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R H Michell
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Articles

Regulation of neurite outgrowth from differentiated human neuroepithelial cells: a comparison of the activities of prothrombin and thrombin

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A S Turnell, D P Brant, G R Brown, M Finney, P H Gallimore, C J Kirk, T R V Pagliuca, C J Campbell, R H Michell, R J A Grand
Journal: Biochemical Journal
Biochem J (1995) 308 (3): 965–973.
https://doi.org/10.1042/bj3080965
Published: 15 June 1995
View articletitled, Regulation of neurite outgrowth from differentiated human neuroepithelial cells: a comparison of the activities of prothrombin and thrombin
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Articles

Inositol 1,2,3-trisphosphate and inositol 1,2- and/or 2,3-bisphosphate are normal constituents of mammalian cells

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C J Barker, P J French, A J Moore, T Nilsson, P O Berggren, C M Bunce, C J Kirk, R H Michell
Journal: Biochemical Journal
Biochem J (1995) 306 (2): 557–564.
https://doi.org/10.1042/bj3060557
Published: 01 March 1995
View articletitled, Inositol 1,2,3-trisphosphate and inositol 1,2- and/or 2,3-bisphosphate are normal constituents of mammalian cells
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Articles

The intracellular distribution of inositol polyphosphates in HL60 promyeloid cells

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J A Stuart, K L Anderson, P J French, C J Kirk, R H Michell
Journal: Biochemical Journal
Biochem J (1994) 303 (2): 517–525.
https://doi.org/10.1042/bj3030517
Published: 15 October 1994
View articletitled, The intracellular distribution of inositol polyphosphates in HL60 promyeloid cells
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Articles

Bovine testis and human erythrocytes contain different subtypes of membrane-associated Ins(1,4,5) P 3 /Ins(1,3,4,5) P 4 5-phosphomonoesterases

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M Hodgkin, A Craxton, J B Parry, P J Hughes, B V Potter, R H Michell, C J Kirk
Journal: Biochemical Journal
Biochem J (1994) 297 (3): 637–645.
https://doi.org/10.1042/bj2970637
Published: 01 February 1994
View articletitled, Bovine testis and human erythrocytes contain different subtypes of membrane-associated Ins(1,4,5) P 3 /Ins(1,3,4,5) P 4 5-phosphomonoesterases
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Articles

Simultaneous oscillations of cytoplasmic free Ca 2+ concentration and Ins(1,4,5) P 3 concentration in mouse pancreatic β -cells

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C J Barker, T Nilsson, C J Kirk, R H Michell, P O Berggren
Journal: Biochemical Journal
Biochem J (1994) 297 (2): 265–268.
https://doi.org/10.1042/bj2970265
Published: 15 January 1994
View articletitled, Simultaneous oscillations of cytoplasmic free Ca 2+ concentration and Ins(1,4,5) P 3 concentration in mouse pancreatic β -cells
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Articles

Comparison of the levels of inositol metabolites in transformed haemopoietic cells and their normal counterparts

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C M Bunce, P J French, P Allen, J C Mountford, B Moor, M F Greaves, R H Michell, G Brown
Journal: Biochemical Journal
Biochem J (1993) 289 (3): 667–673.
https://doi.org/10.1042/bj2890667
Published: 01 February 1993
View articletitled, Comparison of the levels of inositol metabolites in transformed haemopoietic cells and their normal counterparts
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Articles

The effects of thimerosal on calcium uptake and inositol 1,4,5-trisphosphate-induced calcium release in cerebellar microsomes

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L G Sayers, G R Brown, R H Michell, F Michelangeli
Journal: Biochemical Journal
Biochem J (1993) 289 (3): 883–887.
https://doi.org/10.1042/bj2890883
Published: 01 February 1993
View articletitled, The effects of thimerosal on calcium uptake and inositol 1,4,5-trisphosphate-induced calcium release in cerebellar microsomes
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Articles

