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Articles

The emerging role of AMPK in the regulation of breathing and oxygen supply

A. Mark Evans, Amira D. Mahmoud, Javier Moral-Sanz, Sandy Hartmann

Biochem J (2016) 473 (17): 2561–2572.

https://doi.org/10.1042/BCJ20160002

Published: 30 August 2016

... the AMP-activated protein kinase (AMPK), which is key to the cell-autonomous regulation of metabolic homoeostasis. This observation is significant for many reasons, not least because recent studies suggest that the gene for the AMPK-α1 catalytic subunit has been subjected to natural selection in high...

View articletitled, The emerging role of AMPK in the regulation of breathing and oxygen supply

Articles

The interaction between AMPKβ2 and the PP1-targeting subunit R6 is dynamically regulated by intracellular glycogen content

Yvonne Oligschlaeger, Marie Miglianico, Vivian Dahlmans, Carla Rubio-Villena, Dipanjan Chanda, Maria Adelaida Garcia-Gimeno, Will A. Coumans, Yilin Liu, J. Willem Voncken, Joost J.F.P. Luiken, Jan F.C. Glatz, Pascual Sanz, Dietbert Neumann

Biochem J (2016) 473 (7): 937–947.

https://doi.org/10.1042/BJ20151035

Published: 29 March 2016

...Yvonne Oligschlaeger; Marie Miglianico; Vivian Dahlmans; Carla Rubio-Villena; Dipanjan Chanda; Maria Adelaida Garcia-Gimeno; Will A. Coumans; Yilin Liu; J. Willem Voncken; Joost J.F.P. Luiken; Jan F.C. Glatz; Pascual Sanz; Dietbert Neumann AMP-activated protein kinase (AMPK) is a metabolic stress...

View articletitled, The interaction between AMPKβ2 and the PP1-targeting subunit R6 is dynamically regulated by intracellular glycogen content

Articles

Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators

Francis Rajamohan, Allan R. Reyes, Richard K. Frisbie, Lise R. Hoth, Parag Sahasrabudhe, Rachelle Magyar, James A. Landro, Jane M. Withka, Nicole L. Caspers, Matthew F. Calabrese, Jessica Ward, Ravi G. Kurumbail

Biochem J (2016) 473 (5): 581–592.

https://doi.org/10.1042/BJ20151051

Published: 24 February 2016

...Francis Rajamohan; Allan R. Reyes; Richard K. Frisbie; Lise R. Hoth; Parag Sahasrabudhe; Rachelle Magyar; James A. Landro; Jane M. Withka; Nicole L. Caspers; Matthew F. Calabrese; Jessica Ward; Ravi G. Kurumbail AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase that serves...

View articletitled, Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators

Articles

Determinants of oligosaccharide specificity of the carbohydrate-binding modules of AMP-activated protein kinase

Jesse I. Mobbs, Ann Koay, Alex Di Paolo, Michael Bieri, Emma J. Petrie, Michael A. Gorman, Larissa Doughty, Michael W. Parker, David I. Stapleton, Michael D.W. Griffin, Paul R. Gooley

Biochem J (2015) 468 (2): 245–257.

https://doi.org/10.1042/BJ20150270

Published: 22 May 2015

...Jesse I. Mobbs; Ann Koay; Alex Di Paolo; Michael Bieri; Emma J. Petrie; Michael A. Gorman; Larissa Doughty; Michael W. Parker; David I. Stapleton; Michael D.W. Griffin; Paul R. Gooley AMP-activated protein kinase (AMPK) is an αβγ heterotrimer that is important in regulating energy metabolism in all...

View articletitled, Determinants of oligosaccharide specificity of the carbohydrate-binding modules of AMP-activated protein kinase

Includes: Supplementary data

Articles

PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain

Thomas E. Jensen, Fiona A. Ross, Maximilian Kleinert, Lykke Sylow, Jonas R. Knudsen, Graeme J. Gowans, D. Grahame Hardie, Erik A. Richter

Biochem J (2015) 467 (3): 461–472.

https://doi.org/10.1042/BJ20141142

Published: 17 April 2015

...Thomas E. Jensen; Fiona A. Ross; Maximilian Kleinert; Lykke Sylow; Jonas R. Knudsen; Graeme J. Gowans; D. Grahame Hardie; Erik A. Richter PT-1 activates AMP-activated protein kinase (AMPK)-γ1- but not-γ3-containing complexes in mouse muscle, but PT-1 activates all three γ isoforms in HEK293 cells...

