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Keywords: β-carbolines
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Nicotinamide N -methyltransferase catalyses the N-methylation of the endogenous β-carboline norharman: evidence for a novel detoxification pathway

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Martin G. Thomas, Davide Sartini, Monica Emanuelli, Matthijs J. van Haren, Nathaniel I. Martin, David M. Mountford, David J. Barlow, Fábio Klamt, David B. Ramsden, Madeehah Reza, Richard B. Parsons
Journal: Biochemical Journal
Biochem J (2016) 473 (19): 3253–3267.
https://doi.org/10.1042/BCJ20160219
Published: 27 September 2016
...-methylnicotinamide. Our recent studies have demonstrated that NNMT regulates cellular processes fundamental to the correct functioning and survival of the cell. It has been proposed that NNMT may possess β-carboline (BC) N -methyltransferase activity, endogenously and exogenously produced pyridine-containing...
View articletitled, Nicotinamide N -methyltransferase catalyses the N-methylation of the endogenous β-carboline norharman: evidence for a novel detoxification pathway
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Includes: Supplementary data