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Articles

A hybrid biosynthetic-catabolic pathway for norspermidine production

Bin Li, Jue Liang, Margaret A. Phillips, Anthony J. Michael

Biochem J (2024) 481 (18): 1241–1253.

https://doi.org/10.1042/BCJ20240411

Published: 16 September 2024

View article titled, A hybrid biosynthetic-catabolic pathway for norspermidine production

Includes: Supplementary data

Articles

Inhibitors identify an auxiliary role for mTOR signalling in necroptosis execution downstream of MLKL activation

In Collection

Cell signaling in the 21st century

Sarah E. Garnish, Christopher R. Horne, Yanxiang Meng, Samuel N. Young, Annette V. Jacobsen, Joanne M. Hildebrand, James M. Murphy

Biochem J (2024) 481 (17): 1125–1142.

https://doi.org/10.1042/BCJ20240255

Published: 27 August 2024

View article titled, Inhibitors identify an auxiliary role for mTOR signalling in necroptosis execution downstream of MLKL activation

Includes: Supplementary data

Articles

Regulation of PARP1/2 and the tankyrases: emerging parallels

Matthew Jessop, Benjamin J. Broadway, Katy Miller, Sebastian Guettler

Biochem J (2024) 481 (17): 1097–1123.

https://doi.org/10.1042/BCJ20230230

Published: 23 August 2024

View article titled, Regulation of PARP1/2 and the tankyrases: emerging parallels

Articles

Regulation of Rubisco activity by interaction with chloroplast metabolites

Ana K.M. Lobo, Douglas J. Orr, Elizabete Carmo-Silva

Biochem J (2024) 481 (15): 1043–1056.

https://doi.org/10.1042/BCJ20240209

Published: 05 August 2024

View article titled, Regulation of Rubisco activity by interaction with chloroplast metabolites

Includes: Supplementary data

Articles

RNA processing by the CRISPR-associated NYN ribonuclease

Haotian Chi, Malcolm F. White

Biochem J (2024) 481 (12): 793–804.

https://doi.org/10.1042/BCJ20240151

Published: 17 June 2024

View article titled, RNA processing by the CRISPR-associated NYN ribonuclease

Includes: Supplementary data

Articles

Gibberellin-biosynthetic ent -kaurene synthases in higher plants do not require their non-catalytic domains for the catalysis

So Oshikawa, Ayaka Naoe, Tomoka Moriya, Yuto Hasegawa, Momoko Nakasato, Yuga Ogawa, Hiroki Wakabayashi, Akira Itoh, Yuri Takeda-Kimura, Sho Miyazaki, Hiroshi Kawaide, Tomonobu Toyomasu

Biochem J (2024) 481 (12): 779–791.

https://doi.org/10.1042/BCJ20240162

Published: 12 June 2024

View article titled, Gibberellin-biosynthetic ent -kaurene synthases in higher plants do not require their non-catalytic domains for the catalysis

Includes: Supplementary data

Articles

The monodomain Kunitz protein Eg KU-7 from the dog tapeworm Echinococcus granulosus is a high-affinity trypsin inhibitor with two interaction sites

Martín Fló, Leonardo Pellizza, Rosario Durán, Beatriz Alvarez, Cecilia Fernández

Biochem J (2024) 481 (11): 717–739.

https://doi.org/10.1042/BCJ20230514

Published: 31 May 2024

View article titled, The monodomain Kunitz protein Eg KU-7 from the dog tapeworm Echinococcus granulosus is a high-affinity trypsin inhibitor with two interaction sites

Includes: Supplementary data

Articles

Expression of neuronal NO synthase α- and β-isoforms in skeletal muscle of mice

Oliver Baum

Biochem J (2024) 481 (9): 601–613.

https://doi.org/10.1042/BCJ20230458

Published: 25 April 2024

View article titled, Expression of neuronal NO synthase α- and β-isoforms in skeletal muscle of mice

Articles

AMP-activated protein kinase can be allosterically activated by ADP but AMP remains the key activating ligand

Simon A. Hawley, Fiona M. Russell, D. Grahame Hardie

Biochem J (2024) 481 (8): 587–599.

https://doi.org/10.1042/BCJ20240082

Published: 22 April 2024

View article titled, AMP-activated protein kinase can be allosterically activated by ADP but AMP remains the key activating ligand

