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Articles

Aldose reductase, fructose and fat production in the liver

Peter Delannoy, Dean R. Tolan, Miguel A. Lanaspa, Iñigo San Millán, So Young Bae, Richard J. Johnson

Biochem J (2025) 482 (05): 295–307.

https://doi.org/10.1042/BCJ20240748

Published: 19 February 2025

View article titled, Aldose reductase, fructose and fat production in the liver

Articles

Biochemical basis and therapeutic potential of mitochondrial uncoupling in cardiometabolic syndrome

Bernardo Gindri dos Santos, Niki F. Brisnovali, Leigh Goedeke

Biochem J (2024) 481 (23): 1831–1854.

https://doi.org/10.1042/BCJ20240005

Published: 04 December 2024

View article titled, Biochemical basis and therapeutic potential of mitochondrial uncoupling in cardiometabolic syndrome

Articles

IL-4 activates the futile triacylglyceride cycle for glucose utilization in white adipocytes

Svetlana Michurina, Margarita Agareva, Ekaterina Zubkova, Mikhail Menshikov, Iurii Stafeev, Yelena Parfyonova

Biochem J (2024) 481 (4): 329–344.

https://doi.org/10.1042/BCJ20230486

Published: 19 February 2024

View article titled, IL-4 activates the futile triacylglyceride cycle for glucose utilization in white adipocytes

Includes: Supplementary data

Articles

Identification of a 10-mer peptide from the death domain of MyD88 which attenuates inflammation and insulin resistance and improves glucose metabolism

Mehmood Ali, Tripti Kumari, Arvind Gupta, Sariyah Akhtar, Rahul Dev Verma, Jimut Kanti Ghosh

Biochem J (2024) 481 (4): 191–218.

https://doi.org/10.1042/BCJ20230369

Published: 13 February 2024

View article titled, Identification of a 10-mer peptide from the death domain of MyD88 which attenuates inflammation and insulin resistance and improves glucose metabolism

Includes: Supplementary data

Articles

Interactions of mitochondrial and skeletal muscle biology in mitochondrial myopathy

In Collection

Awards

Valeria Di Leo, Tiago M. Bernardino Gomes, Amy E. Vincent

Biochem J (2023) 480 (21): 1767–1789.

https://doi.org/10.1042/BCJ20220233

Published: 15 November 2023

View article titled, Interactions of mitochondrial and skeletal muscle biology in mitochondrial myopathy

Articles

Mitophagy in yeast: known unknowns and unknown unknowns

Hagai Abeliovich

Biochem J (2023) 480 (20): 1639–1657.

https://doi.org/10.1042/BCJ20230279

Published: 18 October 2023

View article titled, Mitophagy in yeast: known unknowns and unknown unknowns

Articles

Seasonal cold induces divergent structural/biochemical adaptations in different skeletal muscles of Columba livia : evidence for nonshivering thermogenesis in adult birds

Punyadhara Pani, Gourabamani Swalsingh, Sunil Pani, Unmod Senapati, Bijayashree Sahu, Benudhara Pati, Subhasmita Rout, Naresh C. Bal

Biochem J (2023) 480 (17): 1397–1409.

https://doi.org/10.1042/BCJ20230245

Published: 04 September 2023

View article titled, Seasonal cold induces divergent structural/biochemical adaptations in different skeletal muscles of Columba livia : evidence for nonshivering thermogenesis in adult birds

Includes: Supplementary data

Articles

Shaping mitochondria through fed–fast and circadian cycles

In Collection

Cell signaling in the 21st century

Subhash Khatri, Rubina Kazi, Ullas Kolthur-Seetharam

Biochem J (2023) 480 (13): 909–919.

https://doi.org/10.1042/BCJ20220378

Published: 04 July 2023

View article titled, Shaping mitochondria through fed–fast and circadian cycles

Articles

Mitochondrial metabolism and dynamics in pancreatic beta cell glucose sensing

In Collection

Awards

Guy A. Rutter, Vaibhav Sidarala, Brett A. Kaufman, Scott A. Soleimanpour

Biochem J (2023) 480 (11): 773–789.

https://doi.org/10.1042/BCJ20230167

Published: 07 June 2023

View article titled, Mitochondrial metabolism and dynamics in pancreatic beta cell glucose sensing

Articles

The biochemistry and physiology of long-chain dicarboxylic acid metabolism

Pablo Ranea-Robles, Sander M. Houten

Biochem J (2023) 480 (9): 607–627.

https://doi.org/10.1042/BCJ20230041

Published: 04 May 2023

View article titled, The biochemistry and physiology of long-chain dicarboxylic acid metabolism

Articles

AMPK inhibits liver gluconeogenesis: fact or fiction?

