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Articles

Molecular basis and therapeutic implications of binary YAP On /YAP Off cancer classes

Pinky Sharma, Yale S. Michaels, Joel D. Pearson

Biochem J (2025) 482 (11): 741–761.

https://doi.org/10.1042/BCJ20253077

Published: 28 May 2025

View articletitled, Molecular basis and therapeutic implications of binary YAP On /YAP Off cancer classes

Articles

Reconstituted systems for studying the architecture and dynamics of actin networks

Alice Cantat, Alexandra Colin

Biochem J (2025) 482 (11): BCJ20253044.

https://doi.org/10.1042/BCJ20253044

Published: 23 May 2025

View articletitled, Reconstituted systems for studying the architecture and dynamics of actin networks

Articles

The open to closed D-loop conformational switch determines length in filopodia-like actin bundles

Jonathan R. Gadsby, Pantelis Savvas Ioannou, Richard Butler, Julia Mason, Alison J. Smith, Ulrich Dobramysl, Stacey E. Chin, Claire Dobson, Jennifer L. Gallop

Biochem J (2024) 481 (24): 1977–1995.

https://doi.org/10.1042/BCJ20240367

Published: 23 December 2024

View articletitled, The open to closed D-loop conformational switch determines length in filopodia-like actin bundles

Includes: Multimedia, Supplementary data

Articles

USP10 deubiquitinates and stabilizes CD44 leading to enhanced breast cancer cell proliferation, stemness and metastasis

Arppita Sethi, Shivkant Mishra, Vishal Upadhyay, Parul Dubey, Shumaila Siddiqui, Anil Kumar Singh, Sangita Chowdhury, Swati Srivastava, Pragya Srivastava, Prasannajit Sahoo, Madan L. B. Bhatt, Anand Mishra, Arun Kumar Trivedi

Biochem J (2024) 481 (24): 1877–1900.

https://doi.org/10.1042/BCJ20240611

Published: 09 December 2024

View articletitled, USP10 deubiquitinates and stabilizes CD44 leading to enhanced breast cancer cell proliferation, stemness and metastasis

Includes: Supplementary data

Articles

Charting the importance of filamin A posttranslational modifications

Kyle D. Shead, Veneta Salyahetdinova, George S. Baillie

Biochem J (2024) 481 (13): 865–881.

https://doi.org/10.1042/BCJ20240121

Published: 03 July 2024

View articletitled, Charting the importance of filamin A posttranslational modifications

Articles

Molecular basis of Tick Born encephalitis virus NS5 mediated subversion of apico-basal cell polarity signalling

Airah Javorsky, Patrick O. Humbert, Marc Kvansakul

Biochem J (2022) 479 (12): 1303–1315.

https://doi.org/10.1042/BCJ20220037

Published: 22 June 2022

View articletitled, Molecular basis of Tick Born encephalitis virus NS5 mediated subversion of apico-basal cell polarity signalling

Includes: Supplementary data

Articles

Tunneling nanotubes and related structures: molecular mechanisms of formation and function

Sunayana Dagar, Diksha Pathak, Harsh V. Oza, Sivaram V. S. Mylavarapu

Biochem J (2021) 478 (22): 3977–3998.

https://doi.org/10.1042/BCJ20210077

Published: 23 November 2021

View articletitled, Tunneling nanotubes and related structures: molecular mechanisms of formation and function

Articles

What we can learn from embryos to understand the mesenchymal-to-epithelial transition in tumor progression

Yanel Bernardi, Pablo Hernán Strobl-Mazzulla

Biochem J (2021) 478 (9): 1809–1825.

https://doi.org/10.1042/BCJ20210083

Published: 14 May 2021

View articletitled, What we can learn from embryos to understand the mesenchymal-to-epithelial transition in tumor progression

Articles

Computational and experimental characterization of the novel ECM glycoprotein SNED1 and prediction of its interactome

Sylvain D. Vallet, Martin N. Davis, Anna Barqué, Ali H. Thahab, Sylvie Ricard-Blum, Alexandra Naba

Biochem J (2021) 478 (7): 1413–1434.

https://doi.org/10.1042/BCJ20200675

Published: 16 April 2021

View articletitled, Computational and experimental characterization of the novel ECM glycoprotein SNED1 and prediction of its interactome

Includes: Supplementary data

Articles

Structural basis of the human Scribble–Vangl2 association in health and disease

Jing Yuan How, Rebecca K. Stephens, Krystle Y.B. Lim, Patrick O. Humbert, Marc Kvansakul

