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P. D. Lawley
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Articles

Direct assay for O 6 -methylguanine-DNA methyltransferase and comparison of detection methods for the methylated enzyme in polyacrylamide gels and electroblots

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G N Major, E J Gardner, P D Lawley
Journal: Biochemical Journal
Biochem J (1991) 277 (1): 89–96.
https://doi.org/10.1042/bj2770089
Published: 01 July 1991
View articletitled, Direct assay for O 6 -methylguanine-DNA methyltransferase and comparison of detection methods for the methylated enzyme in polyacrylamide gels and electroblots
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Articles

Alkylation of deoxyribonucleic acid in vivo in various organs of C57BL mice by the carcinogens N -methyl- N -nitrosourea, N -ethyl- N -nitrosourea and ethyl methanesulphonate in relation to induction of thymic lymphoma. Some applications of high-pressure liquid chromatography

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J V Frei, D H Swenson, W Warren, P D Lawley
Journal: Biochemical Journal
Biochem J (1978) 174 (3): 1031–1044.
https://doi.org/10.1042/bj1741031
Published: 15 September 1978
View articletitled, Alkylation of deoxyribonucleic acid in vivo in various organs of C57BL mice by the carcinogens N -methyl- N -nitrosourea, N -ethyl- N -nitrosourea and ethyl methanesulphonate in relation to induction of thymic lymphoma. Some applications of high-pressure liquid chromatography
Open the PDF for Alkylation of deoxyribonucleic acid in vivo in various organs of C57BL mice by the carcinogens N -methyl- N -nitrosourea, N -ethyl- N -nitrosourea and ethyl methanesulphonate in relation to induction of thymic lymphoma. Some applications of high-pressure liquid chromatography in another window
Articles

Alkylation of deoxyribonucleic acid by carcinogens dimethyl sulphate, ethyl methanesulphonate, N -ethyl- N -nitrosourea and N -methyl- N -nitrosourea. Relative reactivity of the phosphodiester site thymidylyl(3′-5′)thymidine

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D H Swenson, P D Lawley
Journal: Biochemical Journal
Biochem J (1978) 171 (3): 575–587.
https://doi.org/10.1042/bj1710575
Published: 01 June 1978
View articletitled, Alkylation of deoxyribonucleic acid by carcinogens dimethyl sulphate, ethyl methanesulphonate, N -ethyl- N -nitrosourea and N -methyl- N -nitrosourea. Relative reactivity of the phosphodiester site thymidylyl(3′-5′)thymidine
Open the PDF for Alkylation of deoxyribonucleic acid by carcinogens dimethyl sulphate, ethyl methanesulphonate, N -ethyl- N -nitrosourea and N -methyl- N -nitrosourea. Relative reactivity of the phosphodiester site thymidylyl(3′-5′)thymidine in another window
Articles

Isolation and identification of products from alkylation of nucleic acids: ethyl- and isopropyl-purines

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P D Lawley, D J Orr, M Jarman
Journal: Biochemical Journal
Biochem J (1975) 145 (1): 73–84.
https://doi.org/10.1042/bj1450073
Published: 01 January 1975
View articletitled, Isolation and identification of products from alkylation of nucleic acids: ethyl- and isopropyl-purines
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Articles

Molecular mechanisms in alkylation mutagenesis. Induced reversion of bacteriophage T4 r II AP72 by ethyl methanesulphonate in relation to extent and mode of ethylation of purines in bacteriophage deoxyribonucleic acid

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P D Lawley, C N Martin
Journal: Biochemical Journal
Biochem J (1975) 145 (1): 85–91.
https://doi.org/10.1042/bj1450085
Published: 01 January 1975
View articletitled, Molecular mechanisms in alkylation mutagenesis. Induced reversion of bacteriophage T4 r II AP72 by ethyl methanesulphonate in relation to extent and mode of ethylation of purines in bacteriophage deoxyribonucleic acid
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Articles

Reaction products from N -methyl- N -nitrosourea and deoxyribonucleic acid containing thymidine residues. Synthesis and identification of a new methylation product, O 4 -methyl-thymidine

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P. D. Lawley, D. J. Orr, S. A. Shah, P. B. Farmer, M. Jarman
Journal: Biochemical Journal
Biochem J (1973) 135 (1): 193–201.
https://doi.org/10.1042/bj1350193
Published: 01 September 1973
View articletitled, Reaction products from N -methyl- N -nitrosourea and deoxyribonucleic acid containing thymidine residues. Synthesis and identification of a new methylation product, O 4 -methyl-thymidine
Open the PDF for Reaction products from N -methyl- N -nitrosourea and deoxyribonucleic acid containing thymidine residues. Synthesis and identification of a new methylation product, O 4 -methyl-thymidine in another window
Articles

Differences in the patterns of methylation in rat liver ribosomal ribonucleic acid after reaction in vivo with methyl methanesulphonate and NN -dimethylnitrosamine

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P. J. O'Connor, M. J. Capps, A. W. Craig, P. D. Lawley, S. A. Shah
Journal: Biochemical Journal
Biochem J (1972) 129 (3): 519–528.
https://doi.org/10.1042/bj1290519
Published: 01 September 1972
View articletitled, Differences in the patterns of methylation in rat liver ribosomal ribonucleic acid after reaction in vivo with methyl methanesulphonate and NN -dimethylnitrosamine
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Articles

