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1-39 of 39
Keywords: ATPase
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Articles
Journal:
Biochemical Journal
Biochem J (2025) 482 (03): 103–117.
Published: 31 January 2025
...-mediated ATPase activity at the secondary binding site (SBS). The pre-bound Rho to this long DNA reduces the rate and efficiency of its transcription termination activities in vitro . Elevated concentrations of Rho reduced the in vitro transcription level suggesting that Rho might also function...
Includes: Supplementary data
Articles
Structure-based drug repurposing to inhibit the DNA gyrase of Mycobacterium tuberculosis
Available to PurchaseBalasubramani GL, Rinky Rajput, Manish Gupta, Pradeep Dahiya, Jitendra K. Thakur, Rakesh Bhatnagar, Abhinav Grover
Journal:
Biochemical Journal
Biochem J (2020) 477 (21): 4167–4190.
Published: 09 November 2020
... the drugbank database to identify novel inhibitors of the Mtb target enzyme, DNA gyrase. The compounds were screened against the ATPase domain of the gyrase B subunit (MtbGyrB47), and the docking results showed that echinacoside, doxorubicin, epirubicin, and idarubicin possess high binding affinities against...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2020) 477 (1): 213–226.
Published: 10 January 2020
...Keane J. Dye; Zhaomin Yang PilB is the assembly ATPase for the bacterial type IV pilus (T4P), and as a consequence, it is essential for T4P-mediated bacterial motility. In some cases, PilB has been demonstrated to regulate the production of exopolysaccharide (EPS) during bacterial biofilm...
Includes: Supplementary data
Articles
The β-hairpin region of the cyanobacterial F 1 -ATPase γ-subunit plays a regulatory role in the enzyme activity
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Journal:
Biochemical Journal
Biochem J (2019) 476 (12): 1771–1780.
Published: 26 June 2019
...Kentaro Akiyama; Kumiko Kondo; Kosuke Inabe; Satoshi Murakami; Ken-ichi Wakabayashi; Toru Hisabori The γ-subunit of cyanobacterial and chloroplast ATP synthase, the rotary shaft of F 1 -ATPase, equips a specific insertion region that is only observed in photosynthetic organisms. This region plays...
Includes: Supplementary data
Articles
Stimulation of the ATPase activity of Hsp90 by zerumbone modification of its cysteine residues destabilizes its clients and causes cytotoxicity
Available to PurchaseHitoshi Nakamoto, Yosuke Amaya, Taiwa Komatsu, Takehiro Suzuki, Naoshi Dohmae, Yusuke Nakamura, Ibrahim Jantan, Yoshihiko Miyata
Journal:
Biochemical Journal
Biochem J (2018) 475 (15): 2559–2576.
Published: 16 August 2018
... cyclic sesquiterpene, zerumbone, which inhibits proliferation of a wide variety of tumor cells, on the activity of Hsp90. Zerumbone enhanced the ATPase activity of cyanobacterial Hsp90 (Hsp90 SE ), yeast Hsp90, and human Hsp90α. It also enhanced the catalytic efficiency of Hsp90 SE by greatly increasing...
Includes: Supplementary data
Articles
MinD directly interacting with FtsZ at the H10 helix suggests a model for robust activation of MinC to destabilize FtsZ polymers
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Journal:
Biochemical Journal
Biochem J (2017) 474 (18): 3189–3205.
Published: 08 September 2017
.... Correspondence: Tushar Kant Beuria ( [email protected] ) 12 5 2017 10 7 2017 25 7 2017 25 7 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 ATPase cell division cytoskeleton Escherichia coli FtsZ MinD...
Includes: Multimedia, Supplementary data
Articles
Probing native metal ion association sites through quenching of fluorophores in the nucleotide-binding domains of the ABC transporter MsbA
Available to PurchaseDaiki Tatsumi, Kei Nanatani, Yuto Koike, Kiyoto Kamagata, Satoshi Takahashi, Ayumu Konno, Tadaomi Furuta, Minoru Sakurai, Nobuyuki Uozumi
Journal:
Biochemical Journal
Biochem J (2017) 474 (12): 1993–2007.
Published: 30 May 2017
...: Nobuyuki Uozumi ( [email protected] ) 2 12 2016 24 3 2017 21 4 2017 21 4 2017 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 ATPase conformational change FRET metal ion–protein interaction nucleotide...