Includes: Supplementary data

Articles

Enzyme function and evolution through the lens of bioinformatics

In Collection

Cell signaling in the 21st century

Antonio J. M. Ribeiro, Ioannis G. Riziotis, Neera Borkakoti, Janet M. Thornton

Biochem J (2023) 480 (22): 1845–1863.

https://doi.org/10.1042/BCJ20220405

Published: 22 November 2023

View article titled, Enzyme function and evolution through the lens of bioinformatics

Articles

Catalysis of non-canonical protein ubiquitylation by the ARIH1 ubiquitin ligase

Nicholas Purser, Ishita Tripathi-Giesgen, Jerry Li, Daniel C. Scott, Daniel Horn-Ghetko, Kheewoong Baek, Brenda A. Schulman, Arno F. Alpi, Gary Kleiger

Biochem J (2023) 480 (22): 1817–1831.

https://doi.org/10.1042/BCJ20230373

Published: 17 November 2023

View article titled, Catalysis of non-canonical protein ubiquitylation by the ARIH1 ubiquitin ligase

Includes: Supplementary data

Articles

Functional annotation of haloacid dehalogenase superfamily structural genomics proteins

Lakindu S. Pathira Kankanamge, Lydia A. Ruffner, Mong Mary Touch, Manuel Pina, Penny J. Beuning, Mary Jo Ondrechen

Biochem J (2023) 480 (19): 1553–1569.

https://doi.org/10.1042/BCJ20230057

Published: 06 October 2023

View article titled, Functional annotation of haloacid dehalogenase superfamily structural genomics proteins

Includes: Supplementary data

Articles

Incorporation of inosine into DNA by human polymerase eta (Polη): kinetics of nucleotide misincorporation and structural basis for the mutagenicity

Qi Zhang, Natalia Tretyakova

Biochem J (2023) 480 (18): 1479–1483.

https://doi.org/10.1042/BCJ20230159

Published: 25 September 2023

View article titled, Incorporation of inosine into DNA by human polymerase eta (Polη): kinetics of nucleotide misincorporation and structural basis for the mutagenicity

Articles

Michael D. Waterfield

Julian Downward, Peter J. Parker, Bart Vanhaesebroeck

Biochem J (2023) 480 (18): 1475–1478.

https://doi.org/10.1042/BCJ20230368

Published: 21 September 2023

View article titled, Michael D. Waterfield

Articles

Cancer-associated somatic mutations in human phosphofructokinase-1 reveal a critical electrostatic interaction for allosteric regulation of enzyme activity

Maria A. Voronkova, Heather L. Hansen, Madison P. Cooper, Jacob Miller, Narayanasami Sukumar, Werner J. Geldenhuys, Aaron R. Robart, Bradley A. Webb

Biochem J (2023) 480 (17): 1411–1427.

https://doi.org/10.1042/BCJ20230207

Published: 04 September 2023

View article titled, Cancer-associated somatic mutations in human phosphofructokinase-1 reveal a critical electrostatic interaction for allosteric regulation of enzyme activity

Includes: Supplementary data

Articles

An efficient triose phosphate synthesis and distribution in wheat provides tolerance to higher field temperatures

In Collection

Plants and climate change: the role of plants in achieving net zero

Andrea Romero-Reyes, Sergio G. Hernandez-Leon, Lilia Leyva-Carrillo, Gloria Yepiz-Plascencia, Matthew P. Reynolds, Matthew J. Paul, Sigrid Heuer, Elisa M. Valenzuela-Soto

Biochem J (2023) 480 (16): 1365–1377.

https://doi.org/10.1042/BCJ20230117

Published: 29 August 2023

View article titled, An efficient triose phosphate synthesis and distribution in wheat provides tolerance to higher field temperatures

Includes: Supplementary data

Articles

How many kinases are druggable? A review of our current understanding

Brian Anderson, Peter Rosston, Han Wee Ong, Mohammad Anwar Hossain, Zachary W. Davis-Gilbert, David H. Drewry

Biochem J (2023) 480 (16): 1331–1363.

https://doi.org/10.1042/BCJ20220217

Published: 29 August 2023

View article titled, How many kinases are druggable? A review of our current understanding

Includes: Supplementary data

Articles

In search for structural targets for engineering d-amino acid transaminase: modulation of pH optimum and substrate specificity

Sofia A. Shilova, Ilya O. Matyuta, Maria G. Khrenova, Alena Y. Nikolaeva, Natalia L. Klyachko, Mikhail E. Minyaev, Alex R. Khomutov, Konstantin M. Boyko, Vladimir O. Popov, Ekaterina Yu. Bezsudnova