View articletitled, PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain

Articles

Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1β MYPT1 phosphatase complex and the SCF βTrCP E3 ubiquitin ligase

Sourav Banerjee, Anna Zagórska, Maria Deak, David G. Campbell, Alan R. Prescott, Dario R. Alessi

Biochem J (2014) 461 (2): 233–245.

https://doi.org/10.1042/BJ20140408

Published: 26 June 2014

.... It demonstrates NUAK1 inhibitors suppress cell proliferation and PLK1. AMP-activated protein kinase (AMPK) AMPK-related kinase 5 (ARK5) cell cycle degron mitosis Polo kinase (PLK) ubiquitylation NUAK1 [NUAK family SnF1-like kinase-1; also known as ARK5 (AMPK-related kinase 5)] and the closely...

View articletitled, Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1β MYPT1 phosphatase complex and the SCF βTrCP E3 ubiquitin ligase

Includes: Supplementary data

Articles

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

Simon A. Hawley, Fiona A. Ross, Graeme J. Gowans, Priyanka Tibarewal, Nicholas R. Leslie, D. Grahame Hardie

Biochem J (2014) 459 (2): 275–287.

https://doi.org/10.1042/BJ20131344

Published: 28 March 2014

... antibodies against Ser 487 /Ser 491 on AMPK-α1/α2 (pS487/p491), Ser 9 on GSK3β (pS9), Thr 308 and Ser 473 on Akt (pT308, pS473), and Thr 389 on S6K1 (S6 kinase 1) (pT389) were from Cell Signaling Technology. Akt AMP-activated protein kinase (AMPK) cancer cross-talk tumour suppressor...

View articletitled, Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

Includes: Supplementary data

Articles

Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases

Sourav Banerjee, Sara J. Buhrlage, Hai-Tsang Huang, Xianming Deng, Wenjun Zhou, Jinhua Wang, Ryan Traynor, Alan R. Prescott, Dario R. Alessi, Nathanael S. Gray

Biochem J (2014) 457 (1): 215–225.

https://doi.org/10.1042/BJ20131152

Published: 10 December 2013

... AMP-activated protein kinase (AMPK) AMPK-related kinase 5 (ARK5) kinase inhibitor kinase profiling liver kinase B1 (LKB1) myosin phosphate-targeting subunit 1(MYPT1) sucrose-non-fermenting protein kinase/AMPKrelated protein kinase (SNARK) NUAK family SNF1-like kinase-1 [NUAK1, also known...

View articletitled, Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases

Includes: Multimedia, Supplementary data

Articles

PIKfyve: a new fish in the growing pool of AMPK substrates

James S. V. Lally, Gregory R. Steinberg

Biochem J (2013) 455 (2): e1–e3.

https://doi.org/10.1042/BJ20131138

Published: 27 September 2013

... with PKB/Akt signalling and may be critical for the control of glucose uptake in skeletal muscle. AMP-activated protein kinase (AMPK) glucose uptake insulin PIKfyve protein kinase B (PKB)/Akt skeletal muscle PIKfyve is a phosphoinositide phosphate kinase responsible for the synthesis of both...

View articletitled, PIKfyve: a new fish in the growing pool of AMPK substrates

Articles

Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle

Yang Liu, Yu-Chiang Lai, Elaine V. Hill, Donatienne Tyteca, Sarah Carpentier, Ada Ingvaldsen, Didier Vertommen, Louise Lantier, Marc Foretz, Franck Dequiedt, Pierre J. Courtoy, Christophe Erneux, Benoît Viollet, Peter R. Shepherd, Jeremy M. Tavaré, Jørgen Jensen, Mark H. Rider

Biochem J (2013) 455 (2): 195–206.

https://doi.org/10.1042/BJ20130644

Published: 27 September 2013

... ]. Similar to PKB, AMPK phosphorylates AS160 and TBC1D1, thereby promoting GLUT4 translocation [ 3 , 23 – 25 ]. AMP-activated protein kinase (AMPK) contraction glucose uptake insulin protein kinase B (PKB) PtdIns(3,5) P 2 Skeletal muscle is the main tissue responsible for glucose disposal...

