

Basil M. Hantash, Andrew P. Thomas, John P. Reeves

Biochem J (2006) 400 (3): 411–419.

https://doi.org/10.1042/BJ20060742

Published: 28 November 2006

View articletitled, Regulation of the cardiac L-type calcium channel in L6 cells by arginine-vasopressin

Articles

Transcriptional repression of the CTP:phosphocholine cytidylyltransferase gene by sphingosine

Alan J. RYAN, Kurt FISHER, Christie P. THOMAS, Rama K. MALLAMPALLI

Biochem J (2004) 382 (2): 741–750.

https://doi.org/10.1042/BJ20040105

Published: 24 August 2004

View articletitled, Transcriptional repression of the CTP:phosphocholine cytidylyltransferase gene by sphingosine

Articles

Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells

Takashi TSUBOI, Gabriela da SILVA XAVIER, George G. HOLZ, Laurence S. JOUAVILLE, Andrew P. THOMAS, Guy A. RUTTER

Biochem J (2003) 369 (2): 287–299.

https://doi.org/10.1042/bj20021288

Published: 15 January 2003

View articletitled, Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells

Articles

Lipid deprivation increases surfactant phosphatidylcholine synthesis via a sterol-sensitive regulatory element within the CTP:phosphocholine cytidylyltransferase promoter

Rama K. MALLAMPALLI, Alan J. RYAN, James L. CARROLL, Timothy F. OSBORNE, Christie P. THOMAS

Biochem J (2002) 362 (1): 81–88.

https://doi.org/10.1042/bj3620081

Published: 08 February 2002

View articletitled, Lipid deprivation increases surfactant phosphatidylcholine synthesis via a sterol-sensitive regulatory element within the CTP:phosphocholine cytidylyltransferase promoter

Articles

Human amiloride-sensitive epithelial Na+ channel γ subunit promoter: functional analysis and identification of a polypurine-polypyrimidine tract with the potential for triplex DNA formation

Scott D. AUERBACH, Randy W. LOFTUS, Omar A. ITANI, Christie P. THOMAS

Biochem J (2000) 347 (1): 105–114.

https://doi.org/10.1042/bj3470105

Published: 27 March 2000

View articletitled, Human amiloride-sensitive epithelial Na+ channel γ subunit promoter: functional analysis and identification of a polypurine-polypyrimidine tract with the potential for triplex DNA formation

Articles

Cellular activation by Ca 2+ release from stores in the endoplasmic reticulum but not by increased free Ca 2+ in the cytosol

David S. STRAYER, Jan B. HOEK, Andrew P. THOMAS, Martyn K. WHITE

Biochem J (1999) 344 (1): 39–46.

https://doi.org/10.1042/bj3440039

Published: 08 November 1999

View articletitled, Cellular activation by Ca 2+ release from stores in the endoplasmic reticulum but not by increased free Ca 2+ in the cytosol

Articles

Functional rescue of a constitutively desensitized β2AR through receptor dimerization

E. Terence HEBERT, P. Thomas LOISEL, Lynda ADAM, Nathalie ETHIER, ST. Stephane ONGE, Michel BOUVIER

Biochem J (1998) 330 (1): 287–293.

https://doi.org/10.1042/bj3300287

Published: 15 February 1998

View articletitled, Functional rescue of a constitutively desensitized β2AR through receptor dimerization

Articles

Ca 2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A 2 -activated pathways

C P Thomas, M J Dunn, R Mattera

Biochem J (1995) 312 (1): 151–158.

https://doi.org/10.1042/bj3120151

Published: 15 November 1995

View articletitled, Ca 2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A 2 -activated pathways

Articles

Effect of oxidized glutathione and temperature on inositol 1,4,5-trisphosphate binding in permeabilized hepatocytes

D C Renard-Rooney, S K Joseph, M B Seitz, A P Thomas

Biochem J (1995) 310 (1): 185–192.

https://doi.org/10.1042/bj3100185

Published: 15 August 1995

View articletitled, Effect of oxidized glutathione and temperature on inositol 1,4,5-trisphosphate binding in permeabilized hepatocytes

Articles

Expression, purification and characterization of 1-aminocyclopropane-1-carboxylate oxidase from tomato in Escherichia coli

Z Zhang, C J Schofield, J E Baldwin, P Thomas, P John

Biochem J (1995) 307 (1): 77–85.

