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W Templeton
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Articles

Identification and characterization of AtI-2, an Arabidopsis homologue of an ancient protein phosphatase 1 (PP1) regulatory subunit

George W. Templeton, Mhairi Nimick, Nicholas Morrice, David Campbell, Marilyn Goudreault, Anne-Claude Gingras, Atsushi Takemiya, Ken-ichiro Shimazaki, Greg B. G. Moorhead
Journal: Biochemical Journal
Biochem J (2011) 435 (1): 73–83.
https://doi.org/10.1042/BJ20101035
Published: 15 March 2011
View article titled, Identification and characterization of AtI-2, an Arabidopsis homologue of an ancient protein phosphatase 1 (PP1) regulatory subunit
Open the PDF for Identification and characterization of AtI-2, an Arabidopsis homologue of an ancient protein phosphatase 1 (PP1) regulatory subunit in another window
Includes: Supplementary data
Articles

Evaluation of hydrogen-bonding and enantiomeric P 2 -S 2 hydrophobic contacts in dynamic aspects of molecular recognition by papain

M Patel, I S Kayani, W Templeton, G W Mellor, E W Thomas, K Brocklehurst
Journal: Biochemical Journal
Biochem J (1992) 287 (3): 881–889.
https://doi.org/10.1042/bj2870881
Published: 01 November 1992
View article titled, Evaluation of hydrogen-bonding and enantiomeric P 2 -S 2 hydrophobic contacts in dynamic aspects of molecular recognition by papain
Open the PDF for Evaluation of hydrogen-bonding and enantiomeric P 2 -S 2 hydrophobic contacts in dynamic aspects of molecular recognition by papain in another window
Articles

Variation in the P 2 -S 2 stereochemical selectivity towards the enantiomeric N -acetylphenylalanylglycine 4-nitroanilides among the cysteine proteinases papain, ficin and actinidin

M Patel, I S Kayani, G W Mellor, S Sreedharan, W Templeton, E W Thomas, M Thomas, K Brocklehurst
Journal: Biochemical Journal
Biochem J (1992) 281 (2): 553–559.
https://doi.org/10.1042/bj2810553
Published: 15 January 1992
View article titled, Variation in the P 2 -S 2 stereochemical selectivity towards the enantiomeric N -acetylphenylalanylglycine 4-nitroanilides among the cysteine proteinases papain, ficin and actinidin
Open the PDF for Variation in the P 2 -S 2 stereochemical selectivity towards the enantiomeric N -acetylphenylalanylglycine 4-nitroanilides among the cysteine proteinases papain, ficin and actinidin in another window
Articles

A re-appraisal of the structural basis of stereochemical recognition in papain. Insensitivity of binding-site-catalytic-site signalling to P 2 -chirality in a time-dependent inhibition

W Templeton, D Kowlessur, E W Thomas, C M Topham, K Brocklehurst
Journal: Biochemical Journal
Biochem J (1990) 266 (3): 645–651.
https://doi.org/10.1042/bj2660645
Published: 15 March 1990
View article titled, A re-appraisal of the structural basis of stereochemical recognition in papain. Insensitivity of binding-site-catalytic-site signalling to P 2 -chirality in a time-dependent inhibition
Open the PDF for A re-appraisal of the structural basis of stereochemical recognition in papain. Insensitivity of binding-site-catalytic-site signalling to P 2 -chirality in a time-dependent inhibition in another window
Articles

Dependence of the P 2 -S 2 stereochemical selectivity of papain on the nature of the catalytic-site chemistry. Quantification of selectivity in the catalysed hydrolysis of the enantiomeric N -acetylphenylalanylglycine 4-nitroanilides

D Kowlessur, E W Thomas, C M Topham, W Templeton, K Brocklehurst
Journal: Biochemical Journal
Biochem J (1990) 266 (3): 653–660.
https://doi.org/10.1042/bj2660653
Published: 15 March 1990
View article titled, Dependence of the P 2 -S 2 stereochemical selectivity of papain on the nature of the catalytic-site chemistry. Quantification of selectivity in the catalysed hydrolysis of the enantiomeric N -acetylphenylalanylglycine 4-nitroanilides
Open the PDF for Dependence of the P 2 -S 2 stereochemical selectivity of papain on the nature of the catalytic-site chemistry. Quantification of selectivity in the catalysed hydrolysis of the enantiomeric N -acetylphenylalanylglycine 4-nitroanilides in another window
Articles

The interplay of electrostatic fields and binding interactions determining catalytic-site reactivity in actinidin. A possible origin of differences in the behaviour of actinidin and papain