The inositol phosphates in WRK1 rat mammary tumour cells

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N S Wong, C J Barker, A J Morris, A Craxton, C J Kirk, R H Michell
Journal: Biochemical Journal
Biochem J (1992) 286 (2): 459–468.
https://doi.org/10.1042/bj2860459
Published: 01 September 1992
View articletitled, The inositol phosphates in WRK1 rat mammary tumour cells
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Articles

The interrelationships of the inositol phosphates formed in vasopressin-stimulated WRK-1 rat mammary tumour cells

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C J Barker, N S Wong, S M Maccallum, P A Hunt, R H Michell, C J Kirk
Journal: Biochemical Journal
Biochem J (1992) 286 (2): 469–474.
https://doi.org/10.1042/bj2860469
Published: 01 September 1992
View articletitled, The interrelationships of the inositol phosphates formed in vasopressin-stimulated WRK-1 rat mammary tumour cells
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Articles

The opening of the inositol 1,4,5-trisphosphate-sensitive Ca 2+ channel in rat cerebellum is inhibited by caffeine

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G R Brown, L G Sayers, C J Kirk, R H Michell, F Michelangeli
Journal: Biochemical Journal
Biochem J (1992) 282 (2): 309–312.
https://doi.org/10.1042/bj2820309
Published: 01 March 1992
View articletitled, The opening of the inositol 1,4,5-trisphosphate-sensitive Ca 2+ channel in rat cerebellum is inhibited by caffeine
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Articles

Mitogen-induced phosphorylation of human B-lymphocyte proteins. Relationship to protein kinase C activation

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G R Guy, M Finney, R H Michell, J Gordon
Journal: Biochemical Journal
Biochem J (1989) 263 (1): 57–64.
https://doi.org/10.1042/bj2630057
Published: 01 October 1989
View articletitled, Mitogen-induced phosphorylation of human B-lymphocyte proteins. Relationship to protein kinase C activation
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Articles

Determination of the steady-state turnover rates of the metabolically active pools of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in human erythrocytes

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C E King, P T Hawkins, L R Stephens, R H Michell
Journal: Biochemical Journal
Biochem J (1989) 259 (3): 893–896.
https://doi.org/10.1042/bj2590893
Published: 01 May 1989
View articletitled, Determination of the steady-state turnover rates of the metabolically active pools of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in human erythrocytes
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Articles

Preferential localization of rat liver d-myo-inositol 1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase in bile-canalicular plasma membrane and ‘late’ endosomal vesicles

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S B Shears, W H Evans, C J Kirk, R H Michell
Journal: Biochemical Journal
Biochem J (1988) 256 (2): 363–369.
https://doi.org/10.1042/bj2560363
Published: 01 December 1988
View articletitled, Preferential localization of rat liver d-myo-inositol 1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase in bile-canalicular plasma membrane and ‘late’ endosomal vesicles
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Articles

1d-myo-inositol 1,4,5-trisphosphate dephosphorylation by rat enterocytes involves an intracellular 5-phosphatase and non-specific phosphatase activity at the cell surface

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C Rubiera, G Velasco, R H Michell, P S Lazo, S B Shears
Journal: Biochemical Journal
Biochem J (1988) 255 (1): 131–137.
https://doi.org/10.1042/bj2550131
Published: 01 October 1988
View articletitled, 1d-myo-inositol 1,4,5-trisphosphate dephosphorylation by rat enterocytes involves an intracellular 5-phosphatase and non-specific phosphatase activity at the cell surface
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Articles

Dephosphorylation of 1d-myo-inositol 1,4-bisphosphate in rat liver

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A J Morris, D J Storey, C P Downes, R H Michell
Journal: Biochemical Journal
Biochem J (1988) 254 (3): 655–660.
https://doi.org/10.1042/bj2540655
Published: 15 September 1988
View articletitled, Dephosphorylation of 1d-myo-inositol 1,4-bisphosphate in rat liver
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Articles

Inositol 1:2(cyclic),4,5-trisphosphate is not a major product of inositol phospholipid metabolism in vasopressin-stimulated WRK1 cells

