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mitochondria

Published: 2023-01-01 TO 2024-01-01
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Biochem J (2023) 480 (13): 909–919.
Published: 04 July 2023
..., and hence contribute to pathophysiological states. Therefore, it is not surprising that mitochondria have emerged as being pivotal in maintaining physiological homeostasis through daily oscillations/fluctuations in nutrient inputs and light–dark/sleep–wake cycles. Moreover, given the inherent association...
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Organelle-level AMPK activity at nucleus, lysosomes, and <span class="search-highlight">mitochondria</span>.  The...
Published: 30 October 2023
Figure 2. Organelle-level AMPK activity at nucleus, lysosomes, and mitochondria. The excitation ratiometric AMPK activity reporter (ExRai AMPKAR) senses AMPK activity using a molecular switch composed of an FHA1 domain and an AMPK substrate, which undergoes a conformational change upon phosphoryl... More about this image found in Organelle-level AMPK activity at nucleus, lysosomes, and mitochondria. The...
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Impact of mitofusin gene deletion selectively in beta cells on <span class="search-highlight">mitochondria</span>...
Published: 07 June 2023
Figure 4. Impact of mitofusin gene deletion selectively in beta cells on mitochondrial structure, mtDNA content and glucose metabolism. ( a ) Three-dimensional renderings of β-cell mitochondrial networks generated on Imaris®, ( b ) mitochondrial morphology and network analysis performed using Mit... More about this image found in Impact of mitofusin gene deletion selectively in beta cells on mitochondria...
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Heterogeneous substrate oxidation in rat skeletal muscle <span class="search-highlight">mitochondria</span>.  ( A...
Published: 15 March 2023
Figure 7. Heterogeneous substrate oxidation in rat skeletal muscle mitochondria. ( A ) Wide-field fluorescence micrographs of TMRM in isolated rat skeletal muscle mitochondria immobilised on glass in the presence of the indicated substrates. The two cropped frames show the same mitochondria befor... More about this image found in Heterogeneous substrate oxidation in rat skeletal muscle mitochondria. ( A...
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Comparison of stochastic (A) and deterministic (B) models for surveilling a...
Published: 18 October 2023
Figure 2. Comparison of stochastic (A) and deterministic (B) models for surveilling and identifying mitochondria for mitophagic engulfment and degradation. ( A ) (i) Phase separation within the mitochondrial matrix (intra-organellar structure is ignored for simplicity) coupled with fusion/fission... More about this image found in Comparison of stochastic (A) and deterministic (B) models for surveilling a...
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Biochem J (2023) 480 (20): 1639–1657.
Published: 18 October 2023
...Figure 2. Comparison of stochastic (A) and deterministic (B) models for surveilling and identifying mitochondria for mitophagic engulfment and degradation. ( A ) (i) Phase separation within the mitochondrial matrix (intra-organellar structure is ignored for simplicity) coupled with fusion...
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Biochem J (2023) 480 (12): 855–873.
Published: 22 June 2023
...John E. Cronan This is a review of the acyl carrier proteins (ACPs) of type II fatty acid synthesis in bacteria and mitochondria, their structures and protein interactions. Type II fatty acid synthesis in bacteria ( Prog. Lipid Res. (2013) 52 , 249–276; Biochim. Biophys. Acta (1996) 1302 , 1–16...
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Mitochondrial heterogeneity as a potential explanation for the selective mi...
Published: 18 October 2023
Figure 1. Mitochondrial heterogeneity as a potential explanation for the selective mitophagic degradation of mitochondrial matrix proteins. ( A ) A simplified model for the localized activation of Atg32 on mitochondria with distinct molecular composition or physiological state. Mitochondrial fiss... More about this image found in Mitochondrial heterogeneity as a potential explanation for the selective mi...
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Western blot and localization analysis of VRK2A proteins in cancer cells.  ...
Published: 28 November 2023
Figure 1. Western blot and localization analysis of VRK2A proteins in cancer cells. ( A ) GST-VRK2A (lanes 1 and 6), 1–397 (lanes 2 and 5), and 1–320 (lanes 3 and 4) protein variants were detected using Anti-VRK2A and Anti-GST antibodies. The anti-VRK2A antibody bound specifically to the full-len... More about this image found in Western blot and localization analysis of VRK2A proteins in cancer cells. ...
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Hydrogen peroxide release and NAD(P)H redox state in Fa2N-4 cells.  ( A ) E...
Published: 15 March 2023
Figure 8. Hydrogen peroxide release and NAD(P)H redox state in Fa2N-4 cells. ( A ) Effect of S1QEL2.1 on hydrogen peroxide release from Fa2N-4 immortalised hepatocytes determined by the Amplex UltraRed/HRP assay in the medium above the cell monolayer. ( B ) NAD(P)H autofluorescence of Fa2N-4 cell... More about this image found in Hydrogen peroxide release and NAD(P)H redox state in Fa2N-4 cells. ( A ) E...
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Biochem J (2023) 480 (21): 1767–1789.
