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Philip E. Thompson
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Articles

Methods to accelerate PROTAC drug discovery

Open Access
Jeyan Osman, Philip E. Thompson, Manuela Jörg, Martin J. Scanlon
Journal: Biochemical Journal
Biochem J (2025) 482 (13): 921–937.
https://doi.org/10.1042/BCJ20243018
Published: 25 June 2025
View article titled, Methods to accelerate PROTAC drug discovery
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Articles

Definition of the binding mode of a new class of phosphoinositide 3-kinase α-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis

Available to Purchase
Zhaohua Zheng, Syazwani I. Amran, Jiuxiang Zhu, Oleg Schmidt-Kittler, Kenneth W. Kinzler, Bert Vogelstein, Peter R. Shepherd, Philip E. Thompson, Ian G. Jennings
Journal: Biochemical Journal
Biochem J (2012) 444 (3): 529–535.
https://doi.org/10.1042/BJ20120499
Published: 29 May 2012
View article titled, Definition of the binding mode of a new class of phosphoinositide 3-kinase α-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis
Open the PDF for Definition of the binding mode of a new class of phosphoinositide 3-kinase α-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis in another window
Includes: Supplementary data
Articles

Dissecting isoform selectivity of PI3K inhibitors: the role of non-conserved residues in the catalytic pocket

Available to Purchase
Mark Frazzetto, Cenk Suphioglu, Jiuxiang Zhu, Oleg Schmidt-Kittler, Ian G. Jennings, Susan L. Cranmer, Shaun P. Jackson, Kenneth W. Kinzler, Bert Vogelstein, Philip E. Thompson
Journal: Biochemical Journal
Biochem J (2008) 414 (3): 383–390.
https://doi.org/10.1042/BJ20080512
Published: 27 August 2008
View article titled, Dissecting isoform selectivity of PI3K inhibitors: the role of non-conserved residues in the catalytic pocket
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Includes: Supplementary data
Articles

Identification of a unique filamin A binding region within the cytoplasmic domain of glycoprotein Ibα

Available to Purchase
Susan L. CRANMER, Inna PIKOVSKI, Pierre MANGIN, Philip E. THOMPSON, Teresa DOMAGALA, Mark FRAZZETTO, Hatem H. SALEM, Shaun P. JACKSON
Journal: Biochemical Journal
Biochem J (2005) 387 (3): 849–858.
https://doi.org/10.1042/BJ20041836
Published: 26 April 2005
View article titled, Identification of a unique filamin A binding region within the cytoplasmic domain of glycoprotein Ibα
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