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Impact of fluoroquinolones and aminoglycosides on P. aeruginosa virulence factor production and cytotoxicity

Daniel M. Foulkes, Keri McLean, Marta Sloniecka, Sophie Rustidge, Dominic P. Byrne, Atikah S. Haneef, Craig Winstanley, Neil Berry, David G. Fernig, Stephen B. Kaye

Biochem J (2022) 479 (24): 2511–2527.

DOI: https://doi.org/10.1042/BCJ20220527

Published: 22 December 2022

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Combinatorial approaches for mitigating resistance to KRAS-targeted therapies

Hannah R. Warren, Sarah J. Ross, Paul D. Smith, Judy M. Coulson, Ian A. Prior

Biochem J (2022) 479 (18): 1985–1997.

DOI: https://doi.org/10.1042/BCJ20220440

Published: 23 September 2022

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Vitamin K3 inhibits FtsZ assembly, disrupts the Z-ring in Streptococcus pneumoniae and displays anti-pneumococcal activity

Athira Pushpakaran, Rachana Rao Battaje, Dulal Panda

Biochem J (2022) 479 (14): 1543–1558.

DOI: https://doi.org/10.1042/BCJ20220077

Published: 21 July 2022

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Targeting the alternative oxidase (AOX) for human health and food security, a pharmaceutical and agrochemical target or a rescue mechanism?

Marten Szibor, Christina Schenkl, Mario R. O. Barsottini, Luke Young, Anthony L. Moore

Biochem J (2022) 479 (12): 1337–1359.

DOI: https://doi.org/10.1042/BCJ20180192

Published: 24 June 2022

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Sialylation-dependent pharmacokinetics and differential complement pathway inhibition are hallmarks of CR1 activity in vivo

Biochem J (2022) 479 (9): 1007–1030.

DOI: https://doi.org/10.1042/BCJ20220054

Published: 13 May 2022

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Immunothrombosis and the molecular control of tissue factor by pyroptosis: prospects for new anticoagulants

Tristram A. J. Ryan, Roger J. S. Preston, Luke A. J. O'Neill

Biochem J (2022) 479 (6): 731–750.

DOI: https://doi.org/10.1042/BCJ20210522

Published: 28 March 2022

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Investigation of USP30 inhibition to enhance Parkin-mediated mitophagy: tools and approaches

Eliona Tsefou, Alison S. Walker, Emily H. Clark, Amy R. Hicks, Christin Luft, Kunitoshi Takeda, Toru Watanabe, Bianca Ramazio, James M. Staddon, Thomas Briston, Robin Ketteler

Biochem J (2021) 478 (23): 4099–4118.

DOI: https://doi.org/10.1042/BCJ20210508

Published: 06 December 2021

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Crystallographic approach to fragment-based hit discovery against Schistosoma mansoni purine nucleoside phosphorylase

Muhammad Faheem, Napoleão Fonseca Valadares, José Brandão-Neto, Dom Bellini, Patrick Collins, Nicholas M. Pearce, Louise Bird, Juliana Roberta Torini, Raymond Owens, Humberto DMuniz Pereira, Frank Von Delft, João Alexandre Ribeiro Gonçalves Barbosa

Biochem J (2021) 478 (19): 3655–3670.

DOI: https://doi.org/10.1042/BCJ20210041

Published: 14 October 2021

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Structural and molecular bases to IRE1 activity modulation

Timothy Langlais, Diana Pelizzari-Raymundo, Sayyed Jalil Mahdizadeh, Nicolas Gouault, Francois Carreaux, Eric Chevet, Leif A. Eriksson, Xavier Guillory

Biochem J (2021) 478 (15): 2953–2975.

DOI: https://doi.org/10.1042/BCJ20200919

Published: 10 August 2021

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Manipulating the exposome to enable better ageing

Paul G. Shiels, Johanna Painer, Barbara Natterson-Horowitz, Richard J. Johnson, Jaime J. Miranda, Peter Stenvinkel

Biochem J (2021) 478 (14): 2889–2898.

DOI: https://doi.org/10.1042/BCJ20200958

Published: 28 July 2021

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Evaluation of artificial signal peptides for secretion of two lysosomal enzymes in CHO cells

Kai-Wen Cheng, Feng Wang, George A. Lopez, Srikanth Singamsetty, Jill Wood, Patricia I. Dickson, Tsui-Fen Chou

Biochem J (2021) 478 (12): 2309–2319.

