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Polyamination with spermidine enhances pathogenic tau conformations while reducing filamentous aggregate formation in vitro

Mohammed M. Alhadidy, Rebecca L. Mueller, Jared Lamp, Nicholas M. Kanaan

Biochem J (2025) 482 (12): 877–899.

https://doi.org/10.1042/BCJ20253079

Published: 17 June 2025

.... The most studied PTMs of tau are phosphorylation and acetylation; however, the salience of other PTMs is not fully explored. Tissue transglutaminase (TG) is an enzyme whose activity is elevated in Alzheimer’s disease (AD). TG action on tau may lead to intramolecular and intermolecular cross-linking along...

View article titled, Polyamination with spermidine enhances pathogenic tau conformations while reducing filamentous aggregate formation in vitro

Includes: Supplementary data

Articles

A nexus of miR-1271, PAX4 and ALK/RYK influences the cytoskeletal architectures in Alzheimer's Disease and Type 2 Diabetes

Piyali Majumder, Kaushik Chanda, Debajyoti Das, Brijesh Kumar Singh, Partha Chakrabarti, Nihar Ranjan Jana, Debashis Mukhopadhyay

Biochem J (2021) 478 (17): 3297–3317.

https://doi.org/10.1042/BCJ20210175

Published: 14 September 2021

...Piyali Majumder; Kaushik Chanda; Debajyoti Das; Brijesh Kumar Singh; Partha Chakrabarti; Nihar Ranjan Jana; Debashis Mukhopadhyay Alzheimer's Disease (AD) and Type 2 Diabetes (T2D) share a common hallmark of insulin resistance. Reportedly, two non-canonical Receptor Tyrosine Kinases (RTKs), ALK...

View article titled, A nexus of miR-1271, PAX4 and ALK/RYK influences the cytoskeletal architectures in Alzheimer's Disease and Type 2 Diabetes

Includes: Supplementary data

Articles

Spontaneous protein–protein crosslinking at glutamine and glutamic acid residues in long-lived proteins

Michael G. Friedrich, Zhen Wang, Kevin L. Schey, Roger J. W. Truscott

Biochem J (2021) 478 (2): 327–339.

https://doi.org/10.1042/BCJ20200798

Published: 22 January 2021

... were enabled. Correspondence: Michael G. Friedrich ([email protected]) 18 10 2020 15 12 2020 18 12 2020 21 12 2020 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 age Alzheimer's disease human lens...

View article titled, Spontaneous protein–protein crosslinking at glutamine and glutamic acid residues in long-lived proteins

Includes: Supplementary data

Articles

Amyloid-beta oligomers induce Parkin-mediated mitophagy by reducing Miro1

Min Kyoung Kam, Dong Gil Lee, Bokyung Kim, Jae-Won Huh, Hong Jun Lee, Young-Ho Park, Dong-Seok Lee

Biochem J (2020) 477 (23): 4581–4597.

https://doi.org/10.1042/BCJ20200488

Published: 08 December 2020

...Min Kyoung Kam; Dong Gil Lee; Bokyung Kim; Jae-Won Huh; Hong Jun Lee; Young-Ho Park; Dong-Seok Lee Alzheimer's disease (AD) is a neurodegenerative disease associated with the accumulation of amyloid-beta oligomers (AβO). Recent studies have demonstrated that mitochondria-specific autophagy...

View article titled, Amyloid-beta oligomers induce Parkin-mediated mitophagy by reducing Miro1

Includes: Supplementary data

Articles

Rationally designed peptide-based inhibitor of Aβ 42 fibril formation and toxicity: a potential therapeutic strategy for Alzheimer's disease

John R. Horsley, Blagojce Jovcevski, Kate L. Wegener, Jingxian Yu, Tara L. Pukala, Andrew D. Abell

Biochem J (2020) 477 (11): 2039–2054.

https://doi.org/10.1042/BCJ20200290

Published: 10 June 2020

...John R. Horsley; Blagojce Jovcevski; Kate L. Wegener; Jingxian Yu; Tara L. Pukala; Andrew D. Abell Amyloid beta peptide (Aβ 42 ) aggregation in the brain is thought to be responsible for the onset of Alzheimer's disease, an insidious condition without an effective treatment or cure. Hence...

