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Articles

Molecular basis and therapeutic implications of binary YAP On /YAP Off cancer classes

Pinky Sharma, Yale S. Michaels, Joel D. Pearson

Biochem J (2025) 482 (11): 741–761.

https://doi.org/10.1042/BCJ20253077

Published: 28 May 2025

View articletitled, Molecular basis and therapeutic implications of binary YAP On /YAP Off cancer classes

Articles

Sequence rules for a long SPOP-binding degron required for protein ubiquitylation

Linda Makhlouf, Mukul Mishra, Hannah Makhlouf, Iain Manfield, Luca Busino, Elton Zeqiraj

Biochem J (2025) 482 (10): 583–600.

https://doi.org/10.1042/BCJ20253041

Published: 15 May 2025

View articletitled, Sequence rules for a long SPOP-binding degron required for protein ubiquitylation

Includes: Supplementary data

Articles

EZH2 promotes chemoresistance in colorectal cancer by inhibiting autophagy through NRP1 suppression

Hong Deng, Qin Xu, Qiang Zhang, Chunfeng Liu, Lei Ren

Biochem J (2025) 482 (10): 569–581.

https://doi.org/10.1042/BCJ20240607

Published: 14 May 2025

View articletitled, EZH2 promotes chemoresistance in colorectal cancer by inhibiting autophagy through NRP1 suppression

Includes: Supplementary data

Articles

Aurora A binds to the transactivation domain of c-Myc and recognizes the phosphorylated N-terminal degron motif

Nidhi Joshi, Katie M. Dunleavy, Kaitlin M. Beel, Tiffany A. Engel, Andrew R. Thompson, Felix L. John, David D. Thomas, Nicholas M. Levinson

Biochem J (2025) 482 (08): 369–381.

https://doi.org/10.1042/BCJ20240726

Published: 16 April 2025

View articletitled, Aurora A binds to the transactivation domain of c-Myc and recognizes the phosphorylated N-terminal degron motif

Includes: Supplementary data

Articles

The PRL2 phosphatase up-regulates miR-21 through activation of the JAK2/STAT3 pathway to down-regulate the PTEN tumor suppressor

Qinglin Li, Yunpeng Bai, Sarah M. Cavender, Yiming Miao, Frederick Nguele Meke, Emily L. Lasse-Opsahl, Peipei Zhu, Gina M. Doody, W. Andy Tao, Zhong-Yin Zhang

Biochem J (2025) 482 (07): 341–356.

https://doi.org/10.1042/BCJ20240626

Published: 10 April 2025

View articletitled, The PRL2 phosphatase up-regulates miR-21 through activation of the JAK2/STAT3 pathway to down-regulate the PTEN tumor suppressor

Includes: Supplementary data

Articles

Structure and function of MDM2 and MDM4 in health and disease

Ivy Yiyi Zhu, Alec Lloyd, William R. Critchley, Queen Saikia, Dhananjay Jade, Aysha Divan, Elton Zeqiraj, Michael A. Harrison, Christopher J. Brown, Sreenivasan Ponnambalam

Biochem J (2025) 482 (04): 241–262.

https://doi.org/10.1042/BCJ20240757

Published: 17 February 2025

View articletitled, Structure and function of MDM2 and MDM4 in health and disease

Articles

Characterisation of RNA guanine-7 methyltransferase (RNMT) using a small molecule approach

Lesley-Anne Pearson, Alain-Pierre Petit, Cesar Mendoza Martinez, Fiona Bellany, De Lin, Sarah Niven, Rachel Swift, Thomas Eadsforth, Paul Fyfe, Marilyn Paul, Vincent Postis, Xiao Hu, Victoria H. Cowling, David W. Gray

Biochem J (2025) 482 (04): 209–224.

https://doi.org/10.1042/BCJ20240608

Published: 17 February 2025

View articletitled, Characterisation of RNA guanine-7 methyltransferase (RNMT) using a small molecule approach

Includes: Supplementary data

Articles

Loss of peroxiredoxin 6 alters lipid composition and distribution resulting in increased sensitivity to ferroptosis

Daniel J. Lagal, Ángel Ortiz-Alcántara, José R. Pedrajas, Brian McDonagh, J. Antonio Bárcena, Raquel Requejo-Aguilar, C. Alicia Padilla