DOI: https://doi.org/10.1042/BCJ20210015

Published: 23 June 2021

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Transforming growth factor-β2-mediated mesenchymal transition in lens epithelial cells is repressed in the absence of RAGE

Mi-Hyun Nam, Mina B. Pantcheva, Johanna Rankenberg, Ram H. Nagaraj

Biochem J (2021) 478 (12): 2285–2296.

DOI: https://doi.org/10.1042/BCJ20210069

Published: 18 June 2021

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Integrin αVβ1 regulates procollagen I production through a non-canonical transforming growth factor β signaling pathway in human hepatic stellate cells

Zuoning Han, Yanling Ma, Gary Cao, Zhengping Ma, Ruihua Chen, Mary Ellen Cvijic, Dong Cheng

Biochem J (2021) 478 (9): 1689–1703.

DOI: https://doi.org/10.1042/BCJ20200749

Published: 10 May 2021

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α-Methyl-l-tryptophan as a weight-loss agent in multiple models of obesity in mice

Sathish Sivaprakasam, Sabarish Ramachandran, Mohd Omar Faruk Sikder, Yangzom D. Bhutia, Mitchell W. Wachtel, Vadivel Ganapathy

Biochem J (2021) 478 (7): 1347–1358.

DOI: https://doi.org/10.1042/BCJ20210100

Published: 06 April 2021

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Organismal roles for the PI3Kα and β isoforms: their specificity, redundancy or cooperation is context-dependent

Silvia Arcucci, Fernanda Ramos-Delgado, Coralie Cayron, Nicole Therville, Marie-Pierre Gratacap, Céline Basset, Benoit Thibault, Julie Guillermet-Guibert

Biochem J (2021) 478 (6): 1199–1225.

DOI: https://doi.org/10.1042/BCJ20210004

Published: 19 March 2021

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A pipeline to evaluate inhibitors of the Pseudomonas aeruginosa exotoxin U

Daniel M. Foulkes, Keri McLean, Yalin Zheng, Joscelyn Sarsby, Atikah S. Haneef, David G. Fernig, Craig Winstanley, Neil Berry, Stephen B. Kaye

Biochem J (2021) 478 (3): 647–668.

DOI: https://doi.org/10.1042/BCJ20200780

Published: 12 February 2021

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Weakening of interaction networks with aging in tip-link protein induces hearing loss

Surbhi Garg, Amin Sagar, Gayathri S. Singaraju, Rahul Dani, Naimat K. Bari, Athi N. Naganathan, Sabyasachi Rakshit

Biochem J (2021) 478 (1): 121–134.

DOI: https://doi.org/10.1042/BCJ20200799

Published: 13 January 2021

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Articles

Multistep optimization of a cell-penetrating peptide towards its antimicrobial activity

Marco Drexelius, Andre Reinhardt, Joshua Grabeck, Tom Cronenberg, Frank Nitsche, Pitter F. Huesgen, Berenike Maier, Ines Neundorf

Biochem J (2021) 478 (1): 63–78.

DOI: https://doi.org/10.1042/BCJ20200698

Published: 08 January 2021

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Articles

Translesion synthesis of the major nitrogen mustard-induced DNA lesion by human DNA polymerase η

Hunmin Jung, Naveen Kumar Rayala, Seongmin Lee

Biochem J (2020) 477 (23): 4543–4558.

DOI: https://doi.org/10.1042/BCJ20200767

Published: 03 December 2020

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Phosphoinositide 3-kinases in platelets, thrombosis and therapeutics

Agnès Ribes, Antoine Oprescu, Julien Viaud, Karim Hnia, Gaëtan Chicanne, Jean-Marie Xuereb, Sonia Severin, Marie-Pierre Gratacap, Bernard Payrastre

Biochem J (2020) 477 (22): 4327–4342.

DOI: https://doi.org/10.1042/BCJ20190402

Published: 26 November 2020

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Structure-based drug repurposing to inhibit the DNA gyrase of Mycobacterium tuberculosis

Balasubramani GL, Rinky Rajput, Manish Gupta, Pradeep Dahiya, Jitendra K. Thakur, Rakesh Bhatnagar, Abhinav Grover

Biochem J (2020) 477 (21): 4167–4190.