View article titled, Rationally designed peptide-based inhibitor of Aβ 42 fibril formation and toxicity: a potential therapeutic strategy for Alzheimer's disease

Articles

Molecular dynamics of C99-bound γ-secretase reveal two binding modes with distinct compactness, stability, and active-site retention: implications for Aβ production

Budheswar Dehury, Ning Tang, Kasper P. Kepp

Biochem J (2019) 476 (7): 1173–1189.

https://doi.org/10.1042/BCJ20190023

Published: 15 April 2019

...Budheswar Dehury; Ning Tang; Kasper P. Kepp The membrane protease γ-secretase cleaves the C99 fragment of the amyloid precursor protein, thus producing the Aβ peptides central to Alzheimer's disease. Cryo-electron microscopy has provided the topology but misses the membrane and loop parts...

View article titled, Molecular dynamics of C99-bound γ-secretase reveal two binding modes with distinct compactness, stability, and active-site retention: implications for Aβ production

Includes: Supplementary data

Articles

Cysteine-rich granulin-3 rapidly promotes amyloid-β fibrils in both redox states

Anukool A. Bhopatkar, Gaurav Ghag, Lauren M. Wolf, Dexter N. Dean, Melissa A. Moss, Vijayaraghavan Rangachari

Biochem J (2019) 476 (5): 859–873.

https://doi.org/10.1042/BCJ20180916

Published: 12 March 2019

...) and Alzheimer's disease (AD). Their precise mechanism in these pathologies remains uncertain, but both inflammatory and lysosomal roles have been observed for GRNs. Among the seven GRNs, GRN-3 is well characterized and is implicated within the context of FTD. However, the relationship between GRN-3 and amyloid-β...

View article titled, Cysteine-rich granulin-3 rapidly promotes amyloid-β fibrils in both redox states

Includes: Supplementary data

Articles

An Aβ42 variant that inhibits intra- and extracellular amyloid aggregation and enhances cell viability

Ofek Oren, Victor Banerjee, Ran Taube, Niv Papo

Biochem J (2018) 475 (19): 3087–3103.

https://doi.org/10.1042/BCJ20180247

Published: 10 October 2018

...Ofek Oren; Victor Banerjee; Ran Taube; Niv Papo Aggregation and accumulation of the 42-residue amyloid β peptide (Aβ42) in the extracellular matrix and within neuronal cells is considered a major cause of neuronal cell cytotoxicity and death in Alzheimer's disease (AD) patients. Therefore...

View article titled, An Aβ42 variant that inhibits intra- and extracellular amyloid aggregation and enhances cell viability

Includes: Supplementary data

Articles

ApoE isoforms and carboxyl-terminal-truncated apoE4 forms affect neuronal BACE1 levels and Aβ production independently of their cholesterol efflux capacity

Ioannis Dafnis, Christina Raftopoulou, Christina Mountaki, Evgenia Megalou, Vassilis I. Zannis, Angeliki Chroni

Biochem J (2018) 475 (10): 1839–1859.

https://doi.org/10.1042/BCJ20180068

Published: 31 May 2018

...Ioannis Dafnis; Christina Raftopoulou; Christina Mountaki; Evgenia Megalou; Vassilis I. Zannis; Angeliki Chroni The β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) initiates the production of amyloid-β peptide (Aβ), which is central to the pathogenesis of Alzheimer's disease (AD...

View article titled, ApoE isoforms and carboxyl-terminal-truncated apoE4 forms affect neuronal BACE1 levels and Aβ production independently of their cholesterol efflux capacity

Includes: Supplementary data

Articles

Molecular basis for the interaction between stress-inducible phosphoprotein 1 (STIP1) and S100A1

Andrzej Maciejewski, Vania F. Prado, Marco A.M. Prado, Wing-Yiu Choy

Biochem J (2017) 474 (11): 1853–1866.

https://doi.org/10.1042/BCJ20161055

Published: 16 May 2017

... ) 1 12 2016 11 4 2017 13 4 2017 13 4 2017 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 Alzheimer's disease calcium signaling co-chaperone NMR spectroscopy tetratricopeptide repeat The S100 family...

View article titled, Molecular basis for the interaction between stress-inducible phosphoprotein 1 (STIP1) and S100A1

Includes: Supplementary data

Articles

Astrocytic transporters in Alzheimer's disease

Chris Ugbode, Yuhan Hu, Benjamin Whalley, Chris Peers, Marcus Rattray, Mark L. Dallas

Biochem J (2017) 474 (3): 333–355.

https://doi.org/10.1042/BCJ20160505

Published: 20 January 2017

... in neurological diseases, including Alzheimer's disease (AD). These changes may reflect a change from a neuroprotective to a neurotoxic phenotype. Given the lack of current disease-modifying therapies for AD, astrocytes have become an interesting and viable target for therapeutic intervention. The astrocyte...