https://doi.org/10.1042/bj3070077

Published: 01 April 1995

View articletitled, Expression, purification and characterization of 1-aminocyclopropane-1-carboxylate oxidase from tomato in Escherichia coli

Articles

The structural origins of the unusual specificities observed in the isolation of chymopapain M and actinidin by covalent chromatography and the lack of inhibition of chymopapain M by cystatin

M P Thomas, C Verma, S M Boyd, K Brocklehurst

Biochem J (1995) 306 (1): 39–46.

https://doi.org/10.1042/bj3060039

Published: 15 February 1995

View articletitled, The structural origins of the unusual specificities observed in the isolation of chymopapain M and actinidin by covalent chromatography and the lack of inhibition of chymopapain M by cystatin

Articles

Structure of chymopapain M the late-eluted chymopapain deduced by comparative modelling techniques and active-centre characteristics determined by pH-dependent kinetics of catalysis and reactions with time-dependent inhibitors: the Cys-25/His-159 ion-pair is insufficient for catalytic competence in both chymopapain M and papain

M P Thomas, C M Topham, D Kowlessur, G W Mellor, E W Thomas, D Whitford, K Brocklehurst

Biochem J (1994) 300 (3): 805–820.

https://doi.org/10.1042/bj3000805

Published: 15 June 1994

View articletitled, Structure of chymopapain M the late-eluted chymopapain deduced by comparative modelling techniques and active-centre characteristics determined by pH-dependent kinetics of catalysis and reactions with time-dependent inhibitors: the Cys-25/His-159 ion-pair is insufficient for catalytic competence in both chymopapain M and papain

Articles

Multiple mechanisms by which protein kinase A potentiates inositol 1,4,5-trisphosphate-induced Ca 2+ mobilization in permeabilized hepatocytes

G Hajnóczky, E Gao, T Nomura, J B Hoek, A P Thomas

Biochem J (1993) 293 (2): 413–422.

https://doi.org/10.1042/bj2930413

Published: 15 July 1993

View articletitled, Multiple mechanisms by which protein kinase A potentiates inositol 1,4,5-trisphosphate-induced Ca 2+ mobilization in permeabilized hepatocytes

Articles

Oxidized glutathione causes sensitization of calcium release to inositol 1,4,5-trisphosphate in permeabilized hepatocytes

D C Renard, M B Seitz, A P Thomas

Biochem J (1992) 284 (2): 507–512.

https://doi.org/10.1042/bj2840507

Published: 01 June 1992

View articletitled, Oxidized glutathione causes sensitization of calcium release to inositol 1,4,5-trisphosphate in permeabilized hepatocytes

Articles

Modified kinetics of platelet-derived growth factor-induced Ca 2+ increases in NIH-3T3 cells overexpressing phospholipase C γ 1

D C Renard, M M Bolton, S G Rhee, B L Margolis, A Zilberstein, J Schlessinger, A P Thomas

Biochem J (1992) 281 (3): 775–784.

https://doi.org/10.1042/bj2810775

Published: 01 February 1992

View articletitled, Modified kinetics of platelet-derived growth factor-induced Ca 2+ increases in NIH-3T3 cells overexpressing phospholipase C γ 1

Articles

Induction of carcinoembryonic-antigen-gene expression in human colorectal carcinoma by sodium butyrate

K Saini, G Steele, P Thomas

Biochem J (1990) 272 (2): 541–544.

https://doi.org/10.1042/bj2720541

Published: 01 December 1990

View articletitled, Induction of carcinoembryonic-antigen-gene expression in human colorectal carcinoma by sodium butyrate

Articles

Phospholipase C activation by ethanol in rat hepatocytes is unaffected by chronic ethanol feeding

J B Hoek, T F Taraschi, K Higashi, E Rubin, A P Thomas

Biochem J (1990) 272 (1): 59–64.

https://doi.org/10.1042/bj2720059

Published: 15 November 1990

View articletitled, Phospholipase C activation by ethanol in rat hepatocytes is unaffected by chronic ethanol feeding

Articles

Effect of guanine nucleotides on polyphosphoinositide synthesis in rat liver plasma membranes

C Benistant, A P Thomas, R Rubin

Biochem J (1990) 271 (3): 591–597.