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N S Wong, C J Barker, S B Shears, C J Kirk, R H Michell
Journal: Biochemical Journal
Biochem J (1988) 252 (1): 1–5.
https://doi.org/10.1042/bj2520001
Published: 15 May 1988
View articletitled, Inositol 1:2(cyclic),4,5-trisphosphate is not a major product of inositol phospholipid metabolism in vasopressin-stimulated WRK1 cells
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Articles

Partial purification and some properties of rat brain inositol 1,4,5-trisphosphate 3-kinase

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A J Morris, K J Murray, P J England, C P Downes, R H Michell
Journal: Biochemical Journal
Biochem J (1988) 251 (1): 157–163.
https://doi.org/10.1042/bj2510157
Published: 01 April 1988
View articletitled, Partial purification and some properties of rat brain inositol 1,4,5-trisphosphate 3-kinase
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Articles

The pathway of myo -inositol 1,3,4-trisphosphate dephosphorylation in liver

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S B Shears, C J Kirk, R H Michell
Journal: Biochemical Journal
Biochem J (1987) 248 (3): 977–980.
https://doi.org/10.1042/bj2480977
Published: 15 December 1987
View articletitled, The pathway of myo -inositol 1,3,4-trisphosphate dephosphorylation in liver
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Articles

Turkey erythrocytes possess a membrane-associated inositol 1,4,5-trisphosphate 3-kinase that is activated by Ca 2+ in the presence of calmodulin

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A J Morris, C P Downes, T K Harden, R H Michell
Journal: Biochemical Journal
Biochem J (1987) 248 (2): 489–493.
https://doi.org/10.1042/bj2480489
Published: 01 December 1987
View articletitled, Turkey erythrocytes possess a membrane-associated inositol 1,4,5-trisphosphate 3-kinase that is activated by Ca 2+ in the presence of calmodulin
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Articles

Metabolism of d-myo-inositol 1,3,4,5-tetrakisphosphate by rat liver, including the synthesis of a novel isomer of myo-inositol tetrakisphosphate

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S B Shears, J B Parry, E K Tang, R F Irvine, R H Michell, C J Kirk
Journal: Biochemical Journal
Biochem J (1987) 246 (1): 139–147.
https://doi.org/10.1042/bj2460139
Published: 15 August 1987
View articletitled, Metabolism of d-myo-inositol 1,3,4,5-tetrakisphosphate by rat liver, including the synthesis of a novel isomer of myo-inositol tetrakisphosphate
Open the PDF for Metabolism of d-myo-inositol 1,3,4,5-tetrakisphosphate by rat liver, including the synthesis of a novel isomer of myo-inositol tetrakisphosphate in another window
Articles

Multiple metabolic pools of phosphoinositides and phosphatidate in human erythrocytes incubated in a medium that permits rapid transmembrane exchange of phosphate

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C E King, L R Stephens, P T Hawkins, G R Guy, R H Michell
Journal: Biochemical Journal
Biochem J (1987) 244 (1): 209–217.
https://doi.org/10.1042/bj2440209
Published: 15 May 1987
View articletitled, Multiple metabolic pools of phosphoinositides and phosphatidate in human erythrocytes incubated in a medium that permits rapid transmembrane exchange of phosphate
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Articles

Dephosphorylation of myo -inositol 1,4,5-trisphosphate and myo -inositol 1,3,4-triphosphate

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S B Shears, D J Storey, A J Morris, A B Cubitt, J B Parry, R H Michell, C J Kirk
Journal: Biochemical Journal
Biochem J (1987) 242 (2): 393–402.
https://doi.org/10.1042/bj2420393
Published: 01 March 1987
View articletitled, Dephosphorylation of myo -inositol 1,4,5-trisphosphate and myo -inositol 1,3,4-triphosphate
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Articles

The labelling of polyphosphoinositides with [ 32 P]P i and the accumulation of inositol phosphates in vasopressin-stimulated hepatocytes

