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Articles

Interplay of constipation, intestinal barrier dysfunction and fungal exposome in aetiopathogenesis of Parkinson’s disease: hypothesis with supportive data

Chianna Umamahesan, Aleksandra Pilcicka, Jennifer Yick, Kieran Baker, Melvyn Smith, David Taylor, Yun Ma, Benjamin H. Mullish, Julian R. Marchesi, Steven Gilbert, Shervin D. Sadeghi Nasab, David Moyes, Polychronis Pavlidis, Bu’Hussain Hayee, Sylvia M. Dobbs, R. John Dobbs, André Charlett

Biochem J (2025) 482 (12): 807–821.

https://doi.org/10.1042/BCJ20240621

Published: 11 June 2025

View articletitled, Interplay of constipation, intestinal barrier dysfunction and fungal exposome in aetiopathogenesis of Parkinson’s disease: hypothesis with supportive data

Includes: Supplementary data

Articles

Structural commonalities determined by physicochemical principles in the complex polymorphism of the amyloid state of proteins

Silvia Errico, Giulia Fani, Salvador Ventura, Joost Schymkowitz, Frederic Rousseau, Antonio Trovato, Michele Vendruscolo, Francesco Bemporad, Fabrizio Chiti

Biochem J (2025) 482 (2): 87–101.

https://doi.org/10.1042/BCJ20240602

Published: 22 January 2025

View articletitled, Structural commonalities determined by physicochemical principles in the complex polymorphism of the amyloid state of proteins

Includes: Supplementary data

Articles

Mechanisms and pathologies of human mitochondrial DNA replication and deletion formation

Tiago M. Bernardino Gomes, Amy E. Vincent, Katja E. Menger, James B. Stewart, Thomas J. Nicholls

Biochem J (2024) 481 (11): 683–715.

https://doi.org/10.1042/BCJ20230262

Published: 28 May 2024

View articletitled, Mechanisms and pathologies of human mitochondrial DNA replication and deletion formation

Articles

Cardiomyocyte-specific deletion of GCN5L1 reduces lysine acetylation and attenuates diastolic dysfunction in aged mice by improving cardiac fatty acid oxidation

Jackson E. Stewart, Jenna M. Crawford, William E. Mullen, Angelica Jacques, Michael W. Stoner, Iain Scott, Dharendra Thapa

Biochem J (2024) 481 (6): 423–436.

https://doi.org/10.1042/BCJ20230421

Published: 11 March 2024

View articletitled, Cardiomyocyte-specific deletion of GCN5L1 reduces lysine acetylation and attenuates diastolic dysfunction in aged mice by improving cardiac fatty acid oxidation

Articles

Non-cross-linking advanced glycation end products affect prohormone processing

Sebastian Brings, Walter Mier, Barbro Beijer, Elisabeth Kliemank, Stephan Herzig, Julia Szendroedi, Peter P. Nawroth, Thomas Fleming

Biochem J (2024) 481 (1): 33–44.

https://doi.org/10.1042/BCJ20230321

Published: 04 January 2024

View articletitled, Non-cross-linking advanced glycation end products affect prohormone processing

Includes: Supplementary data

Articles

Understanding interleukin 11 as a disease gene and therapeutic target

Stuart A. Cook

Biochem J (2023) 480 (23): 1987–2008.

https://doi.org/10.1042/BCJ20220160

Published: 06 December 2023

View articletitled, Understanding interleukin 11 as a disease gene and therapeutic target

Articles

WHIRLY proteins maintain seed longevity by effects on seed oxygen signalling during imbibition

In Collection

Plants and climate change: the role of plants in achieving net zero

Rachel E. Taylor, Wanda Waterworth, Christopher E West, Christine H. Foyer

Biochem J (2023) 480 (13): 941–956.

https://doi.org/10.1042/BCJ20230008

Published: 06 July 2023

View articletitled, WHIRLY proteins maintain seed longevity by effects on seed oxygen signalling during imbibition

Includes: Supplementary data

Articles

Shaping mitochondria through fed–fast and circadian cycles

In Collection

Cell signaling in the 21st century

Subhash Khatri, Rubina Kazi, Ullas Kolthur-Seetharam

Biochem J (2023) 480 (13): 909–919.

https://doi.org/10.1042/BCJ20220378

Published: 04 July 2023

View articletitled, Shaping mitochondria through fed–fast and circadian cycles

Articles

Site I Q in mitochondrial complex I generates S1QEL-sensitive superoxide/hydrogen peroxide in both the reverse and forward reactions

Edwin T. Gibbs, II, Chad A. Lerner, Mark A. Watson, Hoi-Shan Wong, Akos A. Gerencser, Martin D. Brand

