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Keywords: Aβ42 (amyloid-β 42)
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Articles
Specific aromatic foldamers potently inhibit spontaneous and seeded Aβ42 and Aβ43 fibril assembly
Open AccessKatelyn M. Seither, Heather A. McMahon, Nikita Singh, Hejia Wang, Mimi Cushman-Nick, Geronda L. Montalvo, William F. DeGrado, James Shorter
Journal:
Biochemical Journal
Biochem J (2014) 464 (1): 85–98.
Published: 23 October 2014
... with Alzheimer's disease. One foldamer inhibits formation of toxic Aβ-species as well as the self-templating activity of Aβ fibrils, properties that could have therapeutic utility. Alzheimer’s disease amyloid Aβ42 (amyloid-β 42) Aβ43 (amyloid-β 43) foldamer protein misfolding Protein misfolding...