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Keywords: Akt/protein kinase B (PKB)
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Articles

The expression of the tumour suppressor HBP1 is down-regulated by growth factors via the PI3K/PKB/FOXO pathway

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Alexandra Coomans de Brachène, Emeline Bollaert, Astrid Eijkelenboom, Audrey de Rocca Serra, Kristan E. van der Vos, Boudewijn M. T. Burgering, Paul J. Coffer, Ahmed Essaghir, Jean-Baptiste Demoulin
Journal: Biochemical Journal
Biochem J (2014) 460 (1): 25–36.
https://doi.org/10.1042/BJ20131467
Published: 25 April 2014
... the PI3K/PKB/FOXO pathway. A FOXO-binding site was characterized in the HBP1 promoter. HBP1 knockdown was enough to enhance cell proliferation downstream of growth factors. Akt/protein kinase B (PKB) cell proliferation forkhead box O (FOXO) growth factor high-mobility group-box protein 1...
View articletitled, The expression of the tumour suppressor HBP1 is down-regulated by growth factors via the PI3K/PKB/FOXO pathway
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Includes: Supplementary data
Articles

Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)

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Laura R. Pearce, Gordon R. Alton, Daniel T. Richter, John C. Kath, Laura Lingardo, Justin Chapman, Catherine Hwang, Dario R. Alessi
Journal: Biochemical Journal
Biochem J (2010) 431 (2): 245–255.
https://doi.org/10.1042/BJ20101024
Published: 28 September 2010
... (phosphoinositide-dependent kinase 1) via its PIF pocket and subsequently the T-loop (Thr 229 in S6K1) is phosphorylated [ 13 ]. Akt/protein kinase B (PKB) cancer kinase inhibitor phosphoinositide 3-kinase (PI3K) p70 ribosomal S6 kinase (S6K) serum- and glucocorticoid-induced protein kinase (SGK...
View articletitled, Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)
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Includes: Supplementary data
Articles

Electrostatic interactions play a minor role in the binding of ExoS to 14-3-3 proteins

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Lubna Yasmin, Jeffrey L. Veesenmeyer, Maureen H. Diaz, Matthew S. Francis, Christian Ottmann, Ruth H. Palmer, Alan R. Hauser, Bengt Hallberg
Journal: Biochemical Journal
Biochem J (2010) 427 (2): 217–224.
https://doi.org/10.1042/BJ20100043
Published: 29 March 2010
... Road, Atlanta, GA 30333, U.S.A. 4 To whom correspondence should be addressed (email [email protected] ). 5 1 2010 8 2 2010 9 2 2010 9 2 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 ADP-ribosyltransferase Akt/protein kinase...
View articletitled, Electrostatic interactions play a minor role in the binding of ExoS to 14-3-3 proteins
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Includes: Supplementary data
Articles

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

Open Access
Juan M. García-Martínez, Jennifer Moran, Rosemary G. Clarke, Alex Gray, Sabina C. Cosulich, Christine M. Chresta, Dario R. Alessi
Journal: Biochemical Journal
Biochem J (2009) 421 (1): 29–42.
https://doi.org/10.1042/BJ20090489
Published: 12 June 2009
... of the Creative Commons Attribution Non-Commercial Licence ( http://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. Akt/protein kinase B (PKB) cancer kinase inhibitor...
View articletitled, Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)
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Articles

Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR

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Kathryn M. Geraghty, Shuai Chen, Jean E. Harthill, Adel F. Ibrahim, Rachel Toth, Nick A. Morrice, Franck Vandermoere, Greg B. Moorhead, D. Grahame Hardie, Carol MacKintosh
Journal: Biochemical Journal
Biochem J (2007) 407 (2): 231–241.
https://doi.org/10.1042/BJ20070649
Published: 25 September 2007
... the activation of the classical MAPK pathway (results not shown). 14-3-3 Akt/protein kinase B (PKB) Akt substrate of 160 kDa (AS160) GTPase-activating protein (GAP) p90 ribosomal S6 kinase (RSK) serum- and glucocorticoid-induced protein kinase (SGK) 14-3-3s are C-shaped proteins that dock...
View articletitled, Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR
Open the PDF for Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR in another window
Includes: Supplementary data