View article titled, Astrocytic transporters in Alzheimer's disease

Articles

Dementia-related Bri2 BRICHOS is a versatile molecular chaperone that efficiently inhibits Aβ42 toxicity in Drosophila

Helen Poska, Martin Haslbeck, Firoz Roshan Kurudenkandy, Erik Hermansson, Gefei Chen, George Kostallas, Axel Abelein, Henrik Biverstål, Sophie Crux, André Fisahn, Jenny Presto, Jan Johansson

Biochem J (2016) 473 (20): 3683–3704.

https://doi.org/10.1042/BCJ20160277

Published: 11 October 2016

... in Alzheimer's disease (AD), for which no effective treatment exists. The BRICHOS domain is a part of several disease-related proproteins, the most studied ones being Bri2 associated with familial dementia and prosurfactant protein C (proSP-C) associated with lung amyloid. BRICHOS from proSP-C has been found...

View article titled, Dementia-related Bri2 BRICHOS is a versatile molecular chaperone that efficiently inhibits Aβ42 toxicity in Drosophila

Includes: Supplementary data

Articles

Physiological and pathophysiological functions of Swiprosin-1/EFhd2 in the nervous system

Dirk Mielenz, Frank Gunn-Moore

Biochem J (2016) 473 (16): 2429–2437.

https://doi.org/10.1042/BCJ20160168

Published: 11 August 2016

...Dirk Mielenz; Frank Gunn-Moore Synaptic dysfunction and dysregulation of Ca 2+ are linked to neurodegenerative processes and behavioural disorders. Our understanding of the causes and factors involved in behavioural disorders and neurodegeneration, especially Alzheimer's disease (AD), a tau-related...

View article titled, Physiological and pathophysiological functions of Swiprosin-1/EFhd2 in the nervous system

Articles

Domains of STIP1 responsible for regulating PrP C -dependent amyloid-β oligomer toxicity

Andrzej Maciejewski, Valeriy G. Ostapchenko, Flavio H. Beraldo, Vania F. Prado, Marco A.M. Prado, Wing-Yiu Choy

Biochem J (2016) 473 (14): 2119–2130.

https://doi.org/10.1042/BCJ20160087

Published: 12 July 2016

...Andrzej Maciejewski; Valeriy G. Ostapchenko; Flavio H. Beraldo; Vania F. Prado; Marco A.M. Prado; Wing-Yiu Choy Soluble oligomers of amyloid-beta peptide (AβO) transmit neurotoxic signals through the cellular prion protein (PrP C ) in Alzheimer's disease (AD). Secreted stress-inducible...

View article titled, Domains of STIP1 responsible for regulating PrP C -dependent amyloid-β oligomer toxicity

Articles

BRICHOS binds to a designed amyloid-forming β-protein and reduces proteasomal inhibition and aggresome formation

Lisa Dolfe, Bengt Winblad, Jan Johansson, Jenny Presto

Biochem J (2016) 473 (2): 167–178.

https://doi.org/10.1042/BJ20150920

Published: 05 January 2016

...Lisa Dolfe; Bengt Winblad; Jan Johansson; Jenny Presto The BRICHOS domain is associated with proliferative, degenerative and amyloid diseases, and it has been shown to inhibit fibril formation and toxicity of the Alzheimer's disease-associated amyloid β-peptide. ProSP-C (prosurfactant protein C...

View article titled, BRICHOS binds to a designed amyloid-forming β-protein and reduces proteasomal inhibition and aggresome formation

Includes: Supplementary data

Articles

Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions

Yasuhiko Kizuka, Miyako Nakano, Shinobu Kitazume, Takashi Saito, Takaomi C. Saido, Naoyuki Taniguchi

Biochem J (2016) 473 (1): 21–30.

https://doi.org/10.1042/BJ20150607

Published: 09 December 2015

...Yasuhiko Kizuka; Miyako Nakano; Shinobu Kitazume; Takashi Saito; Takaomi C. Saido; Naoyuki Taniguchi β-Site amyloid precursor protein-cleaving enzyme-1 (BACE1) is a protease essential for amyloid-β (Aβ) production in Alzheimer's disease (AD). BACE1 protein is known to be up-regulated by oxidative...

View article titled, Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions

Includes: Supplementary data

Articles

Phosphorylation of FE65 Ser 610 by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer's disease amyloid precursor protein processing

Wan Ning Vanessa Chow, Jacky Chi Ki Ngo, Wen Li, Yu Wai Chen, Ka Ming Vincent Tam, Ho Yin Edwin Chan, Christopher C.J. Miller, Kwok-Fai Lau

Biochem J (2015) 470 (3): 303–317.

https://doi.org/10.1042/BJ20141485

Published: 04 September 2015

...Wan Ning Vanessa Chow; Jacky Chi Ki Ngo; Wen Li; Yu Wai Chen; Ka Ming Vincent Tam; Ho Yin Edwin Chan; Christopher C.J. Miller; Kwok-Fai Lau Alzheimer's disease (AD) is a fatal neurodegenerative disease affecting 36 million people worldwide. Genetic and biochemical research indicate...

