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Immunoregulatory signal networks and tumor immune evasion mechanisms: insights into therapeutic targets and agents in clinical development

Qian Wei, Kjetil Taskén

Biochem J (2022) 479 (20): 2219–2260.

DOI: https://doi.org/10.1042/BCJ20210233

Published: 28 October 2022

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Immunothrombosis and the molecular control of tissue factor by pyroptosis: prospects for new anticoagulants

Tristram A. J. Ryan, Roger J. S. Preston, Luke A. J. O'Neill

Biochem J (2022) 479 (6): 731–750.

DOI: https://doi.org/10.1042/BCJ20210522

Published: 28 March 2022

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Differential effect of canagliflozin, a sodium–glucose cotransporter 2 (SGLT2) inhibitor, on slow and fast skeletal muscles from nondiabetic mice

Hiroko Otsuka, Hisashi Yokomizo, Shintaro Nakamura, Yoshihiro Izumi, Masatomo Takahashi, Sachiko Obara, Motonao Nakao, Yosuke Ikeda, Naoichi Sato, Ryuichi Sakamoto, Yasutaka Miyachi, Takashi Miyazawa, Takeshi Bamba, Yoshihiro Ogawa

Biochem J (2022) 479 (3): 425–444.

DOI: https://doi.org/10.1042/BCJ20210700

Published: 11 February 2022

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Mycolactone enhances the Ca 2+ leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca 2+ permeable state

Pratiti Bhadra, Scott Dos Santos, Igor Gamayun, Tillman Pick, Clarissa Neumann, Joy Ogbechi, Belinda S. Hall, Richard Zimmermann, Volkhard Helms, Rachel E. Simmonds, Adolfo Cavalié

Biochem J (2021) 478 (22): 4005–4024.

DOI: https://doi.org/10.1042/BCJ20210345

Published: 23 November 2021

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Impact of Type II LRRK2 inhibitors on signaling and mitophagy

Anna Tasegian, Francois Singh, Ian G. Ganley, Alastair D. Reith, Dario R. Alessi

Biochem J (2021) 478 (19): 3555–3573.

DOI: https://doi.org/10.1042/BCJ20210375

Published: 06 October 2021

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Conformational plasticity of the ULK3 kinase domain

Sebastian Mathea, Eidarus Salah, Cynthia Tallant, Deep Chatterjee, Benedict-Tilman Berger, Rebecca Konietzny, Susanne Müller, Benedikt M. Kessler, Stefan Knapp

Biochem J (2021) 478 (14): 2811–2823.

DOI: https://doi.org/10.1042/BCJ20210257

Published: 23 July 2021

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The cAMP-phosphodiesterase 4 (PDE4) controls β-adrenoceptor- and CFTR-dependent saliva secretion in mice

Abigail Boyd, Ileana V. Aragon, Lina Abou Saleh, Dylan Southers, Wito Richter

Biochem J (2021) 478 (10): 1891–1906.

DOI: https://doi.org/10.1042/BCJ20210212

Published: 24 May 2021

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Cancer cachexia: molecular mechanism and pharmacological management

Yonghua Li, Huan Jin, Yibing Chen, Ting Huang, Yanjun Mi, Zhengzhi Zou

Biochem J (2021) 478 (9): 1663–1688.

DOI: https://doi.org/10.1042/BCJ20201009

Published: 10 May 2021

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Role of macrophage autophagy in atherosclerosis: modulation by bioactive compounds

MD Khurshidul Zahid, Hazera Binte Sufian, Mahua Choudhury, Masao Yamasaki, Ahmed Al-Harrasi, Naima Moustaid-Moussa, Shaikh Mizanoor Rahman

Biochem J (2021) 478 (7): 1359–1375.

DOI: https://doi.org/10.1042/BCJ20200894

Published: 16 April 2021

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Rivastigmine attenuates the Alzheimer's disease related protein degradation and apoptotic neuronal death signalling

Parul Gupta, Shubhangini Tiwari, Abhishek Singh, Amit Pal, Amit Mishra, Sarika Singh

Biochem J (2021) 478 (7): 1435–1451.

