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Keywords: α-methyltryptophan
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Biochem J (2021) 478 (10): 1999–2017.
Published: 28 May 2021
... Biochemical Society 2021 α-methyltryptophan disordered termini exosite human tryptophan 2 3-dioxygenase surface DEpSpT clusters Ub-dependent proteasomal degradation Tryptophan 2,3-dioxygenase (TDO) is the rate-limiting enzyme in the kynurenine pathway. It catalyzes the oxidative breakdown...
Includes: Supplementary data
Biochem J (2020) 477 (10): 1923–1937.
Published: 29 May 2020
... cancer and that it is a viable therapeutic target. α-Methyltryptophan (α-MT) is a blocker of SLC6A14 and is effective against pancreatic cancer in vitro and in vivo . In the present study, we tested the hypothesis that α-MT could synergize with gemcitabine in the treatment of pancreatic cancer. We...
Includes: Supplementary data
Biochem J (2020) 477 (8): 1409–1425.
Published: 23 April 2020
... most human colon cancer cell lines and also in a majority of patient-derived xenografts. These findings are supported by publicly available TCGA (The Cancer Genome Atlas) database. Treatment of colon cancer cells with α-methyltryptophan (α-MT), a blocker of SLC6A14, induces amino acid deprivation...
Includes: Supplementary data