Biochem J (2021) 478 (7): 1321–1332.

https://doi.org/10.1042/BCJ20200816

Published: 06 April 2021

View articletitled, Structural basis of the human Scribble–Vangl2 association in health and disease

Includes: Supplementary data

Articles

Protein tyrosine phosphatases in cell adhesion

Katherine A. Young, Laura Biggins, Hayley J. Sharpe

Biochem J (2021) 478 (5): 1061–1083.

https://doi.org/10.1042/BCJ20200511

Published: 10 March 2021

View articletitled, Protein tyrosine phosphatases in cell adhesion

Includes: Supplementary data

Articles

The RNA-binding protein HuR regulates intestinal epithelial restitution by modulating Caveolin-1 gene expression

Shan Cao, Lan Xiao, Junyao Wang, Guodong Chen, Yulan Liu

Biochem J (2021) 478 (1): 247–260.

https://doi.org/10.1042/BCJ20200372

Published: 15 January 2021

View articletitled, The RNA-binding protein HuR regulates intestinal epithelial restitution by modulating Caveolin-1 gene expression

Articles

SUMO E3 ligase CBX4 regulates hTERT-mediated transcription of CDH1 and promotes breast cancer cell migration and invasion

Sulagna Sanyal, Payel Mondal, Sabyasachi Sen, Sumita Sengupta (Bandyopadhyay), Chandrima Das

Biochem J (2020) 477 (19): 3803–3818.

https://doi.org/10.1042/BCJ20200359

Published: 12 October 2020

View articletitled, SUMO E3 ligase CBX4 regulates hTERT-mediated transcription of CDH1 and promotes breast cancer cell migration and invasion

Includes: Supplementary data

Articles

Merkel cell polyomavirus small tumour antigen activates the p38 MAPK pathway to enhance cellular motility

Samuel J. Dobson, Anthony Anene, James R. Boyne, Jamel Mankouri, Andrew Macdonald, Adrian Whitehouse

Biochem J (2020) 477 (14): 2721–2733.

https://doi.org/10.1042/BCJ20200399

Published: 31 July 2020

View articletitled, Merkel cell polyomavirus small tumour antigen activates the p38 MAPK pathway to enhance cellular motility

Articles

Molecular mechanism of Fast Endophilin-Mediated Endocytosis

Alessandra Casamento, Emmanuel Boucrot

Biochem J (2020) 477 (12): 2327–2345.

https://doi.org/10.1042/BCJ20190342

Published: 26 June 2020

View articletitled, Molecular mechanism of Fast Endophilin-Mediated Endocytosis

Articles

Direct interaction of metastasis-inducing S100P protein with tubulin causes enhanced cell migration without changes in cell adhesion

Min Du, Guozheng Wang, Igor L. Barsukov, Stephane R. Gross, Richard Smith, Philip S. Rudland

Biochem J (2020) 477 (6): 1159–1178.

https://doi.org/10.1042/BCJ20190644

Published: 27 March 2020

View articletitled, Direct interaction of metastasis-inducing S100P protein with tubulin causes enhanced cell migration without changes in cell adhesion

Includes: Supplementary data

Articles

Actin polymerization downstream of integrins: signaling pathways and mechanotransduction

Stéphane Romero, Christophe Le Clainche, Alexis M. Gautreau

Biochem J (2020) 477 (1): 1–21.

https://doi.org/10.1042/BCJ20170719

Published: 08 January 2020

View articletitled, Actin polymerization downstream of integrins: signaling pathways and mechanotransduction

Articles

IGF1R undergoes active and directed centripetal transport on filopodia upon receptor activation

Denis Krndija, Michael Fairhead

Biochem J (2019) 476 (23): 3583–3593.

https://doi.org/10.1042/BCJ20190665

Published: 03 December 2019

View articletitled, IGF1R undergoes active and directed centripetal transport on filopodia upon receptor activation

Includes: Supplementary data

Articles

Induction of erythrocyte microvesicles by Escherichia Coli Alpha hemolysin

Karen Strack, Natalia Lauri, Sabina María Maté, Andrés Saralegui, Carlos Muñoz-Garay, Pablo J. Schwarzbaum, Vanesa Herlax

Biochem J (2019) 476 (22): 3455–3473.

https://doi.org/10.1042/BCJ20190546

Published: 21 November 2019

View articletitled, Induction of erythrocyte microvesicles by Escherichia Coli Alpha hemolysin

