1-26 of 26 Search Results for

cancer

Cancer
Close
Published: 01/01/2021 TO 12/31/2021
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Articles
Biochem J (2021) 478 (21): 3957–3976.
Published: 12 November 2021
...Sabarish Ramachandran; Souad R. Sennoune; Monica Sharma; Muthusamy Thangaraju; Varshini V. Suresh; Tyler Sneigowski; Yangzom D. Bhutia; Kevin Pruitt; Vadivel Ganapathy Metabolic reprogramming in cancer necessitates increased amino acid uptake, which is accomplished by up-regulation of specific...
Includes: Supplementary data
Articles
Biochem J (2021) 478 (20): 3757–3774.
Published: 21 October 2021
...-regulation to cancer progression and the mechanism of up-regulation have not been investigated. Herein, we show that PEPT1 is not just up-regulated in a large panel of PDAC cell lines and PDXs but is also functional and transport-competent. PEPT2, another proton-coupled peptide transporter, is also...
Includes: Supplementary data
Articles
Biochem J (2021) 478 (19): 3621–3642.
Published: 14 October 2021
...Botheina Ghandour; Ghassan Dbaibo; Nadine Darwiche Sphingolipid-mediated regulation in cancer development and treatment is largely ceramide-centered with the complex sphingolipid metabolic pathways unfolding as attractive targets for anticancer drug discovery. The dynamic interconversion...
Articles
Biochem J (2021) 478 (17): 3373–3393.
Published: 14 September 2021
...Jocelyn F. Chen; Qin Yan Cancer metastasis remains a major clinical challenge for cancer treatment. It is therefore crucial to understand how cancer cells establish and maintain their metastatic traits. However, metastasis-specific genetic mutations have not been identified in most exome or genome...
Articles
Biochem J (2021) 478 (14): 2899–2920.
Published: 28 July 2021
...Majid Momeny; Tiina Arsiola; Jukka Westermarck Cancer stem cells (CSCs) are involved in the initiation and progression of human malignancies by enabling cancer tissue self-renewal capacity and constituting the therapy-resistant population of tumor cells. However, despite the exhausting...
Articles
Biochem J (2021) 478 (9): 1663–1688.
Published: 10 May 2021
...Yonghua Li; Huan Jin; Yibing Chen; Ting Huang; Yanjun Mi; Zhengzhi Zou Cancer cachexia often occurs in malignant tumors and is a multifactorial and complex symptom characterized by wasting of skeletal muscle and adipose tissue, resulting in weight loss, poor life quality and shorter survival...
Articles
Biochem J (2021) 478 (6): 1283–1286.
Published: 23 March 2021
... experimental system, (2) appear differentially regulated, and (3) might execute different functions in cancer biology. This has implications for the field of ICMTC research. First, the authors describe the generation of two new glioblastoma stem cell lines from a more infiltrative tumor region of one...
Articles
Biochem J (2021) 478 (2): 341–355.
Published: 27 January 2021
...Hannah Tovell; Alexandra C. Newton Protein kinase signalling, which transduces external messages to mediate cellular growth and metabolism, is frequently deregulated in human disease, and specifically in cancer. As such, there are 77 kinase inhibitors currently approved for the treatment of human...
Articles
Biochem J (2021) 478 (1): 99–120.
Published: 13 January 2021
... infections, arthritis, metabolic diseases, cognitive dysfunction, and cancer development. These pathologies are controlled, in part, by the genetic background, exposure to environmental factors, age-related epigenetic, proteomic, and genetic changes in the cell, and by the integrity of the host immune...
Includes: Supplementary data
Articles
Biochem J (2021) 478 (21): 3905–3921.
Published: 09 November 2021
...Nicole M. Naranjo; Israa Salem; Maisha A. Harris; Lucia R. Languino We have previously shown that the αvβ6 integrin plays a key role in promoting prostate cancer (PrCa) and it can be transferred to recipient cells via small extracellular vesicles (sEVs). Furthermore, we have reported in a proteomic...
Includes: Supplementary data
Articles
Biochem J (2021) 478 (2): 389–406.
Published: 27 January 2021
... (PRMT) has been shown to be up-regulated in various cancers. PRMTs have emerged as attractive targets for the development of new cancer therapies. Here, we describe the identification of a natural compound, licochalcone A, as a novel, reversible and selective inhibitor of PRMT6. Since expression...
Includes: Supplementary data
Articles
Biochem J (2021) 478 (17): 3351–3371.
Published: 14 September 2021
... the biological functions of receptor tyrosine pseudokinases are incompletely understood, changes in their expression level are typically linked to proliferative diseases like cancer. Many pseudokinases exert their non-catalytic functions by allosterically regulating the kinase activity of their kinase-active...
Includes: Supplementary data
Articles
Biochem J (2021) 478 (8): 1485–1509.
Published: 21 April 2021
... Press Limited on behalf of the Biochemical Society 2021 antibodies antigens autoimmunity cancer glycobiology Antibodies, immunoglobulin proteins produced by B cells, are a critical component of the immune system. The primary function of an antibody is to bind a target molecule...
Articles
Biochem J (2021) 478 (12): 2265–2283.
