Skip Nav Destination
Close Modal
Update search
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
NARROW
Format
Subjects
Article Type
Date
Availability
1-29 of 29
Keywords: AMPK
Close
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Sort by
Articles
Jordana B. Freemantle, Dinesh Shah, Dylan M. Lynch, Alessio Ciulli, Harinder S. Hundal, D. Grahame Hardie
Journal:
Biochemical Journal
Biochem J (2024) 481 (18): 1203–1219.
Published: 12 September 2024
...Jordana B. Freemantle; Dinesh Shah; Dylan M. Lynch; Alessio Ciulli; Harinder S. Hundal; D. Grahame Hardie The AMP-activated protein kinase (AMPK) is a sensor of cellular energy status that is expressed in almost all eukaryotic cells. In the canonical activation mechanism, it is activated...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2024) 481 (8): 587–599.
Published: 22 April 2024
...Simon A. Hawley; Fiona M. Russell; D. Grahame Hardie The AMP-activated protein kinase (AMPK) is a sensor of cellular energy status. When activated by increases in ADP:ATP and/or AMP:ATP ratios (signalling energy deficit), AMPK acts to restore energy balance. Binding of AMP to one or more of three...
Includes: Supplementary data
Articles
Sophia Bustraan, Jane Bennett, Chad Whilding, Betheney R. Pennycook, David Smith, Alexis R. Barr, Jon Read, David Carling, Alice Pollard
Journal:
Biochemical Journal
Biochem J (2024) 481 (5): 345–362.
Published: 23 February 2024
... of adipogenic potential in adipose stem cells, or impairment of adipogenesis is now recognised as an underlying cause of adipose tissue dysfunction and is associated with metabolic disease. In this study, we sought to determine the role of AMP-activated protein kinase (AMPK), an evolutionarily conserved master...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2023) 480 (23): 1951–1968.
Published: 01 December 2023
...Fiona A. Ross; Simon A. Hawley; Fiona M. Russell; Nicola Goodman; D. Grahame Hardie The AMP-activated protein kinase (AMPK) is a sensor of cellular energy status activated by increases in AMP or ADP relative to ATP. Once activated, it phosphorylates targets that promote ATP-generating catabolic...
Articles
AMPK inhibits liver gluconeogenesis: fact or fiction?
Available to PurchaseIn Collection
Cell signaling in the 21st century
Journal:
Biochemical Journal
Biochem J (2023) 480 (1): 105–125.
Published: 13 January 2023
...Manuel Johanns; Louis Hue; Mark H. Rider Is there a role for AMPK in the control of hepatic gluconeogenesis and could targeting AMPK in liver be a viable strategy for treating type 2 diabetes? These are frequently asked questions this review tries to answer. After describing properties of AMPK...
Articles
Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator
Open AccessAshley J. Ovens, Yi Sing Gee, Naomi X.Y. Ling, Dingyi Yu, Justin P. Hardee, Jin D. Chung, Kevin R.W. Ngoei, Nicholas J. Waters, Nolan J. Hoffman, John W. Scott, Kim Loh, Katrin Spengler, Regine Heller, Michael W. Parker, Gordon S. Lynch, Fei Huang, Sandra Galic, Bruce E. Kemp, Jonathan B. Baell, Jonathan S. Oakhill, Christopher G. Langendorf
Journal:
Biochemical Journal
Biochem J (2022) 479 (11): 1181–1204.
Published: 08 June 2022
...; Jonathan S. Oakhill; Christopher G. Langendorf The AMP-activated protein kinase (AMPK) αβγ heterotrimer is a primary cellular energy sensor and central regulator of energy homeostasis. Activating skeletal muscle AMPK with small molecule drugs improves glucose uptake and provides an opportunity for new...
