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Keywords: AMP-activated protein kinase (AMPK)
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Articles
Biochem J (2016) 473 (17): 2561–2572.
Published: 30 August 2016
... the AMP-activated protein kinase (AMPK), which is key to the cell-autonomous regulation of metabolic homoeostasis. This observation is significant for many reasons, not least because recent studies suggest that the gene for the AMPK-α1 catalytic subunit has been subjected to natural selection in high...
Articles
Biochem J (2016) 473 (7): 937–947.
Published: 29 March 2016
...Yvonne Oligschlaeger; Marie Miglianico; Vivian Dahlmans; Carla Rubio-Villena; Dipanjan Chanda; Maria Adelaida Garcia-Gimeno; Will A. Coumans; Yilin Liu; J. Willem Voncken; Joost J.F.P. Luiken; Jan F.C. Glatz; Pascual Sanz; Dietbert Neumann AMP-activated protein kinase (AMPK) is a metabolic stress...
Articles
Biochem J (2016) 473 (5): 581–592.
Published: 24 February 2016
...Francis Rajamohan; Allan R. Reyes; Richard K. Frisbie; Lise R. Hoth; Parag Sahasrabudhe; Rachelle Magyar; James A. Landro; Jane M. Withka; Nicole L. Caspers; Matthew F. Calabrese; Jessica Ward; Ravi G. Kurumbail AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase that serves...
Articles
Biochem J (2015) 468 (2): 245–257.
Published: 22 May 2015
...Jesse I. Mobbs; Ann Koay; Alex Di Paolo; Michael Bieri; Emma J. Petrie; Michael A. Gorman; Larissa Doughty; Michael W. Parker; David I. Stapleton; Michael D.W. Griffin; Paul R. Gooley AMP-activated protein kinase (AMPK) is an αβγ heterotrimer that is important in regulating energy metabolism in all...
Includes: Supplementary data
Articles
Biochem J (2015) 467 (3): 461–472.
Published: 17 April 2015
...Thomas E. Jensen; Fiona A. Ross; Maximilian Kleinert; Lykke Sylow; Jonas R. Knudsen; Graeme J. Gowans; D. Grahame Hardie; Erik A. Richter PT-1 activates AMP-activated protein kinase (AMPK)-γ1- but not-γ3-containing complexes in mouse muscle, but PT-1 activates all three γ isoforms in HEK293 cells...
Articles
Biochem J (2014) 461 (2): 233–245.
Published: 26 June 2014
... to quantitative measurement of DNA content by flow cytometry using a FACSCalibur™ (BD Biosciences) and cell cycle distribution and the percentage of G 2 –S–G 1 cells determined by the Watson (pragmatic) modelling algorithm using FlowJo software (Treestar). AMP-activated protein kinase (AMPK) AMPK...
Includes: Supplementary data
Articles
Biochem J (2014) 459 (2): 275–287.
Published: 28 March 2014
... allosteric activation, but bind at a different site involving the β subunit [ 16 – 18 ]. Akt AMP-activated protein kinase (AMPK) cancer cross-talk tumour suppressor GSK3β (0.5 μg, D200A or D200A/S9A mutants), AMPK (α1β2γ1 complex, D157A or D157A/S487A mutants, or α2β2γ1 complex, D157A...
Includes: Supplementary data
Articles
Biochem J (2014) 457 (1): 215–225.
Published: 10 December 2013
... AMP-activated protein kinase (AMPK) AMPK-related kinase 5 (ARK5) kinase inhibitor kinase profiling liver kinase B1 (LKB1) myosin phosphate-targeting subunit 1(MYPT1) sucrose-non-fermenting protein kinase/AMPKrelated protein kinase (SNARK) NUAK family SNF1-like kinase-1 [NUAK1, also known...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2013) 455 (2): e1–e3.
Published: 27 September 2013
...-stimulated glucose uptake in skeletal muscle Biochem. J. 2013 455 195 206 16 O’Neill H. M. Maarbjerg S. J. Crane J. D. Jeppesen J. Jorgensen S. B. Schertzer J. D. Shyroka O. Kiens B. van Denderen B. J. Tarnopolsky M. A. AMP-activated protein kinase...
Articles
Biochem J (2013) 455 (2): 195–206.
Published: 27 September 2013
..., favouring GLUT4 translocation [ 4 ]. AMP-activated protein kinase (AMPK) contraction glucose uptake insulin protein kinase B (PKB) PtdIns(3,5) P 2 We propose that PIKfyve activity is required for the stimulation of skeletal muscle glucose uptake by contraction/AMPK activation. AMPK...
