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Articles

Dynamic interchange of local residue–residue interactions in the largely extended single alpha-helix in Drebrin

Soma Varga, Bálint Ferenc Péterfia, Dániel Dudola, Viktor Farkas, Cy M. Jeffries, Perttu Permi, Zoltán Gáspári

Biochem J (2025) 482 (08): 383–399.

https://doi.org/10.1042/BCJ20253036

Published: 23 April 2025

View articletitled, Dynamic interchange of local residue–residue interactions in the largely extended single alpha-helix in Drebrin

Includes: Supplementary data

Articles

Characterisation of RNA guanine-7 methyltransferase (RNMT) using a small molecule approach

Lesley-Anne Pearson, Alain-Pierre Petit, Cesar Mendoza Martinez, Fiona Bellany, De Lin, Sarah Niven, Rachel Swift, Thomas Eadsforth, Paul Fyfe, Marilyn Paul, Vincent Postis, Xiao Hu, Victoria H. Cowling, David W. Gray

Biochem J (2025) 482 (04): 209–224.

https://doi.org/10.1042/BCJ20240608

Published: 17 February 2025

View articletitled, Characterisation of RNA guanine-7 methyltransferase (RNMT) using a small molecule approach

Includes: Supplementary data

Articles

The C-terminal structure of the N 6 -methyladenosine deaminase YerA and its role in deamination

Qian Jia, Hui Zeng, Nan Xiao, Jing Tang, Shangfang Gao, Wei Xie

Biochem J (2025) 482 (04): 197–208.

https://doi.org/10.1042/BCJ20240728

Published: 12 February 2025

View articletitled, The C-terminal structure of the N 6 -methyladenosine deaminase YerA and its role in deamination

Includes: Supplementary data

Articles

Macromolecular crowding and bicarbonate enhance the hydrogen peroxide-induced inactivation of glyceraldehyde-3-phosphate dehydrogenase

Rebecca H. J. Bloemen, Rafael Radi, Michael J. Davies, Eduardo Fuentes-Lemus

Biochem J (2024) 481 (23): 1855–1866.

https://doi.org/10.1042/BCJ20240597

Published: 04 December 2024

View articletitled, Macromolecular crowding and bicarbonate enhance the hydrogen peroxide-induced inactivation of glyceraldehyde-3-phosphate dehydrogenase

Includes: Supplementary data

Articles

ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding

Grace Q. Gong, Glenn R. Masson, Woo-Jeong Lee, James M. J. Dickson, Jackie D. Kendall, Manoj K. Rathinaswamy, Christina M. Buchanan, Martin Middleditch, Brady M. Owen, Julie A. Spicer, Gordon W. Rewcastle, William A. Denny, John E. Burke, Peter R. Shepherd, Roger L. Williams, Jack U. Flanagan

Biochem J (2024) 481 (23): 1787–1802.

https://doi.org/10.1042/BCJ20240479

Published: 28 November 2024

View articletitled, ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding

Includes: Supplementary data

Articles

Mitigating methylglyoxal-induced glycation stress: the protective role of iron, copper, and manganese coordination compounds in Saccharomyces cerevisiae

Maria Eduarda S. F. do Espírito Santo, Bárbara F. Frascino, Larissa M. M. Mattos, Daniele C. Pires, Simone S. C. de Oliveira, Lucas B. Menezes, Bernardo F. Braz, Ricardo E. Santeli, André L. S. Santos, Adolfo Horn, Jr, Christiane Fernandes, Marcos D. Pereira

Biochem J (2024) 481 (23): 1771–1786.

https://doi.org/10.1042/BCJ20240390

Published: 28 November 2024

View articletitled, Mitigating methylglyoxal-induced glycation stress: the protective role of iron, copper, and manganese coordination compounds in Saccharomyces cerevisiae

Includes: Supplementary data

Articles

Mitigating neuroinflammation in cognitive areas: exploring the impact of HMG-CoA reductase inhibitor