Includes: Supplementary data
Articles
AMPK activation by SC4 inhibits noradrenaline-induced lipolysis and insulin-stimulated lipogenesis in white adipose tissue
Available to PurchaseSheng-Ju Chuang, Manuel Johanns, Sébastien Pyr dit Ruys, Gregory R. Steinberg, Bruce E. Kemp, Benoît Viollet, Mark H. Rider
Journal:
Biochemical Journal
Biochem J (2021) 478 (21): 3869–3889.
Published: 09 November 2021
...Sheng-Ju Chuang; Manuel Johanns; Sébastien Pyr dit Ruys; Gregory R. Steinberg; Bruce E. Kemp; Benoît Viollet; Mark H. Rider The effects of small-molecule AMP-activated protein kinase (AMPK) activators in rat epididymal adipocytes were compared. SC4 was the most effective and submaximal doses of SC4...
Includes: Supplementary data
Articles
Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965
Open AccessDanial Ahwazi, Katyayanee Neopane, Greg R. Markby, Franziska Kopietz, Ashley J. Ovens, Morten Dall, Anna S. Hassing, Pamina Gräsle, Yazeed Alshuweishi, Jonas T. Treebak, Ian P. Salt, Olga Göransson, Elton Zeqiraj, John W. Scott, Kei Sakamoto
Journal:
Biochemical Journal
Biochem J (2021) 478 (15): 2977–2997.
Published: 10 August 2021
... of the autophagy initiator kinase ULK1, has recently been reported as a more potent and selective AMP-activated protein kinase (AMPK) inhibitor relative to the widely used, but promiscuous inhibitor Compound C/Dorsomorphin. Here, we studied the effects of SBI-0206965 on AMPK signalling and metabolic readouts...
Includes: Supplementary data
Articles
A-769662 inhibits adipocyte glucose uptake in an AMPK-independent manner
Available to PurchaseFranziska Kopietz, Yazeed Alshuweishi, Silvia Bijland, Fatmah Alghamdi, Eva Degerman, Kei Sakamoto, Ian P. Salt, Olga Göransson
Journal:
Biochemical Journal
Biochem J (2021) 478 (3): 633–646.
Published: 12 February 2021
...Franziska Kopietz; Yazeed Alshuweishi; Silvia Bijland; Fatmah Alghamdi; Eva Degerman; Kei Sakamoto; Ian P. Salt; Olga Göransson Activation of AMP-activated protein kinase (AMPK) is considered a valid strategy for the treatment of type 2 diabetes. However, despite the importance of adipose tissue...
Includes: Supplementary data
Articles
Protein kinase A negatively regulates VEGF-induced AMPK activation by phosphorylating CaMKK2 at serine 495
Available to PurchaseKatrin Spengler, Darya Zibrova, Angela Woods, Christopher G. Langendorf, John W. Scott, David Carling, Regine Heller
Journal:
Biochemical Journal
Biochem J (2020) 477 (17): 3453–3469.
Published: 17 September 2020
...Katrin Spengler; Darya Zibrova; Angela Woods; Christopher G. Langendorf; John W. Scott; David Carling; Regine Heller Activation of AMP-activated protein kinase (AMPK) in endothelial cells by vascular endothelial growth factor (VEGF) via the Ca 2+ /calmodulin-dependent protein kinase kinase 2...
Includes: Supplementary data
Articles
The SGLT2 inhibitor canagliflozin suppresses lipid synthesis and interleukin-1 beta in ApoE deficient mice
Available to PurchaseIn Collection
Celebrating 100 years of insulin research
Emily A. Day, Rebecca J. Ford, Jessie H. Lu, Rachel Lu, Lucie Lundenberg, Eric M. Desjardins, Alex E. Green, James S.V. Lally, Jonathan D. Schertzer, Gregory R. Steinberg
Journal:
Biochemical Journal
Biochem J (2020) 477 (12): 2347–2361.
Published: 26 June 2020
... with type 2 diabetes through mechanisms that are not fully understood. Canagliflozin has been shown to increase the activity of the AMP-activated protein kinase (AMPK), a metabolic energy sensor important for increasing fatty acid oxidation and energy expenditure and suppressing lipogenesis and inflammation...