DOI: https://doi.org/10.1042/BCJ20200754

Published: 16 April 2021

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α-Methyl-l-tryptophan as a weight-loss agent in multiple models of obesity in mice

Sathish Sivaprakasam, Sabarish Ramachandran, Mohd Omar Faruk Sikder, Yangzom D. Bhutia, Mitchell W. Wachtel, Vadivel Ganapathy

Biochem J (2021) 478 (7): 1347–1358.

DOI: https://doi.org/10.1042/BCJ20210100

Published: 06 April 2021

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Licochalcone A is a natural selective inhibitor of arginine methyltransferase 6

Shuai Gong, Shinji Maegawa, Yanwen Yang, Vidya Gopalakrishnan, Guangrong Zheng, Donghang Cheng

Biochem J (2021) 478 (2): 389–406.

DOI: https://doi.org/10.1042/BCJ20200411

Published: 27 January 2021

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Heteromeric complex formation between human cytochrome P450 CYP1A1 and heme oxygenase-1

J. Patrick Connick, James R. Reed, George F. Cawley, Wayne L. Backes

Biochem J (2021) 478 (2): 377–388.

DOI: https://doi.org/10.1042/BCJ20200768

Published: 27 January 2021

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Modified organophosphorus fire retardant with low toxicity/high flame retardancy using the pharmacophore model associated with Mamdani fuzzy inference approach

Jiawen Yang, Yilin Hou, Qing Li, Yu Li

Biochem J (2020) 477 (23): 4655–4674.

DOI: https://doi.org/10.1042/BCJ20200779

Published: 11 December 2020

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Translesion synthesis of the major nitrogen mustard-induced DNA lesion by human DNA polymerase η

Hunmin Jung, Naveen Kumar Rayala, Seongmin Lee

Biochem J (2020) 477 (23): 4543–4558.

DOI: https://doi.org/10.1042/BCJ20200767

Published: 03 December 2020

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A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding

Alexander Pflug, Marianne Schimpl, J. Willem M. Nissink, Ross C. Overman, Philip B. Rawlins, Caroline Truman, Elizabeth Underwood, Juli Warwicker, Jon Winter-Holt, William McCoull

Biochem J (2020) 477 (22): 4443–4452.

DOI: https://doi.org/10.1042/BCJ20200735

Published: 27 November 2020

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Functional analysis of a species-specific inhibitor selective for human Na + -coupled citrate transporter (NaCT/SLC13A5/mINDY)

Kei Higuchi, Jonathan J. Kopel, Sathish Sivaprakasam, Valeria Jaramillo-Martinez, R. Bryan Sutton, Ina L. Urbatsch, Vadivel Ganapathy

Biochem J (2020) 477 (21): 4149–4165.

DOI: https://doi.org/10.1042/BCJ20200592

Published: 05 November 2020

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Maurocalcin and its analog MCa E12A facilitate Ca 2+ mobilization in cardiomyocytes

Stephan De Waard, Jérome Montnach, Charly Cortinovis, Olfa Chkir, Morteza Erfanian, Philippe Hulin, Nathalie Gaborit, Patricia Lemarchand, Pietro Mesirca, Isabelle Bidaud, Matteo E. Mangoni, Michel De Waard, Michel Ronjat

Biochem J (2020) 477 (20): 3985–3999.

DOI: https://doi.org/10.1042/BCJ20200206

Published: 29 October 2020

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Includes: Supplementary data

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Dopamine is an aryl hydrocarbon receptor agonist

Hyejin Park, Un-ho Jin, Keshav Karki, Arul Jayaraman, Clint Allred, Sharon K. Michelhaugh, Sandeep Mittal, Robert S. Chapkin, Stephen Safe

Biochem J (2020) 477 (19): 3899–3910.

DOI: https://doi.org/10.1042/BCJ20200440

Published: 16 October 2020

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RORα phosphorylation by casein kinase 1α as glucose signal to regulate estrogen sulfation in human liver cells

Hao Hu, Masahiko Negishi

Biochem J (2020) 477 (18): 3583–3598.

DOI: https://doi.org/10.1042/BCJ20200427

Published: 28 September 2020

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Enantioseparation, in vitro testing, and structural characterization of triple-binding reactivators of organophosphate-inhibited cholinesterases

Nikola Maraković, Anamarija Knežević, Igor Rončević, Xavier Brazzolotto, Zrinka Kovarik, Goran Šinko

Biochem J (2020) 477 (15): 2771–2790.