View articletitled, Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle

Includes: Supplementary data

Articles

N-Myristoylation is essential for protein phosphatases PPM1A and PPM1B to dephosphorylate their physiological substrates in cells

Toko Chida, Masakatsu Ando, Tasuku Matsuki, Yutaro Masu, Yuko Nagaura, Teruko Takano-Yamamoto, Shinri Tamura, Takayasu Kobayashi

Biochem J (2013) 449 (3): 741–749.

https://doi.org/10.1042/BJ20121201

Published: 09 January 2013

... at 450 nm was measured using a microplate reader. © The Authors Journal compilation © 2013 Biochemical Society 2013 AMP-activated protein kinase (AMPK) N-myristoylation protein phosphatase 2C (PP2C) metal-dependent protein phosphatase 1A (PPM1A) metal-dependent protein phosphatase 1B...

View articletitled, N-Myristoylation is essential for protein phosphatases PPM1A and PPM1B to dephosphorylate their physiological substrates in cells

Includes: Supplementary data

Articles

Glucose induces autophagy under starvation conditions by a p38 MAPK-dependent pathway

Jose Félix Moruno-Manchón, Eva Pérez-Jiménez, Erwin Knecht

Biochem J (2013) 449 (2): 497–506.

https://doi.org/10.1042/BJ20121122

Published: 14 December 2012

... The Authors Journal compilation © 2013 Biochemical Society 2013 AMP-activated protein kinase (AMPK) autophagy energy glucose p38 mitogen-activated protein kinase (MAPK) proteolysis Autophagy has been implicated in many processes, including differentiation, growth, development and survival...

View articletitled, Glucose induces autophagy under starvation conditions by a p38 MAPK-dependent pathway

Includes: Supplementary data

Articles

AMP-activated protein kinase: new regulation, new roles?

David Carling, Claire Thornton, Angela Woods, Matthew J. Sanders

Biochem J (2012) 445 (1): 11–27.

https://doi.org/10.1042/BJ20120546

Published: 15 June 2012

... AMPK is thought to play an important role. 1 To whom correspondence should be addressed ( [email protected] ). 30 3 2012 2 5 2012 3 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 AMP-activated protein kinase (AMPK) cancer cell growth...

View articletitled, AMP-activated protein kinase: new regulation, new roles?

Articles

AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase

Laurent Bultot, Bruno Guigas, Alexander Von Wilamowitz-Moellendorff, Liliane Maisin, Didier Vertommen, Nusrat Hussain, Monique Beullens, Joan J. Guinovart, Marc Foretz, Benoît Viollet, Kei Sakamoto, Louis Hue, Mark H. Rider

Biochem J (2012) 443 (1): 193–203.

https://doi.org/10.1042/BJ20112026

Published: 14 March 2012

... 1 2012 11 1 2012 11 1 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 A769662 5-aminoimidazole-4-carboxamide-1-β- D -ribofuranoside (AICA riboside) AMP-activated protein kinase (AMPK) glucagon glycogen synthase hepatocyte Glycogen...

View articletitled, AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase

Includes: Supplementary data

Articles

The serine/threonine kinase ULK1 is a target of multiple phosphorylation events

Markus Bach, Mark Larance, David E. James, Georg Ramm

Biochem J (2011) 440 (2): 283–291.

https://doi.org/10.1042/BJ20101894

Published: 14 November 2011

... compilation © 2011 Biochemical Society 2011 AMP-activated protein kinase (AMPK) autophagy 14-3-3 protein mammalian target of rapamycin (mTOR) receptor tyrosine kinase (RTK) unc51-like kinase 1 (ULK1) Autophagy is a highly regulated cellular degradation pathway [ 1 ]. It forms an important...

View articletitled, The serine/threonine kinase ULK1 is a target of multiple phosphorylation events

Includes: Supplementary data

Articles

Laforin, a dual-specificity phosphatase involved in Lafora disease, is phosphorylated at Ser 25 by AMP-activated protein kinase

Carlos Romá-Mateo, Maria del Carmen Solaz-Fuster, José Vicente Gimeno-Alcañiz, Vikas V. Dukhande, Jordi Donderis, Carolyn A. Worby, Alberto Marina, Olga Criado, Antonius Koller, Santiago Rodriguez De Cordoba, Matthew S. Gentry, Pascual Sanz

Biochem J (2011) 439 (2): 265–275.

https://doi.org/10.1042/BJ20110150

Published: 28 September 2011

... ). 24 1 2011 27 5 2011 28 6 2011 28 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 alanine scanning mutagenesis AMP-activated protein kinase (AMPK) glucan-phosphatase laforin phosphorylation protein–protein interaction Lafora...

