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Steven C. Ley
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Articles

CARD14 signalosome formation is associated with its endosomal relocation and mTORC1-induced keratinocyte proliferation

Open Access
Paul A. O'Sullivan, Aigerim Aidarova, Inna S. Afonina, Joan Manils, Teresa L. M. Thurston, Rachael Instrell, Michael Howell, Stefan Boeing, Sashini Ranawana, Melanie B. Herpels, Riwia Chetian, Matilda Bassa, Helen Flynn, David Frith, Ambrosius P. Snijders, Ashleigh Howes, Rudi Beyaert, Anne M. Bowcock, Steven C. Ley
Journal: Biochemical Journal
Biochem J (2024) 481 (18): 1143–1171.
https://doi.org/10.1042/BCJ20240058
Published: 06 September 2024
View article titled, CARD14 signalosome formation is associated with its endosomal relocation and mTORC1-induced keratinocyte proliferation
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Includes: Supplementary data
Articles

Assaying kinase activity of the TPL-2/NF-κB1 p105/ABIN-2 complex using an optimal peptide substrate

Open Access
Sandra Kümper, Thorsten Gantke, Chao-Sheng Chen, Yasmina Soneji, Michael J. Pattison, Probir Chakravarty, Svend Kjær, Daniel Thomas, Carl Haslam, Bill J. Leavens, David House, David J. Powell, Steven C. Ley
Journal: Biochemical Journal
Biochem J (2018) 475 (1): 329–340.
https://doi.org/10.1042/BCJ20170579
Published: 11 January 2018
View article titled, Assaying kinase activity of the TPL-2/NF-κB1 p105/ABIN-2 complex using an optimal peptide substrate
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Includes: Supplementary data
Articles

Protein CoAlation: a redox-linked post-translational modification

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Steven C. Ley, Luiz Pedro S. de Carvalho
Journal: Biochemical Journal
Biochem J (2017) 474 (16): 2897–2899.
https://doi.org/10.1042/BCJ20170168
Published: 10 August 2017
View article titled, Protein CoAlation: a redox-linked post-translational modification
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Articles

TLR and TNF-R1 activation of the MKK3/MKK6–p38α axis in macrophages is mediated by TPL-2 kinase

Open Access
Michael J. Pattison, Olivia Mitchell, Helen R. Flynn, Chao-Sheng Chen, Huei-Ting Yang, Hakem Ben-Addi, Stefan Boeing, Ambrosius P. Snijders, Steven C. Ley
Journal: Biochemical Journal
Biochem J (2016) 473 (18): 2845–2861.
https://doi.org/10.1042/BCJ20160502
Published: 12 September 2016
View article titled, TLR and TNF-R1 activation of the MKK3/MKK6–p38α axis in macrophages is mediated by TPL-2 kinase
Open the PDF for TLR and TNF-R1 activation of the MKK3/MKK6–p38α axis in macrophages is mediated by TPL-2 kinase in another window
Includes: Supplementary data
Articles

Psoriasis mutations disrupt CARD14 autoinhibition promoting BCL10-MALT1-dependent NF-κB activation

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Ashleigh Howes, Paul A. O'Sullivan, Felix Breyer, Ashavari Ghose, Li Cao, Daniel Krappmann, Anne M. Bowcock, Steven C. Ley
Journal: Biochemical Journal
Biochem J (2016) 473 (12): 1759–1768.
https://doi.org/10.1042/BCJ20160270
Published: 10 June 2016
View article titled, Psoriasis mutations disrupt CARD14 autoinhibition promoting BCL10-MALT1-dependent NF-κB activation
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Articles

Priming IKKβ kinase for action

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Steven C. Ley, Rudi Beyaert
Journal: Biochemical Journal
Biochem J (2014) 463 (1): e1–e2.
https://doi.org/10.1042/BJ20140989
Published: 08 September 2014
View article titled, Priming IKKβ kinase for action
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Articles

Ebola virus VP35 induces high-level production of recombinant TPL-2–ABIN-2–NF-κB1 p105 complex in co-transfected HEK-293 cells

Open Access
Thorsten Gantke, Sabrina Boussouf, Julia Janzen, Nicholas A. Morrice, Steven Howell, Elke MÜHLBERGER, Steven C. Ley
Journal: Biochemical Journal
Biochem J (2013) 452 (2): 359–365.
https://doi.org/10.1042/BJ20121873
Published: 10 May 2013
View article titled, Ebola virus VP35 induces high-level production of recombinant TPL-2–ABIN-2–NF-κB1 p105 complex in co-transfected HEK-293 cells
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Includes: Supplementary data
Articles

Functions of NF-κB1 and NF-κB2 in immune cell biology

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Sören BEINKE, Steven C. LEY
Journal: Biochemical Journal
Biochem J (2004) 382 (2): 393–409.
https://doi.org/10.1042/BJ20040544
Published: 24 August 2004
View article titled, Functions of NF-κB1 and NF-κB2 in immune cell biology
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