DOI: https://doi.org/10.1042/BCJ20200462

Published: 09 November 2020

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Exploiting S- nitrosylation for cancer therapy: facts and perspectives

Salvatore Rizza, Giuseppe Filomeni

Biochem J (2020) 477 (19): 3649–3672.

DOI: https://doi.org/10.1042/BCJ20200064

Published: 05 October 2020

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New insights on the interaction mechanism of rhTNFα with its antagonists Adalimumab and Etanercept

María Angélica Contreras, Luis Macaya, Pedro Neira, Frank Camacho, Alaín González, Jannel Acosta, Raquel Montesino, Jorge Roberto Toledo, Oliberto Sánchez

Biochem J (2020) 477 (17): 3299–3311.

DOI: https://doi.org/10.1042/BCJ20200568

Published: 10 September 2020

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RAS Function in cancer cells: translating membrane biology and biochemistry into new therapeutics

Walaa E. Kattan, John F. Hancock

Biochem J (2020) 477 (15): 2893–2919.

DOI: https://doi.org/10.1042/BCJ20190839

Published: 14 August 2020

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Enantioseparation, in vitro testing, and structural characterization of triple-binding reactivators of organophosphate-inhibited cholinesterases

Nikola Maraković, Anamarija Knežević, Igor Rončević, Xavier Brazzolotto, Zrinka Kovarik, Goran Šinko

Biochem J (2020) 477 (15): 2771–2790.

DOI: https://doi.org/10.1042/BCJ20200192

Published: 07 August 2020

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Use of the Polo-like kinase 4 (PLK4) inhibitor centrinone to investigate intracellular signalling networks using SILAC-based phosphoproteomics

Dominic P. Byrne, Christopher J. Clarke, Philip J. Brownridge, Anton Kalyuzhnyy, Simon Perkins, Amy Campbell, David Mason, Andrew R. Jones, Patrick A. Eyers, Claire E. Eyers

Biochem J (2020) 477 (13): 2451–2475.

DOI: https://doi.org/10.1042/BCJ20200309

Published: 02 July 2020

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Synergism between SLC6A14 blockade and gemcitabine in pancreactic cancer: a 1 H-NMR-based metabolomic study in pancreatic cancer cells

Aimin Cai, Hailun Zheng, Zhiwei Chen, Xinlu Lin, Chen Li, Qing yao, Yangzom D. Bhutia, Vadivel Ganapathy, Ruijie Chen, Longfa Kou

Biochem J (2020) 477 (10): 1923–1937.

DOI: https://doi.org/10.1042/BCJ20200275

Published: 29 May 2020

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Cell-penetrating peptides: two faces of the same coin

Giovanna Maria Pierantoni, Simona Paladino

Biochem J (2020) 477 (8): 1363–1366.

DOI: https://doi.org/10.1042/BCJ20200006

Published: 23 April 2020

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SLC6A14, a Na + /Cl − -coupled amino acid transporter, functions as a tumor promoter in colon and is a target for Wnt signaling

Mohd O. F. Sikder, Sathish Sivaprakasam, Timothy P. Brown, Muthusamy Thangaraju, Yangzom D. Bhutia, Vadivel Ganapathy

Biochem J (2020) 477 (8): 1409–1425.

DOI: https://doi.org/10.1042/BCJ20200099

Published: 23 April 2020

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The antifungal peptide CGA-N12 inhibits cell wall synthesis of Candida tropicalis by interacting with KRE9

Ruifang Li, Zhengwei Liu, Weibing Dong, Lan Zhang, Beibei Zhang, Dandan Li, Caiwei Fu

Biochem J (2020) 477 (3): 747–762.

DOI: https://doi.org/10.1042/BCJ20190678

Published: 14 February 2020

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Lysosomal protein thermal stability does not correlate with cellular half-life: global observations and a case study of tripeptidyl-peptidase 1

Aaron M. Collier, Yuliya Nemtsova, Narendra Kuber, Whitney Banach-Petrosky, Anurag Modak, David E. Sleat, Vikas Nanda, Peter Lobel

Biochem J (2020) 477 (3): 727–745.

DOI: https://doi.org/10.1042/BCJ20190874

Published: 14 February 2020

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Proteostasis regulators modulate proteasomal activity and gene expression to attenuate multiple phenotypes in Fabry disease

Susanne Seemann, Mathias Ernst, Chiara Cimmaruta, Stephan Struckmann, Claudia Cozma, Dirk Koczan, Anne-Marie Knospe, Linda Rebecca Haake, Valentina Citro, Anja U. Bräuer, Giuseppina Andreotti, Maria Vittoria Cubellis, Georg Fuellen, Andreas Hermann, Anne-Katrin Giese, Arndt Rolfs, Jan Lukas

Biochem J (2020) 477 (2): 359–380.

