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Keywords: AAL-149
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Articles
Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins
Available to PurchaseKimberly Romero Rosales, Gurpreet Singh, Kevin Wu, Jie Chen, Matthew R. Janes, Michael B. Lilly, Eigen R. Peralta, Leah J. Siskind, Michael J. Bennett, David A. Fruman, Aimee L. Edinger
Journal:
Biochemical Journal
Biochem J (2011) 439 (2): 299–311.
Published: 28 September 2011
... or by reducing nutrient demand, but blocking apoptosis was ineffective. Importantly, AAL-149, a FTY720 analogue that lacks FTY720's dose-limiting toxicity, also triggered transporter loss and killed patient-derived leukaemias while sparing cells isolated from normal donors. As they target the metabolic profile...
Includes: Supplementary data