In Collection

Cell signaling in the 21st century

Manuel Johanns, Louis Hue, Mark H. Rider

Biochem J (2023) 480 (1): 105–125.

https://doi.org/10.1042/BCJ20220582

Published: 13 January 2023

View article titled, AMPK inhibits liver gluconeogenesis: fact or fiction?

Articles

Inhibition of basal and glucagon-induced hepatic glucose production by 991 and other pharmacological AMPK activators

Manuel Johanns, Cyril Corbet, Roxane Jacobs, Melissa Drappier, Guido T. Bommer, Gaëtan Herinckx, Didier Vertommen, Nicolas Tajeddine, David Young, Joris Messens, Olivier Feron, Gregory R. Steinberg, Louis Hue, Mark H. Rider

Biochem J (2022) 479 (12): 1317–1336.

https://doi.org/10.1042/BCJ20220170

Published: 22 June 2022

View article titled, Inhibition of basal and glucagon-induced hepatic glucose production by 991 and other pharmacological AMPK activators

Includes: Supplementary data

Articles

Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator

Biochem J (2022) 479 (11): 1181–1204.

https://doi.org/10.1042/BCJ20220067

Published: 08 June 2022

View article titled, Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator

Includes: Supplementary data

Articles

FoxO transcription factors in mitochondrial homeostasis

Zhiyong Cheng

Biochem J (2022) 479 (4): 525–536.

https://doi.org/10.1042/BCJ20210777

Published: 23 February 2022

View article titled, FoxO transcription factors in mitochondrial homeostasis

Articles

Differential effect of canagliflozin, a sodium–glucose cotransporter 2 (SGLT2) inhibitor, on slow and fast skeletal muscles from nondiabetic mice

Hiroko Otsuka, Hisashi Yokomizo, Shintaro Nakamura, Yoshihiro Izumi, Masatomo Takahashi, Sachiko Obara, Motonao Nakao, Yosuke Ikeda, Naoichi Sato, Ryuichi Sakamoto, Yasutaka Miyachi, Takashi Miyazawa, Takeshi Bamba, Yoshihiro Ogawa

Biochem J (2022) 479 (3): 425–444.

https://doi.org/10.1042/BCJ20210700

Published: 11 February 2022

View article titled, Differential effect of canagliflozin, a sodium–glucose cotransporter 2 (SGLT2) inhibitor, on slow and fast skeletal muscles from nondiabetic mice

Includes: Supplementary data

Articles

GLUT4 On the move

Daniel J. Fazakerley, Francoise Koumanov, Geoffrey D. Holman

Biochem J (2022) 479 (3): 445–462.

https://doi.org/10.1042/BCJ20210073

Published: 11 February 2022

View article titled, GLUT4 On the move

Includes: Supplementary data

Articles

Fetuin-A regulates adipose tissue macrophage content and activation in insulin resistant mice through MCP-1 and iNOS: involvement of IFNγ-JAK2-STAT1 pathway

Dipanjan Chattopadhyay, Snehasis Das, Suktara Guria, Soumyadeep Basu, Sutapa Mukherjee

Biochem J (2021) 478 (22): 4027–4043.

https://doi.org/10.1042/BCJ20210442

Published: 26 November 2021

View article titled, Fetuin-A regulates adipose tissue macrophage content and activation in insulin resistant mice through MCP-1 and iNOS: involvement of IFNγ-JAK2-STAT1 pathway

Includes: Supplementary data

Articles

Revisiting the contribution of mitochondrial biology to the pathophysiology of skeletal muscle insulin resistance

In Collection

Celebrating 100 years of insulin research

Sara M. Frangos, David J. Bishop, Graham P. Holloway

Biochem J (2021) 478 (21): 3809–3826.