Biochem J (2023) 480 (5): 363–384.

https://doi.org/10.1042/BCJ20220611

Published: 15 March 2023

View articletitled, Site I Q in mitochondrial complex I generates S1QEL-sensitive superoxide/hydrogen peroxide in both the reverse and forward reactions

Articles

Kae1 of Saccharomyces cerevisiae KEOPS complex possesses ADP/GDP nucleotidase activity

Qian-Xi Li, Jia-Cheng Liu, Ming-Hong He, Jin-Qiu Zhou

Biochem J (2022) 479 (23): 2433–2447.

https://doi.org/10.1042/BCJ20220290

Published: 09 December 2022

View articletitled, Kae1 of Saccharomyces cerevisiae KEOPS complex possesses ADP/GDP nucleotidase activity

Articles

Claspin haploinsufficiency leads to defects in fertility, hyperplasia and an increased oncogenic potential

Suzanne Madgwick, Saimir Luli, Helene Sellier, Jacqueline A. Butterworth, Jack Leslie, Adam J. Moore, Emma K. Corbin, Adrian I. Yemm, Robson T. Chiremba, Dina Tiniakos, Fiona Oakley, Neil D. Perkins, Jill E. Hunter

Biochem J (2022) 479 (19): 2115–2130.

https://doi.org/10.1042/BCJ20220101

Published: 14 October 2022

View articletitled, Claspin haploinsufficiency leads to defects in fertility, hyperplasia and an increased oncogenic potential

Includes: Supplementary data

Articles

Systems approaches to investigate the role of NF-κB signaling in aging

In Collection

Towards systems biochemistry

Masatoshi Haga, Mariko Okada

Biochem J (2022) 479 (2): 161–183.

https://doi.org/10.1042/BCJ20210547

Published: 28 January 2022

View articletitled, Systems approaches to investigate the role of NF-κB signaling in aging

Articles

Proteomic analysis of dietary restriction in yeast reveals a role for Hsp26 in replicative lifespan extension

Richard Campion, Leanne Bloxam, Kimberley Burrow, Philip J. Brownridge, Daniel R. Pentland, Patricia Thomas, Campbell W. Gourlay, Claire E. Eyers, Jeff W. Barclay, Alan Morgan

Biochem J (2021) 478 (24): 4153–4167.

https://doi.org/10.1042/BCJ20210432

Published: 16 December 2021

View articletitled, Proteomic analysis of dietary restriction in yeast reveals a role for Hsp26 in replicative lifespan extension

Includes: Supplementary data

Articles

Hydrogen sulfide in ageing, longevity and disease

Stephen E. Wilkie, Gillian Borland, Roderick N. Carter, Nicholas M. Morton, Colin Selman

Biochem J (2021) 478 (19): 3485–3504.

https://doi.org/10.1042/BCJ20210517

Published: 06 October 2021

View articletitled, Hydrogen sulfide in ageing, longevity and disease

Articles

Manipulating the exposome to enable better ageing

Paul G. Shiels, Johanna Painer, Barbara Natterson-Horowitz, Richard J. Johnson, Jaime J. Miranda, Peter Stenvinkel

Biochem J (2021) 478 (14): 2889–2898.

https://doi.org/10.1042/BCJ20200958

Published: 28 July 2021

View articletitled, Manipulating the exposome to enable better ageing

Articles

Mechanistic roles for altered O -GlcNAcylation in neurodegenerative disorders

Aaron T. Balana, Matthew R. Pratt

Biochem J (2021) 478 (14): 2733–2758.

https://doi.org/10.1042/BCJ20200609

Published: 23 July 2021

View articletitled, Mechanistic roles for altered O -GlcNAcylation in neurodegenerative disorders

Articles

A home run for human NaCT/SLC13A5/INDY: cryo-EM structure and homology model to predict transport mechanisms, inhibitor interactions and mutational defects

Valeria Jaramillo-Martinez, Vadivel Ganapathy, Ina L. Urbatsch

Biochem J (2021) 478 (11): 2051–2057.

https://doi.org/10.1042/BCJ20210211

Published: 08 June 2021

View articletitled, A home run for human NaCT/SLC13A5/INDY: cryo-EM structure and homology model to predict transport mechanisms, inhibitor interactions and mutational defects

Articles

Understanding amphisomes

Dhasarathan Ganesan, Qian Cai

Biochem J (2021) 478 (10): 1959–1976.

https://doi.org/10.1042/BCJ20200917

Published: 28 May 2021

View articletitled, Understanding amphisomes

Articles

Casting iron into the cell fate mold

Or Kakhlon

Biochem J (2021) 478 (10): 1879–1883.