Carlos Henrique Rocha Catalão, Luis Henrique Angenendt da Costa, Jonathas Rodrigo dos Santos, Luciane Carla Alberici, Luiz Luciano Falconi-Sobrinho, Norberto Cysne Coimbra, Diogo Dominguini, Felipe Dal-Pizzol, Tatiana Barichello, Maria José Alves Rocha

Biochem J (2024) 481 (22): 1585–1602.

https://doi.org/10.1042/BCJ20240217

Published: 07 November 2024

View articletitled, Mitigating neuroinflammation in cognitive areas: exploring the impact of HMG-CoA reductase inhibitor

Includes: Supplementary data

Articles

Identification of inhibitors of human ChaC1, a cytoplasmic glutathione degrading enzyme through high throughput screens in yeast

Shradha Suyal, Chinmayee Choudhury, Deepinder Kaur, Anand K. Bachhawat

Biochem J (2024) 481 (20): 1475–1495.

https://doi.org/10.1042/BCJ20240447

Published: 14 October 2024

View articletitled, Identification of inhibitors of human ChaC1, a cytoplasmic glutathione degrading enzyme through high throughput screens in yeast

Includes: Supplementary data

Articles

The pro-drug C13 activates AMPK by two distinct mechanisms

Jordana B. Freemantle, Dinesh Shah, Dylan M. Lynch, Alessio Ciulli, Harinder S. Hundal, D. Grahame Hardie

Biochem J (2024) 481 (18): 1203–1219.

https://doi.org/10.1042/BCJ20240425

Published: 12 September 2024

View articletitled, The pro-drug C13 activates AMPK by two distinct mechanisms

Includes: Supplementary data

Articles

Regulation of PARP1/2 and the tankyrases: emerging parallels

Matthew Jessop, Benjamin J. Broadway, Katy Miller, Sebastian Guettler

Biochem J (2024) 481 (17): 1097–1123.

https://doi.org/10.1042/BCJ20230230

Published: 23 August 2024

View articletitled, Regulation of PARP1/2 and the tankyrases: emerging parallels

Articles

1-Deoxy-d-xylulose 5-phosphate reductoisomerase as target for anti Toxoplasma gondii agents: crystal structure, biochemical characterization and biological evaluation of inhibitors

Flaminia Mazzone, Astrid Hoeppner, Jens Reiners, Christoph G.W. Gertzen, Violetta Applegate, Mona A. Abdullaziz, Julia Gottstein, Daniel Degrandi, Martina Wesemann, Thomas Kurz, Sander H.J. Smits, Klaus Pfeffer

Biochem J (2024) 481 (16): 1075–1096.

https://doi.org/10.1042/BCJ20240110

Published: 21 August 2024

View articletitled, 1-Deoxy-d-xylulose 5-phosphate reductoisomerase as target for anti Toxoplasma gondii agents: crystal structure, biochemical characterization and biological evaluation of inhibitors

Includes: Supplementary data

Articles

Biophysical and structural analyses of the interaction between the SHANK1 PDZ domain and an internal SLiM

Yue Li, Chi H. Trinh, Amanda Acevedo-Jake, Diana Gimenez, Stuart L. Warriner, Andrew J. Wilson

Biochem J (2024) 481 (14): 945–955.

https://doi.org/10.1042/BCJ20240126

Published: 10 July 2024

View articletitled, Biophysical and structural analyses of the interaction between the SHANK1 PDZ domain and an internal SLiM

Includes: Supplementary data

Articles

Integrating bacterial molecular genetics with chemical biology for renewed antibacterial drug discovery

Susannah L. Parkhill, Eachan O. Johnson

Biochem J (2024) 481 (13): 839–864.

https://doi.org/10.1042/BCJ20220062

Published: 03 July 2024

View articletitled, Integrating bacterial molecular genetics with chemical biology for renewed antibacterial drug discovery