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S Palmer, P T Hawkins, R H Michell, C J Kirk
Journal: Biochemical Journal
Biochem J (1986) 238 (2): 491–499.
https://doi.org/10.1042/bj2380491
Published: 01 September 1986
View articletitled, The labelling of polyphosphoinositides with [ 32 P]P i and the accumulation of inositol phosphates in vasopressin-stimulated hepatocytes
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Articles

Accumulation of inositol phosphates in sympathetic ganglia. Effects of depolarization and of amine and peptide neurotransmitters

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E A Bone, R H Michell
Journal: Biochemical Journal
Biochem J (1985) 227 (1): 263–269.
https://doi.org/10.1042/bj2270263
Published: 01 April 1985
View articletitled, Accumulation of inositol phosphates in sympathetic ganglia. Effects of depolarization and of amine and peptide neurotransmitters
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Articles

Rapid accumulation of inositol phosphates in isolated rat superior cervical sympathetic ganglia exposed to V 1 -vasopressin and muscarinic cholinergic stimuli

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E A Bone, P Fretten, S Palmer, C J Kirk, R H Michell
Journal: Biochemical Journal
Biochem J (1984) 221 (3): 803–811.
https://doi.org/10.1042/bj2210803
Published: 01 August 1984
View articletitled, Rapid accumulation of inositol phosphates in isolated rat superior cervical sympathetic ganglia exposed to V 1 -vasopressin and muscarinic cholinergic stimuli
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Articles

Analysis of the metabolic turnover of the individual phosphate groups of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate. Validation of novel analytical techniques by using 32 P-labelled lipids from erythrocytes

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P T Hawkins, R H Michell, C J Kirk
Journal: Biochemical Journal
Biochem J (1984) 218 (3): 785–793.
https://doi.org/10.1042/bj2180785
Published: 15 March 1984
View articletitled, Analysis of the metabolic turnover of the individual phosphate groups of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate. Validation of novel analytical techniques by using 32 P-labelled lipids from erythrocytes
Open the PDF for Analysis of the metabolic turnover of the individual phosphate groups of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate. Validation of novel analytical techniques by using 32 P-labelled lipids from erythrocytes in another window
Articles

Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca 2+ -mobilizing hormones

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J A Creba, C P Downes, P T Hawkins, G Brewster, R H Michell, C J Kirk
Journal: Biochemical Journal
Biochem J (1983) 212 (3): 733–747.
https://doi.org/10.1042/bj2120733
Published: 15 June 1983
View articletitled, Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca 2+ -mobilizing hormones
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Articles

A simple assay method for determination of the specific radioactivity of the γ-phosphate group of 32 P-labelled ATP.

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P T Hawkins, R H Michell, C J Kirk
Journal: Biochemical Journal
Biochem J (1983) 210 (3): 717–720.
https://doi.org/10.1042/bj2100717
Published: 15 March 1983
View articletitled, A simple assay method for determination of the specific radioactivity of the γ-phosphate group of 32 P-labelled ATP.
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Articles

The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane

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C P Downes, M C Mussat, R H Michell
Journal: Biochemical Journal
Biochem J (1982) 203 (1): 169–177.
https://doi.org/10.1042/bj2030169
Published: 01 April 1982
View articletitled, The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane
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Articles

Studies of receptor-stimulated inositol lipid metabolism should focus upon measurements of inositol lipid breakdown

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R H Michell, C J Kirk
Journal: Biochemical Journal
Biochem J (1981) 198 (1): 247–248.
https://doi.org/10.1042/bj1980247
Published: 15 July 1981
View articletitled, Studies of receptor-stimulated inositol lipid metabolism should focus upon measurements of inositol lipid breakdown
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Articles

Phosphatidylinositol metabolism in rat hepatocytes stimulated by vasopressin

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C J Kirk, R H Michell, D A Hems
Journal: Biochemical Journal
Biochem J (1981) 194 (1): 155–165.
https://doi.org/10.1042/bj1940155
Published: 15 January 1981
View articletitled, Phosphatidylinositol metabolism in rat hepatocytes stimulated by vasopressin
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Articles

Selective release of plasma-membrane enzymes from rat hepatocytes by a phosphatidylinositol-specific phospholipase C

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S D Shukla, R Coleman, J B Finean, R H Michell
Journal: Biochemical Journal
Biochem J (1980) 187 (1): 277–280.
https://doi.org/10.1042/bj1870277
Published: 01 April 1980
View articletitled, Selective release of plasma-membrane enzymes from rat hepatocytes by a phosphatidylinositol-specific phospholipase C
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Articles

Are polyphosphoinositides associated with glycophorin in human erythrocyte membranes?

