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Keywords: ABT-737
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Biochem J (2013) 452 (1): 111–119.
Published: 25 April 2013
... one of its metabolites) and BAX/BAK. ABT-263 ABT-737 apoptosis BCL2 ceramide haematology leukaemia sphingolipid One family of proteins that is a critical regulator of programmed cell death, or apoptosis, is the BCL2 family [ 1 , 2 ]. Since the initial discovery of BCL2 as the genetic...
Includes: Supplementary data
Biochem J (2012) 445 (1): 81–91.
Published: 15 June 2012
..., whereas short-chain ceramides are not well regulated. Inhibitors specific for the hydrophobic groove of Bcl-xL, including 2-methoxyantimycin A 3 , ABT-737 and ABT-263 provide insights into the region of Bcl-xL involved in binding to ceramide channels. Molecular docking simulations of the lowest-energy...
Includes: Supplementary data