Articles

Validation of GCN5L1/BLOC1S1/BLOS1 antibodies using knockout cells and tissue

Paramesha Bugga, Michael W. Stoner, Janet R. Manning, Bellina A.S. Mushala, Nisha Bhattarai, Maryam Sharifi-Sanjani, Bradley R. Webster, Dharendra Thapa, Iain Scott

Biochem J (2024) 481 (10): 643–651.

https://doi.org/10.1042/BCJ20230302

Published: 10 May 2024

View articletitled, Validation of GCN5L1/BLOC1S1/BLOS1 antibodies using knockout cells and tissue

Includes: Supplementary data

Articles

Up-regulation of SLC7A11/xCT creates a vulnerability to selenocystine-induced cytotoxicity

Shawn Lu Wen Tan, Hui Min Tan, Erez Israeli, Indah Fatihah, Vignesh Ramachandran, Shamsia Bte Ali, Shane Jun An Goh, Jillian Wee, Alicia Qian Ler Tan, Wai Leong Tam, Weiping Han

Biochem J (2023) 480 (24): 2045–2058.

https://doi.org/10.1042/BCJ20230317

Published: 18 December 2023

View articletitled, Up-regulation of SLC7A11/xCT creates a vulnerability to selenocystine-induced cytotoxicity

Includes: Supplementary data

Articles

Targeting bacterial degradation machinery as an antibacterial strategy

Radoslav Petkov, Amy H. Camp, Rivka L. Isaacson, James H. Torpey

Biochem J (2023) 480 (21): 1719–1731.

https://doi.org/10.1042/BCJ20230191

Published: 02 November 2023

View articletitled, Targeting bacterial degradation machinery as an antibacterial strategy

Articles

CRISPR/Cas9-based edition of frataxin gene in Dictyostelium discoideum

Hernan G. Gentili, María Florencia Pignataro, Justo Olmos, María Florencia Pavan, Lorena Itatí Ibañez, Javier Santos, Francisco Velazquez Duarte

Biochem J (2023) 480 (19): 1533–1551.

https://doi.org/10.1042/BCJ20230244

Published: 05 October 2023

View articletitled, CRISPR/Cas9-based edition of frataxin gene in Dictyostelium discoideum

Includes: Supplementary data

Articles

The choreography of protein kinase PDK1 and its diverse substrate dance partners

In Collection

Cell signaling in the 21st century

Alejandro E. Leroux, Ricardo M. Biondi

Biochem J (2023) 480 (19): 1503–1532.

https://doi.org/10.1042/BCJ20220396

Published: 04 October 2023

View articletitled, The choreography of protein kinase PDK1 and its diverse substrate dance partners

Articles

Incorporation of inosine into DNA by human polymerase eta (Polη): kinetics of nucleotide misincorporation and structural basis for the mutagenicity

Qi Zhang, Natalia Tretyakova

Biochem J (2023) 480 (18): 1479–1483.

https://doi.org/10.1042/BCJ20230159

Published: 25 September 2023

View articletitled, Incorporation of inosine into DNA by human polymerase eta (Polη): kinetics of nucleotide misincorporation and structural basis for the mutagenicity

Articles

Chemical biology tools for protein labelling: insights into cell–cell communication

In Collection

Cell signaling in the 21st century

Megan H. Wright

Biochem J (2023) 480 (18): 1445–1457.

https://doi.org/10.1042/BCJ20220309

Published: 21 September 2023

View articletitled, Chemical biology tools for protein labelling: insights into cell–cell communication

Articles

How many kinases are druggable? A review of our current understanding

Brian Anderson, Peter Rosston, Han Wee Ong, Mohammad Anwar Hossain, Zachary W. Davis-Gilbert, David H. Drewry

Biochem J (2023) 480 (16): 1331–1363.

https://doi.org/10.1042/BCJ20220217

Published: 29 August 2023

View articletitled, How many kinases are druggable? A review of our current understanding