View article titled, Phosphorylation of FE65 Ser 610 by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer's disease amyloid precursor protein processing

Includes: Supplementary data

Articles

Cu 2+ accentuates distinct misfolding of Aβ (1–40) and Aβ (1–42) peptides, and potentiates membrane disruption

Christian J. Matheou, Nadine D. Younan, John H. Viles

Biochem J (2015) 466 (2): 233–242.

https://doi.org/10.1042/BJ20141168

Published: 20 February 2015

...Christian J. Matheou; Nadine D. Younan; John H. Viles Central to Alzheimer's disease is the misfolding of amyloid-beta (Aβ) peptide, which generates an assorted population of amorphous aggregates, oligomers and fibres. Metal ion homoeostasis is disrupted in the brains of sufferers of Alzheimer's...

View article titled, Cu 2+ accentuates distinct misfolding of Aβ (1–40) and Aβ (1–42) peptides, and potentiates membrane disruption

Articles

Fe65 Ser 228 is phosphorylated by ATM/ATR and inhibits Fe65–APP-mediated gene transcription

Paul A. Jowsey, Peter G. Blain

Biochem J (2015) 465 (3): 413–421.

https://doi.org/10.1042/BJ20140656

Published: 22 January 2015

... of Alzheimer's disease (AD) and AICD has important roles in the regulation of gene transcription (in complex with Fe65). It is therefore important to understand how Fe65 is regulated and how this contributes to the function and/or processing of APP. Studies have also implicated Fe65 in the cellular DNA damage...

View article titled, Fe65 Ser 228 is phosphorylated by ATM/ATR and inhibits Fe65–APP-mediated gene transcription

Articles

Specific aromatic foldamers potently inhibit spontaneous and seeded Aβ42 and Aβ43 fibril assembly

Katelyn M. Seither, Heather A. McMahon, Nikita Singh, Hejia Wang, Mimi Cushman-Nick, Geronda L. Montalvo, William F. DeGrado, James Shorter

Biochem J (2014) 464 (1): 85–98.

https://doi.org/10.1042/BJ20131609

Published: 23 October 2014

...Katelyn M. Seither; Heather A. McMahon; Nikita Singh; Hejia Wang; Mimi Cushman-Nick; Geronda L. Montalvo; William F. DeGrado; James Shorter Amyloid fibrils are self-propagating entities that spread pathology in several devastating disorders including Alzheimer's disease (AD). In AD, amyloid-β (Aβ...

View article titled, Specific aromatic foldamers potently inhibit spontaneous and seeded Aβ42 and Aβ43 fibril assembly

Articles

Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain

D. Allan Butterfield, Fabio Di Domenico, Aaron M. Swomley, Elizabeth Head, Marzia Perluigi

Biochem J (2014) 463 (2): 177–189.

https://doi.org/10.1042/BJ20140772

Published: 22 September 2014

... adults with DS (Down's syndrome) and AD (Alzheimer's disease). Since AD pathology is age-dependent in DS and shows similarities with AD, identification of common oxidized proteins by redox proteomics in both DS and AD can improve our understanding of the overlapping mechanisms that lead from normal aging...

View article titled, Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain

Articles

Lysine methylation is an endogenous post-translational modification of tau protein in human brain and a modulator of aggregation propensity

Kristen E. Funk, Stefani N. Thomas, Kelsey N. Schafer, Grace L. Cooper, Zhongping Liao, David J. Clark, Austin J. Yang, Jeff Kuret

Biochem J (2014) 462 (1): 77–88.

https://doi.org/10.1042/BJ20140372

Published: 24 July 2014

...Kristen E. Funk; Stefani N. Thomas; Kelsey N. Schafer; Grace L. Cooper; Zhongping Liao; David J. Clark; Austin J. Yang; Jeff Kuret In Alzheimer's disease, the microtubule-associated protein tau dissociates from the neuronal cytoskeleton and aggregates to form cytoplasmic inclusions. Although...