DOI: https://doi.org/10.1042/BCJ20190513

Published: 30 January 2020

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EJP18 peptide derived from the juxtamembrane domain of epidermal growth factor receptor represents a novel membrane-active cell-penetrating peptide

N.G. Eissa, E.J. Sayers, D. Birch, S.G. Patel, Y.-H. Tsai, H. Mørck Nielsen, A.T. Jones

Biochem J (2020) 477 (1): 45–60.

DOI: https://doi.org/10.1042/BCJ20190452

Published: 08 January 2020

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Cycloserine enantiomers are reversible inhibitors of human alanine:glyoxylate aminotransferase: implications for Primary Hyperoxaluria type 1

Mirco Dindo, Silvia Grottelli, Giannamaria Annunziato, Giorgio Giardina, Marco Pieroni, Gioena Pampalone, Andrea Faccini, Francesca Cutruzzolà, Paola Laurino, Gabriele Costantino, Barbara Cellini

Biochem J (2019) 476 (24): 3751–3768.

DOI: https://doi.org/10.1042/BCJ20190507

Published: 20 December 2019

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Structural insights into Escherichia coli phosphopantothenoylcysteine synthetase by native ion mobility–mass spectrometry

Daniel Shiu-Hin Chan, Jeannine Hess, Elen Shaw, Christina Spry, Robert Starley, Claudio Dagostin, Marcio V. B. Dias, Ramesh Kale, Vitor Mendes, Tom L. Blundell, Anthony G. Coyne, Chris Abell

Biochem J (2019) 476 (21): 3125–3139.

DOI: https://doi.org/10.1042/BCJ20190318

Published: 05 November 2019

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Molecular, chemical, and structural characterization of prostaglandin A 2 as a novel agonist for Nur77

Sowmya P. Lakshmi, Aravind T. Reddy, Asoka Banno, Raju C. Reddy

Biochem J (2019) 476 (19): 2757–2767.

DOI: https://doi.org/10.1042/BCJ20190253

Published: 11 October 2019

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A novel small molecule A 2A adenosine receptor agonist, indirubin-3′-monoxime, alleviates lipid-induced inflammation and insulin resistance in 3T3-L1 adipocytes

Saynaz A. Choudhary, Nikita Bora, Dipanjan Banerjee, Leena Arora, Anindhya Sundar Das, Rakesh Yadav, Karl-Norbert Klotz, Durba Pal, Anupam Nath Jha, Suman Dasgupta

Biochem J (2019) 476 (16): 2371–2391.

DOI: https://doi.org/10.1042/BCJ20190251

Published: 30 August 2019

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Toxins for decoding interface selectivity in nicotinic acetylcholine receptors

R. Manjunatha Kini

Biochem J (2019) 476 (10): 1515–1520.

DOI: https://doi.org/10.1042/BCJ20190255

Published: 28 May 2019

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A non-catalytic function of carbonic anhydrase IX contributes to the glycolytic phenotype and pH regulation in human breast cancer cells

In Collection

Editors' pick of research highlights published in the Biochemical Journal in 2018 & 2019

Mam Y. Mboge, Zhijuan Chen, Daniel Khokhar, Alyssa Wolff, Lingbao Ai, Coy D. Heldermon, Murat Bozdag, Fabrizio Carta, Claudiu T. Supuran, Kevin D. Brown, Robert McKenna, Christopher J. Frost, Susan C. Frost

Biochem J (2019) 476 (10): 1497–1513.

DOI: https://doi.org/10.1042/BCJ20190177

Published: 28 May 2019

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Characterization of TCDD-inducible poly-ADP-ribose polymerase (TIPARP/ARTD14) catalytic activity

Alvin Gomez, Christian Bindesbøll, Somisetty V. Satheesh, Giulia Grimaldi, David Hutin, Laura MacPherson, Shaimaa Ahmed, Laura Tamblyn, Tiffany Cho, Hilde Irene Nebb, Anders Moen, Jan Haug Anonsen, Denis M. Grant, Jason Matthews

Biochem J (2018) 475 (23): 3827–3846.

