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Simon A. Hawley
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Articles

AMP-activated protein kinase can be allosterically activated by ADP but AMP remains the key activating ligand

Open Access
Simon A. Hawley, Fiona M. Russell, D. Grahame Hardie
Journal: Biochemical Journal
Biochem J (2024) 481 (8): 587–599.
https://doi.org/10.1042/BCJ20240082
Published: 22 April 2024
View articletitled, AMP-activated protein kinase can be allosterically activated by ADP but AMP remains the key activating ligand
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Includes: Supplementary data
Articles

Frequent loss-of-function mutations in the AMPK-α2 catalytic subunit suggest a tumour suppressor role in human skin cancers

Open Access
Fiona A. Ross, Simon A. Hawley, Fiona M. Russell, Nicola Goodman, D. Grahame Hardie
Journal: Biochemical Journal
Biochem J (2023) 480 (23): 1951–1968.
https://doi.org/10.1042/BCJ20230380
Published: 01 December 2023
View articletitled, Frequent loss-of-function mutations in the AMPK-α2 catalytic subunit suggest a tumour suppressor role in human skin cancers
Open the PDF for Frequent loss-of-function mutations in the AMPK-α2 catalytic subunit suggest a tumour suppressor role in human skin cancers in another window
Articles

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

Open Access
Simon A. Hawley, Fiona A. Ross, Graeme J. Gowans, Priyanka Tibarewal, Nicholas R. Leslie, D. Grahame Hardie
Journal: Biochemical Journal
Biochem J (2014) 459 (2): 275–287.
https://doi.org/10.1042/BJ20131344
Published: 28 March 2014
View articletitled, Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells
Open the PDF for Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells in another window
Includes: Supplementary data
Articles

Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: synergistic effects of Ca 2+ and AMP

Open Access
Sarah Fogarty, Simon A. Hawley, Kevin A. Green, Nazan Saner, Kirsty J. Mustard, D. Grahame Hardie
Journal: Biochemical Journal
Biochem J (2010) 426 (1): 109–118.
https://doi.org/10.1042/BJ20091372
Published: 27 January 2010
View articletitled, Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: synergistic effects of Ca 2+ and AMP
Open the PDF for Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: synergistic effects of Ca 2+ and AMP in another window
Articles

A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis

Available to Purchase
Mhairi C. Towler, Sarah Fogarty, Simon A. Hawley, David A. Pan, David M. A. Martin, Nicolas A. Morrice, Afshan McCarthy, María N. Galardo, Silvina B. Meroni, Selva B. Cigorraga, Alan Ashworth, Kei Sakamoto, D. Grahame Hardie
Journal: Biochemical Journal
Biochem J (2008) 416 (1): 1–14.
https://doi.org/10.1042/BJ20081447
Published: 28 October 2008
View articletitled, A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis
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Includes: Supplementary data
Articles

AMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge

Available to Purchase
D. Grahame HARDIE, Ian P. SALT, Simon A. HAWLEY, Stephen P. DAVIES
Journal: Biochemical Journal
Biochem J (1999) 338 (3): 717–722.
https://doi.org/10.1042/bj3380717
Published: 08 March 1999
View articletitled, AMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge
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Articles

AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the α2 isoform

Available to Purchase
Ian SALT, Jakub W. CELLER, Simon A. HAWLEY, Alan PRESCOTT, Angela WOODS, David CARLING, D. Grahame HARDIE
Journal: Biochemical Journal
Biochem J (1998) 334 (1): 177–187.
https://doi.org/10.1042/bj3340177
Published: 15 August 1998
View articletitled, AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the α2 isoform
Open the PDF for AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the α2 isoform in another window