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(trafficking AND membrane)

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Published: 01/01/2021 TO 12/31/2021
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Biochem J (2021) 478 (7): 1315–1319.
Published: 06 April 2021
... (2): 407–422) of complexin-2 as an important contributor to glucose transporter 4 (GLUT4) translocation to muscle cell plasma membrane upon insulin stimulation is essential. The present commentary discusses the biological importance of the findings and proposes future challenges and opportunities...
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Articles
Biochem J (2021) 478 (19): 3643–3654.
Published: 14 October 2021
...Daniel Wirth; Ece Özdemir; Christopher King; Lena Ahlswede; Dirk Schneider; Kalina Hristova The spatial distribution of proteins in cell membranes is crucial for signal transduction, cell communication and membrane trafficking. Members of the Tetraspanin family organize functional protein clusters...
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Articles
Biochem J (2021) 478 (10): 1959–1976.
Published: 28 May 2021
... that Vti1B played no role in autophagic fusion [ 13 ]. The conflicting observations are likely attributed to differential regulation of the binding partners upon autophagy induction in response to distinct stimuli. Additionally, VAMP3/Cellubrevin has been indicated to play a role in membrane trafficking...
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Biochem J (2021) 478 (12): 2339–2357.
Published: 23 June 2021
... interfering RNA (siRNA), we generated CLN5 knockdown (CLN5 KD ) HeLa cells. In these cells, we found less membrane bound RAB7A [ 7 ]. RAB7A is a small GTPases that can bind to and recruit retromer, a protein complex that mediates endosome-to-trans Golgi network (TGN) trafficking. Once recruited, retromer...
Includes: Supplementary data
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Biochem J (2021) 478 (22): 3977–3998.
Published: 23 November 2021
... of IRSp53/VASP/Cdc42, and the TNT-inducing role of Eps8 have been demonstrated in neuronal CAD cells [ 103 ]. Created with BioRender.com. Rab35, another master regulator of membrane recycling, is involved in vesicle trafficking and actin cytoskeleton remodeling [ 152 ]. Active Rab35 promotes TNT...
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Biochem J (2021) 478 (6): 1261–1282.
Published: 19 March 2021
... of the Biochemical Society 2021 ER stress FoxA2 islet amyloid polypeptide nucleolus trafficking transcription Eukaryotic cells consist of several membrane-bound organelles and an elaborate endomembrane system [ 1 ]. Each organelle provides a distinct compartment for specific cellular functions...
Includes: Multimedia, Supplementary data
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Biochem J (2021) 478 (24): 4203–4220.
Published: 23 December 2021
...-type CFTR into F508del CFTR-expressing cells increases SLC26A9 trafficking to the plasma membrane [ 38 ]. Together, these results reveal that F508del CFTR prevents SLC26A9 trafficking to the plasma membrane and increases the degradation of ER-retained SLC26A9. Although a significant body of work...
Includes: Supplementary data
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Biochem J (2021) 478 (8): 1617–1629.
Published: 28 April 2021
... vasopressin-independent aquaporin-2 water channel trafficking to the apical membranes of cells lining the kidney collecting ducts [ 92 ]. AKAP220 has been found to participate in mobilizing a microtubule-associated network in the leading edge of cells by integrating cAMP and calcium signals...
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Biochem J (2021) 478 (1): 21–39.
Published: 08 January 2021
... to be led by GBM stem cells (GSCs). Also, tumor networking and intercellular communication play a major role in driving GBM therapy-resistance. Tunneling Nanotubes (TNTs), thin membranous open-ended channels connecting distant cells, have been observed in several types of cancer, where they emerge to drive...
Includes: Multimedia, Supplementary data
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Biochem J (2021) 478 (1): 261–279.
Published: 15 January 2021
..., such as proteasomal degradation, signal transduction, and protein trafficking. The process is also involved in events for establishing viral infection and replication. The first step in ubiquitination involves ubiquitin (Ub) binding with Ub-activating enzyme (E1, also termed UBE1) via a thioester linkage. Our results...
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Articles
Biochem J (2021) 478 (14): 2921–2925.