Published: 15 November 2023
... and the Biochemical Society under a transformative agreement with JISC. function metabolism mitochondria mitochondrial dysfunction structure Volume wise, skeletal muscle tissue is mostly composed of long, cylindrical, multi-nucleated, and contractile cells, known as muscle fibres, which...
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Biochem J (2023) 480 (11): 773–789.
Published: 07 June 2023
... by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . diabetes glucose homeostasis hormone secretion insulin mitochondria pancreatic beta cell Critical roles for mitochondrial metabolism in glucose...
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Biochem J (2023) 480 (24): 2023–2035.
Published: 15 December 2023
... ]. At fertilization in mouse eggs, the Ca 2+ oscillations are also associated with Ca 2+ increase in mitochondria and the stimulation of mitochondrial activity [ 16 ], as shown by transient changes in NADH and FAD fluorescence [ 16 ]. The Ca 2+ oscillations at fertilization are also associated with an increase...
Includes: Supplementary data
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Biochem J (2023) 480 (9): 607–627.
Published: 04 May 2023
... that are typically handled by mitochondria [ 7 , 8 ]. Under specific physiological or pathological conditions such as fasting or a mitochondrial FAO defect, respectively, long-chain fatty acids undergo microsomal ω-oxidation, generating DCAs, which are chemically defined by two carboxyl groups, one at each side...
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Contribution of site I Q  to overall superoxide/hydrogen peroxide productio...
Published: 15 March 2023
Figure 4. Contribution of site I Q to overall superoxide/hydrogen peroxide production on glycerol-3-phosphate during reverse electron transport (site I Q r) and forward electron transport (site I Q f). Superoxide/hydrogen peroxide production by rat skeletal muscle mitochondria oxidising glycerol... More about this image found in Contribution of site I Q to overall superoxide/hydrogen peroxide productio...
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Biochem J (2023) 480 (1): 105–125.
Published: 13 January 2023
..., the majority of carbons exit mitochondria as aspartate, whereas malate prevails when pyruvate is the sole substrate. Enzymes catalyzing the main reactions of the GNG pathway are represented in green. Those catalyzing unidirectional/rate-limiting reactions are indicated in red. Accessory pathways for glucose...
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Effects of rotenone, piericidin A, FCCP and nigericin on superoxide/hydroge...
Published: 15 March 2023
Figure 5. Effects of rotenone, piericidin A, FCCP and nigericin on superoxide/hydrogen peroxide production during reverse electron transport (site I Q r) and forward electron transport (site I Q f). Plate-reader assays of superoxide/hydrogen peroxide production by rat skeletal muscle mitochondria... More about this image found in Effects of rotenone, piericidin A, FCCP and nigericin on superoxide/hydroge...
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Biochem J (2023) 480 (2): 141–160.
Published: 23 January 2023
... and HSP90A/B ( Supplementary Figure S9C , Supplementary Video S2 ), supporting our experimental finding that revealed the PSKH2 C-tail as the key determinant for interaction with the HSP90 complex in cells. As reported above, clusters of proteins associated with the mitochondria, including TIMM23...
Includes: Multimedia, Supplementary data
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Hepatic GNG from different substrates.  Important gluconeogenic substrates ...
Published: 13 January 2023
Figure 1. Hepatic GNG from different substrates. Important gluconeogenic substrates are lactate (from glycolysis), alanine (from proteolysis), glycerol (released during lipolysis), galactose (from lactose), fructose (from sucrose) and dietary sorbitol. Of note, when lactate is the only substrate,... More about this image found in Hepatic GNG from different substrates. Important gluconeogenic substrates ...
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Biochem J (2023) 480 (5): 319–333.
Published: 15 March 2023
... BY) . complex I electron transfer membrane protein structure proton pumping respiratory chain In the respiratory chain, oxidative phosphorylation (OXPHOS) enzymes are responsible for energy production (in the form of ATP) in eukaryotic cells and in many bacteria [ 1 ]. In mitochondria the chain...
Includes: Multimedia, Supplementary data
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Demonstration of reverse and forward electron transport through complex I i...
Published: 15 March 2023
Figure 2. Demonstration of reverse and forward electron transport through complex I in isolated rat skeletal muscle mitochondria in cuvette-based assays assessed using the effect of rotenone challenge on NAD(P)H redox state; parallel superoxide/hydrogen peroxide production from sites I Q r and I Q... More about this image found in Demonstration of reverse and forward electron transport through complex I i...
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Reverse and forward electron transport through complex I in muscle mitochon...
Published: 15 March 2023
Figure 3. Reverse and forward electron transport through complex I in muscle mitochondria in cuvette-based assays using plate-reader timings; parallel superoxide/hydrogen peroxide production from sites I Q r and I Q f and its suppression by S1QELs in the plate-reader. ( A , B ) Cuvette-based assa... More about this image found in Reverse and forward electron transport through complex I in muscle mitochon...
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Effects of S1QELs on superoxide/hydrogen peroxide production during reverse...
