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Articles

Methods to accelerate PROTAC drug discovery

Jeyan Osman, Philip E. Thompson, Manuela Jörg, Martin J. Scanlon

Biochem J (2025) 482 (13): 921–937.

https://doi.org/10.1042/BCJ20243018

Published: 25 June 2025

View article titled, Methods to accelerate PROTAC drug discovery

Articles

A new naphthalene-based fluorogenic substrate for cytochrome P450 4A11

Dmitri R. Davydov, Kannapiran Ponraj, Nadezhda Davydova, Dilip Kumar Singh, Bhagwat Prasad

Biochem J (2025) 482 (12): 839–857.

https://doi.org/10.1042/BCJ20253130

Published: 17 June 2025

View article titled, A new naphthalene-based fluorogenic substrate for cytochrome P450 4A11

Includes: Supplementary data

Articles

Insights into the cellular function and mechanism of action of quinone reductase 2 (NQO2)

Faiza Islam, Brian Shilton

Biochem J (2025) 482 (06): 309–324.

https://doi.org/10.1042/BCJ20240103

Published: 11 March 2025

View article titled, Insights into the cellular function and mechanism of action of quinone reductase 2 (NQO2)

Articles

Opposing regulation of endoplasmic reticulum retention under stress by ERp44 and PDIA6

Olaya Yassin, Bellam Praveen, Odai Darawshi, Thomas LaFramboise, Miriam Shmuel, Shakti P. Pattanayak, Brian K. Law, Maria Hatzoglou, Boaz Tirosh

Biochem J (2024) 481 (24): 1921–1935.

https://doi.org/10.1042/BCJ20240444

Published: 09 December 2024

View article titled, Opposing regulation of endoplasmic reticulum retention under stress by ERp44 and PDIA6

Includes: Supplementary data

Articles

ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding

Grace Q. Gong, Glenn R. Masson, Woo-Jeong Lee, James M. J. Dickson, Jackie D. Kendall, Manoj K. Rathinaswamy, Christina M. Buchanan, Martin Middleditch, Brady M. Owen, Julie A. Spicer, Gordon W. Rewcastle, William A. Denny, John E. Burke, Peter R. Shepherd, Roger L. Williams, Jack U. Flanagan

Biochem J (2024) 481 (23): 1787–1802.

https://doi.org/10.1042/BCJ20240479

Published: 28 November 2024

View article titled, ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding

Includes: Supplementary data

Articles

Mitigating neuroinflammation in cognitive areas: exploring the impact of HMG-CoA reductase inhibitor

Carlos Henrique Rocha Catalão, Luis Henrique Angenendt da Costa, Jonathas Rodrigo dos Santos, Luciane Carla Alberici, Luiz Luciano Falconi-Sobrinho, Norberto Cysne Coimbra, Diogo Dominguini, Felipe Dal-Pizzol, Tatiana Barichello, Maria José Alves Rocha

Biochem J (2024) 481 (22): 1585–1602.

https://doi.org/10.1042/BCJ20240217

Published: 07 November 2024

View article titled, Mitigating neuroinflammation in cognitive areas: exploring the impact of HMG-CoA reductase inhibitor

Includes: Supplementary data

Articles

The pro-drug C13 activates AMPK by two distinct mechanisms

Jordana B. Freemantle, Dinesh Shah, Dylan M. Lynch, Alessio Ciulli, Harinder S. Hundal, D. Grahame Hardie

Biochem J (2024) 481 (18): 1203–1219.

https://doi.org/10.1042/BCJ20240425

Published: 12 September 2024

View article titled, The pro-drug C13 activates AMPK by two distinct mechanisms

Includes: Supplementary data

Articles

Pregnane X receptor inhibits the transdifferentiation of hepatic stellate cells by down-regulating periostin expression

Takumi Sato, Ryota Shizu, Ryonosuke Baba, Akira Ooka, Takuomi Hosaka, Yuichiro Kanno, Kouichi Yoshinari

