... αB-crystallin (αB-c; HSPB5) and Hsp27 (HSPB1). We show that small (monomeric or dimeric) forms of both αB-c and Hsp27 bind to misfolded or oligomeric forms of the client proteins at early stages of aggregation, resulting in the formation of soluble sHsp–client complexes. Stoichiometric analysis...

... (PCO). Although αB-crystallin is a major protein in LEC, its role in the EMT remains unknown. In a human LEC line (FHL124), TGF-β2 treatment resulted in changes in the EMT-associated proteins at the mRNA and protein levels. This was associated with nuclear localization of αB-crystallin, phosphorylated...

...Heath Ecroyd; Sarah Meehan; Joseph Horwitz; J. Andrew Aquilina; Justin L. P. Benesch; Carol V. Robinson; Cait E. Macphee; John A. Carver αB-crystallin is a member of the sHsp (small heat-shock protein) family that prevents misfolded target proteins from aggregating and precipitating...

...M. Satish Kumar; P. Yadagiri Reddy; B. Sreedhar; G. Bhanuprakash Reddy αB-crystallin, a small heat-shock protein has been shown to prevent the aggregation of other proteins under various stress conditions. We have investigated the role of αB-crystallin in the reactivation of denaturant [GdmCl...