View articletitled, Laforin, a dual-specificity phosphatase involved in Lafora disease, is phosphorylated at Ser 25 by AMP-activated protein kinase

Includes: Supplementary data

Articles

Metabolic oxidative stress elicited by the copper(II) complex [Cu(isaepy) 2 ] triggers apoptosis in SH-SY5Y cells through the induction of the AMP-activated protein kinase/p38 MAPK /p53 signalling axis: evidence for a combined use with 3-bromopyruvate in neuroblastoma treatment

Giuseppe Filomeni, Simone Cardaci, Ana Maria Da Costa Ferreira, Giuseppe Rotilio, Maria Rosa Ciriolo

Biochem J (2011) 437 (3): 443–453.

https://doi.org/10.1042/BJ20110510

Published: 13 July 2011

... compilation © 2011 Biochemical Society 2011 AMP-activated protein kinase (AMPK) 3-bromo-pyruvate delocalized lipophilic cation neuroblastoma p38 mitogen-activated protein kinase (p38 MAPK ) p53 Extracellular lactate concentration was assessed as described previously [ 33 ]. Briefly, 10 μl...

View articletitled, Metabolic oxidative stress elicited by the copper(II) complex [Cu(isaepy) 2 ] triggers apoptosis in SH-SY5Y cells through the induction of the AMP-activated protein kinase/p38 MAPK /p53 signalling axis: evidence for a combined use with 3-bromopyruvate in neuroblastoma treatment

Includes: Supplementary data

Articles

AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure

Claire Thornton, Nicola J. Bright, Magdalena Sastre, Phillip J. Muckett, David Carling

Biochem J (2011) 434 (3): 503–512.

https://doi.org/10.1042/BJ20101485

Published: 24 February 2011

... (email [email protected] ). 14 9 2010 14 12 2010 5 1 2011 5 1 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 Alzheimer's disease AMP-activated protein kinase (AMPK) amyloid-β peptide microtubule-associated protein N -methyl- D...

View articletitled, AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure

Includes: Supplementary data

Articles

LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice

Angela Woods, Amanda J. Heslegrave, Phillip J. Muckett, Adam P. Levene, Melanie Clements, Margaret Mobberley, Timothy A. Ryder, Shadi Abu-Hayyeh, Catherine Williamson, Robert D. Goldin, Alan Ashworth, Dominic J. Withers, David Carling

Biochem J (2011) 434 (1): 49–60.

https://doi.org/10.1042/BJ20101721

Published: 27 January 2011

... permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. AMP-activated protein kinase (AMPK) ATP-binding-cassette subfamily B member 11 (ABCB11) bile salt export pump (BSEP) cholestasis hyperbilirubinaemia polarity...

View articletitled, LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice

Articles

Contraction regulates site-specific phosphorylation of TBC1D1 in skeletal muscle

Kanokwan Vichaiwong, Suneet Purohit, Ding An, Taro Toyoda, Niels Jessen, Michael F. Hirshman, Laurie J. Goodyear

Biochem J (2010) 431 (2): 311–320.

https://doi.org/10.1042/BJ20101100

Published: 28 September 2010

.../2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. Akt AMP-activated protein kinase (AMPK) contraction glucose transport skeletal muscle TBC1D1 The plasmid encoding mouse WT TBC1D1 (long...

View articletitled, Contraction regulates site-specific phosphorylation of TBC1D1 in skeletal muscle

Includes: Supplementary data

Articles

Adipose tissue inflammation and insulin resistance: all obese humans are not created equal

Marie-Soleil Gauthier, Neil B. Ruderman

Biochem J (2010) 430 (2): e1–e4.

https://doi.org/10.1042/BJ20101062

Published: 13 August 2010

... compilation © 2010 Biochemical Society 2010 adipose tissue AMP-activated protein kinase (AMPK) inflammation insulin resistance insulin-sensitive obese (ISO) metabolically healthy obese (MHO) obesity Obesity, when accompanied by insulin resistance, is an important risk factor...