Includes: Supplementary data

Articles

Development of an OTUD1 ubiquitin variant inhibitor

Qi Liu, Evan Mallette, Hui Zheng, Wei Zhang

Biochem J (2023) 480 (16): 1317–1330.

https://doi.org/10.1042/BCJ20230119

Published: 25 August 2023

View articletitled, Development of an OTUD1 ubiquitin variant inhibitor

Includes: Supplementary data

Articles

A global view of the human post-translational modification landscape

In Collection

Cell signaling in the 21st century

Naoya Kitamura, James J. Galligan

Biochem J (2023) 480 (16): 1241–1265.

https://doi.org/10.1042/BCJ20220251

Published: 23 August 2023

View articletitled, A global view of the human post-translational modification landscape

Articles

Capturing the domain crosstalk in full length LRRK2 and LRRK2 RCKW

In Collection

Cell signaling in the 21st century

Eliza Störmer, Jui-Hung Weng, Jian Wu, Daniela Bertinetti, Pallavi Kaila Sharma, Wen Ma, Friedrich W. Herberg, Susan S. Taylor

Biochem J (2023) 480 (11): 815–833.

https://doi.org/10.1042/BCJ20230126

Published: 12 June 2023

View articletitled, Capturing the domain crosstalk in full length LRRK2 and LRRK2 RCKW

Includes: Supplementary data

Articles

LRRC8A is responsible for exosome biogenesis and volume regulation in colon cancer cells

Haifeng Zhang, Shiyu Cui, Zhenghui Jing, Guodan Fu, Rong Liu, Wenbao Zhao, Liting Xu, Lei Yu, Yuhui Bai, Changsheng Lv, Min Wu, Yuan Wei, Liangming Li, Shuang Peng

Biochem J (2023) 480 (9): 701–713.

https://doi.org/10.1042/BCJ20220614

Published: 17 May 2023

View articletitled, LRRC8A is responsible for exosome biogenesis and volume regulation in colon cancer cells

Includes: Supplementary data

Articles

Mutations in an unrecognized internal NPT2A PDZ motif disrupt phosphate transport and cause congenital hypophosphatemia

W. Bruce Sneddon, Peter A. Friedman, Tatyana Mamonova

Biochem J (2023) 480 (9): 685–699.

https://doi.org/10.1042/BCJ20230020

Published: 17 May 2023

View articletitled, Mutations in an unrecognized internal NPT2A PDZ motif disrupt phosphate transport and cause congenital hypophosphatemia

Articles

The VEGFR/PDGFR tyrosine kinase inhibitor, ABT-869, blocks necroptosis by targeting RIPK1 kinase

In Collection

Cell death and survival

Catia L. Pierotti, Annette V. Jacobsen, Christoph Grohmann, Ruby K. Dempsey, Nima Etemadi, Joanne M. Hildebrand, Cheree Fitzgibbon, Samuel N. Young, Katherine A. Davies, Wilhelmus J. A. Kersten, John Silke, Kym N. Lowes, Hélène Jousset Sabroux, David C. S. Huang, Mark F. van Delft, James M. Murphy, Guillaume Lessene

Biochem J (2023) 480 (9): 665–684.

https://doi.org/10.1042/BCJ20230035

Published: 12 May 2023

View articletitled, The VEGFR/PDGFR tyrosine kinase inhibitor, ABT-869, blocks necroptosis by targeting RIPK1 kinase

Includes: Supplementary data

Articles

ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1

In Collection

Cell signaling in the 21st century

Kathryn Balmanno, Andrew M. Kidger, Dominic P. Byrne, Matthew J. Sale, Nejma Nassman, Patrick A. Eyers, Simon J. Cook

Biochem J (2023) 480 (9): 587–605.

https://doi.org/10.1042/BCJ20220598

Published: 04 May 2023

View articletitled, ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1

Includes: Supplementary data

Articles

Genotoxic effects of the major alkylation damage N7-methylguanine and methyl formamidopyrimidine