Biochem J (2023) 480 (16): 1267–1284.

https://doi.org/10.1042/BCJ20230233

Published: 23 August 2023

View article titled, In search for structural targets for engineering d-amino acid transaminase: modulation of pH optimum and substrate specificity

Includes: Supplementary data

Articles

Structural and functional characterization of a mycobacterial methylenetetrahydrofolate reductase utilizing NADH as the exclusive cofactor

Jiacong Li, Mingxia Yang, Weijia Li, Chujie Lu, Deyu Feng, Zhuo Shang, Chengyuan Wang, Wei Lin

Biochem J (2023) 480 (14): 1129–1146.

https://doi.org/10.1042/BCJ20230138

Published: 19 July 2023

View article titled, Structural and functional characterization of a mycobacterial methylenetetrahydrofolate reductase utilizing NADH as the exclusive cofactor

Includes: Supplementary data

Articles

A curated list of targeted optimized promiscuous ketoreductases (TOP-K)

Anirudh P. Shanbhag, Sreenath Rajagopal, Arindam Ghatak, Nainesh Katagihallimath, Ramaswamy Subramanian, Santanu Datta

Biochem J (2023) 480 (13): 975–997.

https://doi.org/10.1042/BCJ20230051

Published: 06 July 2023

View article titled, A curated list of targeted optimized promiscuous ketoreductases (TOP-K)

Includes: Supplementary data

Articles

The acyl carrier proteins of lipid synthesis are busy having other affairs

John E. Cronan

Biochem J (2023) 480 (12): 855–873.

https://doi.org/10.1042/BCJ20230161

Published: 22 June 2023

View article titled, The acyl carrier proteins of lipid synthesis are busy having other affairs

Articles

Capturing the domain crosstalk in full length LRRK2 and LRRK2 RCKW

In Collection

Cell signaling in the 21st century

Eliza Störmer, Jui-Hung Weng, Jian Wu, Daniela Bertinetti, Pallavi Kaila Sharma, Wen Ma, Friedrich W. Herberg, Susan S. Taylor

Biochem J (2023) 480 (11): 815–833.

https://doi.org/10.1042/BCJ20230126

Published: 12 June 2023

View article titled, Capturing the domain crosstalk in full length LRRK2 and LRRK2 RCKW

Includes: Supplementary data

Articles

Key allosteric and active site residues of SARS-CoV-2 3CLpro are promising drug targets

In Collection

Tackling SARS-CoV-2 biochemistry

Kenana Al Adem, Juliana C. Ferreira, Samar Fadl, Morad Mustafa, Wael M. Rabeh

Biochem J (2023) 480 (11): 791–813.

https://doi.org/10.1042/BCJ20230027

Published: 07 June 2023

View article titled, Key allosteric and active site residues of SARS-CoV-2 3CLpro are promising drug targets

Includes: Supplementary data

Articles

Emerging functions of pseudoenzymes

In Collection

Cell signaling in the 21st century

Timea Goldberg, Anju Sreelatha

Biochem J (2023) 480 (10): 715–728.

https://doi.org/10.1042/BCJ20220373

Published: 19 May 2023

View article titled, Emerging functions of pseudoenzymes

Articles

Genotoxic effects of the major alkylation damage N7-methylguanine and methyl formamidopyrimidine

Lillian F. Schmaltz, Myong-Chul Koag, Yi Kou, Louis Zhang, Seongmin Lee

Biochem J (2023) 480 (9): 573–585.

https://doi.org/10.1042/BCJ20220460

Published: 04 May 2023

View article titled, Genotoxic effects of the major alkylation damage N7-methylguanine and methyl formamidopyrimidine

Articles

Diversification in the inositol tris/tetrakisphosphate kinase (ITPK) family: crystal structure and enzymology of the outlier At ITPK4

Hayley L. Whitfield, Sining He, Yinghong Gu, Colleen Sprigg, Hui-Fen Kuo, Tzyy-Jen Chiou, Andrew M. Riley, Barry V.L. Potter, Andrew M. Hemmings, Charles A. Brearley

Biochem J (2023) 480 (6): 433–453.

https://doi.org/10.1042/BCJ20220579

Published: 29 March 2023

View article titled, Diversification in the inositol tris/tetrakisphosphate kinase (ITPK) family: crystal structure and enzymology of the outlier At ITPK4