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S D Shukla, R Coleman, J B Finean, R H Michell
Journal: Biochemical Journal
Biochem J (1979) 179 (2): 441–444.
https://doi.org/10.1042/bj1790441
Published: 01 May 1979
View articletitled, Are polyphosphoinositides associated with glycophorin in human erythrocyte membranes?
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Articles

Calcium ion-dependent diacylglycerol accumulation in erythrocytes is associated with microvesiculation but not with efflux of potassium ions

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D Allan, R H Michell
Journal: Biochemical Journal
Biochem J (1977) 166 (3): 495–499.
https://doi.org/10.1042/bj1660495
Published: 15 September 1977
View articletitled, Calcium ion-dependent diacylglycerol accumulation in erythrocytes is associated with microvesiculation but not with efflux of potassium ions
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Articles

A comparison of the effects of phytohaemagglutinin and of calcium ionophore A23187 on the metabolism of glycerolipids in small lymphocytes

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D Allan, R H Michell
Journal: Biochemical Journal
Biochem J (1977) 164 (2): 389–397.
https://doi.org/10.1042/bj1640389
Published: 15 May 1977
View articletitled, A comparison of the effects of phytohaemagglutinin and of calcium ionophore A23187 on the metabolism of glycerolipids in small lymphocytes
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Articles

Effects of calcium-antagonistic drugs on the stimulation by carbamoylcholine and histamine of phosphatidylinositol turnover in longitudinal smooth muscle of guinea-pig ileum

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S S Jafferji, R H Michell
Journal: Biochemical Journal
Biochem J (1976) 160 (2): 163–169.
https://doi.org/10.1042/bj1600163
Published: 15 November 1976
View articletitled, Effects of calcium-antagonistic drugs on the stimulation by carbamoylcholine and histamine of phosphatidylinositol turnover in longitudinal smooth muscle of guinea-pig ileum
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Articles

Investigation of the relationship between cell-surface calcium-ion gating and phosphatidylinositol turnover by comparison of the effects of elevated extracellular potassium ion concentration on ileium smooth muscle and pancreas

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S S Jafferji, R H Michell
Journal: Biochemical Journal
Biochem J (1976) 160 (2): 397–399.
https://doi.org/10.1042/bj1600397
Published: 15 November 1976
View articletitled, Investigation of the relationship between cell-surface calcium-ion gating and phosphatidylinositol turnover by comparison of the effects of elevated extracellular potassium ion concentration on ileium smooth muscle and pancreas
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Articles

Cholinergically stimulated phosphatidylinositol breakdown in parotid-gland fragments is independent of the ionic environment

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L M Jones, R H Michell
Journal: Biochemical Journal
Biochem J (1976) 158 (2): 505–507.
https://doi.org/10.1042/bj1580505
Published: 15 August 1976
View articletitled, Cholinergically stimulated phosphatidylinositol breakdown in parotid-gland fragments is independent of the ionic environment
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Articles

Production of 1,2-diacylglycerol and phosphatidate in human erythrocytes treated with calcium ions and ionophore A23187

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D Allan, R Watts, R H Michell
Journal: Biochemical Journal
Biochem J (1976) 156 (2): 225–232.
https://doi.org/10.1042/bj1560225
Published: 15 May 1976
View articletitled, Production of 1,2-diacylglycerol and phosphatidate in human erythrocytes treated with calcium ions and ionophore A23187
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Articles