https://doi.org/10.1042/bj2710591

Published: 01 November 1990

View articletitled, Effect of guanine nucleotides on polyphosphoinositide synthesis in rat liver plasma membranes

Articles

Hormonal regulation of stability of glutamine synthetase mRNA in cultured 3T3-L1 adipocytes

K Saini, P Thomas, B Bhandari

Biochem J (1990) 267 (1): 241–244.

https://doi.org/10.1042/bj2670241

Published: 01 April 1990

View articletitled, Hormonal regulation of stability of glutamine synthetase mRNA in cultured 3T3-L1 adipocytes

Articles

Phosphatidylinositol 4,5-bisphosphate hydrolysis in human sperm stimulated with follicular fluid or progesterone is dependent upon Ca 2+ influx

P Thomas, S Meizel

Biochem J (1989) 264 (2): 539–546.

https://doi.org/10.1042/bj2640539

Published: 01 December 1989

View articletitled, Phosphatidylinositol 4,5-bisphosphate hydrolysis in human sperm stimulated with follicular fluid or progesterone is dependent upon Ca 2+ influx

Articles

Ethanol-induced phospholipase C activation is inhibited by phorbol esters in isolated hepatocytes

J B Hoek, R Rubin, A P Thomas

Biochem J (1988) 251 (3): 865–871.

https://doi.org/10.1042/bj2510865

Published: 01 May 1988

View articletitled, Ethanol-induced phospholipase C activation is inhibited by phorbol esters in isolated hepatocytes

Articles

Effects of Ca 2+ and Mg 2+ on the activity of pyruvate dehydrogenase phosphate phosphatase within toluene-permeabilized mitochondria

P J Midgley, G A Rutter, A P Thomas, R M Denton

Biochem J (1987) 241 (2): 371–377.

https://doi.org/10.1042/bj2410371

Published: 15 January 1987

View articletitled, Effects of Ca 2+ and Mg 2+ on the activity of pyruvate dehydrogenase phosphate phosphatase within toluene-permeabilized mitochondria

Articles

Sensitivity of pyruvate dehydrogenase phosphate phosphatase to magnesium ions. Similar effects of spermine and insulin

A P Thomas, T A Diggle, R M Denton

Biochem J (1986) 238 (1): 83–91.

https://doi.org/10.1042/bj2380083

Published: 15 August 1986

View articletitled, Sensitivity of pyruvate dehydrogenase phosphate phosphatase to magnesium ions. Similar effects of spermine and insulin

Articles

Use of toluene-permeabilized mitochondria to study the regulation of adipose tissue pyruvate dehydrogenase in situ . Further evidence that insulin acts through stimulation of pyruvate dehydrogenase phosphate phosphatase

A P Thomas, R M Denton

Biochem J (1986) 238 (1): 93–101.

https://doi.org/10.1042/bj2380093

Published: 15 August 1986

View articletitled, Use of toluene-permeabilized mitochondria to study the regulation of adipose tissue pyruvate dehydrogenase in situ . Further evidence that insulin acts through stimulation of pyruvate dehydrogenase phosphate phosphatase

Articles

Measurement of the intramitochondrial volume in hepatocytes without cell disruption and its elevation by hormones and valinomycin

P T Quinlan, A P Thomas, A E Armston, A P Halestrap

Biochem J (1983) 214 (2): 395–404.

https://doi.org/10.1042/bj2140395

Published: 15 August 1983

View articletitled, Measurement of the intramitochondrial volume in hepatocytes without cell disruption and its elevation by hormones and valinomycin

Articles

A new Kupffer cell receptor mediating plasma clearance of carcinoembryonic antigen by the rat

C A Toth, P Thomas, S A Broitman, N Zamcheck

Biochem J (1982) 204 (2): 377–381.

https://doi.org/10.1042/bj2040377

Published: 15 May 1982

View articletitled, A new Kupffer cell receptor mediating plasma clearance of carcinoembryonic antigen by the rat

Articles

The effects of Ca 2+ and Sr 2+ on Ca 2+ -sensitive biochemical changes in human erythrocytes and their membranes

D Allan, P Thomas

Biochem J (1981) 198 (3): 441–445.

https://doi.org/10.1042/bj1980441

Published: 15 September 1981

View articletitled, The effects of Ca 2+ and Sr 2+ on Ca 2+ -sensitive biochemical changes in human erythrocytes and their membranes