Includes: Supplementary data

Articles

The uncharacterized Pseudomonas aeruginosa PA4189 is a novel and efficient aminoacetaldehyde dehydrogenase

Arline Fernández-Silva, Ana L. Juárez-Vázquez, Lilian González-Segura, Javier Andrés Juárez-Díaz, Rosario A. Muñoz-Clares

Biochem J (2023) 480 (4): 259–281.

https://doi.org/10.1042/BCJ20220567

Published: 23 February 2023

View article titled, The uncharacterized Pseudomonas aeruginosa PA4189 is a novel and efficient aminoacetaldehyde dehydrogenase

Includes: Supplementary data

Articles

A Plasmodium falciparum ubiquitin-specific protease ( Pf USP) is essential for parasite survival and its disruption enhances artemisinin efficacy

Priya Arora, Monika Narwal, Vandana Thakur, Osama Mukhtar, Pawan Malhotra, Asif Mohmmed

Biochem J (2023) 480 (1): 25–39.

https://doi.org/10.1042/BCJ20220429

Published: 06 January 2023

View article titled, A Plasmodium falciparum ubiquitin-specific protease ( Pf USP) is essential for parasite survival and its disruption enhances artemisinin efficacy

Includes: Supplementary data

Articles

Kae1 of Saccharomyces cerevisiae KEOPS complex possesses ADP/GDP nucleotidase activity

Qian-Xi Li, Jia-Cheng Liu, Ming-Hong He, Jin-Qiu Zhou

Biochem J (2022) 479 (23): 2433–2447.

https://doi.org/10.1042/BCJ20220290

Published: 09 December 2022

View article titled, Kae1 of Saccharomyces cerevisiae KEOPS complex possesses ADP/GDP nucleotidase activity

Articles

AMP-activated protein kinase — a journey from 1 to 100 downstream targets

In Collection

Awards

D. Grahame Hardie

Biochem J (2022) 479 (22): 2327–2343.

https://doi.org/10.1042/BCJ20220255

Published: 16 November 2022

View article titled, AMP-activated protein kinase — a journey from 1 to 100 downstream targets

Articles

Structure of the major oxidative damage 7,8-dihydro-8-oxoguanine presented into a catalytically competent DNA glycosylase

Lillian F. Schmaltz, Julia E. Ceniceros, Seongmin Lee

Biochem J (2022) 479 (21): 2297–2309.

https://doi.org/10.1042/BCJ20220438

Published: 04 November 2022

View article titled, Structure of the major oxidative damage 7,8-dihydro-8-oxoguanine presented into a catalytically competent DNA glycosylase

Articles

Therapeutic potential of metal ions for COVID-19: insights from the papain-like protease of SARS-CoV-2

In Collection

Coronavirus

Cameron Lee Shetler, Juliana C. Ferreira, Thyago H. S. Cardoso, Edson M.A. Silva, Nitin K. Saksena, Wael M. Rabeh

Biochem J (2022) 479 (20): 2175–2193.

https://doi.org/10.1042/BCJ20220380

Published: 21 October 2022

View article titled, Therapeutic potential of metal ions for COVID-19: insights from the papain-like protease of SARS-CoV-2

Articles

Synthesis, biochemical characterization and in silico investigation of 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid derivatives: dual action mode inhibitors of urease and virulent bacterial stains

Sajid Irshad, Saeed Ahmad, Shafi Ullah Khan, Mohsin Abbas Khan, Syeda Abida Ejaz, Huma Rao, Umair Khurshid, Aftab Ahmed, Nadeem Shahzad, Hamad M. Al-kahtani, Affan Waheed, Tanveer A. Wani, Abdullahi Tunde Aborode

Biochem J (2022) 479 (19): 2035–2048.

https://doi.org/10.1042/BCJ20220395

Published: 07 October 2022

View article titled, Synthesis, biochemical characterization and in silico investigation of 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid derivatives: dual action mode inhibitors of urease and virulent bacterial stains

Articles

An Arabidopsis thaliana arabinogalactan-protein (AGP31) and several cationic AGP fragments catalyse the boron bridging of rhamnogalacturonan-II

Dayan Sanhueza, Rifat Ara Begum, Cécile Albenne, Elisabeth Jamet, Stephen C. Fry

Biochem J (2022) 479 (18): 1967–1984.