Includes: Supplementary data
Articles
EssC: domain structures inform on the elusive translocation channel in the Type VII secretion system
Open AccessMartin Zoltner, Wui M.A.V. Ng, Jillian J. Money, Paul K. Fyfe, Holger Kneuper, Tracy Palmer, William N. Hunter
Journal:
Biochemical Journal
Biochem J (2016) 473 (13): 1941–1952.
Published: 28 June 2016
.... The protein is predicted to consist of an intracellular repeat of forkhead-associated (FHA) domains at the N-terminus, two transmembrane helices and three P-loop-containing ATPase-type domains, D1–D3, forming the C-terminal intracellular segment. We present crystal structures of the N-terminal FHA domains...
Includes: Supplementary data
Articles
The motor function of Drosophila melanogaster myosin-5 is activated by calcium and cargo-binding protein dRab11
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Journal:
Biochemical Journal
Biochem J (2015) 469 (1): 135–144.
Published: 19 June 2015
... proteins. We found that the actin-activated ATPase activity of DmM5 is significantly lower than that of the truncated DmM5 having the C-terminal globular tail domain (GTD) deleted, indicating that the GTD is the inhibitory domain. The actin-activated ATPase activity of DmM5 is significantly activated...
Articles
Copper chaperone Atox1 interacts with the metal-binding domain of Wilson's disease protein in cisplatin detoxification
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Journal:
Biochemical Journal
Biochem J (2013) 454 (1): 147–156.
Published: 26 July 2013
...-binding sites in the N-terminal domain of ATP7B, and this binding may be an essential step of cisplatin detoxification involving copper ATPases. In the present study, we demonstrate that cisplatin and a related platinum drug carboplatin produce the same adduct following reaction with MBD2 [metal-binding...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2013) 450 (2): 417–425.
Published: 15 February 2013
...Richard F. Collins; Darin Hassan; Vijaykumar Karuppiah; Angela Thistlethwaite; Jeremy P. Derrick Many Gram-negative bacteria contain specific systems for uptake of foreign DNA, which play a critical role in the acquisition of antibiotic resistance. The TtPilF (PilF ATPase from Thermus thermophilus...
Includes: Multimedia, Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2013) 449 (3): 695–705.
Published: 09 January 2013
...Vicki A. M. Gold; Sarah Whitehouse; Alice Robson; Ian Collinson The motor ATPase SecA drives protein secretion through the bacterial Sec complex. The PPXD (pre-protein cross-linking domain) of the enzyme has been observed in different positions, effectively opening and closing a clamp...
Includes: Supplementary data
Articles
Molecular mechanisms of endolysosomal Ca 2+ signalling in health and disease
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Journal:
Biochemical Journal
Biochem J (2011) 439 (3): 349–378.
Published: 13 October 2011
... and functional organization of the cell [ 15 , 17 ]. We now know that the lysosome is the terminal organelle in the endocytic pathway and plays a complex role in multiple aspects of cellular homoeostasis [ 11 , 18 ]. © The Authors Journal compilation © 2011 Biochemical Society 2011 ATPase calcium...
Includes: Supplementary data
Articles
Essential arginine residue of the F o - a subunit in F o F 1 -ATP synthase has a role to prevent the proton shortcut without c -ring rotation in the F o proton channel
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Journal:
Biochemical Journal
Biochem J (2010) 430 (1): 171–177.
Published: 28 July 2010
...-su.ac.jp ). 22 4 2010 24 5 2010 3 6 2010 3 6 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 ATPase F o F 1 -ATP synthase ion transport proton channel proton permeation F o F 1 from thermophilic Bacillus PS3 with a tag of ten histidine...
Articles
Nitration of tyrosine residues 368 and 345 in the β-subunit elicits F o F 1 -ATPase activity loss
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Journal:
Biochemical Journal
Biochem J (2009) 423 (2): 219–231.
Published: 25 September 2009
... established a direct link between this modification and loss of protein function. In the present study, we determined the effect of nitration of Tyr 345 and Tyr 368 in the β-subunit of the F 1 -ATPase using site-directed mutagenesis. Nitration of the β-subunit, achieved by using TNM (tetranitromethane...
Articles
Copper(I)-mediated protein–protein interactions result from suboptimal interaction surfaces
Available to PurchaseLucia Banci, Ivano Bertini, Vito Calderone, Nunzia Della-Malva, Isabella C. Felli, Sara Neri, Anna Pavelkova, Antonio Rosato
Journal:
Biochemical Journal
Biochem J (2009) 422 (1): 37–42.
