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(trafficking AND membrane)

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Biochem J (2021) 478 (7): 1315–1319.
Published: 06 April 2021
... (2): 407–422) of complexin-2 as an important contributor to glucose transporter 4 (GLUT4) translocation to muscle cell plasma membrane upon insulin stimulation is essential. The present commentary discusses the biological importance of the findings and proposes future challenges and opportunities...
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Biochem J (2021) 478 (19): 3643–3654.
Published: 14 October 2021
...Daniel Wirth; Ece Özdemir; Christopher King; Lena Ahlswede; Dirk Schneider; Kalina Hristova The spatial distribution of proteins in cell membranes is crucial for signal transduction, cell communication and membrane trafficking. Members of the Tetraspanin family organize functional protein clusters...
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Biochem J (2021) 478 (10): 1959–1976.
Published: 28 May 2021
... fusion [ 13 ]. The conflicting observations are likely attributed to differential regulation of the binding partners upon autophagy induction in response to distinct stimuli. Additionally, VAMP3/Cellubrevin has been indicated to play a role in membrane trafficking in non-neuronal cells. Studies in K562...
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Biochem J (2021) 478 (12): 2339–2357.
Published: 23 June 2021
... interfering RNA (siRNA), we generated CLN5 knockdown (CLN5 KD ) HeLa cells. In these cells, we found less membrane bound RAB7A [ 7 ]. RAB7A is a small GTPases that can bind to and recruit retromer, a protein complex that mediates endosome-to-trans Golgi network (TGN) trafficking. Once recruited, retromer...
Includes: Supplementary data
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Biochem J (2021) 478 (22): 3977–3998.
Published: 23 November 2021
... endosome (ERC/RE) and the Trans Golgi Network (TGN) and is required for recycling processes directed towards the plasma membrane, cytokinesis and primary cilia formation [ 145 ]. It also acts in a cascade with Rab8a, a post-Golgi network-localized GTPase involved in several trafficking pathways, including...
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Biochem J (2021) 478 (6): 1261–1282.
Published: 19 March 2021
... of the Biochemical Society 2021 ER stress FoxA2 islet amyloid polypeptide nucleolus trafficking transcription Eukaryotic cells consist of several membrane-bound organelles and an elaborate endomembrane system [ 1 ]. Each organelle provides a distinct compartment for specific cellular functions...
Includes: Multimedia, Supplementary data
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Biochem J (2021) 478 (24): 4203–4220.
Published: 23 December 2021
...-type CFTR into F508del CFTR-expressing cells increases SLC26A9 trafficking to the plasma membrane [ 38 ]. Together, these results reveal that F508del CFTR prevents SLC26A9 trafficking to the plasma membrane and increases the degradation of ER-retained SLC26A9. Although a significant body of work...
Includes: Supplementary data
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Biochem J (2021) 478 (8): 1617–1629.
Published: 28 April 2021
... with aquaporin 2, a water channel protein in kidney collecting ducts. The kinase-phosphatase unit maintained by AKAP220 controls vasopressin-independent aquaporin-2 water channel trafficking to the apical membranes of cells lining the kidney collecting ducts [ 92 ]. AKAP220 has been found to participate...
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Biochem J (2021) 478 (1): 21–39.
Published: 08 January 2021
... to be led by GBM stem cells (GSCs). Also, tumor networking and intercellular communication play a major role in driving GBM therapy-resistance. Tunneling Nanotubes (TNTs), thin membranous open-ended channels connecting distant cells, have been observed in several types of cancer, where they emerge to drive...
Includes: Multimedia, Supplementary data
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Biochem J (2021) 478 (1): 261–279.
Published: 15 January 2021
..., such as proteasomal degradation, signal transduction, and protein trafficking. The process is also involved in events for establishing viral infection and replication. The first step in ubiquitination involves ubiquitin (Ub) binding with Ub-activating enzyme (E1, also termed UBE1) via a thioester linkage. Our results...
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Biochem J (2021) 478 (14): 2921–2925.