Articles

Computer simulation of the effects of α-cyano-4-hydroxycinnamate on gluconeogenesis from l-lactate in rat liver cells

A P Thomas, A P Halestrap

Biochem J (1981) 198 (3): 561–564.

https://doi.org/10.1042/bj1980561

Published: 15 September 1981

View articletitled, Computer simulation of the effects of α-cyano-4-hydroxycinnamate on gluconeogenesis from l-lactate in rat liver cells

Articles

The rôle of mitochondrial pyruvate transport in the stimulation by glucagon and phenylephrine of gluconeogenesis from l-lactate in isolated rat hepatocytes

A P Thomas, A P Halestrap

Biochem J (1981) 198 (3): 551–560.

https://doi.org/10.1042/bj1980551

Published: 15 September 1981

View articletitled, The rôle of mitochondrial pyruvate transport in the stimulation by glucagon and phenylephrine of gluconeogenesis from l-lactate in isolated rat hepatocytes

Articles

Ca 2+ -induced biochemical changes in human erythrocytes and their relation to microvesiculation

D Allan, P Thomas

Biochem J (1981) 198 (3): 433–440.

https://doi.org/10.1042/bj1980433

Published: 15 September 1981

View articletitled, Ca 2+ -induced biochemical changes in human erythrocytes and their relation to microvesiculation

Articles

Identification of the protein responsible for pyruvate transport into rat liver and heart mitochondria by specific labelling with [ 3 H] N -phenylmaleimide

A P Thomas, A P Halestrap

Biochem J (1981) 196 (2): 471–479.

https://doi.org/10.1042/bj1960471

Published: 15 May 1981

View articletitled, Identification of the protein responsible for pyruvate transport into rat liver and heart mitochondria by specific labelling with [ 3 H] N -phenylmaleimide

Articles

Studies on the mechanisms of biliary excretion of circulating glycoproteins. The carcinoembryonic antigen

P Thomas

Biochem J (1980) 192 (3): 837–843.

https://doi.org/10.1042/bj1920837

Published: 15 December 1980

View articletitled, Studies on the mechanisms of biliary excretion of circulating glycoproteins. The carcinoembryonic antigen

Articles

1,2-diacylglycerol kinase of human erythrocyte membranes. Assay with endogenously generated substrate

D Allan, P Thomas, S Gatt

Biochem J (1980) 191 (2): 669–672.

https://doi.org/10.1042/bj1910669

Published: 01 November 1980

View articletitled, 1,2-diacylglycerol kinase of human erythrocyte membranes. Assay with endogenously generated substrate

Articles

The isolation and characterization of 60 nm vesicles (‘nanovesicles’) produced during ionophore A23187-induced budding of human erythrocytes

D Allan, P Thomas, A R Limbrick

Biochem J (1980) 188 (3): 881–887.

https://doi.org/10.1042/bj1880881

Published: 15 June 1980

View articletitled, The isolation and characterization of 60 nm vesicles (‘nanovesicles’) produced during ionophore A23187-induced budding of human erythrocytes

Articles

The effects of triton WR1339 and asialo-fetuin on the hepatic uptake of circulating native and asialo-carcinoembryonic antigen

P Thomas, M Jones

Biochem J (1978) 173 (3): 981–983.

https://doi.org/10.1042/bj1730981

Published: 01 September 1978

View articletitled, The effects of triton WR1339 and asialo-fetuin on the hepatic uptake of circulating native and asialo-carcinoembryonic antigen

Articles

Androgenic regulation of elongation of polyribonucleotide chains on rat ventral-prostate chromatin

P Thomas, P Davies, K Griffiths

Biochem J (1978) 170 (2): 211–218.

https://doi.org/10.1042/bj1700211

Published: 15 February 1978

View articletitled, Androgenic regulation of elongation of polyribonucleotide chains on rat ventral-prostate chromatin

Articles

Initiation and elongation of polyribonucleotide chains on rat ventral-prostate chromatin transcribed by homologous ribonucleic acid polymerase B.

P Thomas, P Davies, K Griffiths

Biochem J (1977) 166 (2): 189–198.

https://doi.org/10.1042/bj1660189

Published: 15 August 1977

View articletitled, Initiation and elongation of polyribonucleotide chains on rat ventral-prostate chromatin transcribed by homologous ribonucleic acid polymerase B.

