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Keywords: β-lactam
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Biochem J (2002) 365 (1): 303–309.
Published: 01 July 2002
... indicated that destabilization of the Michaelis—Menten complex accounts for the improved activity with β-lactam substrates. Analysis of pH—activity profiles of wild-type enzyme and the βArg263Lys mutant showed that βArg 263 has to be positively charged for catalysis, but is not involved in substrate binding...
Biochem J (2002) 361 (3): 635–639.
Published: 25 January 2002
... periplasmic side of the membrane. Recombinant PBP1∗ binds benzylpenicillin and several other β-lactams, notably cefotaxime, with high affinity. Truncation of the N-terminal 64 amino acid residues results in an expressed protein present exclusively in inclusion bodies and unable to associate with the membrane...