Published: 29 July 2009
... in one of its partners, namely the P-type copper-transporting ATPase, ATP7A (ATPase, Cu + transporting, α polypeptide). The adduct was structurally characterized in solution, in the presence of copper(I), and through X-ray crystallography, upon replacing copper(I) with cadmium(II). Further insight...
Includes: Supplementary data
Articles
The soluble metal-binding domain of the copper transporter ATP7B binds and detoxifies cisplatin
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Journal:
Biochemical Journal
Biochem J (2009) 419 (1): 51–59.
Published: 13 March 2009
...Nataliya V. Dolgova; Doug Olson; Svetlana Lutsenko; Oleg Y. Dmitriev Wilson disease ATPase (ATP7B) has been implicated in the resistance of cancer cells to cisplatin. Using a simple in vivo assay in bacterial culture, in the present study we demonstrate that ATP7B can confer resistance to cisplatin...
Includes: Supplementary data
Articles
Direct interaction of a small-molecule modulator with G551D-CFTR, a cystic fibrosis-causing mutation associated with severe disease
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Journal:
Biochemical Journal
Biochem J (2009) 418 (1): 185–190.
Published: 28 January 2009
... gating is associated with defective ATP binding and ATPase activity, reflecting the key role of G551 in these functions. Recently, high-throughput screens of chemical libraries led to identification of modulators that enhance channel activity of G551D-CFTR. However, the molecular target(s...
Articles
Analysis of mutant origin recognition complex with reduced ATPase activity in vivo and in vitro
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Journal:
Biochemical Journal
Biochem J (2008) 413 (3): 535–543.
Published: 15 July 2008
...Masaya Takehara; Masaki Makise; Hitomi Takenaka; Teita Asano; Tohru Mizushima In eukaryotes, ORC (origin recognition complex), a six-protein complex, is the most likely initiator of chromosomal DNA replication. ORC belongs to the AAA + (ATPases associated with a variety of cellular activities...
Includes: Supplementary data
Articles
The intact CFTR protein mediates ATPase rather than adenylate kinase activity
Available to PurchaseMohabir Ramjeesingh, Francisca Ugwu, Fiona L. L. Stratford, Ling-Jun Huan, Canhui Li, Christine E. Bear
Journal:
Biochemical Journal
Biochem J (2008) 412 (2): 315–321.
Published: 14 May 2008
...Mohabir Ramjeesingh; Francisca Ugwu; Fiona L. L. Stratford; Ling-Jun Huan; Canhui Li; Christine E. Bear The two NBDs (nucleotide-binding domains) of ABC (ATP-binding-cassette) proteins function in a complex to mediate ATPase activity and this activity has been linked to their regulated transport...
Articles
Identification of a novel nucleoside triphosphatase from Mycoplasma mobile : a prime candidate motor for gliding motility
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Journal:
Biochemical Journal
Biochem J (2007) 403 (1): 71–77.
Published: 13 March 2007
... motility. The gliding motility of M. mobile is driven directly by ATP hydrolysis, but the key ATPase has not been identified. Our results showed that, among these four proteins, only P42 exhibited ATPase activity. Biochemical characteristics – optimal conditions for activity, substrate specificities...
Articles
Biochemical characterization of androgen receptor-interacting protein 4
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Journal:
Biochemical Journal
Biochem J (2006) 393 (3): 789–795.
Published: 13 January 2006
...Andrii Domanskyi; Katja T. Virtanen; Jorma J. Palvimo; Olli A. Jänne ARIP4 [AR (androgen receptor)-interacting protein 4] is a member of the SNF2-like family of proteins. Its sequence similarity to known proteins is restricted to the centrally located SNF2 ATPase domain. ARIP4 is an active ATPase...
Articles
Multidrug-resistant cancer cells contain two populations of P-glycoprotein with differently stimulated P-gp ATPase activities: evidence from atomic force microscopy and biochemical analysis
Available to PurchaseStéphane BARAKAT, Landry GAYET, Guila DAYAN, Stéphane LABIALLE, Adina LAZAR, Vladimir OLEINIKOV, Anthony W. COLEMAN, Loris G. BAGGETTO
Journal:
Biochemical Journal
Biochem J (2005) 388 (2): 563–571.