Methylation of ribonucleic acid by the carcinogens dimethyl sulphate, N -methyl- N -nitrosourea and N -methyl- N′ -nitro- N -nitrosoguanidine. Comparisons of chemical analyses at the nucleoside and base levels

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P. D. Lawley, S. A. Shah
Journal: Biochemical Journal
Biochem J (1972) 128 (1): 117–132.
https://doi.org/10.1042/bj1280117
Published: 01 June 1972
View articletitled, Methylation of ribonucleic acid by the carcinogens dimethyl sulphate, N -methyl- N -nitrosourea and N -methyl- N′ -nitro- N -nitrosoguanidine. Comparisons of chemical analyses at the nucleoside and base levels
Open the PDF for Methylation of ribonucleic acid by the carcinogens dimethyl sulphate, N -methyl- N -nitrosourea and N -methyl- N′ -nitro- N -nitrosoguanidine. Comparisons of chemical analyses at the nucleoside and base levels in another window
Articles

Biomethylation of deoxyribonucleic acid in cultured human tumour cells (HeLa). Methylated bases other than 5-methylcytosine not detected

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P. D. Lawley, A. R. Crathorn, S. A. Shah, B. A. Smith
Journal: Biochemical Journal
Biochem J (1972) 128 (1): 133–138.
https://doi.org/10.1042/bj1280133
Published: 01 June 1972
View articletitled, Biomethylation of deoxyribonucleic acid in cultured human tumour cells (HeLa). Methylated bases other than 5-methylcytosine not detected
Open the PDF for Biomethylation of deoxyribonucleic acid in cultured human tumour cells (HeLa). Methylated bases other than 5-methylcytosine not detected in another window
Articles

Alkylation by propylene oxide of deoxyribonucleic acid, adenine, guanosine and deoxyguanylic acid

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P. D. Lawley, M. Jarman
Journal: Biochemical Journal
Biochem J (1972) 126 (4): 893–900.
https://doi.org/10.1042/bj1260893
Published: 01 February 1972
View articletitled, Alkylation by propylene oxide of deoxyribonucleic acid, adenine, guanosine and deoxyguanylic acid
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Articles

The action of mono- and di-functional sulphur mustards on the ribonucleic acid-containing bacteriophage μ2

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K. V. Shooter, P. A. Edwards, P. D. Lawley
Journal: Biochemical Journal
Biochem J (1971) 125 (3): 829–840.
https://doi.org/10.1042/bj1250829
Published: 01 December 1971
View articletitled, The action of mono- and di-functional sulphur mustards on the ribonucleic acid-containing bacteriophage μ2
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Articles

Methylation of μ2 bacteriophage ribonucleic acid by the carcinogen N-methyl-N-nitrosourea: evidence for O-methylation

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P D Lawley, K V Shooter, W L House, S A Shah
Journal: Biochemical Journal
Biochem J (1971) 122 (1): 22P.
https://doi.org/10.1042/bj1220022Pb
Published: 01 March 1971
View articletitled, Methylation of μ2 bacteriophage ribonucleic acid by the carcinogen N-methyl-N-nitrosourea: evidence for O-methylation
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Articles

Methylation of deoxyribonucleic acid in cultured mammalian cells by N -methyl- N ′-nitro- N -nitrosoguanidine. The influence of cellular thiol concentrations on the extent of methylation and the 6-oxygen atom of guanine as a site of methylation

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P. D. Lawley, Carolyn J. Thatcher
Journal: Biochemical Journal
Biochem J (1970) 116 (4): 693–707.
https://doi.org/10.1042/bj1160693
Published: 01 February 1970
View articletitled, Methylation of deoxyribonucleic acid in cultured mammalian cells by N -methyl- N ′-nitro- N -nitrosoguanidine. The influence of cellular thiol concentrations on the extent of methylation and the 6-oxygen atom of guanine as a site of methylation
Open the PDF for Methylation of deoxyribonucleic acid in cultured mammalian cells by N -methyl- N ′-nitro- N -nitrosoguanidine. The influence of cellular thiol concentrations on the extent of methylation and the 6-oxygen atom of guanine as a site of methylation in another window
Articles

Cytotoxicity of alkylating agents towards sensitive and resistant strains of Escherichia coli in relation to extent and mode of alkylation of cellular macromolecules and repair of alkylation lesions in deoxyribonucleic acids

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P. D. Lawley, P. Brookes
Journal: Biochemical Journal
Biochem J (1968) 109 (3): 433–447.
https://doi.org/10.1042/bj1090433
Published: 01 September 1968
View articletitled, Cytotoxicity of alkylating agents towards sensitive and resistant strains of Escherichia coli in relation to extent and mode of alkylation of cellular macromolecules and repair of alkylation lesions in deoxyribonucleic acids
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Articles

Methylation of Adenine in Deoxyadenylic Acid or Deoxyribonucleic Acid at N-7

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P. D. Lawley, P. Brookes
Journal: Biochemical Journal
Biochem J (1964) 92 (3): 19C–25C.
https://doi.org/10.1042/bj0920019C
Published: 01 September 1964
View articletitled, Methylation of Adenine in Deoxyadenylic Acid or Deoxyribonucleic Acid at N-7
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Articles

The reaction of mustard gas with nucleic acids in vitro and in vivo

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P. Brookes, P. D. Lawley
Journal: Biochemical Journal
Biochem J (1960) 77 (3): 478–484.
https://doi.org/10.1042/bj0770478
Published: 01 December 1960
View articletitled, The reaction of mustard gas with nucleic acids in vitro and in vivo
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