Biochem J (2024) 481 (18): 1173–1186.

https://doi.org/10.1042/BCJ20240172

Published: 06 September 2024

View article titled, Pregnane X receptor inhibits the transdifferentiation of hepatic stellate cells by down-regulating periostin expression

Includes: Supplementary data

Articles

1-Deoxy-d-xylulose 5-phosphate reductoisomerase as target for anti Toxoplasma gondii agents: crystal structure, biochemical characterization and biological evaluation of inhibitors

Flaminia Mazzone, Astrid Hoeppner, Jens Reiners, Christoph G.W. Gertzen, Violetta Applegate, Mona A. Abdullaziz, Julia Gottstein, Daniel Degrandi, Martina Wesemann, Thomas Kurz, Sander H.J. Smits, Klaus Pfeffer

Biochem J (2024) 481 (16): 1075–1096.

https://doi.org/10.1042/BCJ20240110

Published: 21 August 2024

View article titled, 1-Deoxy-d-xylulose 5-phosphate reductoisomerase as target for anti Toxoplasma gondii agents: crystal structure, biochemical characterization and biological evaluation of inhibitors

Includes: Supplementary data

Articles

Revisiting the roles of cAMP signalling in the progression of prostate cancer

Emma C. Parsons, Ralf Hoffmann, George S. Baillie

Biochem J (2023) 480 (20): 1599–1614.

https://doi.org/10.1042/BCJ20230297

Published: 13 October 2023

View article titled, Revisiting the roles of cAMP signalling in the progression of prostate cancer

Articles

Immunoregulatory signal networks and tumor immune evasion mechanisms: insights into therapeutic targets and agents in clinical development

Qian Wei, Kjetil Taskén

Biochem J (2022) 479 (20): 2219–2260.

https://doi.org/10.1042/BCJ20210233

Published: 28 October 2022

View article titled, Immunoregulatory signal networks and tumor immune evasion mechanisms: insights into therapeutic targets and agents in clinical development

Articles

Immunothrombosis and the molecular control of tissue factor by pyroptosis: prospects for new anticoagulants

Tristram A. J. Ryan, Roger J. S. Preston, Luke A. J. O'Neill

Biochem J (2022) 479 (6): 731–750.

https://doi.org/10.1042/BCJ20210522

Published: 28 March 2022

View article titled, Immunothrombosis and the molecular control of tissue factor by pyroptosis: prospects for new anticoagulants

Articles

Differential effect of canagliflozin, a sodium–glucose cotransporter 2 (SGLT2) inhibitor, on slow and fast skeletal muscles from nondiabetic mice

Hiroko Otsuka, Hisashi Yokomizo, Shintaro Nakamura, Yoshihiro Izumi, Masatomo Takahashi, Sachiko Obara, Motonao Nakao, Yosuke Ikeda, Naoichi Sato, Ryuichi Sakamoto, Yasutaka Miyachi, Takashi Miyazawa, Takeshi Bamba, Yoshihiro Ogawa

Biochem J (2022) 479 (3): 425–444.

https://doi.org/10.1042/BCJ20210700

Published: 11 February 2022

View article titled, Differential effect of canagliflozin, a sodium–glucose cotransporter 2 (SGLT2) inhibitor, on slow and fast skeletal muscles from nondiabetic mice

Includes: Supplementary data

Articles

Mycolactone enhances the Ca 2+ leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca 2+ permeable state

Pratiti Bhadra, Scott Dos Santos, Igor Gamayun, Tillman Pick, Clarissa Neumann, Joy Ogbechi, Belinda S. Hall, Richard Zimmermann, Volkhard Helms, Rachel E. Simmonds, Adolfo Cavalié

Biochem J (2021) 478 (22): 4005–4024.

https://doi.org/10.1042/BCJ20210345

Published: 23 November 2021

View article titled, Mycolactone enhances the Ca 2+ leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca 2+ permeable state

