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Keywords: ATP synthase
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Biochem J (2014) 463 (3): e3–e5.
Published: 10 October 2014
... synthase [ 14 , 15 ]. Surprisingly, metformin as well as other complex I inhibitors have been shown to inhibit PTP opening [ 12 , 13 ]. How complex I inhibition can affect a phenomenon involving ATP synthase remains an enigma. It has been proposed that interaction between complex I and ATP synthase...
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Biochem J (2014) 462 (3): 475–487.
Published: 22 August 2014
... that biguanides inhibit complex I by inhibiting ubiquinone reduction (but not competitively) and, independently, stimulate reactive oxygen species production by the complex I flavin. Biguanides also inhibit mitochondrial ATP synthase, and two of them inhibit only ATP hydrolysis, not synthesis. Thus we identify...
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Biochem J (2012) 444 (2): 249–259.
Published: 11 May 2012
... in colon cancer HCT116 cells treated with oligomycin to inhibit ATP synthase is exerted by repression of the synthesis of nuclear-encoded mitochondrial proteins in a process that is regulated at the level of translation. Remarkably, the synthesis of glycolytic proteins is not affected in this situation...
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