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Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC

Tom Snelling, Natalia Shpiro, Robert Gourlay, Frederic Lamoliatte, Philip Cohen

Biochem J (2022) 479 (20): 2195–2216.

https://doi.org/10.1042/BCJ20220401

Published: 21 October 2022

View article titled, Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC

Includes: Supplementary data

Articles

PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the COR B GTPase domain

Asad U. Malik, Athanasios Karapetsas, Raja S. Nirujogi, Deep Chatterjee, Toan K. Phung, Melanie Wightman, Robert Gourlay, Nick Morrice, Sebastian Mathea, Stefan Knapp, Dario R. Alessi

Biochem J (2022) 479 (18): 1941–1965.

https://doi.org/10.1042/BCJ20220308

Published: 23 September 2022

View article titled, PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the COR B GTPase domain

Articles

An ERK5–KLF2 signalling module regulates early embryonic gene expression and telomere rejuvenation in stem cells

Helen A. Brown, Charles A.C. Williams, Houjiang Zhou, Diana Rios-Szwed, Rosalia Fernandez-Alonso, Saria Mansoor, Liam McMulkin, Rachel Toth, Robert Gourlay, Julien Peltier, Nora Dieguez-Martinez, Matthias Trost, Jose M. Lizcano, Marios P. Stavridis, Greg M. Findlay

Biochem J (2021) 478 (23): 4119–4136.

https://doi.org/10.1042/BCJ20210646

Published: 06 December 2021

View article titled, An ERK5–KLF2 signalling module regulates early embryonic gene expression and telomere rejuvenation in stem cells

Articles

Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms

In Collection

Protein structure and function

Asad U. Malik, Athanasios Karapetsas, Raja S. Nirujogi, Sebastian Mathea, Deep Chatterjee, Prosenjit Pal, Pawel Lis, Matthew Taylor, Elena Purlyte, Robert Gourlay, Mark Dorward, Simone Weidlich, Rachel Toth, Nicole K. Polinski, Stefan Knapp, Francesca Tonelli, Dario R. Alessi

Biochem J (2021) 478 (3): 553–578.

https://doi.org/10.1042/BCJ20200937

Published: 10 February 2021

View article titled, Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms

Includes: Supplementary data

Articles

Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44

Nazma Malik, Raja S. Nirujogi, Julien Peltier, Thomas Macartney, Melanie Wightman, Alan R. Prescott, Robert Gourlay, Matthias Trost, Dario R. Alessi, Athanasios Karapetsas

Biochem J (2019) 476 (20): 3081–3107.

https://doi.org/10.1042/BCJ20190608

Published: 30 October 2019

View article titled, Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44

Includes: Supplementary data

Articles

Kinase and channel activity of TRPM6 are co-ordinated by a dimerization motif and pocket interaction

Jenny van der Wijst, Maxime G. Blanchard, Helen I. Woodroof, Thomas J. Macartney, Robert Gourlay, Joost G. Hoenderop, René J. Bindels, Dario R. Alessi

Biochem J (2014) 460 (2): 165–175.

https://doi.org/10.1042/BJ20131639

Published: 13 May 2014

View article titled, Kinase and channel activity of TRPM6 are co-ordinated by a dimerization motif and pocket interaction

Includes: Supplementary data

Articles

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser 65

Agne Kazlauskaite, Chandana Kondapalli, Robert Gourlay, David G. Campbell, Maria Stella Ritorto, Kay Hofmann, Dario R. Alessi, Axel Knebel, Matthias Trost, Miratul M. K. Muqit

Biochem J (2014) 460 (1): 127–141.

https://doi.org/10.1042/BJ20140334

Published: 25 April 2014

View article titled, Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser 65

Includes: Supplementary data

Articles

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K + –Cl − co-transporters

Paola de los Heros, Dario R. Alessi, Robert Gourlay, David G. Campbell, Maria Deak, Thomas J. Macartney, Kristopher T. Kahle, Jinwei Zhang

Biochem J (2014) 458 (3): 559–573.

https://doi.org/10.1042/BJ20131478

Published: 28 February 2014

View article titled, The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K + –Cl − co-transporters

Articles

Investigation of LKB1 Ser 431 phosphorylation and Cys 433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity

Vanessa P. Houde, Maria Stella Ritorto, Robert Gourlay, Joby Varghese, Paul Davies, Natalia Shpiro, Kei Sakamoto, Dario R. Alessi

Biochem J (2014) 458 (1): 41–56.

https://doi.org/10.1042/BJ20131324

Published: 20 January 2014

View article titled, Investigation of LKB1 Ser 431 phosphorylation and Cys 433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity

Includes: Supplementary data

Articles

The role of TBK1 and IKKϵ in the expression and activation of Pellino 1

Hilary Smith, Xin-Yu Liu, Liang Dai, Eddy T. H. Goh, Aye-Thu Chan, Jiajia Xi, Cheah-Chen Seh, Insaf A. Qureshi, Julien Lescar, Christiane Ruedl, Robert Gourlay, Simon Morton, Joanne Hough, Edward G. McIver, Philip Cohen, Peter C. F. Cheung

Biochem J (2011) 434 (3): 537–548.

https://doi.org/10.1042/BJ20101421

Published: 24 February 2011

View article titled, The role of TBK1 and IKKϵ in the expression and activation of Pellino 1

Includes: Supplementary data

Articles

Identification of Protor as a novel Rictor-binding component of mTOR complex-2

Laura R. Pearce, Xu Huang, Jérôme Boudeau, Rafał Pawłowski, Stephan Wullschleger, Maria Deak, Adel F. M. Ibrahim, Robert Gourlay, Mark A. Magnuson, Dario R. Alessi

Biochem J (2007) 405 (3): 513–522.

https://doi.org/10.1042/BJ20070540

Published: 13 July 2007

View article titled, Identification of Protor as a novel Rictor-binding component of mTOR complex-2

Includes: Supplementary data

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Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC

PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the COR B GTPase domain

An ERK5–KLF2 signalling module regulates early embryonic gene expression and telomere rejuvenation in stem cells

Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms

Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44

Kinase and channel activity of TRPM6 are co-ordinated by a dimerization motif and pocket interaction

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser 65

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K + –Cl − co-transporters

Investigation of LKB1 Ser 431 phosphorylation and Cys 433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity

The role of TBK1 and IKKϵ in the expression and activation of Pellino 1

Identification of Protor as a novel Rictor-binding component of mTOR complex-2

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