Published: 28 July 2021
... of the Biochemical Society 2021 Eukaryotic cells are sovereign entities separated from one another by a selectively permeable plasma membrane. While the plasma membrane allows small and nonpolar molecules to cross freely, macromolecules and particles have to explore more intricate mechanisms to traverse...
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Biochem J (2021) 478 (1): 197–215.
Published: 15 January 2021
... of the ferlin family. This group of proteins is involved in calcium-sensitive membrane trafficking and comprises six members including dysferlin, myoferlin, otoferlin, Fer1L4, Fer1L5, and Fer1L6. Dysferlin has been shown to be an important membrane repair protein. Knockout experiments show that mice lacking...
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Biochem J (2021) 478 (18): 3395–3421.
Published: 23 September 2021
...–ATG16L1 complex inserting lipidated LC3 (LC3-II) into phagophores and ATG9A-dependent membrane trafficking to growing phagophore membranes. Stage 4 Autophagosome Maturation : Temporally, as more lipids are incorporated to extend phagophore membranes, the phagophore closes and eventually pinches off...
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Biochem J (2021) 478 (8): 1605–1615.
Published: 28 April 2021
... have demonstrated that phosphorylation of Ser552 in β-catenin is involved in the mechanisms by which insulin regulates the translocation of GLUT4 to the plasma membrane in muscle, indicating a role for this in mechanisms regulating vesicle trafficking in cells [ 10 ]. We have shown that glucose...
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Biochem J (2021) 478 (16): 3099–3123.
Published: 26 August 2021
... released from the membrane and into the cell, the clathrin coat is disassembled. Removal of the clathrin coat allows the vesicle to be trafficked to the early endosome and CME adaptors associated with the clathrin coat to be recycled. Synaptojanin and Oculocerebrorenal syndrome of Lowe inositol...
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Biochem J (2021) 478 (7): 1471–1484.
Published: 16 April 2021
... of intracellular membrane trafficking and cell dynamics by syntaxin-6 . Biosci. Rep. 32 , 383 – 391 10.1042/BSR20120006 33 Yamada , K. , Holth , J.K. , Liao , F. , Stewart , F.R. , Mahan , T.E. , Jiang , H. et al. ( 2014 ) Neuronal activity regulates extracellular tau...
Includes: Supplementary data
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Biochem J (2021) 478 (6): 1199–1225.
Published: 19 March 2021
... of PI3Ks: class I PI3Ks produce PIP 3 at plasma membrane level. Although D. melanogaster and C. elegans have only one form of class I PI3K, vertebrates have four class I PI3Ks called isoforms despite being encoded by four different genes. Hence, duplication of these genes coincides with the acquisition...
Includes: Supplementary data
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Biochem J (2021) 478 (3): 633–646.
Published: 12 February 2021
... protein) that is inhibited upon Akt-mediated phosphorylation, thereby acting to link increased insulin signaling to trafficking/fusion of vesicles containing the insulin-sensitive glucose transporter type 4 (GLUT4) to the plasma membrane [ 23 ]. Phosphorylation of AS160 in response to insulin also...
Includes: Supplementary data
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Biochem J (2021) 478 (14): 2733–2758.
Published: 23 July 2021
... of these assemblies may be causative towards the disruption of intra- and intercellular membrane trafficking, leading to the downstream weakening of synaptic communications between neurons [ 4 ]. In many NDs, mitochondrial health is also compromised, leading to impaired bioenergetics, metabolism, and oxidative stress...
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Biochem J (2021) 478 (8): 1515–1524.
Published: 21 April 2021
... transduction and membrane trafficking . Plant Cell Physiol. 45 , 1543 – 1556 10.1093/pcp/pch209 62 Marmagne , A. , Ferro , M. , Meinnel , T. , Bruley , C. , Kuhn , L. , Garin , J. et al. ( 2007 ) A high content in lipid-modified peripheral proteins and integral receptor...
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Biochem J (2021) 478 (6): 1303–1307.
Published: 23 March 2021
... takes care of key aspects of metabolism during T cell activation, AKT covers trafficking, and differentiation, whilst ERK controls survival, transcription, and differentiation of T cells. Naturally, regulation of T cell activation and differentiation is more complex but this simplistic view helps...
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Biochem J (2021) 478 (14): 2811–2823.