Published: 28 July 2021
... of the Biochemical Society 2021 Eukaryotic cells are sovereign entities separated from one another by a selectively permeable plasma membrane. While the plasma membrane allows small and nonpolar molecules to cross freely, macromolecules and particles have to explore more intricate mechanisms to traverse...
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Biochem J (2021) 478 (1): 197–215.
Published: 15 January 2021
... that is a member of the ferlin family. This group of proteins is involved in calcium-sensitive membrane trafficking and comprises six members including dysferlin, myoferlin, otoferlin, Fer1L4, Fer1L5, and Fer1L6. Dysferlin has been shown to be an important membrane repair protein. Knockout experiments show...
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Biochem J (2021) 478 (18): 3395–3421.
Published: 23 September 2021
... from the mitochrondria [ 109 ], plasma membrane [ 110 ], ER [ 111 ] and Golgi complex [ 112 ]. Additionally, phagophore assembly and autophagosome formation relies on ATG9A, the only multi-spanning transmembrane ATG protein, trafficking to phagophores [ 113 ]. One possible explanation...
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Biochem J (2021) 478 (8): 1605–1615.
Published: 28 April 2021
... in the mechanisms by which insulin regulates the translocation of GLUT4 to the plasma membrane in muscle, indicating a role for this in mechanisms regulating vesicle trafficking in cells [ 10 ]. We have shown that glucose induces phosphorylation of β-catenin on Ser552 but not the Ser675 site in β-cells via...
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Biochem J (2021) 478 (16): 3099–3123.
Published: 26 August 2021
... released from the membrane and into the cell, the clathrin coat is disassembled. Removal of the clathrin coat allows the vesicle to be trafficked to the early endosome and CME adaptors associated with the clathrin coat to be recycled. Synaptojanin and Oculocerebrorenal syndrome of Lowe inositol...
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Biochem J (2021) 478 (7): 1471–1484.
Published: 16 April 2021
... of intracellular membrane trafficking and cell dynamics by syntaxin-6 . Biosci. Rep. 32 , 383 – 391 10.1042/BSR20120006 33 Yamada , K. , Holth , J.K. , Liao , F. , Stewart , F.R. , Mahan , T.E. , Jiang , H. et al. ( 2014 ) Neuronal activity regulates extracellular tau...
Includes: Supplementary data
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Biochem J (2021) 478 (6): 1199–1225.
Published: 19 March 2021
... of PI3Ks: class I PI3Ks produce PIP 3 at plasma membrane level. Although D. melanogaster and C. elegans have only one form of class I PI3K, vertebrates have four class I PI3Ks called isoforms despite being encoded by four different genes. Hence, duplication of these genes coincides with the acquisition...
Includes: Supplementary data
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Biochem J (2021) 478 (8): 1515–1524.
Published: 21 April 2021
.... and Kjellbom , P. ( 2004 ) Arabidopsis plasma membrane proteomics identifies components of transport, signal transduction and membrane trafficking . Plant Cell Physiol. 45 , 1543 – 1556 10.1093/pcp/pch209 62 Marmagne , A. , Ferro , M. , Meinnel , T. , Bruley , C. , Kuhn , L...
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Biochem J (2021) 478 (3): 633–646.
Published: 12 February 2021
... (GLUT4) to the plasma membrane [ 23 ]. Phosphorylation of AS160 in response to insulin also increases its association with the scaffold protein 14-3-3, an interaction important for GLUT4 trafficking in adipocytes [ 24 , 25 ]. A-769662 adipocytes AMPK AMPKβ1 S108A glucose uptake insulin...
Includes: Supplementary data
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Biochem J (2021) 478 (14): 2733–2758.
Published: 23 July 2021
... of these assemblies may be causative towards the disruption of intra- and intercellular membrane trafficking, leading to the downstream weakening of synaptic communications between neurons [ 4 ]. In many NDs, mitochondrial health is also compromised, leading to impaired bioenergetics, metabolism, and oxidative stress...
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Biochem J (2021) 478 (14): 2811–2823.
Published: 23 July 2021
...Sebastian Mathea; Eidarus Salah; Cynthia Tallant; Deep Chatterjee; Benedict-Tilman Berger; Rebecca Konietzny; Susanne Müller; Benedikt M. Kessler; Stefan Knapp The human protein kinase ULK3 regulates the timing of membrane abscission, thus being involved in exosome budding and cytokinesis. Herein...