Published: 15 March 2023
Figure 6. Effects of S1QELs on superoxide/hydrogen peroxide production during reverse electron transport (site I Q r) and forward electron transport (site I Q f). Plate-reader assays of superoxide/hydrogen peroxide production by rat skeletal muscle mitochondria (0.2 mg/ml; 0.01 mg/well) oxidising... More about this image found in Effects of S1QELs on superoxide/hydrogen peroxide production during reverse...
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Biochem J (2023) 480 (19): 1583–1598.
Published: 11 October 2023
... mitochondria damage [ 66 , 67 ], evoked a decrease in NanoBiT split luciferase activity ( Figure 6 ). Since CCCP-induced clustering of mitochondria is Parkin-dependent, we used cells stably expressing Parkin. CCCP treatment for 4 h was enough to stimulate the dissociation of BAG6 and UBL4A ( Figure 6A...
Includes: Supplementary data
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Principle of distinguishing reverse electron transport (RET) from forward e...
Published: 15 March 2023
Figure 1. Principle of distinguishing reverse electron transport (RET) from forward electron transport (FET) and assaying superoxide/hydrogen peroxide production from sites I Q r and I Q f in isolated skeletal muscle mitochondria. Schemes depict the electrochemical topology of the electron transp... More about this image found in Principle of distinguishing reverse electron transport (RET) from forward e...
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Biochem J (2023) 480 (19): 1533–1551.
Published: 05 October 2023
... that mitochondria defective cells present poor growth both in fluid and in bacterial grasses, and also alterations in multicellular development [ 54 ]. Figure 4. Starvation-triggered multicellular development progression. Exponentially growing cells of Ax2 (top) and clone 8 (bottom) were seeded in non...
Includes: Supplementary data
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Biochem J (2023) 480 (13): 941–956.
Published: 06 July 2023
... nucleoids and increased expression of AtWHY3 transcripts compared with the wild type [ 22 ]. The WHY1 and WHY3 proteins are localised to plastids and the nucleus, while the WHY2 protein is targeted to mitochondria but may also traffic to plastids and the nucleus. WHY regulates DNA replication...
Includes: Supplementary data
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Biochem J (2023) 480 (2): 161–176.
Published: 31 January 2023
... , 6 , 8 ]. To a great extent, BCR-ABL1-mediated resistance to apoptosis involves up-regulation of anti-apoptotic and down-regulation of pro-apoptotic BCL-2 (B-cell lymphoma/leukemia-2 gene) family members [ 5 , 6 , 10 ] thereby preventing the translocation of cytochrome c from the mitochondria...
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Biochem J (2023) 480 (20): 1693–1717.
Published: 30 October 2023
...Figure 2. Organelle-level AMPK activity at nucleus, lysosomes, and mitochondria. The excitation ratiometric AMPK activity reporter (ExRai AMPKAR) senses AMPK activity using a molecular switch composed of an FHA1 domain and an AMPK substrate, which undergoes a conformational change upon...
Articles
Biochem J (2023) 480 (14): 1109–1127.
Published: 19 July 2023
... Proteins pulled from HEK293T lysate by RhoGAPΔP but significantly less by RhoGAPΔW were cross-referenced with platelet proteomic data identifying 26 platelet proteins. Fifteen proteins localised to the nucleus and mitochondria and the remaining 11 proteins are listed above. COPI coat components...
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Biochem J (2023) 480 (18): 1445–1457.
Published: 21 September 2023
... cells . Proc. Natl Acad. Sci. U.S.A. 105 , 7405 – 7409 10.1073/pnas.0710346105 51 Rhee , H.W. , Zou , P. , Udeshi , N.D. , Martell , J.D. , Mootha , V.K. , Carr , S.A. et al. ( 2013 ) Proteomic mapping of mitochondria in living cells via spatially restricted...
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Biochem J (2023) 480 (1): 1–23.
Published: 06 January 2023
... translocates KRAS from the PM to the ER, GA, and the mitochondria where it binds to Bcl-XL and subverts the survival function of this protein. In addition, PKC phosphorylation interferes with KRAS deactivation by calmodulin [ 68 ] and by GAPs resulting in enhanced transforming capabilities [ 69 ]. Thus, PKC...
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Biochem J (2023) 480 (8): 539–553.
Published: 26 April 2023
... of these organelles, they are categorized as membrane-bound and membrane-less organelles. Membrane bound organelles such as mitochondria and Golgi bodies have outer coat made of lipid bilayer, whereas membrane less organelles like nucleolus, cajal bodies and p-granules lack lipid bilayer outer membrane and are solely...
Includes: Multimedia, Supplementary data
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Biochem J (2023) 480 (16): 1241–1265.
Published: 23 August 2023
.... , Slentz , D.H. et al. ( 2019 ) Respiratory phenomics across multiple models of protein hyperacylation in cardiac mitochondria reveals a marginal impact on bioenergetics . Cell Rep. 26 , 1557 – 1572.e1558 10.1016/j.celrep.2019.01.057 130 Miller , K.D. , Pniewski , K. , Perry...