Includes: Supplementary data
Articles
Biochem J (2013) 449 (3): 741–749.
Published: 09 January 2013
... tyrosine kinase Cell 2003 112 859 871 7 Oakhill J. S. Chen Z. P. Scott J. W. Steel R. Castelli L. A. Ling N. Macaulay S. L. Kemp B. E. β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK...
Includes: Supplementary data
Articles
Biochem J (2013) 449 (2): 497–506.
Published: 14 December 2012
... inhibiting the formation of the Ulk1–Atg13–FIP200 complex needed to initiate autophagosome formation [ 5 ]. Many signalling pathways converge on mTOR, and an important regulator of this kinase is AMPK (AMP-activated protein kinase). AMPK is activated by an increased AMP/ATP ratio, leading to inactivation...
Includes: Supplementary data
Articles
Biochem J (2012) 445 (1): 11–27.
Published: 15 June 2012
... correspondence should be addressed ( dcarling@imperial.ac.uk ). 30 3 2012 2 5 2012 3 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 AMP-activated protein kinase (AMPK) cancer cell growth energy homoeostasis metabolism Figure 1 Roadmap of AMPK...
Articles
Biochem J (2012) 443 (1): 193–203.
Published: 14 March 2012
... 1 2012 11 1 2012 11 1 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 A769662 5-aminoimidazole-4-carboxamide-1-β- D -ribofuranoside (AICA riboside) AMP-activated protein kinase (AMPK) glucagon glycogen synthase hepatocyte Glycogen...
Includes: Supplementary data
Articles
Biochem J (2011) 440 (2): 283–291.
Published: 14 November 2011
... georg.ramm@monash.edu ). 22 11 2010 4 8 2011 5 8 2011 5 8 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 AMP-activated protein kinase (AMPK) autophagy 14-3-3 protein mammalian target of rapamycin (mTOR) receptor tyrosine kinase (RTK) unc51-like...
Includes: Supplementary data
Articles
Biochem J (2011) 439 (2): 265–275.
Published: 28 September 2011
... ). 24 1 2011 27 5 2011 28 6 2011 28 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 alanine scanning mutagenesis AMP-activated protein kinase (AMPK) glucan-phosphatase laforin phosphorylation protein–protein interaction The yeast strain...
Includes: Supplementary data
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Biochem J (2011) 437 (3): 443–453.
Published: 13 July 2011
... compilation © 2011 Biochemical Society 2011 AMP-activated protein kinase (AMPK) 3-bromo-pyruvate delocalized lipophilic cation neuroblastoma p38 mitogen-activated protein kinase (p38 MAPK ) p53 A 5 mM solution of [Cu(isaepy) 2 ] was prepared just before the experiments by dissolving...
Includes: Supplementary data
Articles
Biochem J (2011) 434 (3): 503–512.
Published: 24 February 2011
... be addressed (email claire.thornton@imperial.ac.uk ). 14 9 2010 14 12 2010 5 1 2011 5 1 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 Alzheimer's disease AMP-activated protein kinase (AMPK) amyloid-β peptide microtubule-associated protein N...
Includes: Supplementary data
Articles
Biochem J (2011) 434 (1): 49–60.
Published: 27 January 2011
... medium, provided the original work is properly cited. AMP-activated protein kinase (AMPK) ATP-binding-cassette subfamily B member 11 (ABCB11) bile salt export pump (BSEP) cholestasis hyperbilirubinaemia polarity Production of mice harbouring Lkb1 -floxed alleles has been described...
Articles
Biochem J (2010) 431 (2): 311–320.
Published: 28 September 2010
... and reproduction in any medium, provided the original work is properly cited. Akt AMP-activated protein kinase (AMPK) contraction glucose transport skeletal muscle TBC1D1 Our previous study identified multiple phosphorylation sites on endogenous TBC1D1 from skeletal muscle [ 21...
Includes: Supplementary data
Articles
Biochem J (2010) 430 (2): e1–e4.
Published: 13 August 2010
..., as well as to identify the pathogenetic factors that determine whether or not adipose tissue of an obese individual becomes inflamed. 15 7 2010 19 7 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 adipose tissue AMP-activated protein kinase (AMPK...
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Biochem J (2010) 429 (2): 323–333.
Published: 28 June 2010
... unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. AMP-activated protein kinase (AMPK) ATP-sensitive potassium channel (K ATP ) β-cell glucokinase pancreas uncoupling protein 2 (UCP2) Raised plasma glucose increases...