Includes: Supplementary data

Articles

Impact of Type II LRRK2 inhibitors on signaling and mitophagy

Anna Tasegian, Francois Singh, Ian G. Ganley, Alastair D. Reith, Dario R. Alessi

Biochem J (2021) 478 (19): 3555–3573.

https://doi.org/10.1042/BCJ20210375

Published: 06 October 2021

View article titled, Impact of Type II LRRK2 inhibitors on signaling and mitophagy

Includes: Supplementary data

Articles

Conformational plasticity of the ULK3 kinase domain

Sebastian Mathea, Eidarus Salah, Cynthia Tallant, Deep Chatterjee, Benedict-Tilman Berger, Rebecca Konietzny, Susanne Müller, Benedikt M. Kessler, Stefan Knapp

Biochem J (2021) 478 (14): 2811–2823.

https://doi.org/10.1042/BCJ20210257

Published: 23 July 2021

View article titled, Conformational plasticity of the ULK3 kinase domain

Includes: Supplementary data

Articles

The cAMP-phosphodiesterase 4 (PDE4) controls β-adrenoceptor- and CFTR-dependent saliva secretion in mice

Abigail Boyd, Ileana V. Aragon, Lina Abou Saleh, Dylan Southers, Wito Richter

Biochem J (2021) 478 (10): 1891–1906.

https://doi.org/10.1042/BCJ20210212

Published: 24 May 2021

View article titled, The cAMP-phosphodiesterase 4 (PDE4) controls β-adrenoceptor- and CFTR-dependent saliva secretion in mice

Includes: Supplementary data

Articles

Cancer cachexia: molecular mechanism and pharmacological management

Yonghua Li, Huan Jin, Yibing Chen, Ting Huang, Yanjun Mi, Zhengzhi Zou

Biochem J (2021) 478 (9): 1663–1688.

https://doi.org/10.1042/BCJ20201009

Published: 10 May 2021

View article titled, Cancer cachexia: molecular mechanism and pharmacological management

Articles

Rivastigmine attenuates the Alzheimer's disease related protein degradation and apoptotic neuronal death signalling

Parul Gupta, Shubhangini Tiwari, Abhishek Singh, Amit Pal, Amit Mishra, Sarika Singh

Biochem J (2021) 478 (7): 1435–1451.

https://doi.org/10.1042/BCJ20200754

Published: 16 April 2021

View article titled, Rivastigmine attenuates the Alzheimer's disease related protein degradation and apoptotic neuronal death signalling

Articles

Role of macrophage autophagy in atherosclerosis: modulation by bioactive compounds

MD Khurshidul Zahid, Hazera Binte Sufian, Mahua Choudhury, Masao Yamasaki, Ahmed Al-Harrasi, Naima Moustaid-Moussa, Shaikh Mizanoor Rahman

Biochem J (2021) 478 (7): 1359–1375.

https://doi.org/10.1042/BCJ20200894

Published: 16 April 2021

View article titled, Role of macrophage autophagy in atherosclerosis: modulation by bioactive compounds

Articles

α-Methyl-l-tryptophan as a weight-loss agent in multiple models of obesity in mice

Sathish Sivaprakasam, Sabarish Ramachandran, Mohd Omar Faruk Sikder, Yangzom D. Bhutia, Mitchell W. Wachtel, Vadivel Ganapathy

Biochem J (2021) 478 (7): 1347–1358.

https://doi.org/10.1042/BCJ20210100

Published: 06 April 2021

View article titled, α-Methyl-l-tryptophan as a weight-loss agent in multiple models of obesity in mice

Articles

Licochalcone A is a natural selective inhibitor of arginine methyltransferase 6

Shuai Gong, Shinji Maegawa, Yanwen Yang, Vidya Gopalakrishnan, Guangrong Zheng, Donghang Cheng

