...José Canales; Ascensión Fernández; João Meireles Ribeiro; Alicia Cabezas; Joaquim Rui Rodrigues; José Carlos Cameselle; María Jesús Costas ADPRibase-Mn (Mn 2+ -dependent ADP-ribose/CDP-alcohol pyrophosphatase) was earlier isolated from rat liver supernatants after separation from ADPRibase-I...

... mechanism of Ca 2+ uptake into monocytes which is triggered by NAD + or its degradation product, ADP-ribose. These observations point to a hitherto unknown Ca 2+ -influx mechanism and underscore the potential significance of NAD + and ADP-ribose as signalling molecules on the extracellular side...

... + results in a rapid concentration-dependent elevation of [Ca 2+ ] i (intracellular free Ca 2+ concentration) caused by the influx of extracellular Ca 2+ . NAD + derivatives containing a modified adenine or nicotinamide ring failed to trigger a Ca 2+ increase. Treating monocytes with ADPR (ADP-ribose...

... proteins of rat pheochromocytoma cells (PC12 cells) was not greatly increased following oxidative stress induced by H 2 O 2 , but was significantly increased following alkylating stress induced by N -methyl- N ´-nitro- N -nitrosoguanidine or by combined oxidative and alkylating stress. Free ADP-ribose...

...Lakhdar GASMI; Jared L. CARTWRIGHT; Alexander G. MCLENNAN The human homologue of the Saccharomyces cerevisiae YSA1 protein, YSA1H, has been expressed as a thioredoxin fusion protein in Escherichia coli . It is an ADP-sugar pyrophosphatase with similar activities towards ADP-ribose and ADP-mannose...