View articletitled, Adipose tissue inflammation and insulin resistance: all obese humans are not created equal

Articles

Loss of AMP-activated protein kinase α2 subunit in mouse β-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia

Craig Beall, Kaisa Piipari, Hind Al-Qassab, Mark A. Smith, Nadeene Parker, David Carling, Benoit Viollet, Dominic J. Withers, Michael L. J. Ashford

Biochem J (2010) 429 (2): 323–333.

https://doi.org/10.1042/BJ20100231

Published: 28 June 2010

... medium, provided the original work is properly cited. AMP-activated protein kinase (AMPK) ATP-sensitive potassium channel (K ATP ) β-cell glucokinase pancreas uncoupling protein 2 (UCP2) Antibodies used were mouse anti-insulin (I-2018; Sigma–Aldrich), rabbit anti-glucagon (ab9379...

View articletitled, Loss of AMP-activated protein kinase α2 subunit in mouse β-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia

Includes: Supplementary data

Articles

Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: synergistic effects of Ca 2+ and AMP

Sarah Fogarty, Simon A. Hawley, Kevin A. Green, Nazan Saner, Kirsty J. Mustard, D. Grahame Hardie

Biochem J (2010) 426 (1): 109–118.

https://doi.org/10.1042/BJ20091372

Published: 27 January 2010

.... AMP-activated protein kinase (AMPK) AMPactivated protein kinase-related kinase (ARK) Ca 2+ /calmodulindependent protein kinase (CaMK) Ca 2+ /calmodulin-dependent protein kinase kinase (CaMKK) AMPK (AMP-activated protein kinase) is an energy-sensing system involved in regulating energy...

View articletitled, Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: synergistic effects of Ca 2+ and AMP

Articles

AMPK and the biochemistry of exercise: implications for human health and disease

Erik A. Richter, Neil B. Ruderman

Biochem J (2009) 418 (2): 261–275.

https://doi.org/10.1042/BJ20082055

Published: 11 February 2009

... 2 diabetes and Alzheimer's disease. 1 To whom correspondence should be addressed (email [email protected] ). 15 10 2008 21 11 2008 1 12 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 AMP-activated protein kinase (AMPK) exercise muscle...

View articletitled, AMPK and the biochemistry of exercise: implications for human health and disease

Articles

A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis

Mhairi C. Towler, Sarah Fogarty, Simon A. Hawley, David A. Pan, David M. A. Martin, Nicolas A. Morrice, Afshan McCarthy, María N. Galardo, Silvina B. Meroni, Selva B. Cigorraga, Alan Ashworth, Kei Sakamoto, D. Grahame Hardie

Biochem J (2008) 416 (1): 1–14.

https://doi.org/10.1042/BJ20081447

Published: 28 October 2008

... in diethylpyrocarbonate-treated water. RNA was then purified using the DNA-free kit (Ambion) and RT–PCR carried out using the Promega Access Quick RT–PCR system. AMP-activated protein kinase (AMPK) LKB1 male fertility spermiogenesis splice variants The LKB1 (STK11) gene, encoding a tumour suppressor...

View articletitled, A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis

Includes: Supplementary data

Articles

LKB1: cancer, polarity, metabolism, and now fertility

Reuben J. Shaw

Biochem J (2008) 416 (1): e1–e3.

https://doi.org/10.1042/BJ20082023

Published: 28 October 2008

... a role in this process. Another question raised by these findings is the nature of the signal leading to the dramatic up-regulation of LKB1 s protein at the time of sperm maturation. alternative splicing AMP-activated protein kinase (AMPK) kinase LKB1 spermatogenesis How the cell...

View articletitled, LKB1: cancer, polarity, metabolism, and now fertility

Articles

Signalling cascades integrating light-enhanced nitrate metabolism

Cathrine Lillo

Biochem J (2008) 415 (1): 11–19.

https://doi.org/10.1042/BJ20081115

Published: 12 September 2008

.... 1 To whom correspondence should be addressed (email [email protected] ). 3 6 2008 20 6 2008 20 6 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 AMP-activated protein kinase (AMPK) light nitrate metabolism phytochrome protein phosphatase...