DOI: https://doi.org/10.1042/BCJ20180347

Published: 10 December 2018

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GPCR structure and function relationship: identification of a biased apelin receptor mutant

Ting Ban, Xun Li, Xiaochuan Ma, Hui Yang, Yunpeng Song, Yaping Sun, Michelle Shen, Na Li, Mei-Yun Zhang, Yingli Ma, Wenge Zhong, Mingqiang Zhang, Liaoyuan A. Hu

Biochem J (2018) 475 (23): 3813–3826.

DOI: https://doi.org/10.1042/BCJ20180740

Published: 06 December 2018

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Chemical validation and optimization of pharmacoperones targeting vasopressin type 2 receptor mutant

Jo Ann Janovick, Timothy P. Spicer, Thomas D. Bannister, Emery Smith, Vadivel Ganapathy, Louis Scampavia

Biochem J (2018) 475 (18): 2941–2953.

DOI: https://doi.org/10.1042/BCJ20180065

Published: 25 September 2018

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A frog cathelicidin peptide effectively promotes cutaneous wound healing in mice

Jing Wu, Jun Yang, Xiaofang Wang, Lin Wei, Kai Mi, Yan Shen, Tong Liu, Hailong Yang, Lixian Mu

Biochem J (2018) 475 (17): 2785–2799.

DOI: https://doi.org/10.1042/BCJ20180286

Published: 11 September 2018

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Nucleic acid-induced potentiation of matrix metalloproteinase-9 enzymatic activity

Tyler Duellman, Xi Chen, Rie Wakamiya, Jay Yang

Biochem J (2018) 475 (9): 1597–1610.

DOI: https://doi.org/10.1042/BCJ20180035

Published: 09 May 2018

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Residues contributing to drug transport by ABCG2 are localised to multiple drug-binding pockets

Megan H. Cox, Parth Kapoor, Deborah A. Briggs, Ian D. Kerr

Biochem J (2018) 475 (9): 1553–1567.

DOI: https://doi.org/10.1042/BCJ20170923

Published: 04 May 2018

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Silencing carboxylesterase 1 in human THP-1 macrophages perturbs genes regulated by PPARγ/RXR and RAR/RXR: down-regulation of CYP27A1–LXRα signaling

Lee C. Mangum, Xiang Hou, Abdolsamad Borazjani, Jung Hwa Lee, Matthew K. Ross, J. Allen Crow

Biochem J (2018) 475 (3): 621–642.

DOI: https://doi.org/10.1042/BCJ20180008

Published: 09 February 2018

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Topoisomerases as anticancer targets

In Collection

Editors' pick of review article highlights published in the Biochemical Journal in 2018 & 2019

Justine L. Delgado, Chao-Ming Hsieh, Nei-Li Chan, Hiroshi Hiasa

Biochem J (2018) 475 (2): 373–398.

DOI: https://doi.org/10.1042/BCJ20160583

Published: 23 January 2018

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Therapeutic targeting of non-coding RNAs in cancer

Ondrej Slaby, Richard Laga, Ondrej Sedlacek

Biochem J (2017) 474 (24): 4219–4251.

DOI: https://doi.org/10.1042/BCJ20170079

Published: 14 December 2017

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Nutlin-3 plus tanshinone IIA exhibits synergetic anti-leukemia effect with imatinib by reactivating p53 and inhibiting the AKT/mTOR pathway in Ph+ ALL

Yong Guo, Yi Li, Bing Xiang, Xiao-Ou Huang, Hong-Bing Ma, Fang-Fang Wang, Yu-Ping Gong

Biochem J (2017) 474 (24): 4153–4170.

DOI: https://doi.org/10.1042/BCJ20170386

Published: 06 December 2017

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TSPO mutations in rats and a human polymorphism impair the rate of steroid synthesis

David R. Owen, Jinjiang Fan, Enrico Campioli, Sathvika Venugopal, Andrew Midzak, Edward Daly, Aline Harlay, Leeyah Issop, Vincenzo Libri, Dimitra Kalogiannopoulou, Eduardo Oliver, Enrique Gallego-Colon, Alessandro Colasanti, Les Huson, Eugenii A. Rabiner, Puvan Suppiah, Charles Essagian, Paul M. Matthews, Vassilios Papadopoulos

Biochem J (2017) 474 (23): 3985–3999.

DOI: https://doi.org/10.1042/BCJ20170648

Published: 21 November 2017

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