...Brie Sorrenson; Waruni C. Dissanayake; Fengyun Hu; Kate L. Lee; Peter R. Shepherd The presence of adherens junctions and the associated protein β-catenin are requirements for the development of glucose-stimulated insulin secretion (GSIS) in β-cells. Evidence indicates that modulation of β-catenin...

... in two different experimental models (inflammation-associated colon cancer and genetically driven colon cancer). In colon cancer cells, expression of the transporter is reduced by Wnt antagonist or by silencing of β-catenin whereas Wnt agonist or overexpression of β-catenin shows the opposite effect...

... Ríos; Maria Eugenia Gutierrez-Castillo; Irma Alicia Martínez-Dávila; Nicolás Villegas-Sepúlveda; Daniel Martinez-Fong; Porfirio Nava The mechanisms controlling degradation of cytosolic β-catenin are important for regulating β-catenin co-transcriptional activity. Loss of von Hippel–Lindau protein (pVHL...

... sites of β-catenin-mediated transcription. In the present study, we report that Pygo2 itself is transiently acetylated when bound to the activated TCF/β-catenin transcription complex, which correlated with β-catenin binding and Axin2 gene activation. The HAT CBP/p300, but not GCN5/PCAF, targeted...

...Md. Kamrul H. Chowdhury; Lindsay E. Wu; James L.J. Coleman; Nicola J. Smith; Margaret J. Morris; Peter R. Shepherd; Greg C. Smith Recently, it has been found that glucagon is able to activate the β-catenin signalling pathway leading to increased cyclin D1 and c-Myc expression in liver. Therefore...

..., whereas HOXB5 -down-regulated cells showed decreased invasion and migration activity. Up-regulation of HOXB5 resulted in up-regulation of β-catenin, whereas inhibition of HOXB5 expression by siRNA led to the down-regulation of β-catenin. Moreover, a significant correlation between HOXB5 and CTNNB1 (β...

.... Accordingly, cell treatment with PyrPam has no significant effect on the phosphorylation of β-catenin Ser 45 . By contrast, the phosphorylation of β-catenin Thr 41 is increased upon cell treatment with PyrPam, through a mechanism that implies the upstream dephosphorylation of Akt/PKB (protein kinase B...

...Wantae Kim; Minseong Kim; Eek-hoon Jho Wnt/β-catenin signalling plays essential roles in embryonic development as well as tissue homoeostasis in adults. Thus abnormal regulation of Wnt/β-catenin signalling is linked to a variety of human diseases, including cancer, osteoporosis and Alzheimer's...

...Emmanuelle Cognard; Coralie G. Dargaville; Deborah L. Hay; Peter R. Shepherd Pancreatic β-cells are highly responsive to changes in glucose, but the mechanisms involved are only partially understood. There is increasing evidence that the β-catenin signalling pathway plays an important role...

...Maria V. Barbolina; Rebecca J. Burkhalter; M. Sharon Stack Wnt signalling pathways have been shown to play key roles in both normal development and tumorigenesis. Progression of many human cancers is associated with defined mutations in Wnt pathway components that result in dysregulated β-catenin...

...Mark W. L. Kennedy; Kenneth R. Kao In Xenopus laevis embryonic development, activation of the Wnt/β-catenin pathway promotes mesoderm cell fate determination via Xnr ( Xenopus nodal-related) expression. We have demonstrated previously that Rel/NF-κB (nuclear factor κB) proteins expressed...

... phosphorylation of Akt (also known as protein kinase B) and the Akt substrate GSK3β (glycogen synthase kinase 3β), and reduced the levels of β-catenin, a transcriptional activator regulated by GSK3β. It also caused the activation of the pro-apoptotic protein Bax and inhibited the expression of the anti-apoptotic...

... failure and increased tumour susceptibility. Akt β-catenin Fanconi anaemia (FA) glycogen synthase kinase 3β (GSK3β) interleukin-1β (IL-1β) nuclear factor-κB (NF-κB) The association between chronic inflammation and cancer has been known for some time and is supported by animal models [ 11...

...Sasha H. Anagnostou; Peter R. Shepherd The canonical Wnt signalling pathway acts by slowing the rate of ubiquitin-mediated β-catenin degradation. This results in the accumulation and subsequent nuclear translocation of β-catenin, which induces the expression of a number of genes involved in growth...

...Thilo HAGEN; Jaswinder K. SETHI; Neale FOXWELL; Antonio VIDAL-PUIG β-Catenin plays a dual role as an adhesion molecule in adherens junctions at the plasma membrane and as a key intermediate in the canonical Wnt signalling pathway. The cytosolic soluble pool of β-catenin, involved...

... for LAR have not been identified unequivocally, β-catenin associates with LAR and is a substrate in vitro . With the implication that LAR may play a role in regulating E-cadherin-dependent cell—cell communication and contact inhibition, the relationship of LAR with E-cadherin was investigated. LAR...

... established that the Tcf-4 transcription factor is subjected exclusively to regulation through the β-catenin/E(epithelial)-cadherin pathway, this implies the specific expression of MMP-26 in cancer cells of epithelial origin. The nucleotide sequence data reported will appear in DDBJ, EMBL, GenBank ®...

...Josep BAULIDA; Eduard BATLLE; Antonio GARCÍA DE HERREROS Alterations in the transcriptional activity of the β-catenin-Tcf complex have been associated with the earlier stages of colonic transformation. We show here that the activation of protein kinase C by the phorbol ester PMA in several...