View articletitled, Signalling cascades integrating light-enhanced nitrate metabolism

Articles

AMPK, MAPK and Bax in the heart: some questions answered

Vilmante Borutaite

Biochem J (2008) 412 (2): e15–e16.

https://doi.org/10.1042/BJ20080712

Published: 14 May 2008

... on the molecular mechanism of Bax activation and migration during ischaemia-induced apoptosis in cardiomyocytes. 1 email [email protected] 4 4 2008 8 4 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 AMP-activated protein kinase (AMPK) apoptosis Bax...

View articletitled, AMPK, MAPK and Bax in the heart: some questions answered

Articles

Important role of the LKB1–AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

Xu Huang, Stephan Wullschleger, Natalia Shpiro, Victoria A. McGuire, Kei Sakamoto, Yvonne L. Woods, Wendy Mcburnie, Stewart Fleming, Dario R. Alessi

Biochem J (2008) 412 (2): 211–221.

https://doi.org/10.1042/BJ20080557

Published: 14 May 2008

... Correspondence may be addressed to either of these authors (email [email protected] or [email protected] ). 13 3 2008 1 4 2008 3 4 2008 3 4 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 AMP-activated protein kinase (AMPK) cancer LKB1...

View articletitled, Important role of the LKB1–AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

Includes: Supplementary data

Articles

Cancer therapy: staying current with AMPK

David A. Fruman, Aimee L. Edinger

Biochem J (2008) 412 (2): e3–e5.

https://doi.org/10.1042/BJ20080823

Published: 14 May 2008

... Society 2008 AMP-activated protein kinase (AMPK) cancer LKB1 mammalian target of rapamycin (mTOR) phosphatase and tensin homologue deleted on chromosome 10 (PTEN) signal transduction The rapid proliferation of cancer cells requires extensive rewiring of metabolic pathways to meet increased...

View articletitled, Cancer therapy: staying current with AMPK

Articles

Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators

Shuai Chen, Jane Murphy, Rachel Toth, David G. Campbell, Nick A. Morrice, Carol Mackintosh

Biochem J (2008) 409 (2): 449–459.

https://doi.org/10.1042/BJ20071114

Published: 21 December 2007

... that TBC1D1 and AS160 may have complementary roles in regulating vesicle trafficking in response to insulin and AMPK-activating stimuli in skeletal muscle. 14-3-3 Akt substrate of 160 kDa (AS160) AMP-activated protein kinase (AMPK) metformin obesity protein kinase B (PKB) TBC1D1 1 To whom...

View articletitled, Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators

Includes: Supplementary data

Articles

Polyamines modulate the subcellular localization of RNA-binding protein HuR through AMP-activated protein kinase-regulated phosphorylation and acetylation of importin α1

Tongtong Zou, Lan Liu, Jaladanki N. Rao, Bernard S. Marasa, Jie Chen, Lan Xiao, Huiping Zhou, Myriam Gorospe, Jian-Ying Wang

Biochem J (2008) 409 (2): 389–398.

https://doi.org/10.1042/BJ20070860

Published: 21 December 2007

... levels of HuR as a result of inactivation of the AMPK-driven Impα1 pathway. 29 6 2007 18 9 2007 8 10 2007 8 10 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 AMP-activated protein kinase (AMPK) growth arrest HuR importin α1 intestinal...

View articletitled, Polyamines modulate the subcellular localization of RNA-binding protein HuR through AMP-activated protein kinase-regulated phosphorylation and acetylation of importin α1

Articles

Regulation of the renal-specific Na + –K + –2Cl − co-transporter NKCC2 by AMP-activated protein kinase (AMPK)

Scott A. Fraser, Ignacio Gimenez, Natasha Cook, Ian Jennings, Marina Katerelos, Frosa Katsis, Vicki Levidiotis, Bruce E. Kemp, David A. Power

Biochem J (2007) 405 (1): 85–93.

https://doi.org/10.1042/BJ20061850

Published: 13 June 2007

... be addressed (email [email protected] ). 12 12 2006 7 3 2007 7 3 2007 © 2007 Biochemical Society 2007 AMP-activated protein kinase (AMPK) cation co-transporter co-transporter activity Na + –K + –2Cl − co-transporter 2 (NKCC2) phosphorylation Xenopus laevis oocytes...