Muscarinic cholinergic stimulation of phosphatidylinositol turnover in the longitudinal smooth muscle of guinea-pig ileum

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S S. Jafferji, R H. Michell
Journal: Biochemical Journal
Biochem J (1976) 154 (3): 653–657.
https://doi.org/10.1042/bj1540653
Published: 15 March 1976
View articletitled, Muscarinic cholinergic stimulation of phosphatidylinositol turnover in the longitudinal smooth muscle of guinea-pig ileum
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Articles

Basolateral plasma membranes of intestinal epithelial cells. Identification by lactoperoxidase-catalysed iodination and isolation after density perturbation with digitonin

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B A Lewis, A Elkin, R H Michell, R Coleman
Journal: Biochemical Journal
Biochem J (1975) 152 (1): 71–84.
https://doi.org/10.1042/bj1520071
Published: 01 October 1975
View articletitled, Basolateral plasma membranes of intestinal epithelial cells. Identification by lactoperoxidase-catalysed iodination and isolation after density perturbation with digitonin
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Articles

The relationship of calcium to receptor-controlled stimulation of phosphatidylinositol turnover. Effects of acetylcholine, adrenaline, calcium ions, cinchocaine and a bivalent cation ionophore on rat parotid-gland fragments

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L M Jones, R H Michell
Journal: Biochemical Journal
Biochem J (1975) 148 (3): 479–485.
https://doi.org/10.1042/bj1480479
Published: 01 June 1975
View articletitled, The relationship of calcium to receptor-controlled stimulation of phosphatidylinositol turnover. Effects of acetylcholine, adrenaline, calcium ions, cinchocaine and a bivalent cation ionophore on rat parotid-gland fragments
Open the PDF for The relationship of calcium to receptor-controlled stimulation of phosphatidylinositol turnover. Effects of acetylcholine, adrenaline, calcium ions, cinchocaine and a bivalent cation ionophore on rat parotid-gland fragments in another window
Articles

Enhanced synthesis de novo of phosphatidylinositol in lymphocytes treated with cationic amphiphilic drugs

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D Allan, R H Michell
Journal: Biochemical Journal
Biochem J (1975) 148 (3): 471–478.
https://doi.org/10.1042/bj1480471
Published: 01 June 1975
View articletitled, Enhanced synthesis de novo of phosphatidylinositol in lymphocytes treated with cationic amphiphilic drugs
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Articles

Phosphatidylinositol kinase activity in Saccharomyces cerevisiae

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G E Wheeler, R H Michell, A H Rose
Journal: Biochemical Journal
Biochem J (1972) 127 (3): 64P.
https://doi.org/10.1042/bj1270064Pa
Published: 01 April 1972
View articletitled, Phosphatidylinositol kinase activity in Saccharomyces cerevisiae
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Articles

Glycerylphosphorylcholine phosphodiesterase in rat liver plasma membranes

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K A Lloyd-Davies, R H Michell, R Coleman
Journal: Biochemical Journal
Biochem J (1972) 127 (2): 36P.
https://doi.org/10.1042/bj1270036Pa
Published: 01 April 1972
View articletitled, Glycerylphosphorylcholine phosphodiesterase in rat liver plasma membranes
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Articles

Phosphatidylinositol turnover stimulated by acetylcholine: subcellular distribution in rat cerebral cortex

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E G Lapetina, R H Michell
Journal: Biochemical Journal
Biochem J (1972) 127 (2): 36P–37P.
https://doi.org/10.1042/bj1270036Pb
Published: 01 April 1972
View articletitled, Phosphatidylinositol turnover stimulated by acetylcholine: subcellular distribution in rat cerebral cortex
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Articles

Lipase activity against 1,2-diglyceride in rat erythrocyte membranes

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R H Michell, R Coleman
Journal: Biochemical Journal
Biochem J (1971) 124 (5): 49P–50P.
https://doi.org/10.1042/bj1240049Pb
Published: 01 October 1971
View articletitled, Lipase activity against 1,2-diglyceride in rat erythrocyte membranes
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