Biochem J (2024) 481 (24): 1997–2015.

https://doi.org/10.1042/BCJ20240445

Published: 23 December 2024

View articletitled, Loss of peroxiredoxin 6 alters lipid composition and distribution resulting in increased sensitivity to ferroptosis

Includes: Supplementary data

Articles

USP10 deubiquitinates and stabilizes CD44 leading to enhanced breast cancer cell proliferation, stemness and metastasis

Arppita Sethi, Shivkant Mishra, Vishal Upadhyay, Parul Dubey, Shumaila Siddiqui, Anil Kumar Singh, Sangita Chowdhury, Swati Srivastava, Pragya Srivastava, Prasannajit Sahoo, Madan L. B. Bhatt, Anand Mishra, Arun Kumar Trivedi

Biochem J (2024) 481 (24): 1877–1900.

https://doi.org/10.1042/BCJ20240611

Published: 09 December 2024

View articletitled, USP10 deubiquitinates and stabilizes CD44 leading to enhanced breast cancer cell proliferation, stemness and metastasis

Includes: Supplementary data

Articles

Opposing regulation of endoplasmic reticulum retention under stress by ERp44 and PDIA6

Olaya Yassin, Bellam Praveen, Odai Darawshi, Thomas LaFramboise, Miriam Shmuel, Shakti P. Pattanayak, Brian K. Law, Maria Hatzoglou, Boaz Tirosh

Biochem J (2024) 481 (24): 1921–1935.

https://doi.org/10.1042/BCJ20240444

Published: 09 December 2024

View articletitled, Opposing regulation of endoplasmic reticulum retention under stress by ERp44 and PDIA6

Includes: Supplementary data

Articles

ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding

Grace Q. Gong, Glenn R. Masson, Woo-Jeong Lee, James M. J. Dickson, Jackie D. Kendall, Manoj K. Rathinaswamy, Christina M. Buchanan, Martin Middleditch, Brady M. Owen, Julie A. Spicer, Gordon W. Rewcastle, William A. Denny, John E. Burke, Peter R. Shepherd, Roger L. Williams, Jack U. Flanagan

Biochem J (2024) 481 (23): 1787–1802.

https://doi.org/10.1042/BCJ20240479

Published: 28 November 2024

View articletitled, ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding

Includes: Supplementary data

Articles

Protein kinase A and local signaling in cancer

Kacey J. Rosenthal, John D. Gordan, John D. Scott

Biochem J (2024) 481 (22): 1659–1677.

https://doi.org/10.1042/BCJ20230352

Published: 14 November 2024

View articletitled, Protein kinase A and local signaling in cancer

Articles

Exploring the dynamics and interactions of the N-myc transactivation domain through solution nuclear magnetic resonance spectroscopy

Ewa Rejnowicz, Matthew Batchelor, Eoin Leen, Mohd Syed Ahangar, Selena G. Burgess, Mark W. Richards, Arnout P. Kalverda, Richard Bayliss

Biochem J (2024) 481 (21): 1535–1556.

https://doi.org/10.1042/BCJ20240248

Published: 21 October 2024

View articletitled, Exploring the dynamics and interactions of the N-myc transactivation domain through solution nuclear magnetic resonance spectroscopy

Includes: Supplementary data

Articles

Epigenetics and alternative splicing in cancer: old enemies, new perspectives

Madhura R. Pandkar, Sanjeev Shukla

Biochem J (2024) 481 (21): 1497–1518.

https://doi.org/10.1042/BCJ20240221

Published: 18 October 2024

View articletitled, Epigenetics and alternative splicing in cancer: old enemies, new perspectives

Articles

Pregnane X receptor inhibits the transdifferentiation of hepatic stellate cells by down-regulating periostin expression

Takumi Sato, Ryota Shizu, Ryonosuke Baba, Akira Ooka, Takuomi Hosaka, Yuichiro Kanno, Kouichi Yoshinari

Biochem J (2024) 481 (18): 1173–1186.

https://doi.org/10.1042/BCJ20240172

Published: 06 September 2024

View articletitled, Pregnane X receptor inhibits the transdifferentiation of hepatic stellate cells by down-regulating periostin expression