DOI: https://doi.org/10.1042/BCJ20200192

Published: 07 August 2020

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Impact of pesticide exposure on adipose tissue development and function

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Adipose biology

Robert M. Gutgesell, Evangelia E. Tsakiridis, Shanza Jamshed, Gregory R. Steinberg, Alison C. Holloway

Biochem J (2020) 477 (14): 2639–2653.

DOI: https://doi.org/10.1042/BCJ20200324

Published: 29 July 2020

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Cr(VI)-induced overactive mitophagy contributes to mitochondrial loss and cytotoxicity in L02 hepatocytes

Yujing Zhang, Huanfeng Bian, Yu Ma, Yuanyuan Xiao, Fang Xiao

Biochem J (2020) 477 (14): 2607–2619.

DOI: https://doi.org/10.1042/BCJ20200262

Published: 24 July 2020

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Rationally designed peptide-based inhibitor of Aβ 42 fibril formation and toxicity: a potential therapeutic strategy for Alzheimer's disease

John R. Horsley, Blagojce Jovcevski, Kate L. Wegener, Jingxian Yu, Tara L. Pukala, Andrew D. Abell

Biochem J (2020) 477 (11): 2039–2054.

DOI: https://doi.org/10.1042/BCJ20200290

Published: 10 June 2020

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Interaction of the neutral amino acid transporter ASCT2 with basic amino acids

Elias Ndaru, Rachel-Ann A. Garibsingh, Laura Zielewicz, Avner Schlessinger, Christof Grewer

Biochem J (2020) 477 (8): 1443–1457.

DOI: https://doi.org/10.1042/BCJ20190859

Published: 27 April 2020

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Includes: Supplementary data

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Kir6.2-D323 and SUR2A-Q1336: an intersubunit interaction pairing for allosteric information transfer in the K ATP channel complex

Sean Brennan, Hussein N. Rubaiy, Saba Imanzadeh, Ruth Reid, David Lodwick, Robert I. Norman, Richard D. Rainbow

Biochem J (2020) 477 (3): 671–689.

DOI: https://doi.org/10.1042/BCJ20190753

Published: 11 February 2020

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Proteostasis regulators modulate proteasomal activity and gene expression to attenuate multiple phenotypes in Fabry disease

Susanne Seemann, Mathias Ernst, Chiara Cimmaruta, Stephan Struckmann, Claudia Cozma, Dirk Koczan, Anne-Marie Knospe, Linda Rebecca Haake, Valentina Citro, Anja U. Bräuer, Giuseppina Andreotti, Maria Vittoria Cubellis, Georg Fuellen, Andreas Hermann, Anne-Katrin Giese, Arndt Rolfs, Jan Lukas

Biochem J (2020) 477 (2): 359–380.

DOI: https://doi.org/10.1042/BCJ20190513

Published: 30 January 2020

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Toward a systems approach to cytochrome P450 ensemble: interactions of CYP2E1 with other P450 species and their impact on CYP1A2

Nadezhda Y. Davydova, Bikash Dangi, Marc A. Maldonado, Nikita E. Vavilov, Victor G. Zgoda, Dmitri R. Davydov

Biochem J (2019) 476 (23): 3661–3685.

DOI: https://doi.org/10.1042/BCJ20190532

Published: 12 December 2019

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Discovery of novel inhibitors of ribosome biogenesis by innovative high throughput screening strategies

Catherine E. Scull, Yinfeng Zhang, Nichole Tower, Lynn Rasmussen, Indira Padmalayam, Robert Hunter, Ling Zhai, Robert Bostwick, David A. Schneider

Biochem J (2019) 476 (15): 2209–2219.

DOI: https://doi.org/10.1042/BCJ20190207

Published: 09 August 2019

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Toxins for decoding interface selectivity in nicotinic acetylcholine receptors

R. Manjunatha Kini

Biochem J (2019) 476 (10): 1515–1520.

