... to the molecular mechanism that governs the activity of AGC kinases through their HMs intramolecularly. PDK1 has been instrumental in illustrating the bi-directional allosteric communication between the PIF-pocket and the ATP-binding site and the potential of the system for drug discovery. PDK1's interaction...

... The Authors Journal compilation © 2013 Biochemical Society 2013 AGC kinase Akt cancer protein kinase protein kinase B (PKB) resistance serum- and glucocorticoid-regulated kinase (SGK) signalling therapy Activation of the PI3K (phosphoinositide 3-kinase) pathway is one of the most common...

... (protein kinase C). AGC kinases are also highly conserved and play a myriad of roles in cellular growth, proliferation and survival. The AGC kinases are regulated by a common scheme that involves phosphorylation of the kinase activation loop by PDK1 (phosphoinositide-dependent kinase 1...

... the RSK (p90 ribosomal S6 kinase) group of protein kinases, which are members of an important family of kinases (the ‘AGC kinases’) that have overlapping specificities. In fact, the RSKs have the unusual feature of possessing two functional catalytic domains. ERK1/2 actually phosphorylate the C-terminal...

... negatively by blocking cell cycle progression in early S phase, resulting in inhibition of DNA synthesis and cell death. Human PP2Cδ is 98% similar to murine PP2Cδ and has been identified as an ILKAP (integrin-linked kinase-associated phosphatase) [ 31 ]. AGC kinase extracellular-signal-regulated...

... and the possibility that some of the currently postulated PKB substrates targets might in fact be phosphorylated by PDK1-regulated kinases other than PKB. 1 To whom correspondence should be addressed (e-mail bartvanh@;ludwig.ucl.ac.uk). The Biochemical Society, London © 2000 2000 AGC kinase Akt...