https://doi.org/10.1042/BCJ20210108

Published: 24 May 2021

View articletitled, Casting iron into the cell fate mold

Articles

Syntaxins 6 and 8 facilitate tau into secretory pathways

Wei Siang Lee, Daniel CS Tan, Yuanyuan Deng, Annika van Hummel, Stefania Ippati, Claire Stevens, Paulina Carmona-Mora, Daryl Ariawan, Liming Hou, Holly Stefen, Tamara Tomanic, Mian Bi, Florence Tomasetig, Adam Martin, Thomas Fath, Stephen Palmer, Yazi D. Ke, Lars M. Ittner

Biochem J (2021) 478 (7): 1471–1484.

https://doi.org/10.1042/BCJ20200664

Published: 16 April 2021

View articletitled, Syntaxins 6 and 8 facilitate tau into secretory pathways

Includes: Supplementary data

Articles

Rivastigmine attenuates the Alzheimer's disease related protein degradation and apoptotic neuronal death signalling

Parul Gupta, Shubhangini Tiwari, Abhishek Singh, Amit Pal, Amit Mishra, Sarika Singh

Biochem J (2021) 478 (7): 1435–1451.

https://doi.org/10.1042/BCJ20200754

Published: 16 April 2021

View articletitled, Rivastigmine attenuates the Alzheimer's disease related protein degradation and apoptotic neuronal death signalling

Articles

Bulk autophagy induction and life extension is achieved when iron is the only limited nutrient in Saccharomyces cerevisiae

Sandra Montella-Manuel, Nuria Pujol-Carrion, Mónica A. Mechoud, Maria Angeles de la Torre-Ruiz

Biochem J (2021) 478 (4): 811–837.

https://doi.org/10.1042/BCJ20200849

Published: 24 February 2021

View articletitled, Bulk autophagy induction and life extension is achieved when iron is the only limited nutrient in Saccharomyces cerevisiae

Articles

Consequences of NaCT/SLC13A5/mINDY deficiency: good versus evil, separated only by the blood–brain barrier

Jonathan J. Kopel, Yangzom D. Bhutia, Sathish Sivaprakasam, Vadivel Ganapathy

Biochem J (2021) 478 (3): 463–486.

https://doi.org/10.1042/BCJ20200877

Published: 05 February 2021

View articletitled, Consequences of NaCT/SLC13A5/mINDY deficiency: good versus evil, separated only by the blood–brain barrier

Articles

Spontaneous protein–protein crosslinking at glutamine and glutamic acid residues in long-lived proteins

Michael G. Friedrich, Zhen Wang, Kevin L. Schey, Roger J. W. Truscott

Biochem J (2021) 478 (2): 327–339.

https://doi.org/10.1042/BCJ20200798

Published: 22 January 2021

View articletitled, Spontaneous protein–protein crosslinking at glutamine and glutamic acid residues in long-lived proteins

Includes: Supplementary data

Articles

Weakening of interaction networks with aging in tip-link protein induces hearing loss

Surbhi Garg, Amin Sagar, Gayathri S. Singaraju, Rahul Dani, Naimat K. Bari, Athi N. Naganathan, Sabyasachi Rakshit

Biochem J (2021) 478 (1): 121–134.

https://doi.org/10.1042/BCJ20200799

Published: 13 January 2021

View articletitled, Weakening of interaction networks with aging in tip-link protein induces hearing loss

Includes: Multimedia, Supplementary data

Articles

PROTEIN l-ISOASPARTYL METHYLTRANSFERASE (PIMT) in plants: regulations and functions

Nitin Uttam Kamble, Manoj Majee

Biochem J (2020) 477 (22): 4453–4471.

https://doi.org/10.1042/BCJ20200794

Published: 27 November 2020

View articletitled, PROTEIN l-ISOASPARTYL METHYLTRANSFERASE (PIMT) in plants: regulations and functions

Articles

Mitochondrial control of cellular protein homeostasis

Karthik Mohanraj, Urszula Nowicka, Agnieszka Chacinska

Biochem J (2020) 477 (16): 3033–3054.

https://doi.org/10.1042/BCJ20190654

Published: 26 August 2020

View articletitled, Mitochondrial control of cellular protein homeostasis

Articles

Lamin B receptor: role on chromatin structure, cellular senescence and possibly aging

Susana Castro-Obregón

Biochem J (2020) 477 (14): 2715–2720.

https://doi.org/10.1042/BCJ20200165

Published: 29 July 2020

View articletitled, Lamin B receptor: role on chromatin structure, cellular senescence and possibly aging

