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Articles

Leucine-rich repeat kinase 2 biomarkers for Parkinson’s disease

Open Access
Nicolas Dzamko
Journal: Biochemical Journal
Biochem J (2025) 482 (11): 709–720.
https://doi.org/10.1042/BCJ20253099
Published: 29 May 2025
View articletitled, Leucine-rich repeat kinase 2 biomarkers for Parkinson’s disease
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Articles

Efficient overexpression and purification of severe acute respiratory syndrome coronavirus 2 nucleocapsid proteins in Escherichia coli

Open Access
In Collection
Coronavirus
Emma L. Brudenell, Manoj B. Pohare, Domen Zafred, Janine Phipps, Hailey R. Hornsby, John F. Darby, Junxiao Dai, Ellen Liggett, Kathleen M. Cain, Perdita E. Barran, Thushan I. de Silva, Jon R. Sayers
Journal: Biochemical Journal
Biochem J (2024) 481 (11): 669–682.
https://doi.org/10.1042/BCJ20240019
Published: 24 May 2024
View articletitled, Efficient overexpression and purification of severe acute respiratory syndrome coronavirus 2 nucleocapsid proteins in Escherichia coli
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Includes: Supplementary data
Articles

CRISPR/Cas9-based edition of frataxin gene in Dictyostelium discoideum

Available to Purchase
Hernan G. Gentili, María Florencia Pignataro, Justo Olmos, María Florencia Pavan, Lorena Itatí Ibañez, Javier Santos, Francisco Velazquez Duarte
Journal: Biochemical Journal
Biochem J (2023) 480 (19): 1533–1551.
https://doi.org/10.1042/BCJ20230244
Published: 05 October 2023
View articletitled, CRISPR/Cas9-based edition of frataxin gene in Dictyostelium discoideum
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Includes: Supplementary data
Articles

LRRC8A is responsible for exosome biogenesis and volume regulation in colon cancer cells

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Haifeng Zhang, Shiyu Cui, Zhenghui Jing, Guodan Fu, Rong Liu, Wenbao Zhao, Liting Xu, Lei Yu, Yuhui Bai, Changsheng Lv, Min Wu, Yuan Wei, Liangming Li, Shuang Peng
Journal: Biochemical Journal
Biochem J (2023) 480 (9): 701–713.
https://doi.org/10.1042/BCJ20220614
Published: 17 May 2023
View articletitled, LRRC8A is responsible for exosome biogenesis and volume regulation in colon cancer cells
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Includes: Supplementary data
Articles

Construction of mouse cochlin mutants with different GAG-binding specificities and their use for immunohistochemistry

Open Access
Karin Murakami, Ryo Tamura, Sanae Ikehara, Hayato Ota, Tomomi Ichimiya, Naoki Matsumoto, Hisahiro Matsubara, Shoko Nishihara, Yuzuru Ikehara, Kazuo Yamamoto
Journal: Biochemical Journal
Biochem J (2023) 480 (1): 41–56.
https://doi.org/10.1042/BCJ20220339
Published: 06 January 2023
View articletitled, Construction of mouse cochlin mutants with different GAG-binding specificities and their use for immunohistochemistry
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Includes: Supplementary data
Articles

Development of a colorimetric assay for the detection of SARS-CoV-2 3CLpro activity

Open Access
In Collection
Coronavirus
Gavin D. Garland, Robert F. Harvey, Thomas E. Mulroney, Mie Monti, Stewart Fuller, Richard Haigh, Pehuén Pereyra Gerber, Michael R. Barer, Nicholas J. Matheson, Anne E. Willis
Journal: Biochemical Journal
Biochem J (2022) 479 (8): 901–920.
https://doi.org/10.1042/BCJ20220105
Published: 21 April 2022
View articletitled, Development of a colorimetric assay for the detection of SARS-CoV-2 3CLpro activity
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Includes: Supplementary data
Articles

Deletion of Slc6a14 reduces cancer growth and metastatic spread and improves survival in KPC mouse model of spontaneous pancreatic cancer