Published: 24 May 2005
..., in particular concerning the potential modulating role of the closely related lipids and proteins on P-gp activity. Our observation of the opposite effect of verapamil on P-gp ATPase activity from DRM and solubilized-membrane fractions of CEM-resistant leukaemia cells, and results from Langmuir experiments...
Articles
Role of cis -acting elements in the control of SERCA2b Ca 2+ pump mRNA decay by nuclear proteins
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Journal:
Biochemical Journal
Biochem J (2005) 388 (1): 291–297.
Published: 10 May 2005
... decay by nuclear proteins. 1 To whom correspondence should be addressed (email [email protected] ). 13 9 2004 29 11 2004 19 1 2005 19 1 2005 The Biochemical Society, London 2005 ATPase calcium pump nuclear protein RNA stability SERCA2b 3...
Articles
Positive co-operative activity and dimerization of the isolated ABC ATPase domain of HlyB from Escherichia coli
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Journal:
Biochemical Journal
Biochem J (2005) 386 (3): 489–495.
Published: 08 March 2005
...Houssain BENABDELHAK; Lutz SCHMITT; Carsten HORN; Kornelia JUMEL; Mark A. BLIGHT; I. Barry HOLLAND The ATPase activity of the ABC (ATP-binding cassette) ATPase domain of the HlyB (haemolysin B) transporter is required for secretion of Escherichia coli haemolysin via the type I pathway. Although ABC...
Articles
Probing the active site of YjeE: a vital Escherichia coli protein of unknown function
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Journal:
Biochemical Journal
Biochem J (2004) 384 (3): 577–584.
Published: 07 December 2004
... whose members are broadly conserved in bacteria, absent from eukaryotes and contain both Walker A and B motifs, characteristic of P-loop ATPases. We have revisited the dispensability of the yjeE gene in E. coli and describe efforts to probe the function of the YjeE protein with in vitro biochemistry. We...
Articles
Protein kinase A regulates ATP hydrolysis and dimerization by a CFTR (cystic fibrosis transmembrane conductance regulator) domain
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Journal:
Biochemical Journal
Biochem J (2004) 378 (1): 151–159.
Published: 15 February 2004
...–GST, a related fusion protein lacking the NBD1 domain. Finally, an MBP (maltose-binding protein) fusion protein containing the NBD2 domain (NBD2–MBP) associated with and regulated the ATPase activity of PKA-phosphorylated NBD1–R–GST. Thus when the R domain in NBD1–R–GST is phosphorylated by PKA, ATP...
Articles
Arginyl-tRNA synthetase with signature sequence KMSK from Bacillus stearothermophilus
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Journal:
Biochemical Journal
Biochem J (2003) 376 (3): 773–779.
Published: 15 December 2003
... tRNA Arg (ACG) was synthesized. ArgRS contained 557 amino acid residues including the canonical KMKS sequence. Recombinant ArgRS and tRNA Arg (ACG) were expressed in Escherichia coli . ArgRS purified by nickel-affinity chromatography had no ATPase activity. The kinetics of ArgRS and cross-recognition...
Articles
ATP-binding sites in brain p97/VCP (valosin-containing protein), a multifunctional AAA ATPase
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Journal:
Biochemical Journal
Biochem J (2003) 374 (2): 473–480.
Published: 01 September 2003
... 5′-[β,γ-methylene]triphosphate, whereas AMP, GTP and CTP were ineffective. VCP was observed to possess very low ATPase activity, with nucleotide specificity similar to that for BzATP binding. Conformational changes induced by an alternating site mechanism for ATP binding are suggested as a molecular...
Articles
Journal:
Biochemical Journal
Biochem J (2003) 371 (2): 451–462.
Published: 15 April 2003
... in the absence of a fusion partner. Here, we report that such a protein can be obtained following its overexpression in bacteria. The pure NBF1+R protein exhibits significant ATPase activity [catalytic-centre activity (turnover number) 6.7min −1 ] and an apparent affinity for ATP ( K m , 8.7 μ M) higher than...
Articles
Interdomain communication in the molecular chaperone DnaK
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Journal:
Biochemical Journal
Biochem J (2003) 369 (3): 627–634.
Published: 01 February 2003
...Wanjiang HAN; Philipp CHRISTEN DnaK, a heat-shock protein 70 (Hsp70) homologue in Escherichia coli , possesses a single tryptophan residue in its ATPase domain. Changes in the intrinsic fluorescence of DnaK offer a simple means not only to follow the binding of ATP and of ADP plus the co-chaperone...