D Kowlessur, M O'Driscoll, C M Topham, W Templeton, E W Thomas, K Brocklehurst
Journal: Biochemical Journal
Biochem J (1989) 259 (2): 443–452.
https://doi.org/10.1042/bj2590443
Published: 15 April 1989
View article titled, The interplay of electrostatic fields and binding interactions determining catalytic-site reactivity in actinidin. A possible origin of differences in the behaviour of actinidin and papain
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Articles

Identification of signalling and non-signalling binding contributions to enzyme reactivity. Alternative combinations of binding interactions provide for change in transition-state geometry in reactions of papain

D Kowlessur, C M Topham, E W Thomas, M O'Driscoll, W Templeton, K Brocklehurst
Journal: Biochemical Journal
Biochem J (1989) 258 (3): 755–764.
https://doi.org/10.1042/bj2580755
Published: 15 March 1989
View article titled, Identification of signalling and non-signalling binding contributions to enzyme reactivity. Alternative combinations of binding interactions provide for change in transition-state geometry in reactions of papain
Open the PDF for Identification of signalling and non-signalling binding contributions to enzyme reactivity. Alternative combinations of binding interactions provide for change in transition-state geometry in reactions of papain in another window
Articles

The interplay of electrostatic and binding interactions determining active centre chemistry and catalytic activity in actinidin and papain

K Brocklehurst, M O'Driscoll, D Kowlessur, I R Phillips, W Templeton, E W Thomas, C M Topham, C W Wharton
Journal: Biochemical Journal
Biochem J (1989) 257 (1): 309–310.
https://doi.org/10.1042/bj2570309
Published: 01 January 1989
View article titled, The interplay of electrostatic and binding interactions determining active centre chemistry and catalytic activity in actinidin and papain
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Articles

Supracrystallographic resolution of interactions contributing to enzyme catalysis by use of natural structural variants and reactivity-probe kinetics

K Brocklehurst, S M Brocklehurst, D Kowlessur, M O'Driscoll, G Patel, E Salih, W Templeton, E Thomas, C M Topham, F Willenbrock
Journal: Biochemical Journal
Biochem J (1988) 256 (2): 543–558.
https://doi.org/10.1042/bj2560543
Published: 01 December 1988
View article titled, Supracrystallographic resolution of interactions contributing to enzyme catalysis by use of natural structural variants and reactivity-probe kinetics
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Articles

Consequences of molecular recognition in the S 1 -S 2 intersubsite region of papain for catalytic-site chemistry. Change in pH-dependence characteristics and generation of an inverse solvent kinetic isotope effect by introduction of a P 1 -P 2 amide bond into a two-protonic-state reactivity probe

K Brocklehurst, D Kowlessur, G Patel, W Templeton, K Quigley, E W Thomas, C W Wharton, F Willenbrock, R J Szawelski
Journal: Biochemical Journal
Biochem J (1988) 250 (3): 761–772.
https://doi.org/10.1042/bj2500761
Published: 15 March 1988
View article titled, Consequences of molecular recognition in the S 1 -S 2 intersubsite region of papain for catalytic-site chemistry. Change in pH-dependence characteristics and generation of an inverse solvent kinetic isotope effect by introduction of a P 1 -P 2 amide bond into a two-protonic-state reactivity probe
Open the PDF for Consequences of molecular recognition in the S 1 -S 2 intersubsite region of papain for catalytic-site chemistry. Change in pH-dependence characteristics and generation of an inverse solvent kinetic isotope effect by introduction of a P 1 -P 2 amide bond into a two-protonic-state reactivity probe in another window
Articles

Substrate-derived two-protonic-state electrophiles as sensitive kinetic specificity probes for cysteine proteinases. Activation of 2-pyridyl disulphides by hydrogen-bonding

K Brocklehurst, D Kowlessur, M O'Driscoll, G Patel, S Quenby, E Salih, W Templeton, E W Thomas, F Willenbrock
Journal: Biochemical Journal
Biochem J (1987) 244 (1): 173–181.
https://doi.org/10.1042/bj2440173
Published: 15 May 1987
View article titled, Substrate-derived two-protonic-state electrophiles as sensitive kinetic specificity probes for cysteine proteinases. Activation of 2-pyridyl disulphides by hydrogen-bonding
Open the PDF for Substrate-derived two-protonic-state electrophiles as sensitive kinetic specificity probes for cysteine proteinases. Activation of 2-pyridyl disulphides by hydrogen-bonding in another window