Biochem J (2021) 478 (2): 389–406.

https://doi.org/10.1042/BCJ20200411

Published: 27 January 2021

View article titled, Licochalcone A is a natural selective inhibitor of arginine methyltransferase 6

Includes: Supplementary data

Articles

Heteromeric complex formation between human cytochrome P450 CYP1A1 and heme oxygenase-1

J. Patrick Connick, James R. Reed, George F. Cawley, Wayne L. Backes

Biochem J (2021) 478 (2): 377–388.

https://doi.org/10.1042/BCJ20200768

Published: 27 January 2021

View article titled, Heteromeric complex formation between human cytochrome P450 CYP1A1 and heme oxygenase-1

Includes: Supplementary data

Articles

Modified organophosphorus fire retardant with low toxicity/high flame retardancy using the pharmacophore model associated with Mamdani fuzzy inference approach

Jiawen Yang, Yilin Hou, Qing Li, Yu Li

Biochem J (2020) 477 (23): 4655–4674.

https://doi.org/10.1042/BCJ20200779

Published: 11 December 2020

View article titled, Modified organophosphorus fire retardant with low toxicity/high flame retardancy using the pharmacophore model associated with Mamdani fuzzy inference approach

Includes: Supplementary data

Articles

Translesion synthesis of the major nitrogen mustard-induced DNA lesion by human DNA polymerase η

Hunmin Jung, Naveen Kumar Rayala, Seongmin Lee

Biochem J (2020) 477 (23): 4543–4558.

https://doi.org/10.1042/BCJ20200767

Published: 03 December 2020

View article titled, Translesion synthesis of the major nitrogen mustard-induced DNA lesion by human DNA polymerase η

Articles

A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding

Alexander Pflug, Marianne Schimpl, J. Willem M. Nissink, Ross C. Overman, Philip B. Rawlins, Caroline Truman, Elizabeth Underwood, Juli Warwicker, Jon Winter-Holt, William McCoull

Biochem J (2020) 477 (22): 4443–4452.

https://doi.org/10.1042/BCJ20200735

Published: 27 November 2020

View article titled, A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding

Includes: Supplementary data

Articles

Functional analysis of a species-specific inhibitor selective for human Na + -coupled citrate transporter (NaCT/SLC13A5/mINDY)

Kei Higuchi, Jonathan J. Kopel, Sathish Sivaprakasam, Valeria Jaramillo-Martinez, R. Bryan Sutton, Ina L. Urbatsch, Vadivel Ganapathy

Biochem J (2020) 477 (21): 4149–4165.

https://doi.org/10.1042/BCJ20200592

Published: 05 November 2020

View article titled, Functional analysis of a species-specific inhibitor selective for human Na + -coupled citrate transporter (NaCT/SLC13A5/mINDY)

Articles

Maurocalcin and its analog MCa E12A facilitate Ca 2+ mobilization in cardiomyocytes

Stephan De Waard, Jérome Montnach, Charly Cortinovis, Olfa Chkir, Morteza Erfanian, Philippe Hulin, Nathalie Gaborit, Patricia Lemarchand, Pietro Mesirca, Isabelle Bidaud, Matteo E. Mangoni, Michel De Waard, Michel Ronjat

Biochem J (2020) 477 (20): 3985–3999.

https://doi.org/10.1042/BCJ20200206

Published: 29 October 2020

View article titled, Maurocalcin and its analog MCa E12A facilitate Ca 2+ mobilization in cardiomyocytes

Includes: Supplementary data

Articles

Dopamine is an aryl hydrocarbon receptor agonist

Hyejin Park, Un-ho Jin, Keshav Karki, Arul Jayaraman, Clint Allred, Sharon K. Michelhaugh, Sandeep Mittal, Robert S. Chapkin, Stephen Safe

Biochem J (2020) 477 (19): 3899–3910.