DOI: https://doi.org/10.1042/BCJ20190255

Published: 28 May 2019

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Glycolic acid attenuates UVB-induced aquaporin-3, matrix metalloproteinase-9 expression, and collagen degradation in keratinocytes and mouse skin

Sheau-Chung Tang, Lee-Chun Tang, Chin-Hung Liu, Pei-Yun Liao, Ji-Ching Lai, Jen-Hung Yang

Biochem J (2019) 476 (10): 1387–1400.

DOI: https://doi.org/10.1042/BCJ20180974

Published: 21 May 2019

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Stem cell models as an in vitro model for predictive toxicology

Stephen Lynch, Chris S. Pridgeon, Carrie A. Duckworth, Parveen Sharma, B. Kevin Park, Chris E.P. Goldring

Biochem J (2019) 476 (7): 1149–1158.

DOI: https://doi.org/10.1042/BCJ20170780

Published: 15 April 2019

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New insights into niclosamide action: autophagy activation in colorectal cancer

Phillip T. Newton

Biochem J (2019) 476 (5): 779–781.

DOI: https://doi.org/10.1042/BCJ20190020

Published: 06 March 2019

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Exosomal KLF3-AS1 from hMSCs promoted cartilage repair and chondrocyte proliferation in osteoarthritis

Yubao Liu, Rui Zou, Zhen Wang, Chuanyang Wen, Fan Zhang, Fuqing Lin

Biochem J (2018) 475 (22): 3629–3638.

DOI: https://doi.org/10.1042/BCJ20180675

Published: 28 November 2018

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Role of ATP during the initiation of microvascularization: acceleration of an autocrine sensing mechanism facilitating chemotaxis by inorganic polyphosphate

Werner E.G. Müller, Maximilian Ackermann, Emad Tolba, Meik Neufurth, Ivan Ivetac, Maria Kokkinopoulou, Heinz C. Schröder, Xiaohong Wang

Biochem J (2018) 475 (20): 3255–3273.

DOI: https://doi.org/10.1042/BCJ20180535

Published: 31 October 2018

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An Aβ42 variant that inhibits intra- and extracellular amyloid aggregation and enhances cell viability

Ofek Oren, Victor Banerjee, Ran Taube, Niv Papo

Biochem J (2018) 475 (19): 3087–3103.

DOI: https://doi.org/10.1042/BCJ20180247

Published: 10 October 2018

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New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors

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Editors' pick of research highlights published in the Biochemical Journal in 2018 & 2019

Dominic P. Byrne, Yong Li, Pawin Ngamlert, Krithika Ramakrishnan, Claire E. Eyers, Carrow Wells, David H. Drewry, William J. Zuercher, Neil G. Berry, David G. Fernig, Patrick A. Eyers

Biochem J (2018) 475 (15): 2435–2455.

DOI: https://doi.org/10.1042/BCJ20180266

Published: 14 August 2018

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New tools for carbohydrate sulfation analysis: heparan sulfate 2- O -sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors

Dominic P. Byrne, Yong Li, Krithika Ramakrishnan, Igor L. Barsukov, Edwin A. Yates, Claire E. Eyers, Dulcé Papy-Garcia, Sandrine Chantepie, Vijayakanth Pagadala, Jian Liu, Carrow Wells, David H. Drewry, William J. Zuercher, Neil G. Berry, David G. Fernig, Patrick A. Eyers

Biochem J (2018) 475 (15): 2417–2433.

DOI: https://doi.org/10.1042/BCJ20180265

Published: 14 August 2018

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The role of metabolism and tunneling nanotube-mediated intercellular mitochondria exchange in cancer drug resistance

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Editors' pick of review article highlights published in the Biochemical Journal in 2018 & 2019

Yalda Hekmatshoar, Jean Nakhle, Mireille Galloni, Marie-Luce Vignais

Biochem J (2018) 475 (14): 2305–2328.

DOI: https://doi.org/10.1042/BCJ20170712

Published: 31 July 2018

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Stereochemistry as a determining factor for the effect of a cell-penetrating peptide on cellular viability and epithelial integrity

Ditlev Birch, Malene V. Christensen, Dan Staerk, Henrik Franzyk, Hanne Mørck Nielsen

Biochem J (2018) 475 (10): 1773–1788.