Includes: Supplementary data

Articles

Regulation of PARP1/2 and the tankyrases: emerging parallels

Matthew Jessop, Benjamin J. Broadway, Katy Miller, Sebastian Guettler

Biochem J (2024) 481 (17): 1097–1123.

https://doi.org/10.1042/BCJ20230230

Published: 23 August 2024

View articletitled, Regulation of PARP1/2 and the tankyrases: emerging parallels

Articles

Insights into the mechanisms driven by H3K4 KMTs in pancreatic cancer

In Collection

Epigenetics

Kayla C. LaRue-Nolan, Glancis Luzeena Raja Arul, Ashley N. Sigafoos, Jiaqi Shi, Martin E. Fernandez-Zapico

Biochem J (2024) 481 (15): 983–997.

https://doi.org/10.1042/BCJ20230374

Published: 30 July 2024

View articletitled, Insights into the mechanisms driven by H3K4 KMTs in pancreatic cancer

Articles

Cancer-associated mutations in protein kinase C theta are loss-of-function

Stefanie J. Hodapp, Nathan Gravel, Natarajan Kannan, Alexandra C. Newton

Biochem J (2024) 481 (12): 759–775.

https://doi.org/10.1042/BCJ20240148

Published: 10 June 2024

View articletitled, Cancer-associated mutations in protein kinase C theta are loss-of-function

Articles

Ring finger protein 138 inhibits transcription factor C/EBPα protein turnover leading to differentiation arrest in acute myeloid leukemia

Anil Kumar Singh, Vishal Upadhyay, Arppita Sethi, Sangita Chowdhury, Shivkant Mishra, Shailendra Prasad Verma, Madan Lal Brahma Bhatt, Arun Kumar Trivedi

Biochem J (2024) 481 (10): 653–666.

https://doi.org/10.1042/BCJ20240027

Published: 10 May 2024

View articletitled, Ring finger protein 138 inhibits transcription factor C/EBPα protein turnover leading to differentiation arrest in acute myeloid leukemia

Includes: Supplementary data

Articles

Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks

Uday Kiran Velagapudi, Élise Rouleau-Turcotte, Ramya Billur, Xuwei Shao, Manisha Patil, Ben E. Black, John M. Pascal, Tanaji T. Talele

Biochem J (2024) 481 (6): 437–460.

https://doi.org/10.1042/BCJ20230406

Published: 13 March 2024

View articletitled, Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks

Includes: Supplementary data

Articles

Reporter cell lines to screen for inhibitors or regulators of the KRAS-RAF-MEK1/2-ERK1/2 pathway

In Collection

Cell signaling in the 21st century

Laura Weatherdon, Kate Stuart, Megan Cassidy, Alberto Moreno de la Gándara, Hanneke Okkenhaug, Markus Muellener, Grahame Mckenzie, Simon J. Cook, Rebecca Gilley

Biochem J (2024) 481 (6): 405–422.

https://doi.org/10.1042/BCJ20240015

Published: 07 March 2024

View articletitled, Reporter cell lines to screen for inhibitors or regulators of the KRAS-RAF-MEK1/2-ERK1/2 pathway

Includes: Supplementary data

Articles

MicroRNA, miR-501 regulate the V(D)J recombination in B cells

Rupa Kumari, Urbi Roy, Sagar Desai, Arannya S. Mondal, Rajshree R. Nair, Namrata Nilavar, Bibha Choudhary, Sathees C. Raghavan

Biochem J (2023) 480 (24): 2061–2077.

https://doi.org/10.1042/BCJ20230250

Published: 20 December 2023

View articletitled, MicroRNA, miR-501 regulate the V(D)J recombination in B cells

Includes: Supplementary data

Articles

Up-regulation of SLC7A11/xCT creates a vulnerability to selenocystine-induced cytotoxicity

Shawn Lu Wen Tan, Hui Min Tan, Erez Israeli, Indah Fatihah, Vignesh Ramachandran, Shamsia Bte Ali, Shane Jun An Goh, Jillian Wee, Alicia Qian Ler Tan, Wai Leong Tam, Weiping Han

Biochem J (2023) 480 (24): 2045–2058.

https://doi.org/10.1042/BCJ20230317

Published: 18 December 2023

View articletitled, Up-regulation of SLC7A11/xCT creates a vulnerability to selenocystine-induced cytotoxicity