Articles

The purification and properties of a β- N -acetylhexosaminidase from Trichomonas foetus

R G Edwards, P Thomas, J H Westwood

Biochem J (1975) 151 (1): 145–148.

https://doi.org/10.1042/bj1510145

Published: 01 October 1975

View articletitled, The purification and properties of a β- N -acetylhexosaminidase from Trichomonas foetus

Articles

The deoxyfluoro-D-glucopyranose 6-phosphates and their effect on yeast glucose phosphate isomerase

E M Bessell, P Thomas

Biochem J (1972) 130 (1): 20P–21P.

https://doi.org/10.1042/bj1300020P

Published: 01 November 1972

View articletitled, The deoxyfluoro-D-glucopyranose 6-phosphates and their effect on yeast glucose phosphate isomerase

Articles

The effect of substitution at C-2 of D-glucose 6-phosphate on the rate of dehydrogenation by yeast glucose 6-phosphate dehydrogenase

P Thomas, E M Bessel

Biochem J (1972) 130 (1): 21P.

https://doi.org/10.1042/bj1300021Pa

Published: 01 November 1972

View articletitled, The effect of substitution at C-2 of D-glucose 6-phosphate on the rate of dehydrogenation by yeast glucose 6-phosphate dehydrogenase

Articles

The role of histidine residues in glutamate dehydrogenase

N. Tudball, R. Bailey-Wood, P. Thomas

Biochem J (1972) 129 (2): 419–425.

https://doi.org/10.1042/bj1290419

Published: 01 September 1972

View articletitled, The role of histidine residues in glutamate dehydrogenase

Articles

Studies on the l-serine O-sulphate-degrading activity of pig liver

N Tudball, P Thomas

Biochem J (1972) 128 (4): 133P.

https://doi.org/10.1042/bj1280133Pa

Published: 01 July 1972

View articletitled, Studies on the l-serine O-sulphate-degrading activity of pig liver

Articles

The enzymic degradation of l-serine O-sulphate. Mechanism of the reaction

N. Tudball, P. Thomas

Biochem J (1972) 128 (1): 41–46.

https://doi.org/10.1042/bj1280041

Published: 01 June 1972

View articletitled, The enzymic degradation of l-serine O-sulphate. Mechanism of the reaction

Articles

The enzymic degradation of l-serine O-sulphate by a specific system from pig liver. Studies on the mechanism of the reaction

N. Tudball, P. Thomas

Biochem J (1972) 126 (1): 187–191.

https://doi.org/10.1042/bj1260187

Published: 01 January 1972

View articletitled, The enzymic degradation of l-serine O-sulphate by a specific system from pig liver. Studies on the mechanism of the reaction

Articles

The inhibition of glutamate dehydrogenase by l-serine O-sulphate and related compounds and by photo-oxidation in the presence of Rose Bengal

N. Tudball, P. Thomas

Biochem J (1971) 123 (3): 421–426.

https://doi.org/10.1042/bj1230421

Published: 01 July 1971

View articletitled, The inhibition of glutamate dehydrogenase by l-serine O-sulphate and related compounds and by photo-oxidation in the presence of Rose Bengal

Articles

The purification and properties of the l-serine O-sulphate-degrading system of pig liver

N. Tudball, P. Thomas, R. Bailey-Wood

Biochem J (1971) 121 (5): 747–752.

https://doi.org/10.1042/bj1210747

Published: 01 March 1971

View articletitled, The purification and properties of the l-serine O-sulphate-degrading system of pig liver

Articles

Preparation of d-glycerate 3-O-sulphate, dl-glycerate 3[35S]-O-sulphate and d-glucose 6-O-sulphate

J W Fitzgerald, P Thomas, N Tudball, P J Winterburn

Biochem J (1971) 121 (3): 529–530.

https://doi.org/10.1042/bj1210529

Published: 01 February 1971

View articletitled, Preparation of d-glycerate 3-O-sulphate, dl-glycerate 3[35S]-O-sulphate and d-glucose 6-O-sulphate

Articles

Cytochromes of ovary mitochondria: effect of human chorionic gonadotrophin

J M Cooper, P Thomas

Biochem J (1970) 117 (2): 24P–25P.

https://doi.org/10.1042/bj1170024Pb

Published: 01 April 1970

View articletitled, Cytochromes of ovary mitochondria: effect of human chorionic gonadotrophin

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