Includes: Supplementary data
Articles
Biochem J (2010) 426 (1): 109–118.
Published: 27 January 2010
... in response to a small increase in the cellular AMP/ATP ratio. AMP-activated protein kinase (AMPK) AMPactivated protein kinase-related kinase (ARK) Ca 2+ /calmodulindependent protein kinase (CaMK) Ca 2+ /calmodulin-dependent protein kinase kinase (CaMKK) © 2010 The Authors 2010...
Articles
Biochem J (2009) 418 (2): 261–275.
Published: 11 February 2009
... 2008 21 11 2008 1 12 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 AMP-activated protein kinase (AMPK) exercise muscle metabolic syndrome AMPK is an heterotrimeric enzyme composed of a catalytic α-subunit and regulatory β- and γ-subunits. The α...
Articles
Biochem J (2008) 416 (1): 1–14.
Published: 28 October 2008
...-activated protein kinase (AMPK) LKB1 male fertility spermiogenesis splice variants The LKB1 (STK11) gene, encoding a tumour suppressor protein kinase, was discovered as the gene mutated in human PJS (Peutz-Jeghers syndrome), a cancer predisposition that is inherited in an autosomal dominant...
Includes: Supplementary data
Articles
Biochem J (2008) 416 (1): e1–e3.
Published: 28 October 2008
... a role in this process. Another question raised by these findings is the nature of the signal leading to the dramatic up-regulation of LKB1 s protein at the time of sperm maturation. alternative splicing AMP-activated protein kinase (AMPK) kinase LKB1 spermatogenesis How the cell...
Articles
Biochem J (2008) 415 (1): 11–19.
Published: 12 September 2008
... in other recent reviews [ 1 , 2 ] 1 To whom correspondence should be addressed (email cathrine.lillo@uis.no ). 3 6 2008 20 6 2008 20 6 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 AMP-activated protein kinase (AMPK) light nitrate metabolism...
Articles
Biochem J (2008) 412 (2): e15–e16.
Published: 14 May 2008
..., e.g. p38 MAPK (mitogen-activated protein kinase) and AMPK (AMP-activated protein kinase) have any impact on that. 1 email vilbor@vector.kmu.lt 4 4 2008 8 4 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 AMP-activated protein kinase (AMPK...
Articles
Biochem J (2008) 412 (2): 211–221.
Published: 14 May 2008
.... Nakagawara A. Kizaki H. Activation of AMP-activated protein kinase (AMPK) induces p53-dependent apototic cell death in response to energetic stress J. Biol. Chem. 2008 283 3979 3987 46 Zheng B. Cantley L. C. Regulation of epithelial tight junction assembly and disassembly...
Includes: Supplementary data
Articles
Biochem J (2008) 412 (2): e3–e5.
Published: 14 May 2008
... Society 2008 AMP-activated protein kinase (AMPK) cancer LKB1 mammalian target of rapamycin (mTOR) phosphatase and tensin homologue deleted on chromosome 10 (PTEN) signal transduction The rapid proliferation of cancer cells requires extensive rewiring of metabolic pathways to meet increased...
Articles
Biochem J (2008) 409 (2): 449–459.
Published: 21 December 2007
... that TBC1D1 and AS160 may have complementary roles in regulating vesicle trafficking in response to insulin and AMPK-activating stimuli in skeletal muscle. 14-3-3 Akt substrate of 160 kDa (AS160) AMP-activated protein kinase (AMPK) metformin obesity protein kinase B (PKB) TBC1D1 Rabs are GTP...
Includes: Supplementary data
Articles
Biochem J (2008) 409 (2): 389–398.
Published: 21 December 2007
... (Cambridge, MA, U.S.A.). © The Authors Journal compilation © 2008 Biochemical Society 2008 AMP-activated protein kinase (AMPK) growth arrest HuR importin α1 intestinal epithelium ornithine decarboxylase The mammalian intestinal mucosa has the most rapid turnover rate of any tissue...
Articles
Biochem J (2007) 405 (1): 85–93.
Published: 13 June 2007
..., immunohistochemical secondary antibodies were obtained from Molecular Probes. AMP-activated protein kinase (AMPK) cation co-transporter co-transporter activity Na + –K + –2Cl − co-transporter 2 (NKCC2) phosphorylation Xenopus laevis oocytes Rabbit NKCC2A in the oocyte expression vector Pol1...