Includes: Supplementary data

Articles

Active FHOD1 promotes the formation of functional actin stress fibers

Xuemeng Shi, Shuangshuang Zhao, Jinping Cai, Gary Wong, Yaming Jiu

Biochem J (2019) 476 (20): 2953–2963.

https://doi.org/10.1042/BCJ20190535

Published: 18 October 2019

View articletitled, Active FHOD1 promotes the formation of functional actin stress fibers

Includes: Supplementary data

Articles

Phosphatase of regenerating liver sensitizes MET to functional activation by hepatocyte growth factor

Takuya Kojima, Yosuke Funato, Hiroaki Miki

Biochem J (2019) 476 (10): 1419–1431.

https://doi.org/10.1042/BCJ20190071

Published: 21 May 2019

View articletitled, Phosphatase of regenerating liver sensitizes MET to functional activation by hepatocyte growth factor

Includes: Supplementary data

Articles

N-terminal acetylation and methylation differentially affect the function of MYL9

Chris Nevitt, John G. Tooley, Christine E. Schaner Tooley

Biochem J (2018) 475 (20): 3201–3219.

https://doi.org/10.1042/BCJ20180638

Published: 23 October 2018

View articletitled, N-terminal acetylation and methylation differentially affect the function of MYL9

Includes: Supplementary data

Articles

Effect of the actin- and calcium-regulating activities of ITPKB on the metastatic potential of lung cancer cells

Selina Bäder, Elina Glaubke, Saskia Grüb, Stefanie Muhs, Jasmin Wellbrock, Marcus Nalaskowski, Tobias Lange, Sabine Windhorst

Biochem J (2018) 475 (12): 2057–2071.

https://doi.org/10.1042/BCJ20180238

Published: 26 June 2018

View articletitled, Effect of the actin- and calcium-regulating activities of ITPKB on the metastatic potential of lung cancer cells

Includes: Supplementary data

Articles

The type IV pilus assembly motor PilB is a robust hexameric ATPase with complex kinetics

Andreas Sukmana, Zhaomin Yang

Biochem J (2018) 475 (11): 1979–1993.

https://doi.org/10.1042/BCJ20180167

Published: 15 June 2018

View articletitled, The type IV pilus assembly motor PilB is a robust hexameric ATPase with complex kinetics

Includes: Supplementary data

Articles

Biological role of site-specific O-glycosylation in cell adhesion activity and phosphorylation of osteopontin

Midori Oyama, Yoshinobu Kariya, Yukiko Kariya, Kana Matsumoto, Mayumi Kanno, Yoshiki Yamaguchi, Yasuhiro Hashimoto

Biochem J (2018) 475 (9): 1583–1595.

https://doi.org/10.1042/BCJ20170205

Published: 09 May 2018

View articletitled, Biological role of site-specific O-glycosylation in cell adhesion activity and phosphorylation of osteopontin

Includes: Supplementary data

Articles

Stromal cell-derived factor-1 (CXCL12) activates integrins by direct binding to an allosteric ligand-binding site (site 2) of integrins without CXCR4

Masaaki Fujita, Parastoo Davari, Yoko K. Takada, Yoshikazu Takada

Biochem J (2018) 475 (4): 723–732.

https://doi.org/10.1042/BCJ20170867

Published: 16 February 2018

View articletitled, Stromal cell-derived factor-1 (CXCL12) activates integrins by direct binding to an allosteric ligand-binding site (site 2) of integrins without CXCR4

Includes: Supplementary data

Articles

The functions of Reelin in membrane trafficking and cytoskeletal dynamics: implications for neuronal migration, polarization and differentiation

Jessica Santana, María-Paz Marzolo

Biochem J (2017) 474 (18): 3137–3165.

https://doi.org/10.1042/BCJ20160628

Published: 08 September 2017

View articletitled, The functions of Reelin in membrane trafficking and cytoskeletal dynamics: implications for neuronal migration, polarization and differentiation

Articles

The helicase, DDX3X, interacts with poly(A)-binding protein 1 (PABP1) and caprin-1 at the leading edge of migrating fibroblasts and is required for efficient cell spreading

Alice C. Copsey, Simon Cooper, Robert Parker, Ella Lineham, Cuzack Lapworth, Deema Jallad, Steve Sweet, Simon J. Morley

Biochem J (2017) 474 (18): 3109–3120.

https://doi.org/10.1042/BCJ20170354

Published: 31 August 2017

View articletitled, The helicase, DDX3X, interacts with poly(A)-binding protein 1 (PABP1) and caprin-1 at the leading edge of migrating fibroblasts and is required for efficient cell spreading