Includes: Supplementary data
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Biochem J (2021) 478 (6): 1303–1307.
Published: 23 March 2021
...), which subsequently activates AKT (termed PKB in the U.K.) at the plasma membrane. AKT signals connect to mTOR (see Figure 1 ) by phosphorylating tuberous sclerosis complex 2 (TSC2) GTPase activating protein (GAP). AKT phosphorylation of TSC2 releases TSC inhibition of the GTPase Ras homolog enriched...
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Biochem J (2021) 478 (3): 463–486.
Published: 05 February 2021
... undergoing lithium therapy [ 37 , 38 ]. The therapeutically relevant concentration of Li + in circulation is 1.5–2 mM, a concentration that elicits a two-to-three fold increase in the transport activity of human NaCT [ 29 , 36 ]. Since human NaCT is expressed in the sinusoidal membrane of hepatocytes [ 26...
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Biochem J (2021) 478 (1): 247–260.
Published: 15 January 2021
... into a defect in a process independent of epithelial cell proliferation [ 2 , 3 ]. Cell migration is a complex process that involves cytoskeletal changes, matrix adhesion sites and membrane trafficking in response to stress [ 4 , 5 ]. This process is tightly regulated by numerous factors, but its exact...
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Biochem J (2021) 478 (2): 341–355.
Published: 27 January 2021
... and also cell death and senescence. PKC isozymes were initially studied in cancer following their identification as the ‘receptors’ for tumour promoting phorbol esters. These compounds embed in cell membranes and mimic binding of the natural agonist diacylglycerol (DAG) to acutely activate PKC [ 1 , 2...
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Biochem J (2021) 478 (12): 2309–2319.
Published: 23 June 2021
..., are first synthesized in the endoplasmic reticulum (ER), but only 5–20% of each lysosomal enzyme synthesized is secreted directly outside the cell via the secretory pathway, while the rest are trafficked to lysosomes [ 13 ]. Altering the native signal peptide sequence, therefore, offers a method...
Includes: Supplementary data
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Biochem J (2021) 478 (15): 2977–2997.
Published: 10 August 2021
..., at least in part through phosphorylation of TBC1D1 [ 9 , 10 ], a Rab GTPase-activating protein (GAP) which modulates trafficking of GLUT4-containing vesicles [ 11 ]. AMPK exists as hetero-complexes of three subunits; a catalytic α and two regulatory β and γ subunits. Each exists as multiple isoforms (α1/α2...
Includes: Supplementary data
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Biochem J (2021) 478 (2): 357–375.
Published: 27 January 2021
... and for competition with other organisms. Yeast cells have a wide array of nutrient-sensing systems for rapid adaptation to changes in the nutrient supply, including several types of plasma membrane nutrient sensors [ 1 ]. The latter include the glucose/sucrose-sensing G-protein coupled receptor (GPCR) Gpr1 [ 2...
Includes: Supplementary data
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Biochem J (2021) 478 (19): 3613–3619.
Published: 08 October 2021
... regulators of various metabolite and carbohydrate processing systems, ion transport, membrane trafficking and cellular signaling ( Supplementary Table S1 and Figure 2c ) Interestingly, some of hits identified, such as the peptidyl-prolyl cis - trans isomerase FKBP5, had an inhibitor already occupying...
Includes: Supplementary data
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Biochem J (2021) 478 (2): 443–461.
Published: 29 January 2021
..., already suggested some hierarchical organization in the nucleus [ 52–54 ]. Further development in imaging techniques revealed that many other nuclear components concentrate in compartments that are not delimited by membranes [ 55 , 56 ]. Moreover, many of these membraneless compartments respond...
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Biochem J (2021) 478 (5): 1009–1021.
Published: 04 March 2021
... encounter PG GAGs in different locations and forms — on the epithelium and endothelium, glycocalyx that lies in the proximity of the luminal surfaces of the epithelium and endothelium, and in the extracellular and pericellular matrices [ 2 , 3 ]. Cell surface PGs either span the membrane or anchored via...