DOI: https://doi.org/10.1042/BCJ20180155

Published: 24 May 2018

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A transcription factor network represses CFTR gene expression in airway epithelial cells

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Editors' pick of research highlights published in the Biochemical Journal in 2018 & 2019

Michael J. Mutolo, Shih-Hsing Leir, Sara L. Fossum, James A. Browne, Ann Harris

Biochem J (2018) 475 (7): 1323–1334.

DOI: https://doi.org/10.1042/BCJ20180044

Published: 16 April 2018

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CGA-N12, a peptide derived from chromogranin A, promotes apoptosis of Candida tropicalis by attenuating mitochondrial functions

Ruifang Li, Ruiling Zhang, Yanhui Yang, Xueqin Wang, Yanjie Yi, Pei Fan, Zhengwei Liu, Chen Chen, Junpeng Chang

Biochem J (2018) 475 (7): 1385–1396.

DOI: https://doi.org/10.1042/BCJ20170894

Published: 16 April 2018

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Restricted HIV-1 Env glycan engagement by lectin-reengineered DAVEI protein chimera is sufficient for lytic inactivation of the virus

Bibek Parajuli, Kriti Acharya, Harry C. Bach, Bijay Parajuli, Shiyu Zhang, Amos B. Smith, III, Cameron F. Abrams, Irwin Chaiken

Biochem J (2018) 475 (5): 931–957.

DOI: https://doi.org/10.1042/BCJ20170662

Published: 09 March 2018

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Synergistic drug combination GC7/DFMO suppresses hypusine/spermidine-dependent eIF5A activation and induces apoptotic cell death in neuroblastoma

Chad R. Schultz, Dirk Geerts, Marie Mooney, Raid El-Khawaja, Jan Koster, André S. Bachmann

Biochem J (2018) 475 (2): 531–545.

DOI: https://doi.org/10.1042/BCJ20170597

Published: 31 January 2018

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Topoisomerases as anticancer targets

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Editors' pick of review article highlights published in the Biochemical Journal in 2018 & 2019

Justine L. Delgado, Chao-Ming Hsieh, Nei-Li Chan, Hiroshi Hiasa

Biochem J (2018) 475 (2): 373–398.

DOI: https://doi.org/10.1042/BCJ20160583

Published: 23 January 2018

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Assaying kinase activity of the TPL-2/NF-κB1 p105/ABIN-2 complex using an optimal peptide substrate

Sandra Kümper, Thorsten Gantke, Chao-Sheng Chen, Yasmina Soneji, Michael J. Pattison, Probir Chakravarty, Svend Kjær, Daniel Thomas, Carl Haslam, Bill J. Leavens, David House, David J. Powell, Steven C. Ley

Biochem J (2018) 475 (1): 329–340.

DOI: https://doi.org/10.1042/BCJ20170579

Published: 11 January 2018

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Therapeutic targeting of non-coding RNAs in cancer

Ondrej Slaby, Richard Laga, Ondrej Sedlacek

Biochem J (2017) 474 (24): 4219–4251.

DOI: https://doi.org/10.1042/BCJ20170079

Published: 14 December 2017

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Recognition of hyperacetylated N-terminus of H2AZ by TbBDF2 from Trypanosoma brucei

Xiao Yang, Xuelei Wu, Jiahai Zhang, Xuecheng Zhang, Chao Xu, Shanhui Liao, Xiaoming Tu

Biochem J (2017) 474 (22): 3817–3830.

DOI: https://doi.org/10.1042/BCJ20170619

Published: 09 November 2017

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Carbidopa: a selective Ah receptor modulator (SAhRM)

Stephen Safe

Biochem J (2017) 474 (22): 3763–3765.

DOI: https://doi.org/10.1042/BCJ20170728

Published: 06 November 2017

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Targeting epithelial–mesenchymal plasticity in cancer: clinical and preclinical advances in therapy and monitoring

Sugandha Bhatia, James Monkman, Alan Kie Leong Toh, Shivashankar H. Nagaraj, Erik W. Thompson

Biochem J (2017) 474 (19): 3269–3306.

DOI: https://doi.org/10.1042/BCJ20160782

Published: 20 September 2017

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