Includes: Supplementary data

Articles

Frequent loss-of-function mutations in the AMPK-α2 catalytic subunit suggest a tumour suppressor role in human skin cancers

Fiona A. Ross, Simon A. Hawley, Fiona M. Russell, Nicola Goodman, D. Grahame Hardie

Biochem J (2023) 480 (23): 1951–1968.

https://doi.org/10.1042/BCJ20230380

Published: 01 December 2023

View articletitled, Frequent loss-of-function mutations in the AMPK-α2 catalytic subunit suggest a tumour suppressor role in human skin cancers

Articles

Skin in the game: pannexin channels in healthy and cancerous skin

Brooke L. O'Donnell, Silvia Penuela

Biochem J (2023) 480 (23): 1929–1949.

https://doi.org/10.1042/BCJ20230176

Published: 01 December 2023

View articletitled, Skin in the game: pannexin channels in healthy and cancerous skin

Articles

A guide to ERK dynamics, part 1: mechanisms and models

In Collection

Cell signaling in the 21st century

Abhineet Ram, Devan Murphy, Nicholaus DeCuzzi, Madhura Patankar, Jason Hu, Michael Pargett, John G. Albeck

Biochem J (2023) 480 (23): 1887–1907.

https://doi.org/10.1042/BCJ20230276

Published: 01 December 2023

View articletitled, A guide to ERK dynamics, part 1: mechanisms and models

Articles

A guide to ERK dynamics, part 2: downstream decoding

In Collection

Cell signaling in the 21st century

Abhineet Ram, Devan Murphy, Nicholaus DeCuzzi, Madhura Patankar, Jason Hu, Michael Pargett, John G. Albeck

Biochem J (2023) 480 (23): 1909–1928.

https://doi.org/10.1042/BCJ20230277

Published: 01 December 2023

View articletitled, A guide to ERK dynamics, part 2: downstream decoding

Articles

Elucidating the interaction of C-terminal domain of Vaccinia-Related Kinase 2A (VRK2A) with B-cell lymphoma-extra Large (Bcl-xL) to decipher its anti-apoptotic role in cancer

Rashmi Puja, Shubhankar Dutta, Kakoli Bose

Biochem J (2023) 480 (22): 1871–1885.

https://doi.org/10.1042/BCJ20230349

Published: 28 November 2023

View articletitled, Elucidating the interaction of C-terminal domain of Vaccinia-Related Kinase 2A (VRK2A) with B-cell lymphoma-extra Large (Bcl-xL) to decipher its anti-apoptotic role in cancer

Includes: Supplementary data

Articles

Loss of the methylarginine reader function of SND1 confers resistance to hepatocellular carcinoma

In Collection

Epigenetics

Tanner Wright, Yalong Wang, Sabrina A. Stratton, Manu Sebastian, Bin Liu, David G. Johnson, Mark T. Bedford

Biochem J (2023) 480 (22): 1805–1816.

https://doi.org/10.1042/BCJ20230384

Published: 17 November 2023

View articletitled, Loss of the methylarginine reader function of SND1 confers resistance to hepatocellular carcinoma

Articles

Microrchidia 2/histone deacetylase 1 complex regulates E-cadherin gene expression and function

Liz Thomas, Namita Chutani, Krishna R, Asha S. Nair, Nanda Kumar Yellapu, Prashanthi Karyala, Suresh B. Pakala

Biochem J (2023) 480 (20): 1675–1691.

https://doi.org/10.1042/BCJ20230304

Published: 19 October 2023

View articletitled, Microrchidia 2/histone deacetylase 1 complex regulates E-cadherin gene expression and function

Includes: Supplementary data

Articles

Revisiting the roles of cAMP signalling in the progression of prostate cancer

Emma C. Parsons, Ralf Hoffmann, George S. Baillie

Biochem J (2023) 480 (20): 1599–1614.

https://doi.org/10.1042/BCJ20230297

Published: 13 October 2023

View articletitled, Revisiting the roles of cAMP signalling in the progression of prostate cancer

Articles

ISGylation-independent protection of cell growth by USP18 following interferon stimulation

Anne Clancy, Emma V. Rusilowicz-Jones, Iona Wallace, Kirby N. Swatek, Sylvie Urbé, Michael J. Clague

Biochem J (2023) 480 (19): 1571–1581.