https://doi.org/10.1042/BCJ20220340

Published: 23 September 2022

View article titled, An Arabidopsis thaliana arabinogalactan-protein (AGP31) and several cationic AGP fragments catalyse the boron bridging of rhamnogalacturonan-II

Includes: Supplementary data

Articles

Structural and functional characterisation of a stable, broad-specificity multimeric sialidase from the oral pathogen Tannerella forsythia

Marianne J. Satur, Paulina A. Urbanowicz, Daniel I. R. Spencer, John Rafferty, Graham P. Stafford

Biochem J (2022) 479 (17): 1785–1806.

https://doi.org/10.1042/BCJ20220244

Published: 06 September 2022

View article titled, Structural and functional characterisation of a stable, broad-specificity multimeric sialidase from the oral pathogen Tannerella forsythia

Includes: Supplementary data

Articles

Differential roles and regulation of the protein kinases PAK4, PAK5 and PAK6 in melanoma cells

Gavuthami Murugesan, Alan R. Prescott, Rachel Toth, David G. Campbell, Claire M. Wells, Carol MacKintosh

Biochem J (2022) 479 (16): 1709–1725.

https://doi.org/10.1042/BCJ20220184

Published: 31 August 2022

View article titled, Differential roles and regulation of the protein kinases PAK4, PAK5 and PAK6 in melanoma cells

Includes: Supplementary data

Articles

Binding of the Mycobacterium tuberculosis EccCb1 ATPase double hexameric ring to the EsxAB virulence factor is enhanced by ATP

Arkita Bandyopadhyay, Ramesh Kumar, Jyotsna Singh, Ajay K. Saxena

Biochem J (2022) 479 (14): 1559–1579.

https://doi.org/10.1042/BCJ20210430

Published: 21 July 2022

View article titled, Binding of the Mycobacterium tuberculosis EccCb1 ATPase double hexameric ring to the EsxAB virulence factor is enhanced by ATP

Includes: Supplementary data

Articles

Gain of function of a metalloproteinase associated with multiple myeloma, bicuspid aortic valve, and Von Hippel–Lindau syndrome

Scott J. Snipas, Roberto Jappelli, Ali Torkamani, Giovanni Paternostro, Guy S. Salvesen

Biochem J (2022) 479 (14): 1533–1542.

https://doi.org/10.1042/BCJ20220166

Published: 21 July 2022

View article titled, Gain of function of a metalloproteinase associated with multiple myeloma, bicuspid aortic valve, and Von Hippel–Lindau syndrome

Includes: Supplementary data

Articles

Binding partners regulate unfolding of myosin VI to activate the molecular motor

Ália dos Santos, Natalia Fili, Yukti Hari-Gupta, Rosemarie E. Gough, Lin Wang, Marisa Martin-Fernandez, Jesse Aaron, Eric Wait, Teng-Leong Chew, Christopher P. Toseland

Biochem J (2022) 479 (13): 1409–1428.

https://doi.org/10.1042/BCJ20220025

Published: 04 July 2022

View article titled, Binding partners regulate unfolding of myosin VI to activate the molecular motor

Includes: Supplementary data

Articles

Characterization of uridine-cytidine kinase like-1 nucleoside kinase activity and its role in tumor growth

Emily C. Matchett, Elise C. Ambrose, Jacki Kornbluth

Biochem J (2022) 479 (11): 1149–1164.

https://doi.org/10.1042/BCJ20210770

Published: 08 June 2022

View article titled, Characterization of uridine-cytidine kinase like-1 nucleoside kinase activity and its role in tumor growth

Articles

NAD-catabolizing ectoenzymes of Schistosoma mansoni

Catherine S. Nation, Akram A. Da'Dara, Patrick J. Skelly

Biochem J (2022) 479 (11): 1165–1180.

https://doi.org/10.1042/BCJ20210784

Published: 08 June 2022

View article titled, NAD-catabolizing ectoenzymes of Schistosoma mansoni

Articles

Improved furfural tolerance in Escherichia coli mediated by heterologous NADH-dependent benzyl alcohol dehydrogenases

Benjamin James Willson, Reyme Herman, Swen Langer, Gavin Hugh Thomas

Biochem J (2022) 479 (10): 1045–1058.

https://doi.org/10.1042/BCJ20210811

Published: 23 May 2022

View article titled, Improved furfural tolerance in Escherichia coli mediated by heterologous NADH-dependent benzyl alcohol dehydrogenases

Includes: Supplementary data

Articles

Distinct phosphorylation signals drive acceptor versus free ubiquitin chain targeting by parkin