https://doi.org/10.1042/BCJ20210145

Published: 09 November 2021

View article titled, Revisiting the contribution of mitochondrial biology to the pathophysiology of skeletal muscle insulin resistance

Articles

SREBP-1c and lipogenesis in the liver: an update

In Collection

Celebrating 100 years of insulin research

Pascal Ferré, Franck Phan, Fabienne Foufelle

Biochem J (2021) 478 (20): 3723–3739.

https://doi.org/10.1042/BCJ20210071

Published: 21 October 2021

View article titled, SREBP-1c and lipogenesis in the liver: an update

Articles

Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965

Danial Ahwazi, Katyayanee Neopane, Greg R. Markby, Franziska Kopietz, Ashley J. Ovens, Morten Dall, Anna S. Hassing, Pamina Gräsle, Yazeed Alshuweishi, Jonas T. Treebak, Ian P. Salt, Olga Göransson, Elton Zeqiraj, John W. Scott, Kei Sakamoto

Biochem J (2021) 478 (15): 2977–2997.

https://doi.org/10.1042/BCJ20210284

Published: 10 August 2021

View article titled, Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965

Includes: Supplementary data

Articles

A home run for human NaCT/SLC13A5/INDY: cryo-EM structure and homology model to predict transport mechanisms, inhibitor interactions and mutational defects

Valeria Jaramillo-Martinez, Vadivel Ganapathy, Ina L. Urbatsch

Biochem J (2021) 478 (11): 2051–2057.

https://doi.org/10.1042/BCJ20210211

Published: 08 June 2021

View article titled, A home run for human NaCT/SLC13A5/INDY: cryo-EM structure and homology model to predict transport mechanisms, inhibitor interactions and mutational defects

Articles

α-Methyl-l-tryptophan as a weight-loss agent in multiple models of obesity in mice

Sathish Sivaprakasam, Sabarish Ramachandran, Mohd Omar Faruk Sikder, Yangzom D. Bhutia, Mitchell W. Wachtel, Vadivel Ganapathy

Biochem J (2021) 478 (7): 1347–1358.

https://doi.org/10.1042/BCJ20210100

Published: 06 April 2021

View article titled, α-Methyl-l-tryptophan as a weight-loss agent in multiple models of obesity in mice

Articles

FoxA2 and RNA Pol II mediate human islet amyloid polypeptide turnover in ER-stressed pancreatic β-cells

Diti Chatterjee Bhowmick, Lydia Burnett, Zhanar Kudaibergenova, Aleksandar M. Jeremic

Biochem J (2021) 478 (6): 1261–1282.

https://doi.org/10.1042/BCJ20200984

Published: 19 March 2021

View article titled, FoxA2 and RNA Pol II mediate human islet amyloid polypeptide turnover in ER-stressed pancreatic β-cells

Includes: Multimedia, Supplementary data

Articles

Resveratrol promotes lysosomal function via ER calcium-dependent TFEB activation to ameliorate lipid accumulation

Rong Shao, Jiahui Shi, Kaili Du, Na Wang, Weijie Cai, Siyu Liu, Zongxian Ding, Yihan Wang, Dan Li

Biochem J (2021) 478 (5): 1159–1173.

https://doi.org/10.1042/BCJ20200676

Published: 12 March 2021

View article titled, Resveratrol promotes lysosomal function via ER calcium-dependent TFEB activation to ameliorate lipid accumulation

Articles

Altered intestinal epithelial nutrient transport: an underappreciated factor in obesity modulated by diet and microbiota

Shanmuga Sundaram, Alip Borthakur

Biochem J (2021) 478 (5): 975–995.

https://doi.org/10.1042/BCJ20200902

Published: 04 March 2021

View article titled, Altered intestinal epithelial nutrient transport: an underappreciated factor in obesity modulated by diet and microbiota

Articles

Whole-body metabolic fate of branched-chain amino acids

Megan C. Blair, Michael D. Neinast, Zoltan Arany

Biochem J (2021) 478 (4): 765–776.