View articletitled, Regulation of the renal-specific Na + –K + –2Cl − co-transporter NKCC2 by AMP-activated protein kinase (AMPK)

Articles

AMP-activated protein kinase-independent inhibition of hepatic mitochondrial oxidative phosphorylation by AICA riboside

Bruno Guigas, Nellie Taleux, Marc Foretz, Dominique Detaille, Fabrizio Andreelli, Benoit Viollet, Louis Hue

Biochem J (2007) 404 (3): 499–507.

https://doi.org/10.1042/BJ20070105

Published: 29 May 2007

... measured using enzymatic methods coupled with spectrophotometric determinations of NADH, as described previously [ 23 ]. AICA riboside AMP-activated protein kinase (AMPK) hepatocyte mitochondrial biogenesis mitochondrial oxidative phosphorylation ZMP AICA riboside (5-aminoimidazole-4...

View articletitled, AMP-activated protein kinase-independent inhibition of hepatic mitochondrial oxidative phosphorylation by AICA riboside

Includes: Supplementary data

Articles

Interference with energy metabolism by 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside induces HPV suppression in cervical carcinoma cells and apoptosis in the absence of LKB11

Julia Nafz, Johanna De-Castro Arce, Verena Fleig, Andrea Patzelt, Sybille Mazurek, Frank Rösl

Biochem J (2007) 403 (3): 501–510.

https://doi.org/10.1042/BJ20061053

Published: 12 April 2007

..., AICAR can even induce apoptosis without AMPK activation [ 16 ], which is evidently causally linked to the absence of LKB1, a serine/threonine tumour suppressor kinase, which normally phosphorylates AMPK [ 17 ]. activator protein-1 (AP-1) AMP-activated protein kinase (AMPK) human papillomavirus...

View articletitled, Interference with energy metabolism by 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside induces HPV suppression in cervical carcinoma cells and apoptosis in the absence of LKB11

Includes: Supplementary data

Articles

Adrenaline is a critical mediator of acute exercise-induced AMP-activated protein kinase activation in adipocytes

Ho-Jin Koh, Michael F. Hirshman, Huamei He, Yangfeng Li, Yasuko Manabe, James A. Balschi, Laurie J. Goodyear

Biochem J (2007) 403 (3): 473–481.

https://doi.org/10.1042/BJ20061479

Published: 12 April 2007

... activation of adrenaline-induced lipolysis in rat adipocytes. The Authors Journal compilation, The Biochemical Society, London 2007 adrenaline AMP-activated protein kinase (AMPK) cAMP-dependent protein kinase (PKA) exercise fatty acid synthesis lipolysis It is widely accepted...

View articletitled, Adrenaline is a critical mediator of acute exercise-induced AMP-activated protein kinase activation in adipocytes

Articles

Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade

Matthew J. Sanders, Pascal O. Grondin, Bronwyn D. Hegarty, Michael A. Snowden, David Carling

Biochem J (2007) 403 (1): 139–148.

https://doi.org/10.1042/BJ20061520

Published: 13 March 2007

.... 1 To whom correspondence should be addressed (email [email protected] ). 6 10 2006 24 11 2006 6 12 2006 6 12 2006 The Biochemical Society, London 2007 AMP-activated protein kinase (AMPK) Ca 2+ /calmodulin-dependent protein kinase kinase (CaMKK) energy...

View articletitled, Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade

Articles

A physiological role of AMP-activated protein kinase in phenobarbital-mediated constitutive androstane receptor activation and CYP2B induction

Sawako Shindo, Satoshi Numazawa, Takemi Yoshida

Biochem J (2007) 401 (3): 735–741.

https://doi.org/10.1042/BJ20061238

Published: 12 January 2007

... for CYP2B induction in vivo . 1 To whom correspondence should be addressed (email [email protected] ). 11 8 2006 25 9 2006 11 10 2006 11 10 2006 The Biochemical Society, London 2007 AMP-activated protein kinase (AMPK) constitutive androstane receptor...