Includes: Supplementary data
Articles
DhHP-6 ameliorates hepatic oxidative stress and insulin resistance in type 2 diabetes mellitus through the PI3K/AKT and AMPK pathway
Available to PurchaseIn Collection
Celebrating 100 years of insulin research
Journal:
Biochemical Journal
Biochem J (2020) 477 (12): 2363–2381.
Published: 26 June 2020
... resistance models. The results suggested that DhHP-6 decreased blood glucose, increased antioxidant enzyme activity, and inhibited glycogen synthesis in T2DM mice. In addition, DhHP-6 improved insulin resistance by activating phosphatidylinositol 3-kinase (PI3K)/AKT, and AMP-activated protein kinase (AMPK...
Articles
AMP-activated protein kinase regulates alternative pre-mRNA splicing by phosphorylation of SRSF1
Available to PurchaseEri Matsumoto, Kaho Akiyama, Takuya Saito, Yu Matsumoto, Ken-Ichi Kobayashi, Jun Inoue, Yuji Yamamoto, Tsukasa Suzuki
Journal:
Biochemical Journal
Biochem J (2020) 477 (12): 2237–2248.
Published: 24 June 2020
...Eri Matsumoto; Kaho Akiyama; Takuya Saito; Yu Matsumoto; Ken-Ichi Kobayashi; Jun Inoue; Yuji Yamamoto; Tsukasa Suzuki AMP-activated protein kinase (AMPK) regulates cellular energy homeostasis by inhibiting anabolic processes and activating catabolic processes. Recent studies have demonstrated...
Articles
Biochemical adaptations in white adipose tissue following aerobic exercise: from mitochondrial biogenesis to browning
Available to PurchaseIn Collection
Adipose biology
Journal:
Biochemical Journal
Biochem J (2020) 477 (6): 1061–1081.
Published: 18 March 2020
... muscle [ 19 ]. Correspondence: Greg L. McKie ( [email protected] ) 3 12 2019 24 2 2020 28 2 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 AMPK exercise mice white adipose tissue PGC-1α lacks a DNA...
Articles
Two isoprenylated flavonoids from Dorstenia psilurus activate AMPK, stimulate glucose uptake, inhibit glucose production and lower glycemia
Available to PurchaseAphrodite T. Choumessi, Manuel Johanns, Claire Beaufay, Marie-France Herent, Vincent Stroobant, Didier Vertommen, Cyril Corbet, Roxane Jacobs, Gaëtan Herinckx, Gregory R. Steinberg, Olivier Feron, Joëlle Quetin-Leclercq, Mark H. Rider
Journal:
Biochemical Journal
Biochem J (2019) 476 (24): 3687–3704.
Published: 17 December 2019
... , were purified by screening for AMP-activated protein kinase (AMPK) activation in incubated mouse embryo fibroblasts (MEFs). Two isoprenylated flavones that activated AMPK were isolated. Compound 1 was identified as artelasticin by high-resolution electrospray ionization mass spectrometry and 2D-NMR...
Includes: Supplementary data
Articles
Cancerous inhibitor of protein phosphatase 2A (CIP2A) modifies energy metabolism via 5′ AMP-activated protein kinase signalling in malignant cells
Available to PurchaseJames A. Austin, Rosalind E. Jenkins, Gemma M. Austin, Mark A. Glenn, Karen Dunn, Laura Scott, Claire M. Lucas, Richard E. Clark
Journal:
Biochemical Journal
Biochem J (2019) 476 (15): 2255–2269.
Published: 15 August 2019
... associated proteins, several of which co-vary with CIP2A level. Many of these CIP2A associating and co-varying proteins are involved in energy metabolism including OXPHOS, or in 5′ AMP-activated protein kinase (AMPK) signalling, and manipulating AMPK activity mimics the effects of low/high CIP2A on OXPHOS...