https://doi.org/10.1042/BCJ20200686

Published: 24 February 2021

View article titled, Whole-body metabolic fate of branched-chain amino acids

Articles

A-769662 inhibits adipocyte glucose uptake in an AMPK-independent manner

Franziska Kopietz, Yazeed Alshuweishi, Silvia Bijland, Fatmah Alghamdi, Eva Degerman, Kei Sakamoto, Ian P. Salt, Olga Göransson

Biochem J (2021) 478 (3): 633–646.

https://doi.org/10.1042/BCJ20200659

Published: 12 February 2021

View article titled, A-769662 inhibits adipocyte glucose uptake in an AMPK-independent manner

Includes: Supplementary data

Articles

Consequences of NaCT/SLC13A5/mINDY deficiency: good versus evil, separated only by the blood–brain barrier

Jonathan J. Kopel, Yangzom D. Bhutia, Sathish Sivaprakasam, Vadivel Ganapathy

Biochem J (2021) 478 (3): 463–486.

https://doi.org/10.1042/BCJ20200877

Published: 05 February 2021

View article titled, Consequences of NaCT/SLC13A5/mINDY deficiency: good versus evil, separated only by the blood–brain barrier

Articles

Complexin-2 redistributes to the membrane of muscle cells in response to insulin and contributes to GLUT4 translocation

Martin Alejandro Pavarotti, Victoria Tokarz, Scott Frendo-Cumbo, Philip J. Bilan, Zhi Liu, Emilia Zanni-Ruiz, Luis Segundo Mayorga, Amira Klip

Biochem J (2021) 478 (2): 407–422.

https://doi.org/10.1042/BCJ20200542

Published: 29 January 2021

View article titled, Complexin-2 redistributes to the membrane of muscle cells in response to insulin and contributes to GLUT4 translocation

Includes: Supplementary data

Articles

Functional analysis of a species-specific inhibitor selective for human Na + -coupled citrate transporter (NaCT/SLC13A5/mINDY)

Kei Higuchi, Jonathan J. Kopel, Sathish Sivaprakasam, Valeria Jaramillo-Martinez, R. Bryan Sutton, Ina L. Urbatsch, Vadivel Ganapathy

Biochem J (2020) 477 (21): 4149–4165.

https://doi.org/10.1042/BCJ20200592

Published: 05 November 2020

View article titled, Functional analysis of a species-specific inhibitor selective for human Na + -coupled citrate transporter (NaCT/SLC13A5/mINDY)

Articles

Current and emerging roles of adipose tissue in health and disease

In Collection

Adipose biology

Emilio P. Mottillo, Gregory R. Steinberg

Biochem J (2020) 477 (19): 3645–3647.

https://doi.org/10.1042/BCJ20200718

Published: 05 October 2020

View article titled, Current and emerging roles of adipose tissue in health and disease

Articles

Arylsulfatase K inactivation causes mucopolysaccharidosis due to deficient glucuronate desulfation of heparan and chondroitin sulfate

Christof Trabszo, Bastian Ramms, Pradeep Chopra, Renate Lüllmann-Rauch, Stijn Stroobants, Jens Sproß, Anke Jeschke, Thorsten Schinke, Geert-Jan Boons, Jeffrey D. Esko, Torben Lübke, Thomas Dierks

Biochem J (2020) 477 (17): 3433–3451.

https://doi.org/10.1042/BCJ20200546

Published: 17 September 2020

View article titled, Arylsulfatase K inactivation causes mucopolysaccharidosis due to deficient glucuronate desulfation of heparan and chondroitin sulfate

Includes: Supplementary data

Articles

Loss of APJ mediated β-arrestin signalling improves high-fat diet induced metabolic dysfunction but does not alter cardiac function in mice

Na Li, Xiaochuan Ma, Ting Ban, Shaohua Xu, Yingli Ma, Brandon Ason, Liaoyuan A. Hu

Biochem J (2020) 477 (17): 3313–3327.

https://doi.org/10.1042/BCJ20200343

Published: 10 September 2020

View article titled, Loss of APJ mediated β-arrestin signalling improves high-fat diet induced metabolic dysfunction but does not alter cardiac function in mice

Includes: Supplementary data

Articles

MAPK-interacting kinase 2 (MNK2) regulates adipocyte metabolism independently of its catalytic activity

