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Peter R. Shepherd
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Articles

ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding

Open Access
Grace Q. Gong, Glenn R. Masson, Woo-Jeong Lee, James M. J. Dickson, Jackie D. Kendall, Manoj K. Rathinaswamy, Christina M. Buchanan, Martin Middleditch, Brady M. Owen, Julie A. Spicer, Gordon W. Rewcastle, William A. Denny, John E. Burke, Peter R. Shepherd, Roger L. Williams, Jack U. Flanagan
Journal: Biochemical Journal
Biochem J (2024) 481 (23): 1787–1802.
https://doi.org/10.1042/BCJ20240479
Published: 28 November 2024
View articletitled, ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding
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Includes: Supplementary data
Articles

A role for PAK1 mediated phosphorylation of β-catenin Ser552 in the regulation of insulin secretion

Open Access
Brie Sorrenson, Waruni C. Dissanayake, Fengyun Hu, Kate L. Lee, Peter R. Shepherd
Journal: Biochemical Journal
Biochem J (2021) 478 (8): 1605–1615.
https://doi.org/10.1042/BCJ20200862
Published: 28 April 2021
View articletitled, A role for PAK1 mediated phosphorylation of β-catenin Ser552 in the regulation of insulin secretion
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Articles

α-catenin isoforms are regulated by glucose and involved in regulating insulin secretion in rat clonal β-cell models

Open Access
Waruni C. Dissanayake, Brie Sorrenson, Kate L. Lee, Sandra Barre, Peter R. Shepherd
Journal: Biochemical Journal
Biochem J (2020) 477 (4): 763–772.
https://doi.org/10.1042/BCJ20190832
Published: 20 February 2020
View articletitled, α-catenin isoforms are regulated by glucose and involved in regulating insulin secretion in rat clonal β-cell models
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Articles

Combining properties of different classes of PI3Kα inhibitors to understand the molecular features that confer selectivity

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Grace Q. Gong, Jackie D. Kendall, James M.J. Dickson, Gordon W. Rewcastle, Christina M. Buchanan, William A. Denny, Peter R. Shepherd, Jack U. Flanagan
Journal: Biochemical Journal
Biochem J (2017) 474 (13): 2261–2276.
https://doi.org/10.1042/BCJ20161098
Published: 26 June 2017
View articletitled, Combining properties of different classes of PI3Kα inhibitors to understand the molecular features that confer selectivity
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Includes: Supplementary data
Articles

Niclosamide blocks glucagon phosphorylation of Ser 552 on β-catenin in primary rat hepatocytes via PKA signalling

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Md. Kamrul H. Chowdhury, Lindsay E. Wu, James L.J. Coleman, Nicola J. Smith, Margaret J. Morris, Peter R. Shepherd, Greg C. Smith
Journal: Biochemical Journal
Biochem J (2016) 473 (9): 1247–1255.
https://doi.org/10.1042/BCJ20160121
Published: 26 April 2016
View articletitled, Niclosamide blocks glucagon phosphorylation of Ser 552 on β-catenin in primary rat hepatocytes via PKA signalling
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Articles

Biochemical Journal strengthens links in Asia

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Peter R. Shepherd
Journal: Biochemical Journal
Biochem J (2014) 464 (1): 1.
https://doi.org/10.1042/BJ20140874
Published: 23 October 2014
View articletitled, Biochemical Journal strengthens links in Asia
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Includes: Supplementary data
Articles

Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle

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Yang Liu, Yu-Chiang Lai, Elaine V. Hill, Donatienne Tyteca, Sarah Carpentier, Ada Ingvaldsen, Didier Vertommen, Louise Lantier, Marc Foretz, Franck Dequiedt, Pierre J. Courtoy, Christophe Erneux, Benoît Viollet, Peter R. Shepherd, Jeremy M. Tavaré, Jørgen Jensen, Mark H. Rider
Journal: Biochemical Journal
Biochem J (2013) 455 (2): 195–206.
https://doi.org/10.1042/BJ20130644
Published: 27 September 2013
View articletitled, Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle
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Includes: Supplementary data
Articles

Identification of a pathway by which glucose regulates β-catenin signalling via the cAMP/protein kinase A pathway in β-cell models