Includes: Supplementary data
Articles
Omar J. Katwan, Fatmah Alghamdi, Tarek A. Almabrouk, Sarah J. Mancini, Simon Kennedy, Jonathan S. Oakhill, John W. Scott, Ian P. Salt
Journal:
Biochemical Journal
Biochem J (2019) 476 (12): 1725–1740.
Published: 26 June 2019
...Omar J. Katwan; Fatmah Alghamdi; Tarek A. Almabrouk; Sarah J. Mancini; Simon Kennedy; Jonathan S. Oakhill; John W. Scott; Ian P. Salt AMP-activated protein kinase (AMPK) is a heterotrimer of α-catalytic and β- and γ-regulatory subunits that acts to regulate cellular and whole-body nutrient...
Includes: Supplementary data
Articles
Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity
Open AccessIn Collection
Editors' pick of research highlights published in the Biochemical Journal in 2018 & 2019
Elaine C. Thomas, Sharon C. Hook, Alexander Gray, Alexandra Chadt, David Carling, Hadi Al-Hasani, Kate J. Heesom, D. Grahame Hardie, Jeremy M. Tavaré
Journal:
Biochemical Journal
Biochem J (2018) 475 (18): 2969–2983.
Published: 25 September 2018
...Elaine C. Thomas; Sharon C. Hook; Alexander Gray; Alexandra Chadt; David Carling; Hadi Al-Hasani; Kate J. Heesom; D. Grahame Hardie; Jeremy M. Tavaré AMP-activated protein kinase (AMPK) is a key regulator of cellular and systemic energy homeostasis which achieves this through the phosphorylation...
Includes: Supplementary data
Articles
Robin Willows, Matthew J. Sanders, Bing Xiao, Bhakti R. Patel, Stephen R. Martin, Jon Read, Jon R. Wilson, Julia Hubbard, Steven J. Gamblin, David Carling
Journal:
Biochemical Journal
Biochem J (2017) 474 (17): 3059–3073.
Published: 22 August 2017
...Robin Willows; Matthew J. Sanders; Bing Xiao; Bhakti R. Patel; Stephen R. Martin; Jon Read; Jon R. Wilson; Julia Hubbard; Steven J. Gamblin; David Carling AMP-activated protein kinase (AMPK) plays a major role in regulating metabolism and has attracted significant attention as a therapeutic target...
Articles
Journal:
Biochemical Journal
Biochem J (2017) 474 (10): 1741–1754.
Published: 09 May 2017
...Robin Willows; Naveenan Navaratnam; Ana Lima; Jon Read; David Carling AMP-activated protein kinase (AMPK) plays a key role in integrating metabolic pathways in response to energy demand. AMPK activation results in a wide range of downstream responses, many of which are associated with improved...
Articles
The lysosome: a crucial hub for AMPK and mTORC1 signalling
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2017) 474 (9): 1453–1466.
Published: 13 April 2017
...-activated protein kinase (AMPK), at the lysosome and how both AMPK and mTORC1 signalling pathways feedback to lysosomal biogenesis and regeneration following autophagy. This review will cover the classical role of the lysosome in autophagy, the dynamic signalling interactions which take place...
Articles
The sweet side of AMPK signaling: regulation of GFAT1
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2017) 474 (7): 1289–1292.
Published: 23 March 2017
... of energy in all cells. A key sensor of cellular energy is the adenosine-5′-monophosphate (AMP)-activated protein kinase (AMPK), which is the core component of a signaling network that regulates energy and nutrient metabolism. AMPK is activated by metabolic stresses that decrease cellular ATP, and functions...
Articles
GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis
Available to PurchaseDarya Zibrova, Franck Vandermoere, Olga Göransson, Mark Peggie, Karina V. Mariño, Anne Knierim, Katrin Spengler, Cora Weigert, Benoit Viollet, Nicholas A. Morrice, Kei Sakamoto, Regine Heller
Journal:
Biochemical Journal
Biochem J (2017) 474 (6): 983–1001.