James E. Merrett, Jianling Xie, Peter J. Psaltis, Christopher G. Proud

Biochem J (2020) 477 (14): 2735–2754.

https://doi.org/10.1042/BCJ20200433

Published: 31 July 2020

View article titled, MAPK-interacting kinase 2 (MNK2) regulates adipocyte metabolism independently of its catalytic activity

Includes: Supplementary data

Articles

Impact of pesticide exposure on adipose tissue development and function

In Collection

Adipose biology

Robert M. Gutgesell, Evangelia E. Tsakiridis, Shanza Jamshed, Gregory R. Steinberg, Alison C. Holloway

Biochem J (2020) 477 (14): 2639–2653.

https://doi.org/10.1042/BCJ20200324

Published: 29 July 2020

View article titled, Impact of pesticide exposure on adipose tissue development and function

Articles

The autocrine role of FGF21 in cultured adipocytes

Sarah Justesen, Kirsten V. Haugegaard, Jacob B. Hansen, Harald S. Hansen, Birgitte Andersen

Biochem J (2020) 477 (13): 2477–2487.

https://doi.org/10.1042/BCJ20200220

Published: 10 July 2020

View article titled, The autocrine role of FGF21 in cultured adipocytes

Includes: Supplementary data

Articles

Identification and characterization of adipose surface epitopes

In Collection

Adipose biology

Yasuhiro Onogi, Ahmed Elagamy Mohamed Mahmoud Khalil, Siegfried Ussar

Biochem J (2020) 477 (13): 2509–2541.

https://doi.org/10.1042/BCJ20190462

Published: 10 July 2020

View article titled, Identification and characterization of adipose surface epitopes

Articles

The SGLT2 inhibitor canagliflozin suppresses lipid synthesis and interleukin-1 beta in ApoE deficient mice

In Collection

Celebrating 100 years of insulin research

Emily A. Day, Rebecca J. Ford, Jessie H. Lu, Rachel Lu, Lucie Lundenberg, Eric M. Desjardins, Alex E. Green, James S.V. Lally, Jonathan D. Schertzer, Gregory R. Steinberg

Biochem J (2020) 477 (12): 2347–2361.

https://doi.org/10.1042/BCJ20200278

Published: 26 June 2020

View article titled, The SGLT2 inhibitor canagliflozin suppresses lipid synthesis and interleukin-1 beta in ApoE deficient mice

Includes: Supplementary data

Articles

DhHP-6 ameliorates hepatic oxidative stress and insulin resistance in type 2 diabetes mellitus through the PI3K/AKT and AMPK pathway

In Collection

Celebrating 100 years of insulin research

Kai Wang, Yuting Liang, Yu Su, Liping Wang

Biochem J (2020) 477 (12): 2363–2381.

https://doi.org/10.1042/BCJ20200402

Published: 26 June 2020

View article titled, DhHP-6 ameliorates hepatic oxidative stress and insulin resistance in type 2 diabetes mellitus through the PI3K/AKT and AMPK pathway

Articles

Thermogenic adipocytes: lineage, function and therapeutic potential

In Collection

Adipose biology

Alice E. Pollard, David Carling

Biochem J (2020) 477 (11): 2071–2093.

https://doi.org/10.1042/BCJ20200298

Published: 15 June 2020

View article titled, Thermogenic adipocytes: lineage, function and therapeutic potential

Articles

Hereditary hemochromatosis disrupts uric acid homeostasis and causes hyperuricemia via altered expression/activity of xanthine oxidase and ABCG2

Bojana Ristic, Sathish Sivaprakasam, Monisha Narayanan, Vadivel Ganapathy

Biochem J (2020) 477 (8): 1499–1513.

https://doi.org/10.1042/BCJ20190873

Published: 29 April 2020

View article titled, Hereditary hemochromatosis disrupts uric acid homeostasis and causes hyperuricemia via altered expression/activity of xanthine oxidase and ABCG2

Includes: Supplementary data

Articles

Functional characterization of human brown adipose tissue metabolism

In Collection

Adipose biology

Marie Anne Richard, Hannah Pallubinsky, Denis P. Blondin

Biochem J (2020) 477 (7): 1261–1286.

