... a physiologically pivotal role in enzyme regulation, such as in ADP inhibition and redox response. Recently solved crystal structures of the γ-subunit of F 1 -ATPase from photosynthetic organisms revealed that the insertion region forms a β-hairpin structure, which is positioned along the central stalk...

... plays a critical role and accounts for a significant interaction in the α 3 β 3 complex to induce ADP inhibition during ATP hydrolysis. In addition, we found that truncating the β-hairpin insertion structure resulted in a marked impairment of the interaction with the ε subunit, which binds...

... required for a continuous catalytic turnover. 1 To whom correspondence should be addressed (e-mail [email protected] ). 17 5 1999 25 6 1999 27 7 1999 The Biochemical Society, London © 1999 1999 ADP inhibition F1-ATPase hybrid complex Biochem. J. (1999) 343...