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Emmanuelle Cognard, Coralie G. Dargaville, Deborah L. Hay, Peter R. Shepherd
Journal: Biochemical Journal
Biochem J (2013) 449 (3): 803–811.
https://doi.org/10.1042/BJ20121454
Published: 09 January 2013
View articletitled, Identification of a pathway by which glucose regulates β-catenin signalling via the cAMP/protein kinase A pathway in β-cell models
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Includes: Supplementary data
Articles

Hypothalamic glycogen synthase kinase 3β has a central role in the regulation of food intake and glucose metabolism

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Jonas Benzler, Goutham K. Ganjam, Manon Krüger, Olaf Pinkenburg, Maria Kutschke, Sigrid Stöhr, Juliane Steger, Christiane E. Koch, Rebecca Ölkrug, Michael W. Schwartz, Peter R. Shepherd, David R. Grattan, Alexander Tups
Journal: Biochemical Journal
Biochem J (2012) 447 (1): 175–184.
https://doi.org/10.1042/BJ20120834
Published: 12 September 2012
View articletitled, Hypothalamic glycogen synthase kinase 3β has a central role in the regulation of food intake and glucose metabolism
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Articles

Definition of the binding mode of a new class of phosphoinositide 3-kinase α-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis

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Zhaohua Zheng, Syazwani I. Amran, Jiuxiang Zhu, Oleg Schmidt-Kittler, Kenneth W. Kinzler, Bert Vogelstein, Peter R. Shepherd, Philip E. Thompson, Ian G. Jennings
Journal: Biochemical Journal
Biochem J (2012) 444 (3): 529–535.
https://doi.org/10.1042/BJ20120499
Published: 29 May 2012
View articletitled, Definition of the binding mode of a new class of phosphoinositide 3-kinase α-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis
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Includes: Supplementary data
Articles

How can we make publishing less painful?

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Peter R. Shepherd
Journal: Biochemical Journal
Biochem J (2012) 443 (1): 1.
https://doi.org/10.1042/BJ20120214
Published: 14 March 2012
View articletitled, How can we make publishing less painful?
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Articles

IκB kinase β (IKKβ) does not mediate feedback inhibition of the insulin signalling cascade

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Graeme I. Lancaster, Beata Skiba, Christine Yang, Hayley T. Nicholls, Katherine G. Langley, M. H. Stanley Chan, Clinton R. Bruce, Gordon W. Rewcastle, Peter R. Shepherd, Michael Karin, Mark A. Febbraio
Journal: Biochemical Journal
Biochem J (2012) 442 (3): 723–732.
https://doi.org/10.1042/BJ20112037
Published: 24 February 2012
View articletitled, IκB kinase β (IKKβ) does not mediate feedback inhibition of the insulin signalling cascade
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Includes: Supplementary data
Articles

Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivo

Open Access
Greg C. Smith, Wee Kiat Ong, Gordon W. Rewcastle, Jackie D. Kendall, Weiping Han, Peter R. Shepherd
Journal: Biochemical Journal
Biochem J (2012) 442 (1): 161–169.
https://doi.org/10.1042/BJ20111913
Published: 27 January 2012
View articletitled, Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivo
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Includes: Supplementary data
Articles

A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types

Open Access
Stephen Jamieson, Jack U. Flanagan, Sharada Kolekar, Christina Buchanan, Jackie D. Kendall, Woo-Jeong Lee, Gordon W. Rewcastle, William A. Denny, Ripudaman Singh, James Dickson, Bruce C. Baguley, Peter R. Shepherd
Journal: Biochemical Journal
Biochem J (2011) 438 (1): 53–62.
https://doi.org/10.1042/BJ20110502
Published: 27 July 2011
View articletitled, A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types
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Includes: Supplementary data
Articles

Glucose induces an autocrine activation of the Wnt/β-catenin pathway in macrophage cell lines

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Sasha H. Anagnostou, Peter R. Shepherd
Journal: Biochemical Journal
Biochem J (2008) 416 (2): 211–218.
https://doi.org/10.1042/BJ20081426
Published: 12 November 2008
View articletitled, Glucose induces an autocrine activation of the Wnt/β-catenin pathway in macrophage cell lines
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Articles

Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling

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Claire Chaussade, Gordon W. Rewcastle, Jackie D. Kendall, William A. Denny, Kitty Cho, Line M. Grønning, Mei Ling Chong, Sasha H. Anagnostou, Shaun P. Jackson, Nathalie Daniele, Peter R. Shepherd
Journal: Biochemical Journal
Biochem J (2007) 404 (3): 449–458.
https://doi.org/10.1042/BJ20070003
Published: 29 May 2007
View articletitled, Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling
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Articles

Secrets of insulin and IGF-1 regulation of insulin secretion revealed

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Peter R. SHEPHERD
Journal: Biochemical Journal
Biochem J (2004) 377 (1): e1–e2.
https://doi.org/10.1042/bj20031747
Published: 01 January 2004
View articletitled, Secrets of insulin and IGF-1 regulation of insulin secretion revealed
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Articles

Biphasic regulation of extracellular-signal-regulated protein kinase by leptin in macrophages: role in regulating STAT3 Ser727 phosphorylation and DNA binding

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Lisa O'ROURKE, Peter R. SHEPHERD
Journal: Biochemical Journal
Biochem J (2002) 364 (3): 875–879.
https://doi.org/10.1042/bj20020295
Published: 15 June 2002
View articletitled, Biphasic regulation of extracellular-signal-regulated protein kinase by leptin in macrophages: role in regulating STAT3 Ser727 phosphorylation and DNA binding
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Articles

Comparison of the kinetic properties of the lipid- and protein-kinase activities of the p110α and p110β catalytic subunits of class-Ia phosphoinositide 3-kinases

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Carolyn A. BEETON, Edwin M. CHANCE, Lazaros C. FOUKAS, Peter R. SHEPHERD
Journal: Biochemical Journal
Biochem J (2000) 350 (2): 353–359.
https://doi.org/10.1042/bj3500353
Published: 23 August 2000
View articletitled, Comparison of the kinetic properties of the lipid- and protein-kinase activities of the p110α and p110β catalytic subunits of class-Ia phosphoinositide 3-kinases
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Articles

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation

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Barbara T. NAVÉ, D. Margriet OUWENS, Dominic J. WITHERS, Dario R. ALESSI, Peter R. SHEPHERD
Journal: Biochemical Journal
Biochem J (1999) 344 (2): 427–431.
https://doi.org/10.1042/bj3440427
Published: 24 November 1999
View articletitled, Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation
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Articles

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

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Peter R. SHEPHERD, Dominic J. WITHERS, Kenneth SIDDLE
Journal: Biochemical Journal
Biochem J (1998) 333 (3): 471–490.
https://doi.org/10.1042/bj3330471
Published: 01 August 1998
View articletitled, Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling
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Articles

Compartment-specific regulation of phosphoinositide 3-kinase by platelet-derived growth factor and insulin in 3T3-L1 adipocytes

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Barbara T. NAVÉ, RichardHAIGH J, Amanda C HAYWARD, Kenneth SIDDLE, Peter R. SHEPHERD
Journal: Biochemical Journal
Biochem J (1996) 318 (1): 55–60.
https://doi.org/10.1042/bj3180055
Published: 15 August 1996
View articletitled, Compartment-specific regulation of phosphoinositide 3-kinase by platelet-derived growth factor and insulin in 3T3-L1 adipocytes
Open the PDF for Compartment-specific regulation of phosphoinositide 3-kinase by platelet-derived growth factor and insulin in 3T3-L1 adipocytes in another window
Articles

Phorbol esters stimulate phosphatidylinositol 3,4,5-trisphosphate production in 3T3-L1 adipocytes: implications for stimulation of glucose transport

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Barbara T. NAVÉ, Kenneth SIDDLE, Peter R SHEPHERD
Journal: Biochemical Journal
Biochem J (1996) 318 (1): 203–205.
https://doi.org/10.1042/bj3180203
Published: 15 August 1996
View articletitled, Phorbol esters stimulate phosphatidylinositol 3,4,5-trisphosphate production in 3T3-L1 adipocytes: implications for stimulation of glucose transport
Open the PDF for Phorbol esters stimulate phosphatidylinositol 3,4,5-trisphosphate production in 3T3-L1 adipocytes: implications for stimulation of glucose transport in another window