https://doi.org/10.1042/BCJ20230301

Published: 09 October 2023

View articletitled, ISGylation-independent protection of cell growth by USP18 following interferon stimulation

Articles

How many kinases are druggable? A review of our current understanding

Brian Anderson, Peter Rosston, Han Wee Ong, Mohammad Anwar Hossain, Zachary W. Davis-Gilbert, David H. Drewry

Biochem J (2023) 480 (16): 1331–1363.

https://doi.org/10.1042/BCJ20220217

Published: 29 August 2023

View articletitled, How many kinases are druggable? A review of our current understanding

Includes: Supplementary data

Articles

Development of an OTUD1 ubiquitin variant inhibitor

Qi Liu, Evan Mallette, Hui Zheng, Wei Zhang

Biochem J (2023) 480 (16): 1317–1330.

https://doi.org/10.1042/BCJ20230119

Published: 25 August 2023

View articletitled, Development of an OTUD1 ubiquitin variant inhibitor

Includes: Supplementary data

Articles

SUFU promotes GLI activity in a Hedgehog-independent manner in pancreatic cancer

Brooke D. Paradise, Vladimir G. Gainullin, Luciana L. Almada, Ashley N. Sigafoos, Sandhya Sen, Renzo E. Vera, Glancis Luzeena Raja Arul, Murat Toruner, David R. Pease, Alina L. Gonzalez, Fatima M. Mentucci, Daniel H. Grasso, Martin E. Fernandez-Zapico

Biochem J (2023) 480 (15): 1199–1216.

https://doi.org/10.1042/BCJ20220439

Published: 02 August 2023

View articletitled, SUFU promotes GLI activity in a Hedgehog-independent manner in pancreatic cancer

Articles

Computational design of Matrix Metalloproteinase-9 (MMP-9) resistant to auto-cleavage

Alessandro Bonadio, Solomon Oguche, Tali Lavy, Oded Kleifeld, Julia Shifman

Biochem J (2023) 480 (14): 1097–1107.

https://doi.org/10.1042/BCJ20230139

Published: 17 July 2023

View articletitled, Computational design of Matrix Metalloproteinase-9 (MMP-9) resistant to auto-cleavage

Includes: Supplementary data

Articles

The WW domain of IQGAP1 binds directly to the p110α catalytic subunit of PI 3-kinase

A. Jane Bardwell, Madhuri Paul, Kiku C. Yoneda, María D. Andrade-Ludeña, Oanh T. Nguyen, David A. Fruman, Lee Bardwell

Biochem J (2023) 480 (10): 729–750.

https://doi.org/10.1042/BCJ20220493

Published: 26 May 2023

View articletitled, The WW domain of IQGAP1 binds directly to the p110α catalytic subunit of PI 3-kinase

Articles

LRRC8A is responsible for exosome biogenesis and volume regulation in colon cancer cells

Haifeng Zhang, Shiyu Cui, Zhenghui Jing, Guodan Fu, Rong Liu, Wenbao Zhao, Liting Xu, Lei Yu, Yuhui Bai, Changsheng Lv, Min Wu, Yuan Wei, Liangming Li, Shuang Peng

Biochem J (2023) 480 (9): 701–713.

https://doi.org/10.1042/BCJ20220614

Published: 17 May 2023

View articletitled, LRRC8A is responsible for exosome biogenesis and volume regulation in colon cancer cells

Includes: Supplementary data

Articles

ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1

In Collection

Cell signaling in the 21st century

Kathryn Balmanno, Andrew M. Kidger, Dominic P. Byrne, Matthew J. Sale, Nejma Nassman, Patrick A. Eyers, Simon J. Cook

Biochem J (2023) 480 (9): 587–605.

https://doi.org/10.1042/BCJ20220598

Published: 04 May 2023

View articletitled, ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1

Includes: Supplementary data

Articles

Principles of phosphoproteomics and applications in cancer research

In Collection

Cell signaling in the 21st century

Luke Higgins, Henry Gerdes, Pedro R. Cutillas

Biochem J (2023) 480 (6): 403–420.

https://doi.org/10.1042/BCJ20220220

Published: 24 March 2023

View articletitled, Principles of phosphoproteomics and applications in cancer research