https://doi.org/10.1042/BCJ20200440

Published: 16 October 2020

View article titled, Dopamine is an aryl hydrocarbon receptor agonist

Includes: Supplementary data

Articles

RORα phosphorylation by casein kinase 1α as glucose signal to regulate estrogen sulfation in human liver cells

Hao Hu, Masahiko Negishi

Biochem J (2020) 477 (18): 3583–3598.

https://doi.org/10.1042/BCJ20200427

Published: 28 September 2020

View article titled, RORα phosphorylation by casein kinase 1α as glucose signal to regulate estrogen sulfation in human liver cells

Includes: Supplementary data

Articles

Enantioseparation, in vitro testing, and structural characterization of triple-binding reactivators of organophosphate-inhibited cholinesterases

Nikola Maraković, Anamarija Knežević, Igor Rončević, Xavier Brazzolotto, Zrinka Kovarik, Goran Šinko

Biochem J (2020) 477 (15): 2771–2790.

https://doi.org/10.1042/BCJ20200192

Published: 07 August 2020

View article titled, Enantioseparation, in vitro testing, and structural characterization of triple-binding reactivators of organophosphate-inhibited cholinesterases

Includes: Supplementary data

Articles

Impact of pesticide exposure on adipose tissue development and function

In Collection

Adipose biology

Robert M. Gutgesell, Evangelia E. Tsakiridis, Shanza Jamshed, Gregory R. Steinberg, Alison C. Holloway

Biochem J (2020) 477 (14): 2639–2653.

https://doi.org/10.1042/BCJ20200324

Published: 29 July 2020

View article titled, Impact of pesticide exposure on adipose tissue development and function

Articles

Cr(VI)-induced overactive mitophagy contributes to mitochondrial loss and cytotoxicity in L02 hepatocytes

Yujing Zhang, Huanfeng Bian, Yu Ma, Yuanyuan Xiao, Fang Xiao

Biochem J (2020) 477 (14): 2607–2619.

https://doi.org/10.1042/BCJ20200262

Published: 24 July 2020

View article titled, Cr(VI)-induced overactive mitophagy contributes to mitochondrial loss and cytotoxicity in L02 hepatocytes

Articles

Rationally designed peptide-based inhibitor of Aβ 42 fibril formation and toxicity: a potential therapeutic strategy for Alzheimer's disease

John R. Horsley, Blagojce Jovcevski, Kate L. Wegener, Jingxian Yu, Tara L. Pukala, Andrew D. Abell

Biochem J (2020) 477 (11): 2039–2054.

https://doi.org/10.1042/BCJ20200290

Published: 10 June 2020

View article titled, Rationally designed peptide-based inhibitor of Aβ 42 fibril formation and toxicity: a potential therapeutic strategy for Alzheimer's disease

Articles

Interaction of the neutral amino acid transporter ASCT2 with basic amino acids

Elias Ndaru, Rachel-Ann A. Garibsingh, Laura Zielewicz, Avner Schlessinger, Christof Grewer

Biochem J (2020) 477 (8): 1443–1457.

https://doi.org/10.1042/BCJ20190859

Published: 27 April 2020

View article titled, Interaction of the neutral amino acid transporter ASCT2 with basic amino acids

Includes: Supplementary data

Articles

Kir6.2-D323 and SUR2A-Q1336: an intersubunit interaction pairing for allosteric information transfer in the K ATP channel complex

Sean Brennan, Hussein N. Rubaiy, Saba Imanzadeh, Ruth Reid, David Lodwick, Robert I. Norman, Richard D. Rainbow

Biochem J (2020) 477 (3): 671–689.

https://doi.org/10.1042/BCJ20190753

Published: 11 February 2020

View article titled, Kir6.2-D323 and SUR2A-Q1336: an intersubunit interaction pairing for allosteric information transfer in the K ATP channel complex

Articles

Proteostasis regulators modulate proteasomal activity and gene expression to attenuate multiple phenotypes in Fabry disease