Published: 18 June 2021
...Ravichandran Vignesh; Anita Sjölander; Ganesh Venkatraman; Suresh Kumar Rayala; Gopala Krishna Aradhyam The characteristic features of cancer cells are aberrant (acidic) intracellular pH and elevated levels of phosphatidylserine. The primary focus of cancer research is concentrated on the discovery...
Includes: Supplementary data
Articles
Biochem J (2021) 478 (9): 1809–1825.
Published: 14 May 2021
... that have been co-opted by cancer cells to undergo tumor metastasis. These processes are regulated at multiple instances, whereas the post-transcriptional regulation of key genes mediated by microRNAs is gaining major attention as a common and conserved pathway. In this review, we focus on discussing...
Articles
Biochem J (2021) 478 (7): 1453–1470.
Published: 16 April 2021
... M2 (PKM2), a rate-limiting enzyme in glycolysis, is critical for the metabolic shift from glycolysis to the pentose phosphate pathway under oxidative stress in cancer cell growth. The PKM2 tetramer is required for optimal pyruvate kinase (PK) activity, whereas the inhibition of inter-subunit...
Includes: Supplementary data
Articles
Biochem J (2021) 478 (1): 21–39.
Published: 08 January 2021
...Giulia Pinto; Inés Saenz-de-Santa-Maria; Patricia Chastagner; Emeline Perthame; Caroline Delmas; Christine Toulas; Elizabeth Moyal-Jonathan-Cohen; Christel Brou; Chiara Zurzolo Glioblastoma (GBM) is the most aggressive brain cancer and its relapse after surgery, chemo and radiotherapy appears...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2021) 478 (23): 4137–4149.
Published: 06 December 2021
... that are required for proliferation, and pharmaceutical ODC inhibition is pursued for the treatment of hyperproliferative diseases, including cancer and infectious diseases. The most potent ODC inhibitor is 1-amino-oxy-3-aminopropane (APA). A previous crystal structure of an ODC–APA complex indicated that APA non...
Articles
Biochem J (2021) 478 (20): 3791–3805.
Published: 28 October 2021
... explain the frequent re-expression of normally silent meiotic genes in a variety of human cancers. Correspondence: Urszula Lucja McClurg ( Urszula.McClurg@liverpool.ac.uk ) or Wee-Wei Tee ( wwtee@imcb.a-star.edu.sg ) 2 6 2021 29 9 2021 6 10 2021 © 2021 The Author(s) 2021...
Articles
Biochem J (2021) 478 (15): 2999–3014.
Published: 10 August 2021
...Teddy Kamata; Chun-Song Yang; Bryce M. Paschal We recently described a signal transduction pathway that contributes to androgen receptor (AR) regulation based on site-specific ADP-ribosylation by PARP7, a mono-ADP-ribosyltransferase implicated in several human cancers. ADP-ribosylated AR...
Articles
Biochem J (2021) 478 (13): 2619–2664.
Published: 16 July 2021
... processes, NF-κB signalling must be subject to strict spatiotemporal control to ensure measured and context-specific cellular responses. Indeed, deregulation of NF-κB signalling can result in debilitating and even lethal inflammation and also underpins some forms of cancer. In this review, we describe...
Articles
Biochem J (2021) 478 (6): 1179–1197.
Published: 19 March 2021
... including ionizing radiation, radiomimetic drugs and replication fork stalling can also result in different types of mutations in mitochondrial DNA (mtDNA) leading to genome fragility. Mitochondria from myopathies, dystonia, cancer patient samples show frequent mtDNA mutations such as point mutations...
Articles
Biochem J (2021) 478 (3): 597–617.
Published: 12 February 2021
... ) or ( gabriel.r@ibyme.conicet.gov.ar ) 29 11 2020 28 12 2020 21 1 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 cancer galectins lectins metastasis tumor immunity Along with the improvement of surgical techniques...
Articles
Biochem J (2021) 478 (6): 1199–1225.
Published: 19 March 2021
... ] - DNA repair and replication [ 23 ] - Serum withdrawal-induced autophagy through Rab5 (controversial) [ 33 ] - FCY receptor-induced signal (macrophage phagocytosis, neutrophil activation*) [ 34 , 35 ] Role in Cancer - Frequently mutated [ 36 , 37 ] - Lipid kinase activity is required in mutated...
Includes: Supplementary data
Articles
Biochem J (2021) 478 (22): 3999–4004.
Published: 23 November 2021
... 8 de Mingo Pulido , A. , Gardner , A. , Hiebler , S. , Soliman , H. , Rugo , H.S. , Krummel , M.F. et al. ( 2018 ) TIM-3 regulates CD103(+) dendritic cell function and response to chemotherapy in breast cancer . Cancer Cell 33 , 60 – 74.e66 10.1016/j.ccell...
Articles
Biochem J (2021) 478 (3): 463–486.
Published: 05 February 2021
.../reabsorbed [ 1 , 2 ]. Transporters are divided into two major groups: ATP-binding cassette (ABC) proteins and the solute carrier (SLC) proteins [ 1 ]. ABC proteins include transporters such as the multidrug resistance protein 1 (MDR1) and the breast cancer resistance protein (BCRP), which all function...