Published: 23 July 2021
...Sebastian Mathea; Eidarus Salah; Cynthia Tallant; Deep Chatterjee; Benedict-Tilman Berger; Rebecca Konietzny; Susanne Müller; Benedikt M. Kessler; Stefan Knapp The human protein kinase ULK3 regulates the timing of membrane abscission, thus being involved in exosome budding and cytokinesis. Herein...
Includes: Supplementary data
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Biochem J (2021) 478 (3): 463–486.
Published: 05 February 2021
... a transformative agreement with EBSCO. blood-brain barrier brain EIEE25/DEE25 liver metabolic syndrome NACT/SLC13A5/mINDY Transport proteins (transporters) are involved in the movement of several biological molecules (e.g. nutrients, metabolites) across the plasma membrane and membranes...
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Biochem J (2021) 478 (1): 247–260.
Published: 15 January 2021
... ]. Early mucosal restitution after wounding refers to epithelial cell migration into a defect in a process independent of epithelial cell proliferation [ 2 , 3 ]. Cell migration is a complex process that involves cytoskeletal changes, matrix adhesion sites and membrane trafficking in response to stress [ 4...
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Biochem J (2021) 478 (2): 341–355.
Published: 27 January 2021
... with its pseudosubstrate in the active site. ( C ) PKC that does not properly autoinhibit remains in an open conformation and is labile to dephosphorylation by PHLPP1. ( D ) In response to second messengers DAG (pink rectangle) and Ca 2+ (grey circle), PKC translocates to the plasma membrane...
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Biochem J (2021) 478 (12): 2309–2319.
Published: 23 June 2021
... secreted proteins, are first synthesized in the endoplasmic reticulum (ER), but only 5–20% of each lysosomal enzyme synthesized is secreted directly outside the cell via the secretory pathway, while the rest are trafficked to lysosomes [ 13 ]. Altering the native signal peptide sequence, therefore, offers...
Includes: Supplementary data
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Biochem J (2021) 478 (15): 2977–2997.
Published: 10 August 2021
... carboxylase-1 (ACC1) [ 6 , 7 ]. The activation of AMPK also leads to increased fatty acid oxidation through phosphorylation of ACC2 [ 8 ], and glucose uptake in skeletal muscle, at least in part through phosphorylation of TBC1D1 [ 9 , 10 ], a Rab GTPase-activating protein (GAP) which modulates trafficking...
Includes: Supplementary data
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Biochem J (2021) 478 (2): 357–375.
Published: 27 January 2021
... and for competition with other organisms. Yeast cells have a wide array of nutrient-sensing systems for rapid adaptation to changes in the nutrient supply, including several types of plasma membrane nutrient sensors [ 1 ]. The latter include the glucose/sucrose-sensing G-protein coupled receptor (GPCR) Gpr1 [ 2...
Includes: Supplementary data
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Biochem J (2021) 478 (19): 3613–3619.
Published: 08 October 2021
... regulators of various metabolite and carbohydrate processing systems, ion transport, membrane trafficking and cellular signaling ( Supplementary Table S1 and Figure 2c ) Interestingly, some of hits identified, such as the peptidyl-prolyl cis - trans isomerase FKBP5, had an inhibitor already occupying...
Includes: Supplementary data
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Biochem J (2021) 478 (5): 1009–1021.
Published: 04 March 2021
... of the luminal surfaces of the epithelium and endothelium, and in the extracellular and pericellular matrices [ 2 , 3 ]. Cell surface PGs either span the membrane or anchored via glycosylphosphatidylinositol. Extracellular and pericellular PGs are secreted and exist as macromolecular complexes with other PGs...
Includes: Supplementary data
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Biochem J (2021) 478 (2): 443–461.
Published: 29 January 2021
... factors (TFs) that bind membrane-permeable steroid hormones and control gene expression in response to these stimuli. These receptors constitute the nuclear receptor 3 (NR3) subfamily of the nuclear receptors (NRs) superfamily. SRs display a ubiquitous distribution among tissues in vertebrates, and play...
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Biochem J (2021) 478 (14): 2759–2774.