Published: 07 March 2017
...Darya Zibrova; Franck Vandermoere; Olga Göransson; Mark Peggie; Karina V. Mariño; Anne Knierim; Katrin Spengler; Cora Weigert; Benoit Viollet; Nicholas A. Morrice; Kei Sakamoto; Regine Heller Activation of AMP-activated protein kinase (AMPK) in endothelial cells regulates energy homeostasis, stress...
Includes: Supplementary data
Articles
Controlling skeletal muscle CPT-I malonyl-CoA sensitivity: the importance of AMPK-independent regulation of intermediate filaments during exercise
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2017) 474 (4): 557–569.
Published: 03 February 2017
... could be regulated by the intermediate filaments, and whether AMP-activated protein kinase (AMPK) could be involved in this process. Chemical disruption (3,3′-iminodipropionitrile, IDPN) of the intermediate filaments did not alter mitochondrial respiration or sensitivity for numerous substrates...
Articles
A new leptin-mediated mechanism for stimulating fatty acid oxidation: a pivotal role for sarcolemmal FAT/CD36
Available to PurchaseIman Momken, Adrian Chabowski, Ellen Dirkx, Miranda Nabben, Swati S. Jain, Jay T. McFarlan, Jan F.C. Glatz, Joost J.F.P. Luiken, Arend Bonen
Journal:
Biochemical Journal
Biochem J (2017) 474 (1): 149–162.
Published: 22 December 2016
... for their oxidation remains unknown. We examined, in isolated muscle and cardiac myocytes, whether leptin, via AMP-activated protein kinase (AMPK) activation, stimulated fatty acid translocase (FAT/CD36)-mediated fatty acid uptake to enhance fatty acid oxidation. In both mouse skeletal muscle and rat cardiomyocytes...
Articles
Helen R. Heathcote, Sarah J. Mancini, Anastasiya Strembitska, Kunzah Jamal, James A. Reihill, Timothy M. Palmer, Gwyn W. Gould, Ian P. Salt
Journal:
Biochemical Journal
Biochem J (2016) 473 (24): 4681–4697.
Published: 09 December 2016
...Helen R. Heathcote; Sarah J. Mancini; Anastasiya Strembitska; Kunzah Jamal; James A. Reihill; Timothy M. Palmer; Gwyn W. Gould; Ian P. Salt The key metabolic regulator, AMP-activated protein kinase (AMPK), is reported to be down-regulated in metabolic disorders, but the mechanisms are poorly...
Includes: Supplementary data
Articles
Ablation of CD44 induces glycolysis-to-oxidative phosphorylation transition via modulation of the c-Src–Akt–LKB1–AMPKα pathway
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2016) 473 (19): 3013–3030.
Published: 27 September 2016
... including hypoxia inducible factor-1α (HIF-1α) and LDHA was decreased by CD44 silencing. These effects were due to the up-regulation of liver kinase B1 (LKB1)/AMP-activated protein kinase (AMPK)α activity by reduction in c-Src and Akt activity in CD44 knock-down cells. Finally, induction of LKB1/AMPKα...
Includes: Supplementary data
Articles
A paradigm shift in oxygen sensing with a twist in the tale!
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2016) 473 (17): 2687–2689.
Published: 30 August 2016
...Ken D. O'Halloran AMP-activated protein kinase (AMPK) is pivotal to metabolic homoeostasis in eukaryotes, serving as a critical energy sensor. Increased AMPK activity during oxygen deprivation (hypoxia) protects against potentially catastrophic deficits in ATP supply. Although the nervous system...
Articles
5-Aminoimidazole-4-carboxamide riboside induces apoptosis in Jurkat cells, but the AMP-activated protein kinase is not involved
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2003) 370 (3): 1027–1032.
Published: 15 March 2003
... benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone (Z-VAD.fmk) blocks apoptosis. Furthermore, AICAriboside induces mitochondrial cytochrome c release. AICAriboside, when phosphorylated to AICAribotide (ZMP), is a specific activator of the AMP-activated protein kinase (AMPK) in certain cell types. However...