Karen M. Dunkerley, Anne C. Rintala-Dempsey, Giulia Salzano, Roya Tadayon, Dania Hadi, Kathryn R. Barber, Helen Walden, Gary S. Shaw

Biochem J (2022) 479 (6): 751–766.

https://doi.org/10.1042/BCJ20210741

Published: 28 March 2022

View article titled, Distinct phosphorylation signals drive acceptor versus free ubiquitin chain targeting by parkin

Includes: Supplementary data

Articles

Co-evolution of drug resistance and broadened substrate recognition in HIV protease variants isolated from an Escherichia coli genetic selection system

Johanna Maarit Koivisto, Nina Rødtness Poulsen, Benedikte Stoklund Larsen, M.G.M. Weibull, Amelie Stein, Fabio Doro, Jakob Rahr Winther, Kresten Lindorff-Larsen, Martin Willemoës

Biochem J (2022) 479 (4): 479–501.

https://doi.org/10.1042/BCJ20210767

Published: 17 February 2022

View article titled, Co-evolution of drug resistance and broadened substrate recognition in HIV protease variants isolated from an Escherichia coli genetic selection system

Includes: Supplementary data

Articles

The structure and function of modular Escherichia coli O157:H7 bacteriophage FTBEc1 endolysin, LysT84: defining a new endolysin catalytic subfamily

Michael J. Love, David Coombes, Salim Ismail, Craig Billington, Renwick C. J. Dobson

Biochem J (2022) 479 (2): 207–223.

https://doi.org/10.1042/BCJ20210701

Published: 28 January 2022

View article titled, The structure and function of modular Escherichia coli O157:H7 bacteriophage FTBEc1 endolysin, LysT84: defining a new endolysin catalytic subfamily

Includes: Supplementary data

Articles

The optimal pH of AID is skewed from that of its catalytic pocket by DNA-binding residues and surface charge

Atefeh Ghorbani, Justin J. King, Mani Larijani

Biochem J (2022) 479 (1): 39–55.

https://doi.org/10.1042/BCJ20210529

Published: 06 January 2022

View article titled, The optimal pH of AID is skewed from that of its catalytic pocket by DNA-binding residues and surface charge

Includes: Supplementary data

Articles

Serine acetyltransferase from Neisseria gonorrhoeae ; structural and biochemical basis of inhibition

Keely E. A. Oldham, Erica J. Prentice, Emma L. Summers, Joanna L. Hicks

Biochem J (2022) 479 (1): 57–74.

https://doi.org/10.1042/BCJ20210564

Published: 06 January 2022

View article titled, Serine acetyltransferase from Neisseria gonorrhoeae ; structural and biochemical basis of inhibition

Includes: Supplementary data

Articles

A conserved NAG motif is critical to the catalytic activity of galactinol synthase, a key regulatory enzyme of RFO biosynthesis

Prafull Salvi, Bhavnesh Kumar, Nitin Uttam Kamble, Abhijit Hazra, Manoj Majee

Biochem J (2021) 478 (21): 3939–3955.

https://doi.org/10.1042/BCJ20210703

Published: 12 November 2021

View article titled, A conserved NAG motif is critical to the catalytic activity of galactinol synthase, a key regulatory enzyme of RFO biosynthesis

Includes: Supplementary data

Articles

Intelligent host engineering for metabolic flux optimisation in biotechnology

In Collection

Towards systems biochemistry

Lachlan J. Munro, Douglas B. Kell

Biochem J (2021) 478 (20): 3685–3721.

https://doi.org/10.1042/BCJ20210535

Published: 21 October 2021

View article titled, Intelligent host engineering for metabolic flux optimisation in biotechnology

Articles

Crystallographic approach to fragment-based hit discovery against Schistosoma mansoni purine nucleoside phosphorylase

Muhammad Faheem, Napoleão Fonseca Valadares, José Brandão-Neto, Dom Bellini, Patrick Collins, Nicholas M. Pearce, Louise Bird, Juliana Roberta Torini, Raymond Owens, Humberto DMuniz Pereira, Frank Von Delft, João Alexandre Ribeiro Gonçalves Barbosa

Biochem J (2021) 478 (19): 3655–3670.

https://doi.org/10.1042/BCJ20210041

Published: 14 October 2021

View article titled, Crystallographic approach to fragment-based hit discovery against Schistosoma mansoni purine nucleoside phosphorylase

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