Published: 23 July 2021
.... Genet. 5 , 270 10.3389/fgene.2014.00270 4 Offringa , R. and Huang , F. ( 2013 ) Phosphorylation-dependent trafficking of plasma membrane proteins in animal and plant cells . J. Integr. Plant Biol. 55 , 789 – 808 10.1111/jipb.12096 5 Humphrey , S.J. , James...
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Biochem J (2021) 478 (7): 1359–1375.
Published: 16 April 2021
.... In the final step, the outer membrane of the autophagosome fuses with a lysosome and forms a single membrane-structured autolysosome. The lysosomal proteins LAMP2, LAMP1, and GTP-binding protein Rab7 participate in the final step [ 28 ]. Lysosomal contents are then degraded by lipases, nucleases, and protease...
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Biochem J (2021) 478 (12): 2321–2337.
Published: 23 June 2021
... membrane and microtubules are well documented. The microtubule networks determine the spatial patterning of the cytoplasm, the coupling of microtubules to membranes controls the structure and positioning of organelles and directs membrane trafficking between the organelles [ 19 ]. In addition to integral...
Includes: Multimedia, Supplementary data
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Biochem J (2021) 478 (8): 1525–1545.
Published: 21 April 2021
... Silva , L.L.P. ( 2016 ) HIV-1 Nef: taking control of protein trafficking . Traffic 17 , 976 – 996 10.1111/tra.12412 7 Buffalo , C.Z. , Iwamoto , Y. , Hurley , J.H. and Ren , X. ( 2019 ) How HIV Nef proteins hijack membrane traffic To promote infection . J. Virol...
Includes: Supplementary data
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Biochem J (2021) 478 (19): 3621–3642.
Published: 14 October 2021
... the hydrolysis of sphingomyelin by different isoforms of sphingomyelinase, namely in the cytoplasmic membrane. In acidic compartments such as lysosomes, complex sphingolipids can be indirectly recycled via degradation into ceramide. Ceramide synthases (1–6), which are important enzymes in the de novo...
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Biochem J (2021) 478 (5): 1159–1173.
Published: 12 March 2021
... to the cellular degradation pathways, recent studies have revealed that lysosomes play active roles in nutrient sensing, adaption to multiple cellular stress, plasma membrane repair, cell signaling, and membrane trafficking [ 41 ]. Hence, lysosomal dysfunction has been associated to many diseases i.e. lysosomal...
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Biochem J (2021) 478 (19): 3539–3553.
Published: 06 October 2021
... for establishing the 12–15 nm gap junctions between the sarcolemma and SR membranes in the cardiac dyads [ 19–21 ], and is essential for maintaining the integrity of T-tubule system [ 22–26 ], but is down-regulated in response to cardiac stress [ 22 , 27–37 ]. JP2 down-regulation itself contributes...
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Biochem J (2021) 478 (24): 4153–4167.
Published: 16 December 2021
... stained with SimplyBlue SafeStain (Invitrogen, U.K.). SDS–PAGE gels were transferred to a nitrocellulose membrane (BioTrace, Pall Life Sciences) at 100 V for 1 h in low molecular weight transfer buffer (25 mM Tris, 192 mM glycine, 40% methanol) in a Mini Trans-Blot Electrophoretic Transfer Cell (Bio-Rad...
Includes: Supplementary data
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Biochem J (2021) 478 (23): 4099–4118.
Published: 06 December 2021
... to overcome defects in Parkin activity and enhance survival of dopaminergic neurones [ 25 ]. USP30 is localised in the mitochondrial outer membrane and was originally believed to act as the DUB that antagonises the PINK1/Parkin pathway [ 25 , 28 ]. However, recent findings have suggested that USP30 acts...
Includes: Supplementary data
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Biochem J (2021) 478 (8): 1647–1661.
Published: 30 April 2021
... ]. These small molecules are found in all eukaryotic cells, and are involved in the regulation of many cellular processes, including energy and phosphate metabolism, DNA repair, ribosome biogenesis, vesicle trafficking and insulin secretion [ 1–5 ]. In mammals, the most abundant inositol pyrophosphate is 5...
Includes: Supplementary data