Open Access
Bradley K. Schniers, Mitchell S. Wachtel, Meenu Sharma, Ksenija Korac, Devaraja Rajasekaran, Shengping Yang, Tyler Sniegowski, Vadivel Ganapathy, Yangzom D. Bhutia
Journal: Biochemical Journal
Biochem J (2022) 479 (5): 719–730.
https://doi.org/10.1042/BCJ20210855
Published: 16 March 2022
View articletitled, Deletion of Slc6a14 reduces cancer growth and metastatic spread and improves survival in KPC mouse model of spontaneous pancreatic cancer
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Articles

Molecular basis of a redox switch: molecular dynamics simulations and surface plasmon resonance provide insight into reduced and oxidised angiotensinogen

Open Access
Jennifer M. Crowther, Letitia H. Gilmour, Benjamin T. Porebski, Sarah G. Heath, Neil R. Pattinson, Maurice C. Owen, Rayleen Fredericks, Ashley M. Buckle, Conan J. Fee, Christoph Göbl, Renwick C. J. Dobson
Journal: Biochemical Journal
Biochem J (2021) 478 (17): 3319–3330.
https://doi.org/10.1042/BCJ20210476
Published: 14 September 2021
View articletitled, Molecular basis of a redox switch: molecular dynamics simulations and surface plasmon resonance provide insight into reduced and oxidised angiotensinogen
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Articles

PKCα/ERK/C7ORF41 axis regulates epidermal keratinocyte differentiation through the IKKα nuclear translocation

Available to Purchase
Feng-Juan Yan, Yong-Jian Wang, Song-En Wang, Hai-Ting Hong
Journal: Biochemical Journal
Biochem J (2021) 478 (4): 839–854.
https://doi.org/10.1042/BCJ20200879
Published: 24 February 2021
View articletitled, PKCα/ERK/C7ORF41 axis regulates epidermal keratinocyte differentiation through the IKKα nuclear translocation
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Includes: Supplementary data
Articles

Hydrogen deuterium exchange mass spectrometry identifies the dominant paratope in CD20 antigen binding to the NCD1.2 monoclonal antibody

Open Access
Lukas Uhrik, Lenka Hernychova, Petr Muller, Umesh Kalathiya, Malgorzata M. Lisowska, Mikolaj Kocikowski, Maciej Parys, Jakub Faktor, Marta Nekulova, Chris Nortcliffe, Pavlina Zatloukalova, Barbara Ruetgen, Robin Fahraeus, Kathryn L. Ball, David J. Argyle, Borivoj Vojtesek, Ted R. Hupp
Journal: Biochemical Journal
Biochem J (2021) 478 (1): 99–120.
https://doi.org/10.1042/BCJ20200674
Published: 13 January 2021
View articletitled, Hydrogen deuterium exchange mass spectrometry identifies the dominant paratope in CD20 antigen binding to the NCD1.2 monoclonal antibody
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Includes: Supplementary data
Articles

Crystal structure of Leptospira leucine-rich repeat 20 reveals a novel E-cadherin binding protein to induce NGAL expression in HK2 cells

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Shen-Hsing Hsu, Chen-Hsi Chu, Ya-Chung Tian, Ming-Yang Chang, Li-Feng Chou, Yuh-Ju Sun, Chih-Wei Yang
Journal: Biochemical Journal
Biochem J (2020) 477 (21): 4313–4326.
https://doi.org/10.1042/BCJ20200547
Published: 13 November 2020
View articletitled, Crystal structure of Leptospira leucine-rich repeat 20 reveals a novel E-cadherin binding protein to induce NGAL expression in HK2 cells
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Articles

Centrosomal cohesion deficits as cellular biomarker in lymphoblastoid cell lines from LRRK2 Parkinson's disease patients