Lillian F. Schmaltz, Myong-Chul Koag, Yi Kou, Louis Zhang, Seongmin Lee

Biochem J (2023) 480 (9): 573–585.

https://doi.org/10.1042/BCJ20220460

Published: 04 May 2023

View articletitled, Genotoxic effects of the major alkylation damage N7-methylguanine and methyl formamidopyrimidine

Articles

Self-assembly of shell protein and native enzyme in a crowded environment leads to catalytically active phase condensates

Gaurav Kumar, Sharmistha Sinha

Biochem J (2023) 480 (8): 539–553.

https://doi.org/10.1042/BCJ20220551

Published: 26 April 2023

View articletitled, Self-assembly of shell protein and native enzyme in a crowded environment leads to catalytically active phase condensates

Includes: Multimedia, Supplementary data

Articles

Divergent contribution of the MVA and MEP pathways to the formation of polyprenols and dolichols in Arabidopsis

Agata Lipko, Cezary Pączkowski, Laura Perez-Fons, Paul D. Fraser, Magdalena Kania, Marta Hoffman-Sommer, Witold Danikiewicz, Michel Rohmer, Jaroslaw Poznanski, Ewa Swiezewska

Biochem J (2023) 480 (8): 495–520.

https://doi.org/10.1042/BCJ20220578

Published: 21 April 2023

View articletitled, Divergent contribution of the MVA and MEP pathways to the formation of polyprenols and dolichols in Arabidopsis

Includes: Supplementary data

Articles

Chaetocin disrupts the SUV39H1–HP1 interaction independent of SUV39H1 methyltransferase activity

Linna Han, Jessica B. Lee, Elaine W. Indermaur, Albert J. Keung

Biochem J (2023) 480 (6): 421–432.

https://doi.org/10.1042/BCJ20220528

Published: 24 March 2023

View articletitled, Chaetocin disrupts the SUV39H1–HP1 interaction independent of SUV39H1 methyltransferase activity

Includes: Supplementary data

Articles

Structure of the major oxidative damage 7,8-dihydro-8-oxoguanine presented into a catalytically competent DNA glycosylase

Lillian F. Schmaltz, Julia E. Ceniceros, Seongmin Lee

Biochem J (2022) 479 (21): 2297–2309.

https://doi.org/10.1042/BCJ20220438

Published: 04 November 2022

View articletitled, Structure of the major oxidative damage 7,8-dihydro-8-oxoguanine presented into a catalytically competent DNA glycosylase

Articles

An Arabidopsis thaliana arabinogalactan-protein (AGP31) and several cationic AGP fragments catalyse the boron bridging of rhamnogalacturonan-II

Dayan Sanhueza, Rifat Ara Begum, Cécile Albenne, Elisabeth Jamet, Stephen C. Fry

Biochem J (2022) 479 (18): 1967–1984.

https://doi.org/10.1042/BCJ20220340

Published: 23 September 2022

View articletitled, An Arabidopsis thaliana arabinogalactan-protein (AGP31) and several cationic AGP fragments catalyse the boron bridging of rhamnogalacturonan-II

Includes: Supplementary data

Articles

Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator

Biochem J (2022) 479 (11): 1181–1204.

https://doi.org/10.1042/BCJ20220067

Published: 08 June 2022

View articletitled, Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator

Includes: Supplementary data

Articles

Allosteric pluripotency: challenges and opportunities

Madoka Akimoto, Karla Martinez Pomier, Bryan VanSchouwen, Jung Ah Byun, Mariia Khamina, Giuseppe Melacini

Biochem J (2022) 479 (7): 825–838.

https://doi.org/10.1042/BCJ20210528

Published: 11 April 2022

View articletitled, Allosteric pluripotency: challenges and opportunities

Articles

Excess iodide-induced reactive oxygen species elicit iodide efflux via β-tubulin-associated ClC-3 in thyrocytes