Articles
Functional characterization and structural modelling of late gene expression factor 4 from Bombyx mori nucleopolyhedrovirus
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Journal:
Biochemical Journal
Biochem J (2002) 368 (1): 159–169.
Published: 15 November 2002
... of LEF4 but had no effect on the ATPase activity. 1 To whom correspondence should be addressed (e-mail [email protected] ). 22 3 2002 5 8 2002 8 8 2002 8 8 2002 The Biochemical Society, London ©2002 2002 ATPase capping enzyme guanylate transferase mRNA...
Articles
Mechanism by which metal cofactors control substrate specificity in pyrophosphatase
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Journal:
Biochemical Journal
Biochem J (2002) 367 (3): 901–906.
Published: 01 November 2002
...Anton B. ZYRYANOV; Alexander S. SHESTAKOV; Reijo LAHTI; Alexander A. BAYKOV Family I soluble pyrophosphatases (PPases) exhibit appreciable ATPase activity in the presence of a number of transition metal ions, but not the physiological cofactor Mg 2+ . The results of the present study reveal...
Articles
Comparative characterization of two DEAD-box RNA helicases in superfamily II: human translation-initiation factor 4A and hepatitis C virus non-structural protein 3 (NS3) helicase
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Journal:
Biochemical Journal
Biochem J (2002) 363 (1): 147–155.
Published: 22 March 2002
... targeting HCV NS3 helicase but not human eIF4A. 1 To whom correspondence should be addressed (e-mail [email protected] ). 2 10 2001 13 11 2001 31 1 2002 The Biochemical Society, London ©2002 2002 ATPase ATP hydrolysis NTPase unwinding activity Abbreviations used...
Articles
Regulation of SulA cleavage by Lon protease by the C-terminal amino acid of SulA, histidine
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Journal:
Biochemical Journal
Biochem J (2001) 358 (2): 473–480.
Published: 24 August 2001
... ). 20 3 2001 15 6 2001 3 7 2001 The Biochemical Society, London ©2001 2001 amino acid substitution ATPase ATP-dependent protease maltose-binding protein (MBP) Abbreviations used: IPTG, isopropyl β- d -1-thiogalactopyranoside; LB, Luria–Bertani; MBP, maltose-binding...
Articles
The effect of Mg2+ on cardiac muscle function: is CaATP the substrate for priming myofibril cross-bridge formation and Ca2+ reuptake by the sarcoplasmic reticulum?
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Journal:
Biochemical Journal
Biochem J (2001) 354 (3): 539–551.
Published: 08 March 2001
... sites, one for each myosin head, to act as a single unit in initial cross-bridge formation. This defines the first, or activating, ATPase reaction, as distinct from the further activity of the enzyme that continues when a cross-bridge to actin is already established. The pairing of myosin heads to act...
Articles
Modification of cysteine residues in the ChlI and ChlH subunits of magnesium chelatase results in enzyme inactivation
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Journal:
Biochemical Journal
Biochem J (2000) 352 (2): 435–441.
Published: 24 November 2000
... in the partial reactions that comprise the catalytic cycle of Mg 2+ chelatase, such as the ATPase activity of ChlI, and the formation of ChlI–ChlD–MgATP and ChlH–protoporphyrin complexes. It was shown that NEM binds to ChlI and inhibits the ATPase activity of this subunit, and that prior incubation with MgATP...
Articles
Acylphosphatase possesses nucleoside triphosphatase and nucleoside diphosphatase activities
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Journal:
Biochemical Journal
Biochem J (2000) 349 (1): 43–49.
Published: 26 June 2000
... be addressed (e-mail ramponi@;scibio.unifi.it). 20 10 1999 6 4 2000 28 4 2000 The Biochemical Society, London © 2000 2000 acylphosphatase mutant apyrase ADPase ATPase Biochem. J. (2000) 349, 43 49 (Printed in Great Britain) 43 Acylphosphatase possesses nucleoside...
Articles
Control of sarcoplasmic/endoplasmic-reticulum Ca2+ pump expression in cardiac and smooth muscle
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Journal:
Biochemical Journal
Biochem J (1999) 338 (1): 167–173.
Published: 08 February 1999
... in the control of SERCA2 expression in the two tissues is post-transcriptional and pretranslational. 1 To whom correspondence should be addressed (e-mail [email protected] ). 15 9 1998 11 11 1998 1 12 1998 The Biochemical Society, London © 1999 1999 ATPase calcium...