Includes: Supplementary data
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Biochem J (2021) 478 (14): 2759–2774.
Published: 23 July 2021
.... ( 2013 ) Phosphorylation-dependent trafficking of plasma membrane proteins in animal and plant cells . J. Integr. Plant Biol. 55 , 789 – 808 10.1111/jipb.12096 5 Humphrey , S.J. , James , D.E. and Mann , M. ( 2015 ) Protein phosphorylation: a major switch mechanism...
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Biochem J (2021) 478 (12): 2321–2337.
Published: 23 June 2021
... documented. The microtubule networks determine the spatial patterning of the cytoplasm, the coupling of microtubules to membranes controls the structure and positioning of organelles and directs membrane trafficking between the organelles [ 19 ]. In addition to integral membrane tubulin, there is also...
Includes: Multimedia, Supplementary data
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Biochem J (2021) 478 (7): 1359–1375.
Published: 16 April 2021
... ]. It is an ancient and evolutionarily conserved catabolic process and is intensely involved in the degradation and recycling of cytoplasmic products. Essentially, autophagy is a trafficking pathway. It transports cytoplasmic cargo to the lysosome for their subsequent degradation via lysosomal hydrolases. Cytosolic...
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Biochem J (2021) 478 (8): 1525–1545.
Published: 21 April 2021
... control of protein trafficking . Traffic 17 , 976 – 996 10.1111/tra.12412 7 Buffalo , C.Z. , Iwamoto , Y. , Hurley , J.H. and Ren , X. ( 2019 ) How HIV Nef proteins hijack membrane traffic To promote infection . J. Virol. 93 , e01322-19 10.1128/JVI.01322-19 8...
Includes: Supplementary data
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Biochem J (2021) 478 (19): 3621–3642.
Published: 14 October 2021
... that have a backbone of sphingoid base in common and given this name after the Greek Sphinx of Thebes because of their enigmatic properties [ 18 ]. It was long thought that sphingolipids play merely structural roles in the regulation of plasma membrane fluidity and membrane receptors [ 2 ], until emerging...
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Biochem J (2021) 478 (5): 1159–1173.
Published: 12 March 2021
..., and membrane trafficking [ 41 ]. Hence, lysosomal dysfunction has been associated to many diseases i.e. lysosomal storage diseases (LSDs) [ 42 ]. As the role of lysosomes and autophagy in macromolecule metabolism becomes clearer, boosting this innate cellular clearance machinery, such as the TFEB agonists...
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Biochem J (2021) 478 (19): 3539–3553.
Published: 06 October 2021
...–15 nm gap junctions between the sarcolemma and SR membranes in the cardiac dyads [ 19–21 ], and is essential for maintaining the integrity of T-tubule system [ 22–26 ], but is down-regulated in response to cardiac stress [ 22 , 27–37 ]. JP2 down-regulation itself contributes to the development...
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Biochem J (2021) 478 (23): 4099–4118.
Published: 06 December 2021
.... those with loss of membrane potential) through the stabilisation of the PTEN-induced kinase 1 (PINK1) in the outer mitochondrial membrane to result in phosphorylation of PINK1 targets, most notably ubiquitin and the ubiquitin-like domain (Ubl) in Parkin at homologous serine 65 residues [ 14 ]. Phospho...
Includes: Supplementary data
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Biochem J (2021) 478 (24): 4153–4167.
Published: 16 December 2021
... to the predicted size of full-length Hxk1-GFP and Rgi2-GFP, confirming that they are both up-regulated by DR. The arrow for Ste6–GFP indicates free GFP remaining after trafficking to and degradation in the vacuole, confirming that Ste6 is down-regulated by DR. Ctt1–GFP and Tod6–GFP were not detected by the GFP...
Includes: Supplementary data
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Biochem J (2021) 478 (8): 1647–1661.
Published: 30 April 2021
... in the regulation of many cellular processes, including energy and phosphate metabolism, DNA repair, ribosome biogenesis, vesicle trafficking and insulin secretion [ 1–5 ]. In mammals, the most abundant inositol pyrophosphate is 5-diphosphoinositol pentakisphosphate (5-PP-IP5 or 5-IP 7 ), which is synthesized from...
Includes: Supplementary data