Meisheng Yu, Yuan Wei, Pengyuan Wang, Zhiqin Deng, Jianwen Mao, Linyan Zhu, Lixin Chen, Shuang Peng, Liwei Wang

Biochem J (2022) 479 (5): 629–640.

https://doi.org/10.1042/BCJ20210709

Published: 04 March 2022

View articletitled, Excess iodide-induced reactive oxygen species elicit iodide efflux via β-tubulin-associated ClC-3 in thyrocytes

Includes: Supplementary data

Articles

Structural basis of binding and inhibition of ornithine decarboxylase by 1-amino-oxy-3-aminopropane

X. Edward Zhou, Kelly Suino-Powell, Chad R. Schultz, Bilal Aleiwi, Joseph S. Brunzelle, Jared Lamp, Irving E. Vega, Edmund Ellsworth, André S. Bachmann, Karsten Melcher

Biochem J (2021) 478 (23): 4137–4149.

https://doi.org/10.1042/BCJ20210647

Published: 06 December 2021

View articletitled, Structural basis of binding and inhibition of ornithine decarboxylase by 1-amino-oxy-3-aminopropane

Articles

Mycolactone enhances the Ca 2+ leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca 2+ permeable state

Pratiti Bhadra, Scott Dos Santos, Igor Gamayun, Tillman Pick, Clarissa Neumann, Joy Ogbechi, Belinda S. Hall, Richard Zimmermann, Volkhard Helms, Rachel E. Simmonds, Adolfo Cavalié

Biochem J (2021) 478 (22): 4005–4024.

https://doi.org/10.1042/BCJ20210345

Published: 23 November 2021

View articletitled, Mycolactone enhances the Ca 2+ leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca 2+ permeable state

Includes: Supplementary data

Articles

Higher expression of proline dehydrogenase altered mitochondrial function and increased Trypanosoma cruzi differentiation in vitro and in the insect vector

In Collection

Celebrating 100 years of insulin research

Brian S. Mantilla, Lisvane Paes-Vieira, Felipe de Almeida Dias, Simone G. Calderano, Maria Carolina Elias, Daniela Cosentino-Gomes, Pedro L. Oliveira, José Roberto Meyer-Fernandes, Ariel M. Silber

Biochem J (2021) 478 (21): 3891–3903.

https://doi.org/10.1042/BCJ20210428

Published: 09 November 2021

View articletitled, Higher expression of proline dehydrogenase altered mitochondrial function and increased Trypanosoma cruzi differentiation in vitro and in the insect vector

Includes: Supplementary data

Articles

Crystallographic approach to fragment-based hit discovery against Schistosoma mansoni purine nucleoside phosphorylase

Muhammad Faheem, Napoleão Fonseca Valadares, José Brandão-Neto, Dom Bellini, Patrick Collins, Nicholas M. Pearce, Louise Bird, Juliana Roberta Torini, Raymond Owens, Humberto DMuniz Pereira, Frank Von Delft, João Alexandre Ribeiro Gonçalves Barbosa

Biochem J (2021) 478 (19): 3655–3670.

https://doi.org/10.1042/BCJ20210041

Published: 14 October 2021

View articletitled, Crystallographic approach to fragment-based hit discovery against Schistosoma mansoni purine nucleoside phosphorylase

Articles

Identification of first-in-class plasmodium OTU inhibitors with potent anti-malarial activity

Pinar Siyah, Sezer Akgol, Serdar Durdagi, Fatih Kocabas

Biochem J (2021) 478 (18): 3445–3466.

https://doi.org/10.1042/BCJ20210481

Published: 23 September 2021

View articletitled, Identification of first-in-class plasmodium OTU inhibitors with potent anti-malarial activity

Includes: Supplementary data

Articles

Electron inventory of the iron-sulfur scaffold complex HypCD essential in [NiFe]-hydrogenase cofactor assembly