Susanne Seemann, Mathias Ernst, Chiara Cimmaruta, Stephan Struckmann, Claudia Cozma, Dirk Koczan, Anne-Marie Knospe, Linda Rebecca Haake, Valentina Citro, Anja U. Bräuer, Giuseppina Andreotti, Maria Vittoria Cubellis, Georg Fuellen, Andreas Hermann, Anne-Katrin Giese, Arndt Rolfs, Jan Lukas

Biochem J (2020) 477 (2): 359–380.

https://doi.org/10.1042/BCJ20190513

Published: 30 January 2020

View article titled, Proteostasis regulators modulate proteasomal activity and gene expression to attenuate multiple phenotypes in Fabry disease

Includes: Supplementary data

Articles

Toward a systems approach to cytochrome P450 ensemble: interactions of CYP2E1 with other P450 species and their impact on CYP1A2

Nadezhda Y. Davydova, Bikash Dangi, Marc A. Maldonado, Nikita E. Vavilov, Victor G. Zgoda, Dmitri R. Davydov

Biochem J (2019) 476 (23): 3661–3685.

https://doi.org/10.1042/BCJ20190532

Published: 12 December 2019

View article titled, Toward a systems approach to cytochrome P450 ensemble: interactions of CYP2E1 with other P450 species and their impact on CYP1A2

Includes: Supplementary data

Articles

Discovery of novel inhibitors of ribosome biogenesis by innovative high throughput screening strategies

Catherine E. Scull, Yinfeng Zhang, Nichole Tower, Lynn Rasmussen, Indira Padmalayam, Robert Hunter, Ling Zhai, Robert Bostwick, David A. Schneider

Biochem J (2019) 476 (15): 2209–2219.

https://doi.org/10.1042/BCJ20190207

Published: 09 August 2019

View article titled, Discovery of novel inhibitors of ribosome biogenesis by innovative high throughput screening strategies

Includes: Supplementary data

Articles

Toxins for decoding interface selectivity in nicotinic acetylcholine receptors

R. Manjunatha Kini

Biochem J (2019) 476 (10): 1515–1520.

https://doi.org/10.1042/BCJ20190255

Published: 28 May 2019

View article titled, Toxins for decoding interface selectivity in nicotinic acetylcholine receptors

Articles

Glycolic acid attenuates UVB-induced aquaporin-3, matrix metalloproteinase-9 expression, and collagen degradation in keratinocytes and mouse skin

Sheau-Chung Tang, Lee-Chun Tang, Chin-Hung Liu, Pei-Yun Liao, Ji-Ching Lai, Jen-Hung Yang

Biochem J (2019) 476 (10): 1387–1400.

https://doi.org/10.1042/BCJ20180974

Published: 21 May 2019

View article titled, Glycolic acid attenuates UVB-induced aquaporin-3, matrix metalloproteinase-9 expression, and collagen degradation in keratinocytes and mouse skin

Articles

Stem cell models as an in vitro model for predictive toxicology

Stephen Lynch, Chris S. Pridgeon, Carrie A. Duckworth, Parveen Sharma, B. Kevin Park, Chris E.P. Goldring

Biochem J (2019) 476 (7): 1149–1158.

https://doi.org/10.1042/BCJ20170780

Published: 15 April 2019

View article titled, Stem cell models as an in vitro model for predictive toxicology

Articles

New insights into niclosamide action: autophagy activation in colorectal cancer

Phillip T. Newton

Biochem J (2019) 476 (5): 779–781.

https://doi.org/10.1042/BCJ20190020

Published: 06 March 2019

View article titled, New insights into niclosamide action: autophagy activation in colorectal cancer

Articles

Exosomal KLF3-AS1 from hMSCs promoted cartilage repair and chondrocyte proliferation in osteoarthritis

Yubao Liu, Rui Zou, Zhen Wang, Chuanyang Wen, Fan Zhang, Fuqing Lin

Biochem J (2018) 475 (22): 3629–3638.