Articles

GLI1 interaction with p300 modulates SDF1 expression in cancer-associated fibroblasts to promote pancreatic cancer cells migration

Renzo E. Vera, María J. Lamberti, Luciana L. Almada, Ezequiel J. Tolosa, Anne M. Vrabel, Ashley N. Sigafoos, Merih D. Toruner, Luis F. Flores, Viviana A. Rivarola, Natalia B. Rumie Vittar, Martín E. Fernández-Zapico

Biochem J (2023) 480 (3): 225–241.

https://doi.org/10.1042/BCJ20220521

Published: 14 February 2023

View articletitled, GLI1 interaction with p300 modulates SDF1 expression in cancer-associated fibroblasts to promote pancreatic cancer cells migration

Includes: Supplementary data

Articles

BH3 mimetics and TKI combined therapy for Chronic Myeloid Leukemia

In Collection

Cell death and survival

Gabriela Brumatti, Deeksha Kaloni, Fabíola Attié Castro, Gustavo P. Amarante-Mendes

Biochem J (2023) 480 (2): 161–176.

https://doi.org/10.1042/BCJ20210608

Published: 31 January 2023

View articletitled, BH3 mimetics and TKI combined therapy for Chronic Myeloid Leukemia

Articles

Dynamic regulation of RAS and RAS signaling

In Collection

Cell signaling in the 21st century

Walter Kolch, Dénes Berta, Edina Rosta

Biochem J (2023) 480 (1): 1–23.

https://doi.org/10.1042/BCJ20220234

Published: 06 January 2023

View articletitled, Dynamic regulation of RAS and RAS signaling

Articles

Poly-ADP ribosylation of p21 by tankyrases promotes p21 degradation and regulates cell cycle progression

Misun Jung, Wonyoung Kim, Jin Won Cho, Won Ho Yang, In Kwon Chung

Biochem J (2022) 479 (22): 2379–2394.

https://doi.org/10.1042/BCJ20220391

Published: 30 November 2022

View articletitled, Poly-ADP ribosylation of p21 by tankyrases promotes p21 degradation and regulates cell cycle progression

Includes: Supplementary data

Articles

Keeping RelApse in Chk: molecular mechanisms of Chk1 inhibitor resistance in lymphoma

Elizabeth M. Black, Yoon Ki Joo, Lilian Kabeche

Biochem J (2022) 479 (22): 2345–2349.

https://doi.org/10.1042/BCJ20220461

Published: 23 November 2022

View articletitled, Keeping RelApse in Chk: molecular mechanisms of Chk1 inhibitor resistance in lymphoma

Articles

AMP-activated protein kinase — a journey from 1 to 100 downstream targets

In Collection

Awards

D. Grahame Hardie

Biochem J (2022) 479 (22): 2327–2343.

https://doi.org/10.1042/BCJ20220255

Published: 16 November 2022

View articletitled, AMP-activated protein kinase — a journey from 1 to 100 downstream targets

Articles

Immunoregulatory signal networks and tumor immune evasion mechanisms: insights into therapeutic targets and agents in clinical development

Qian Wei, Kjetil Taskén

Biochem J (2022) 479 (20): 2219–2260.

https://doi.org/10.1042/BCJ20210233

Published: 28 October 2022

View articletitled, Immunoregulatory signal networks and tumor immune evasion mechanisms: insights into therapeutic targets and agents in clinical development

Articles

Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance

Biochem J (2022) 479 (19): 2087–2113.

https://doi.org/10.1042/BCJ20220089

Published: 14 October 2022

View articletitled, Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance

Includes: Supplementary data

Articles

Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway

Biochem J (2022) 479 (19): 2063–2086.

https://doi.org/10.1042/BCJ20220102

Published: 14 October 2022

View articletitled, Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway

Includes: Supplementary data

Articles

Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells

Jill E. Hunter, Amy E. Campbell, Scott Kerridge, Callum Fraser, Nicola L. Hannaway, Saimir Luli, Iglika Ivanova, Philip J. Brownridge, Jonathan Coxhead, Leigh Taylor, Peter Leary, Megan S. R. Hasoon, Claire E. Eyers, Neil D. Perkins

Biochem J (2022) 479 (19): 2131–2151.

https://doi.org/10.1042/BCJ20220103

Published: 14 October 2022

View articletitled, Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells

Includes: Supplementary data

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