Sven T. Stripp, Jonathan Oltmanns, Christina S. Müller, David Ehrenberg, Ramona Schlesinger, Joachim Heberle, Lorenz Adrian, Volker Schünemann, Antonio J. Pierik, Basem Soboh

Biochem J (2021) 478 (17): 3281–3295.

https://doi.org/10.1042/BCJ20210224

Published: 07 September 2021

View articletitled, Electron inventory of the iron-sulfur scaffold complex HypCD essential in [NiFe]-hydrogenase cofactor assembly

Includes: Supplementary data

Articles

Structure and function of aerotolerant, multiple-turnover THI4 thiazole synthases

Jaya Joshi, Qiang Li, Jorge D. García-García, Bryan J. Leong, You Hu, Steven D. Bruner, Andrew D. Hanson

Biochem J (2021) 478 (17): 3265–3279.

https://doi.org/10.1042/BCJ20210565

Published: 07 September 2021

View articletitled, Structure and function of aerotolerant, multiple-turnover THI4 thiazole synthases

Includes: Supplementary data

Articles

Kinases leave their mark on caspase substrates

Amy M. Weeks

Biochem J (2021) 478 (17): 3179–3184.

https://doi.org/10.1042/BCJ20210399

Published: 07 September 2021

View articletitled, Kinases leave their mark on caspase substrates

Articles

Engineering potassium activation into biosynthetic thiolase

Andrew C. Marshall, John B. Bruning

Biochem J (2021) 478 (15): 3047–3062.

https://doi.org/10.1042/BCJ20210455

Published: 13 August 2021

View articletitled, Engineering potassium activation into biosynthetic thiolase

Includes: Supplementary data

Articles

Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965

Danial Ahwazi, Katyayanee Neopane, Greg R. Markby, Franziska Kopietz, Ashley J. Ovens, Morten Dall, Anna S. Hassing, Pamina Gräsle, Yazeed Alshuweishi, Jonas T. Treebak, Ian P. Salt, Olga Göransson, Elton Zeqiraj, John W. Scott, Kei Sakamoto

Biochem J (2021) 478 (15): 2977–2997.

https://doi.org/10.1042/BCJ20210284

Published: 10 August 2021

View articletitled, Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965

Includes: Supplementary data

Articles

The intramolecular allostery of GRB2 governing its interaction with SOS1 is modulated by phosphotyrosine ligands

Neda S. Kazemein Jasemi, Christian Herrmann, Eva Magdalena Estirado, Lothar Gremer, Dieter Willbold, Luc Brunsveld, Radovan Dvorsky, Mohammad R. Ahmadian

Biochem J (2021) 478 (14): 2793–2809.

https://doi.org/10.1042/BCJ20210105

Published: 23 July 2021

View articletitled, The intramolecular allostery of GRB2 governing its interaction with SOS1 is modulated by phosphotyrosine ligands

Includes: Supplementary data

Articles

Mechanistic roles for altered O -GlcNAcylation in neurodegenerative disorders

Aaron T. Balana, Matthew R. Pratt

Biochem J (2021) 478 (14): 2733–2758.

https://doi.org/10.1042/BCJ20200609

Published: 23 July 2021

View articletitled, Mechanistic roles for altered O -GlcNAcylation in neurodegenerative disorders

Articles

Molecular basis for recognition of the Group A Carbohydrate backbone by the PlyC streptococcal bacteriophage endolysin

Harley King, Sowmya Ajay Castro, Amol Arunrao Pohane, Cynthia M. Scholte, Vincent A. Fischetti, Natalia Korotkova, Daniel C. Nelson, Helge C. Dorfmueller

Biochem J (2021) 478 (12): 2385–2397.

https://doi.org/10.1042/BCJ20210158

Published: 25 June 2021

View articletitled, Molecular basis for recognition of the Group A Carbohydrate backbone by the PlyC streptococcal bacteriophage endolysin

Includes: Supplementary data

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