View articletitled, A physiological role of AMP-activated protein kinase in phenobarbital-mediated constitutive androstane receptor activation and CYP2B induction

Articles

Bax translocates to mitochondria of heart cells during simulated ischaemia: involvement of AMP-activated and p38 mitogen-activated protein kinases

Michela Capano, Martin Crompton

Biochem J (2006) 395 (1): 57–64.

https://doi.org/10.1042/BJ20051654

Published: 15 March 2006

... The Biochemical Society, London 2006 AMP-activated protein kinase (AMPK) Bax green fluorescent protein imaging ischaemia phosphorylation Apoptosis contributes significantly to heart cell death during ischaemic injury. Apoptotic cells are evident in human myocardial infarcts [ 1 , 2 ], in animal...

View articletitled, Bax translocates to mitochondria of heart cells during simulated ischaemia: involvement of AMP-activated and p38 mitogen-activated protein kinases

Articles

The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation

Mahaboobi Jaleel, Fabrizio Villa, Maria Deak, Rachel Toth, Alan R. Prescott, Daan M. F. van Aalten, Dario R. Alessi

Biochem J (2006) 394 (3): 545–555.

https://doi.org/10.1042/BJ20051844

Published: 24 February 2006

... dithiothreitol. 16 11 2005 3 1 2006 6 1 2006 6 1 2006 The Biochemical Society, London 2006 AMP-activated protein kinase (AMPK) LKB1 tumour suppressor protein kinase Peutz–Jeghers syndrome (PJS) small-angle X-ray scattering analysis (SAXS analysis) ubiquitination...

View articletitled, The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation

Articles

A novel physical and functional association between nucleoside diphosphate kinase A and AMP-activated protein kinase α1 in liver and lung

Russell M. Crawford, Kate J. Treharne, O. Giles Best, Richmond Muimo, Claudia E. Riemen, Anil Mehta

Biochem J (2005) 392 (1): 201–209.

https://doi.org/10.1042/BJ20050269

Published: 08 November 2005

...-3 human lung-derived epithelial cells. 1 To whom correspondence should be addressed (email [email protected] ). 11 2 2005 8 6 2005 18 7 2005 18 7 2005 The Biochemical Society, London 2005 acetyl-CoA carboxylase AMP-activated protein kinase (AMPK...

View articletitled, A novel physical and functional association between nucleoside diphosphate kinase A and AMP-activated protein kinase α1 in liver and lung

Articles

Stimulation of hepatocytic AMP-activated protein kinase by okadaic acid and other autophagy-suppressive toxins

Hamid R. SAMARI, Michael T. N. MØLLER, Lise HOLDEN, Tonje ASMYHR, Per O. SEGLEN

Biochem J (2005) 386 (2): 237–244.

https://doi.org/10.1042/BJ20040609

Published: 22 February 2005

[email protected] ). 13 4 2004 25 8 2004 4 10 2004 4 10 2004 The Biochemical Society, London 2005 AMP-activated protein kinase (AMPK) hepatocyte naringin okadaic acid phosphorylation toxin In rat hepatocytes, overphosphorylation induced by various PP (protein phosphatase...

View articletitled, Stimulation of hepatocytic AMP-activated protein kinase by okadaic acid and other autophagy-suppressive toxins

Articles

Kinase-independent transcriptional co-activation of peroxisome proliferator-activated receptor α by AMP-activated protein kinase

Myriam BRONNER, Rachel HERTZ, Jacob BAR-TANA

Biochem J (2004) 384 (2): 295–305.

https://doi.org/10.1042/BJ20040955

Published: 23 November 2004

... 17 8 2004 The Biochemical Society, London 2004 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) AMP-activated protein kinase (AMPK) ATP/AMP ratio nuclear translocation peroxisome proliferator-activated receptor α (PPARα) transcription Peroxisome proliferators (e.g...

View articletitled, Kinase-independent transcriptional co-activation of peroxisome proliferator-activated receptor α by AMP-activated protein kinase

Articles

Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: modulation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR)

Frédérique DIRAISON, Laura PARTON, Pascal FERRÉ, Fabienne FOUFELLE, Celia P. BRISCOE, Isabelle LECLERC, Guy A. RUTTER

Biochem J (2004) 378 (3): 769–778.

https://doi.org/10.1042/bj20031277

Published: 15 March 2004

..., London ©2004 2004 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) AMP-activated protein kinase (AMPK) insulin secretion lipotoxicity pancreatic islet sterol-regulatory-element-binding protein (SREBP) Abbreviations used: ACC1, acetyl-CoA carboxylase-1; AICAR, 5-aminoimidazole-4...

View articletitled, Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: modulation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR)

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