https://doi.org/10.1042/BCJ20180675

Published: 28 November 2018

View article titled, Exosomal KLF3-AS1 from hMSCs promoted cartilage repair and chondrocyte proliferation in osteoarthritis

Includes: Supplementary data

Articles

Role of ATP during the initiation of microvascularization: acceleration of an autocrine sensing mechanism facilitating chemotaxis by inorganic polyphosphate

Werner E.G. Müller, Maximilian Ackermann, Emad Tolba, Meik Neufurth, Ivan Ivetac, Maria Kokkinopoulou, Heinz C. Schröder, Xiaohong Wang

Biochem J (2018) 475 (20): 3255–3273.

https://doi.org/10.1042/BCJ20180535

Published: 31 October 2018

View article titled, Role of ATP during the initiation of microvascularization: acceleration of an autocrine sensing mechanism facilitating chemotaxis by inorganic polyphosphate

Articles

An Aβ42 variant that inhibits intra- and extracellular amyloid aggregation and enhances cell viability

Ofek Oren, Victor Banerjee, Ran Taube, Niv Papo

Biochem J (2018) 475 (19): 3087–3103.

https://doi.org/10.1042/BCJ20180247

Published: 10 October 2018

View article titled, An Aβ42 variant that inhibits intra- and extracellular amyloid aggregation and enhances cell viability

Includes: Supplementary data

Articles

New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors

In Collection

Editors' pick of research highlights published in the Biochemical Journal in 2018 & 2019

Dominic P. Byrne, Yong Li, Pawin Ngamlert, Krithika Ramakrishnan, Claire E. Eyers, Carrow Wells, David H. Drewry, William J. Zuercher, Neil G. Berry, David G. Fernig, Patrick A. Eyers

Biochem J (2018) 475 (15): 2435–2455.

https://doi.org/10.1042/BCJ20180266

Published: 14 August 2018

View article titled, New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors

Includes: Supplementary data

Articles

New tools for carbohydrate sulfation analysis: heparan sulfate 2- O -sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors

Dominic P. Byrne, Yong Li, Krithika Ramakrishnan, Igor L. Barsukov, Edwin A. Yates, Claire E. Eyers, Dulcé Papy-Garcia, Sandrine Chantepie, Vijayakanth Pagadala, Jian Liu, Carrow Wells, David H. Drewry, William J. Zuercher, Neil G. Berry, David G. Fernig, Patrick A. Eyers

Biochem J (2018) 475 (15): 2417–2433.

https://doi.org/10.1042/BCJ20180265

Published: 14 August 2018

View article titled, New tools for carbohydrate sulfation analysis: heparan sulfate 2- O -sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors

Includes: Supplementary data

Articles

The role of metabolism and tunneling nanotube-mediated intercellular mitochondria exchange in cancer drug resistance

In Collection

Editors' pick of review article highlights published in the Biochemical Journal in 2018 & 2019

Yalda Hekmatshoar, Jean Nakhle, Mireille Galloni, Marie-Luce Vignais

Biochem J (2018) 475 (14): 2305–2328.

https://doi.org/10.1042/BCJ20170712

Published: 31 July 2018

View article titled, The role of metabolism and tunneling nanotube-mediated intercellular mitochondria exchange in cancer drug resistance

Articles

Stereochemistry as a determining factor for the effect of a cell-penetrating peptide on cellular viability and epithelial integrity

Ditlev Birch, Malene V. Christensen, Dan Staerk, Henrik Franzyk, Hanne Mørck Nielsen

Biochem J (2018) 475 (10): 1773–1788.

https://doi.org/10.1042/BCJ20180155

Published: 24 May 2018

View article titled, Stereochemistry as a determining factor for the effect of a cell-penetrating peptide on cellular viability and epithelial integrity

Includes: Supplementary data

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