Open Access
In Collection
Editors' pick of research highlights published in the Biochemical Journal in 2018 & 2019
Belén Fernández, Antonio Jesús Lara Ordóñez, Elena Fdez, Eugénie Mutez, Thomas Comptdaer, Coline Leghay, Alexandre Kreisler, Clémence Simonin, Laurine Vandewynckel, Luc Defebvre, Alain Destée, Séverine Bleuse, Jean-Marc Taymans, Marie-Christine Chartier-Harlin, Sabine Hilfiker
Journal: Biochemical Journal
Biochem J (2019) 476 (19): 2797–2813.
https://doi.org/10.1042/BCJ20190315
Published: 11 October 2019
View articletitled, Centrosomal cohesion deficits as cellular biomarker in lymphoblastoid cell lines from LRRK2 Parkinson's disease patients
Open the PDF for Centrosomal cohesion deficits as cellular biomarker in lymphoblastoid cell lines from LRRK2 Parkinson's disease patients in another window
Includes: Supplementary data
Articles

Cancerous inhibitor of protein phosphatase 2A (CIP2A) modifies energy metabolism via 5′ AMP-activated protein kinase signalling in malignant cells

Available to Purchase
James A. Austin, Rosalind E. Jenkins, Gemma M. Austin, Mark A. Glenn, Karen Dunn, Laura Scott, Claire M. Lucas, Richard E. Clark
Journal: Biochemical Journal
Biochem J (2019) 476 (15): 2255–2269.
https://doi.org/10.1042/BCJ20190121
Published: 15 August 2019
View articletitled, Cancerous inhibitor of protein phosphatase 2A (CIP2A) modifies energy metabolism via 5′ AMP-activated protein kinase signalling in malignant cells
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Includes: Supplementary data
Articles

Metabolites in visceral fat: useful signals of metabolic syndrome?

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Sara Galavotti, Andreas J. Gescher, Alessandro Rufini
Journal: Biochemical Journal
Biochem J (2018) 475 (10): 1789–1791.
https://doi.org/10.1042/BCJ20180088
Published: 31 May 2018
View articletitled, Metabolites in visceral fat: useful signals of metabolic syndrome?
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Articles

Back to the future: new target-validated Rab antibodies for evaluating LRRK2 signalling in cell biology and Parkinson's disease

Open Access
Patrick A. Eyers
Journal: Biochemical Journal
Biochem J (2018) 475 (1): 185–189.
https://doi.org/10.1042/BCJ20170870
Published: 05 January 2018
View articletitled, Back to the future: new target-validated Rab antibodies for evaluating LRRK2 signalling in cell biology and Parkinson's disease
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Articles

Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils

Open Access
In Collection
Editors' pick of research highlights published in the Biochemical Journal in 2018 & 2019
Ying Fan, Andrew J.M. Howden, Adil R. Sarhan, Pawel Lis, Genta Ito, Terina N. Martinez, Kathrin Brockmann, Thomas Gasser, Dario R. Alessi, Esther M. Sammler
Journal: Biochemical Journal
Biochem J (2018) 475 (1): 23–44.
https://doi.org/10.1042/BCJ20170803
Published: 02 January 2018
View articletitled, Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils
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Includes: Supplementary data
Articles

Novel targeted therapies for cancer cachexia

Available to Purchase
Josep M. Argilés, Francisco Javier López-Soriano, Britta Stemmler, Sílvia Busquets
Journal: Biochemical Journal
Biochem J (2017) 474 (16): 2663–2678.
https://doi.org/10.1042/BCJ20170032
Published: 27 July 2017
View articletitled, Novel targeted therapies for cancer cachexia
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Articles

Express incorporation of membrane proteins from various human cell types into phospholipid bilayer nanodiscs

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Stefanie Mak, Ruoyu Sun, Michael Schmalenberg, Carsten Peters, Peter B. Luppa
Journal: Biochemical Journal
Biochem J (2017) 474 (8): 1361–1371.
https://doi.org/10.1042/BCJ20161110
Published: 04 April 2017
View articletitled, Express incorporation of membrane proteins from various human cell types into phospholipid bilayer nanodiscs
Open the PDF for Express incorporation of membrane proteins from various human cell types into phospholipid bilayer nanodiscs in another window
Includes: Supplementary data