Includes: Supplementary data

Articles

A centrosomal protein FOR20 regulates microtubule assembly dynamics and plays a role in cell migration

Shalini Srivastava, Dulal Panda

Biochem J (2017) 474 (16): 2841–2859.

https://doi.org/10.1042/BCJ20170303

Published: 10 August 2017

View articletitled, A centrosomal protein FOR20 regulates microtubule assembly dynamics and plays a role in cell migration

Includes: Supplementary data

Articles

Proteoglycans, ion channels and cell–matrix adhesion

Ioli Mitsou, Hinke A.B. Multhaupt, John R. Couchman

Biochem J (2017) 474 (12): 1965–1979.

https://doi.org/10.1042/BCJ20160747

Published: 25 May 2017

View articletitled, Proteoglycans, ion channels and cell–matrix adhesion

Articles

CCM2 and PAK4 act downstream of atrial natriuretic peptide signaling to promote cell spreading

Koichi Miura, Takashi Nojiri, Yoshiharu Akitake, Koji Ando, Shigetomo Fukuhara, Masahiro Zenitani, Toru Kimura, Jun Hino, Mikiya Miyazato, Hiroshi Hosoda, Kenji Kangawa

Biochem J (2017) 474 (11): 1897–1918.

https://doi.org/10.1042/BCJ20160841

Published: 19 May 2017

View articletitled, CCM2 and PAK4 act downstream of atrial natriuretic peptide signaling to promote cell spreading

Includes: Multimedia, Supplementary data

Articles

Dual histone reader ZMYND8 inhibits cancer cell invasion by positively regulating epithelial genes

Moitri Basu, Isha Sengupta, Md Wasim Khan, Dushyant Kumar Srivastava, Partha Chakrabarti, Siddhartha Roy, Chandrima Das

Biochem J (2017) 474 (11): 1919–1934.

https://doi.org/10.1042/BCJ20170223

Published: 19 May 2017

View articletitled, Dual histone reader ZMYND8 inhibits cancer cell invasion by positively regulating epithelial genes

Includes: Supplementary data

Articles

Interacting post-muscarinic receptor signaling pathways potentiate matrix metalloproteinase-1 expression and invasion of human colon cancer cells

Anan H. Said, Shien Hu, Ameer Abutaleb, Tonya Watkins, Kunrong Cheng, Ahmed Chahdi, Panjamurthy Kuppusamy, Neeraj Saxena, Guofeng Xie, Jean-Pierre Raufman

Biochem J (2017) 474 (5): 647–665.

https://doi.org/10.1042/BCJ20160704

Published: 20 February 2017

View articletitled, Interacting post-muscarinic receptor signaling pathways potentiate matrix metalloproteinase-1 expression and invasion of human colon cancer cells

Includes: Supplementary data

Articles

The CD9, CD81, and CD151 EC2 domains bind to the classical RGD-binding site of integrin αvβ3

Jessica Yu, Chia-Ying Lee, Chun Austin Changou, Dora M. Cedano-Prieto, Yoko K. Takada, Yoshikazu Takada

Biochem J (2017) 474 (4): 589–596.

https://doi.org/10.1042/BCJ20160998

Published: 03 February 2017

View articletitled, The CD9, CD81, and CD151 EC2 domains bind to the classical RGD-binding site of integrin αvβ3

Includes: Supplementary data

Articles

Extracellular vesicles: their role in cancer biology and epithelial–mesenchymal transition

Shashi K. Gopal, David W. Greening, Alin Rai, Maoshan Chen, Rong Xu, Adnan Shafiq, Rommel A. Mathias, Hong-Jian Zhu, Richard J. Simpson

Biochem J (2017) 474 (1): 21–45.

https://doi.org/10.1042/BCJ20160006

Published: 22 December 2016

View articletitled, Extracellular vesicles: their role in cancer biology and epithelial–mesenchymal transition

Articles

The C-terminal dimerization motif of cyclase-associated protein is essential for actin monomer regulation

Shohei Iwase, Shoichiro Ono

Biochem J (2016) 473 (23): 4427–4441.

https://doi.org/10.1042/BCJ20160329

Published: 25 November 2016

View articletitled, The C-terminal dimerization motif of cyclase-associated protein is essential for actin monomer regulation

Includes: Supplementary data

Articles

The role of the mtDNA set point in differentiation, development and tumorigenesis

