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Keywords: 4-hydroxynonenal (HNE)
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Articles

Responses of hypertrophied myocytes to reactive species: implications for glycolysis and electrophile metabolism

Available to Purchase
Brian E. Sansbury, Daniel W. Riggs, Robert E. Brainard, Joshua K. Salabei, Steven P. Jones, Bradford G. Hill
Journal: Biochemical Journal
Biochem J (2011) 435 (2): 519–528.
https://doi.org/10.1042/BJ20101390
Published: 29 March 2011
...) cardiac hypertrophy extracellular flux glycolysis 4-hydroxynonenal (HNE) mitochondrion Electrophilic aldehydes generated from the oxidation of lipids have been detected in nearly all tissues that have experienced oxidative injury. In the heart, they are found in the context of ischaemia [ 1...
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Includes: Supplementary data
Articles

High membrane potential promotes alkenal-induced mitochondrial uncoupling and influences adenine nucleotide translocase conformation

Open Access
Vian Azzu, Nadeene Parker, Martin D. Brand
Journal: Biochemical Journal
Biochem J (2008) 413 (2): 323–332.
https://doi.org/10.1042/BJ20080321
Published: 26 June 2008
.... carboxyatractylate (CAtr) 4-hydroxynonenal (HNE) proton leak rat liver mitochondrion trypsin Excessive ROS (reactive oxygen species) production is deleterious to cells, and is implicated in the aetiology and/or progression of a wide variety of pathologies including cardiovascular and neurodegenerative...
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