Articles
Biochem J (2007) 404 (3): 499–507.
Published: 29 May 2007
... followed by Fisher's protected least significant post-hoc test (Statview 5.0.1.; SAS Institute). AICA riboside AMP-activated protein kinase (AMPK) hepatocyte mitochondrial biogenesis mitochondrial oxidative phosphorylation ZMP AICA riboside (5-aminoimidazole-4-carboxamide-1-β- D...
Includes: Supplementary data
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Biochem J (2007) 403 (3): 501–510.
Published: 12 April 2007
... 30-L (Ortho). Cells were additionally analysed by fluorescence microscopy (Leica DMRD). activator protein-1 (AP-1) AMP-activated protein kinase (AMPK) human papillomavirus (HPV) transcription p53 To circumvent corrections for transfection efficiencies, a luciferase reporter...
Includes: Supplementary data
Articles
Biochem J (2007) 403 (3): 473–481.
Published: 12 April 2007
.... AMP-activated protein kinase (AMPK) is activated in muscle of subjects with type 2 diabetes during exercise Diabetes 2001 50 921 927 21 Bak M. I. Ingwall J. S. NMR-invisible ATP in heart: fact or fiction? Am J. Physiol. 1992 262 E943 E947 22 Galbo H. Hormonal...
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Biochem J (2007) 403 (1): 139–148.
Published: 13 March 2007
... To whom correspondence should be addressed (email dcarling@csc.mrc.ac.uk ). 6 10 2006 24 11 2006 6 12 2006 6 12 2006 The Biochemical Society, London 2007 AMP-activated protein kinase (AMPK) Ca 2+ /calmodulin-dependent protein kinase kinase (CaMKK) energy metabolism...
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Biochem J (2007) 401 (3): 735–741.
Published: 12 January 2007
... 2951 2958 6 Kawamura A. Yoshida Y. Kimura N. Oda H. Kakinuma A. Biochem Biophys. Res. Commun. 1999 264 530 536 7 Rutter G. A. da Silva Xavier G. Leclerc I. Roles of 5′-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis Biochem...
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Biochem J (2006) 395 (1): 57–64.
Published: 15 March 2006
..., London 2006 AMP-activated protein kinase (AMPK) Bax green fluorescent protein imaging ischaemia phosphorylation Figure 3 Ischaemia-induced changes in p38 MAPK phosphorylation ( A , B ) Cells were extracted after incubation for the times indicated with CN and no glucose (ischaemia...
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Biochem J (2006) 394 (3): 545–555.
Published: 24 February 2006
.... 16 11 2005 3 1 2006 6 1 2006 6 1 2006 The Biochemical Society, London 2006 AMP-activated protein kinase (AMPK) LKB1 tumour suppressor protein kinase Peutz–Jeghers syndrome (PJS) small-angle X-ray scattering analysis (SAXS analysis) ubiquitination LKB1 has...
Articles
Biochem J (2005) 392 (1): 201–209.
Published: 08 November 2005
... carboxylase AMP-activated protein kinase (AMPK) catalytic subunit fatty acid synthesis nucleoside diphosphate kinase (NDPK) nucleotide SAMS peptide Nucleoside diphosphate kinase (NDPK, NM23/awd) has been recognized for over 40 years as a ubiquitous enzyme that catalyses the transfer of the γ...
Articles
Biochem J (2005) 386 (2): 237–244.
Published: 22 February 2005
... Merck (Whitehouse Station, NJ, U.S.A.), metrizamide was from Nycomed Pharma AS (Oslo, Norway) and alkaline phosphatase (molecular biology grade) was from Roche Applied Science (Penzberg, Germany). Other biochemicals were purchased from Sigma (St. Louis, MO, U.S.A.). AMP-activated protein kinase...
Articles
Biochem J (2004) 384 (2): 295–305.
Published: 23 November 2004
... 17 8 2004 The Biochemical Society, London 2004 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) AMP-activated protein kinase (AMPK) ATP/AMP ratio nuclear translocation peroxisome proliferator-activated receptor α (PPARα) transcription Peroxisome proliferators (e.g...
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Biochem J (2004) 378 (3): 769–778.
Published: 15 March 2004
..., London ©2004 2004 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) AMP-activated protein kinase (AMPK) insulin secretion lipotoxicity pancreatic islet sterol-regulatory-element-binding protein (SREBP) Abbreviations used: ACC1, acetyl-CoA carboxylase-1; AICAR, 5-aminoimidazole-4...