Articles

Interaction of α-synuclein and Parkin in iron toxicity on SH-SY5Y cells: implications in the pathogenesis of Parkinson's disease

Upasana Ganguly, Anindita Banerjee, Sankha Shubhra Chakrabarti, Upinder Kaur, Oishimaya Sen, Roberto Cappai, Sasanka Chakrabarti

Biochem J (2020) 477 (6): 1109–1122.

https://doi.org/10.1042/BCJ20190676

Published: 23 March 2020

View articletitled, Interaction of α-synuclein and Parkin in iron toxicity on SH-SY5Y cells: implications in the pathogenesis of Parkinson's disease

Includes: Supplementary data

Articles

Aspirin inhibits TGFβ2-induced epithelial to mesenchymal transition of lens epithelial cells: selective acetylation of K56 and K122 in histone H3

Mi-Hyun Nam, Andrew J.O. Smith, Mina B. Pantcheva, Ko Uoon Park, Joseph A. Brzezinski, IV, James J. Galligan, Kristofer Fritz, I. Michael Wormstone, Ram H. Nagaraj

Biochem J (2020) 477 (1): 75–97.

https://doi.org/10.1042/BCJ20190540

Published: 08 January 2020

View articletitled, Aspirin inhibits TGFβ2-induced epithelial to mesenchymal transition of lens epithelial cells: selective acetylation of K56 and K122 in histone H3

Includes: Supplementary data

Articles

Mechanism of protein cleavage at asparagine leading to protein–protein cross-links

Michael G. Friedrich, Zhen Wang, Kevin L. Schey, Roger J. W. Truscott

Biochem J (2019) 476 (24): 3817–3834.

https://doi.org/10.1042/BCJ20190743

Published: 23 December 2019

View articletitled, Mechanism of protein cleavage at asparagine leading to protein–protein cross-links

Includes: Supplementary data

Articles

Glycolic acid attenuates UVB-induced aquaporin-3, matrix metalloproteinase-9 expression, and collagen degradation in keratinocytes and mouse skin

Sheau-Chung Tang, Lee-Chun Tang, Chin-Hung Liu, Pei-Yun Liao, Ji-Ching Lai, Jen-Hung Yang

Biochem J (2019) 476 (10): 1387–1400.

https://doi.org/10.1042/BCJ20180974

Published: 21 May 2019

View articletitled, Glycolic acid attenuates UVB-induced aquaporin-3, matrix metalloproteinase-9 expression, and collagen degradation in keratinocytes and mouse skin

Articles

Abscisic acid-determined seed vigour differences do not influence redox regulation during ageing

In Collection

Seeds

Christina Schausberger, Thomas Roach, Wolfgang Stöggl, Erwann Arc, William E. Finch-Savage, Ilse Kranner

Biochem J (2019) 476 (6): 965–974.

https://doi.org/10.1042/BCJ20180903

Published: 22 March 2019

View articletitled, Abscisic acid-determined seed vigour differences do not influence redox regulation during ageing

Includes: Supplementary data

Articles

Role of ATP during the initiation of microvascularization: acceleration of an autocrine sensing mechanism facilitating chemotaxis by inorganic polyphosphate

Werner E.G. Müller, Maximilian Ackermann, Emad Tolba, Meik Neufurth, Ivan Ivetac, Maria Kokkinopoulou, Heinz C. Schröder, Xiaohong Wang

Biochem J (2018) 475 (20): 3255–3273.

https://doi.org/10.1042/BCJ20180535

Published: 31 October 2018

View articletitled, Role of ATP during the initiation of microvascularization: acceleration of an autocrine sensing mechanism facilitating chemotaxis by inorganic polyphosphate

Articles

Spontaneous cross-linking of proteins at aspartate and asparagine residues is mediated via a succinimide intermediate

Michael G. Friedrich, Zhen Wang, Kevin L. Schey, Roger J. W. Truscott

Biochem J (2018) 475 (20): 3189–3200.

https://doi.org/10.1042/BCJ20180529

Published: 23 October 2018

View articletitled, Spontaneous cross-linking of proteins at aspartate and asparagine residues is mediated via a succinimide intermediate

Includes: Supplementary data

Articles

Matrix-bound AGEs enhance TGFβ2-mediated mesenchymal transition of lens epithelial cells via the noncanonical pathway: implications for secondary cataract formation

Mi-Hyun Nam, Ram H. Nagaraj

Biochem J (2018) 475 (8): 1427–1440.