Xin Sun, Justin C. St. John

Biochem J (2016) 473 (19): 2955–2971.

https://doi.org/10.1042/BCJ20160008

Published: 27 September 2016

View articletitled, The role of the mtDNA set point in differentiation, development and tumorigenesis

Articles

Isoform-specific function of calpains in cell adhesion disruption: studies in postlactational mammary gland and breast cancer

Lucía Rodríguez-Fernández, Iván Ferrer-Vicens, Concha García, Sara S. Oltra, Rosa Zaragozá, Juan R. Viña, Elena R. García-Trevijano

Biochem J (2016) 473 (18): 2893–2909.

https://doi.org/10.1042/BCJ20160198

Published: 12 September 2016

View articletitled, Isoform-specific function of calpains in cell adhesion disruption: studies in postlactational mammary gland and breast cancer

Includes: Supplementary data

Articles

Physiological and pathophysiological functions of Swiprosin-1/EFhd2 in the nervous system

Dirk Mielenz, Frank Gunn-Moore

Biochem J (2016) 473 (16): 2429–2437.

https://doi.org/10.1042/BCJ20160168

Published: 11 August 2016

View articletitled, Physiological and pathophysiological functions of Swiprosin-1/EFhd2 in the nervous system

Articles

Hypertrophic cardiomyopathy mutations in the calponin-homology domain of ACTN2 affect actin binding and cardiomyocyte Z-disc incorporation

Natalie J. Haywood, Marcin Wolny, Brendan Rogers, Chi H. Trinh, Yu Shuping, Thomas A. Edwards, Michelle Peckham

Biochem J (2016) 473 (16): 2485–2493.

https://doi.org/10.1042/BCJ20160421

Published: 11 August 2016

View articletitled, Hypertrophic cardiomyopathy mutations in the calponin-homology domain of ACTN2 affect actin binding and cardiomyocyte Z-disc incorporation

Articles

Zinc transporter ZIP10 forms a heteromer with ZIP6 which regulates embryonic development and cell migration

Kathryn M. Taylor, Issa A. Muraina, Dylan Brethour, Gerold Schmitt-Ulms, Thirayost Nimmanon, Silvia Ziliotto, Peter Kille, Christer Hogstrand

Biochem J (2016) 473 (16): 2531–2544.

https://doi.org/10.1042/BCJ20160388

Published: 11 August 2016

View articletitled, Zinc transporter ZIP10 forms a heteromer with ZIP6 which regulates embryonic development and cell migration

Includes: Supplementary data

Articles

8,9-Dehydrohispanolone-15,16-lactol diterpene prevents LPS-triggered inflammatory responses by inhibiting endothelial activation

Lidia Jiménez-García, Paqui G. Través, Raquel López-Fontal, Sandra Herranz, María Angeles Higueras, Beatriz de las Heras, Sonsoles Hortelano, Alfonso Luque

Biochem J (2016) 473 (14): 2061–2071.

https://doi.org/10.1042/BCJ20160343

Published: 12 July 2016

View articletitled, 8,9-Dehydrohispanolone-15,16-lactol diterpene prevents LPS-triggered inflammatory responses by inhibiting endothelial activation

Articles

The growing landscape of tubulin acetylation: lysine 40 and many more

Karin Sadoul, Saadi Khochbin

Biochem J (2016) 473 (13): 1859–1868.

https://doi.org/10.1042/BCJ20160172

Published: 28 June 2016

View articletitled, The growing landscape of tubulin acetylation: lysine 40 and many more

Articles

PAK5 is auto-activated by a central domain that promotes kinase oligomerization

Bahareh Tabanifar, Zhuoshen Zhao, Ed Manser

Biochem J (2016) 473 (12): 1777–1789.

https://doi.org/10.1042/BCJ20160132

Published: 10 June 2016

View articletitled, PAK5 is auto-activated by a central domain that promotes kinase oligomerization

Includes: Supplementary data

Articles

Secretagogin affects insulin secretion in pancreatic β-cells by regulating actin dynamics and focal adhesion

Seo-Yun Yang, Jae-Jin Lee, Jin-Hee Lee, Kyungeun Lee, Seung Hoon Oh, Yu-Mi Lim, Myung-Shik Lee, Kong-Joo Lee

Biochem J (2016) 473 (12): 1791–1803.

https://doi.org/10.1042/BCJ20160137

Published: 10 June 2016

View articletitled, Secretagogin affects insulin secretion in pancreatic β-cells by regulating actin dynamics and focal adhesion

Includes: Supplementary data

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