https://doi.org/10.1042/BCJ20190464

Published: 09 April 2020

View article titled, Functional characterization of human brown adipose tissue metabolism

Articles

Biochemical adaptations in white adipose tissue following aerobic exercise: from mitochondrial biogenesis to browning

In Collection

Adipose biology

Greg L. McKie, David C. Wright

Biochem J (2020) 477 (6): 1061–1081.

https://doi.org/10.1042/BCJ20190466

Published: 18 March 2020

View article titled, Biochemical adaptations in white adipose tissue following aerobic exercise: from mitochondrial biogenesis to browning

Articles

Adipocyte lipolysis: from molecular mechanisms of regulation to disease and therapeutics

In Collection

Adipose biology

Alexander Yang, Emilio P. Mottillo

Biochem J (2020) 477 (5): 985–1008.

https://doi.org/10.1042/BCJ20190468

Published: 13 March 2020

View article titled, Adipocyte lipolysis: from molecular mechanisms of regulation to disease and therapeutics

Articles

α-catenin isoforms are regulated by glucose and involved in regulating insulin secretion in rat clonal β-cell models

Waruni C. Dissanayake, Brie Sorrenson, Kate L. Lee, Sandra Barre, Peter R. Shepherd

Biochem J (2020) 477 (4): 763–772.

https://doi.org/10.1042/BCJ20190832

Published: 20 February 2020

View article titled, α-catenin isoforms are regulated by glucose and involved in regulating insulin secretion in rat clonal β-cell models

Articles

UCP1-independent thermogenesis

In Collection

Adipose biology

Anna Roesler, Lawrence Kazak

Biochem J (2020) 477 (3): 709–725.

https://doi.org/10.1042/BCJ20190463

Published: 14 February 2020

View article titled, UCP1-independent thermogenesis

Articles

Single cell approaches to address adipose tissue stromal cell heterogeneity

In Collection

Adipose biology

Elizabeth A. Rondini, James G. Granneman

Biochem J (2020) 477 (3): 583–600.

https://doi.org/10.1042/BCJ20190467

Published: 06 February 2020

View article titled, Single cell approaches to address adipose tissue stromal cell heterogeneity

Includes: Supplementary data

Articles

Two isoprenylated flavonoids from Dorstenia psilurus activate AMPK, stimulate glucose uptake, inhibit glucose production and lower glycemia

Aphrodite T. Choumessi, Manuel Johanns, Claire Beaufay, Marie-France Herent, Vincent Stroobant, Didier Vertommen, Cyril Corbet, Roxane Jacobs, Gaëtan Herinckx, Gregory R. Steinberg, Olivier Feron, Joëlle Quetin-Leclercq, Mark H. Rider

Biochem J (2019) 476 (24): 3687–3704.

https://doi.org/10.1042/BCJ20190326

Published: 17 December 2019

View article titled, Two isoprenylated flavonoids from Dorstenia psilurus activate AMPK, stimulate glucose uptake, inhibit glucose production and lower glycemia

Includes: Supplementary data

Articles

Regulation of plasma glycero-lysophospholipid levels by lipoprotein metabolism

Makoto Kurano, Kuniyuki Kano, Masumi Hara, Kazuhisa Tsukamoto, Junken Aoki, Yutaka Yatomi

Biochem J (2019) 476 (23): 3565–3581.

https://doi.org/10.1042/BCJ20190498

Published: 03 December 2019

View article titled, Regulation of plasma glycero-lysophospholipid levels by lipoprotein metabolism

Includes: Supplementary data

Articles

Regulation of human 4-hydroxy-2-oxoglutarate aldolase by pyruvate and α-ketoglutarate: implications for primary hyperoxaluria type-3

Amadeus Huang, Julia Burke, Richard D. Bunker, Yee-Foong Mok, Michael D. Griffin, Edward N. Baker, Kerry M. Loomes

Biochem J (2019) 476 (21): 3369–3383.

https://doi.org/10.1042/BCJ20190548

Published: 15 November 2019

View article titled, Regulation of human 4-hydroxy-2-oxoglutarate aldolase by pyruvate and α-ketoglutarate: implications for primary hyperoxaluria type-3

Includes: Supplementary data

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