https://doi.org/10.1042/BCJ20170856

Published: 23 April 2018

View articletitled, Matrix-bound AGEs enhance TGFβ2-mediated mesenchymal transition of lens epithelial cells via the noncanonical pathway: implications for secondary cataract formation

Articles

Steroidogenic abnormalities in translocator protein knockout mice and significance in the aging male

In Collection

Editors' pick of research highlights published in the Biochemical Journal in 2018 & 2019

Anna M. Barron, Bin Ji, Seiji Kito, Tetsuya Suhara, Makoto Higuchi

Biochem J (2018) 475 (1): 75–85.

https://doi.org/10.1042/BCJ20170645

Published: 02 January 2018

View articletitled, Steroidogenic abnormalities in translocator protein knockout mice and significance in the aging male

Articles

Hotspots of age-related protein degradation: the importance of neighboring residues for the formation of non-disulfide crosslinks derived from cysteine

Michael G. Friedrich, Zhen Wang, Aaron J. Oakley, Kevin L. Schey, Roger J.W. Truscott

Biochem J (2017) 474 (14): 2475–2487.

https://doi.org/10.1042/BCJ20170268

Published: 11 July 2017

View articletitled, Hotspots of age-related protein degradation: the importance of neighboring residues for the formation of non-disulfide crosslinks derived from cysteine

Includes: Supplementary data

Articles

The G2385R risk factor for Parkinson's disease enhances CHIP-dependent intracellular degradation of LRRK2

Iakov N. Rudenko, Alice Kaganovich, Rebekah G. Langston, Aleksandra Beilina, Kelechi Ndukwe, Ravindran Kumaran, Allissa A. Dillman, Ruth Chia, Mark R. Cookson

Biochem J (2017) 474 (9): 1547–1558.

https://doi.org/10.1042/BCJ20160909

Published: 24 April 2017

View articletitled, The G2385R risk factor for Parkinson's disease enhances CHIP-dependent intracellular degradation of LRRK2

Includes: Supplementary data

Articles

Metal-based superoxide dismutase and catalase mimics reduce oxidative stress biomarkers and extend life span of Saccharomyces cerevisiae

Thales de P. Ribeiro, Fernanda L. Fonseca, Mariana D.C. de Carvalho, Rodrigo M. da C. Godinho, Fernando Pereira de Almeida, Tatiana D. Saint'Pierre, Nicolás A. Rey, Christiane Fernandes, Adolfo Horn, Jr, Marcos D. Pereira

Biochem J (2017) 474 (2): 301–315.

https://doi.org/10.1042/BCJ20160480

Published: 06 January 2017

View articletitled, Metal-based superoxide dismutase and catalase mimics reduce oxidative stress biomarkers and extend life span of Saccharomyces cerevisiae

Includes: Supplementary data

Articles

Hsp90-binding immunophilin FKBP52 modulates telomerase activity by promoting the cytoplasmic retrotransport of hTERT

Yu Young Jeong, Joonyoung Her, Sue-Young Oh, In Kwon Chung

Biochem J (2016) 473 (20): 3517–3532.

https://doi.org/10.1042/BCJ20160344

Published: 11 October 2016

View articletitled, Hsp90-binding immunophilin FKBP52 modulates telomerase activity by promoting the cytoplasmic retrotransport of hTERT

Articles

Mitochondrial form, function and signalling in aging

Ignacio Amigo, Fernanda M. da Cunha, Maria Fernanda Forni, Wilson Garcia-Neto, Pâmela A. Kakimoto, Luis A. Luévano-Martínez, Felipe Macedo, Sergio L. Menezes-Filho, Julia Peloggia, Alicia J. Kowaltowski

Biochem J (2016) 473 (20): 3421–3449.

https://doi.org/10.1042/BCJ20160451

Published: 11 October 2016

View articletitled, Mitochondrial form, function and signalling in aging

Articles

Physiological and pathophysiological functions of Swiprosin-1/EFhd2 in the nervous system

Dirk Mielenz, Frank Gunn-Moore

Biochem J (2016) 473 (16): 2429–2437.

https://doi.org/10.1042/BCJ20160168

Published: 11 August 2016

View articletitled, Physiological and pathophysiological functions of Swiprosin-1/EFhd2 in the nervous system

Articles

Unravelling the mechanisms regulating muscle mitochondrial biogenesis

David A. Hood, Liam D. Tryon, Heather N. Carter, Yuho Kim, Chris C.W. Chen

Biochem J (2016) 473 (15): 2295–2314.

https://doi.org/10.1042/BCJ20160009

Published: 28 July 2016

View articletitled, Unravelling the mechanisms regulating muscle mitochondrial biogenesis

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