.... The resistance to platinum has been linked to the activity of divalent transporter ATP7B, which pumps platinum from the cytoplasm into lysosomes, decreasing its concentration in the cytoplasm. Several cancer models show increased expression of ATP7B; however, the reason for such an increase is not known. Here we...

...Michael A. Cater; Sharon La fontaine; Julian F. B. Mercer The Wilson protein (ATP7B) is a copper-translocating P-type ATPase that mediates the excretion of excess copper from hep-atocytes into bile. Excess copper causes the protein to traffic from the TGN ( trans -Golgi network) to subapical...

... the energy of ATP hydrolysis to deliver copper into the secretory pathway and to export excess copper out of the cell [ 1 ]. Mutations in Wilson's disease gene, ATP7B , result in massive accumulation of copper in a number of tissues, particularly in the liver and brain. Copper overload induces severe...

...Michael A. CATER; John FORBES; Sharon La FONTAINE; Diane COX; Julian F. B. MERCER The Wilson protein (ATP7B) is a copper-transporting CPx-type ATPase defective in the copper toxicity disorder Wilson disease. In hepatocytes, ATP7B delivers copper to apo-ceruloplasmin and mediates the excretion...