View article titled, Lysine methylation is an endogenous post-translational modification of tau protein in human brain and a modulator of aggregation propensity

Articles

Aβ dimers differ from monomers in structural propensity, aggregation paths and population of synaptotoxic assemblies

Tiernan T. O’Malley, Nur Alia Oktaviani, Dainan Zhang, Aleksey Lomakin, Brian O’Nuallain, Sara Linse, George B. Benedek, Michael J. Rowan, Frans A. A. Mulder, Dominic M. Walsh

Biochem J (2014) 461 (3): 413–426.

https://doi.org/10.1042/BJ20140219

Published: 10 July 2014

...Tiernan T. O’Malley; Nur Alia Oktaviani; Dainan Zhang; Aleksey Lomakin; Brian O’Nuallain; Sara Linse; George B. Benedek; Michael J. Rowan; Frans A. A. Mulder; Dominic M. Walsh Dimers of Aβ (amyloid β-protein) are believed to play an important role in Alzheimer's disease. In the absence...

View article titled, Aβ dimers differ from monomers in structural propensity, aggregation paths and population of synaptotoxic assemblies

Includes: Supplementary data

Articles

Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase

Florian Nachon, Eugénie Carletti, Cyril Ronco, Marie Trovaslet, Yvain Nicolet, Ludovic Jean, Pierre-Yves Renard

Biochem J (2013) 453 (3): 393–399.

https://doi.org/10.1042/BJ20130013

Published: 12 July 2013

...Florian Nachon; Eugénie Carletti; Cyril Ronco; Marie Trovaslet; Yvain Nicolet; Ludovic Jean; Pierre-Yves Renard The multifunctional nature of Alzheimer's disease calls for MTDLs (multitarget-directed ligands) to act on different components of the pathology, like the cholinergic dysfunction...

View article titled, Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase

Articles

Regulation of cholinergic activity by the vesicular acetylcholine transporter

Vania F. Prado, Ashbeel Roy, Benjamin Kolisnyk, Robert Gros, Marco A. M. Prado

Biochem J (2013) 450 (2): 265–274.

https://doi.org/10.1042/BJ20121662

Published: 15 February 2013

... The Authors Journal compilation © 2013 Biochemical Society 2013 Alzheimer’s disease heart failure Parkinson’s disease sepsis synaptic vesicle vascular dementia Cholinergic neurons in the CNS (central nervous system) and in the periphery secrete the neurotransmitter ACh (acetylcholine...

View article titled, Regulation of cholinergic activity by the vesicular acetylcholine transporter

Includes: Multimedia, Supplementary data

Articles

Engulfment adaptor phosphotyrosine-binding-domain-containing 1 (GULP1) is a nucleocytoplasmic shuttling protein and is transactivationally active together with low-density lipoprotein receptor-related protein 1 (LRP1)

Anke Wahler, Anja-Silke Beyer, Ilona E. Keller, Cathrin Schnack, Björn von Einem, Christian Pröpper, Tobias M. Boeckers, Ithan D. Peltan, Dudley K. Strickland, Bradley T. Hyman, Christine A. F. von Arnim

Biochem J (2013) 450 (2): 333–343.

https://doi.org/10.1042/BJ20121100

Published: 15 February 2013

...) have been implicated in the pathogenesis of AD (Alzheimer's disease). They are functionally linked by Fe65, a PTB (phosphotyrosine-binding)-domain-containing adaptor protein that binds to intracellular NPxY-motifs of APP and LRP1, thereby influencing expression levels, cellular trafficking...

View article titled, Engulfment adaptor phosphotyrosine-binding-domain-containing 1 (GULP1) is a nucleocytoplasmic shuttling protein and is transactivationally active together with low-density lipoprotein receptor-related protein 1 (LRP1)

Articles

Is the Amyloid Hypothesis of Alzheimer's disease therapeutically relevant?

Andrew F. Teich, Ottavio Arancio

Biochem J (2012) 446 (2): 165–177.

https://doi.org/10.1042/BJ20120653

Published: 14 August 2012

...Andrew F. Teich; Ottavio Arancio The conventional view of AD (Alzheimer's disease) is that much of the pathology is driven by an increased load of β-amyloid in the brain of AD patients (the ‘Amyloid Hypothesis’). Yet, many therapeutic strategies based on lowering β-amyloid have so far failed...

View article titled, Is the Amyloid Hypothesis of Alzheimer's disease therapeutically relevant?

Articles

The anti-neurodegenerative agent clioquinol regulates the transcription factor FOXO1a

Amy R. Cameron, Katherine Wallace, Lisa Logie, Alan R. Prescott, Terry G. Unterman, Jean Harthill, Graham Rena

Biochem J (2012) 443 (1): 57–64.

https://doi.org/10.1042/BJ20112124

Published: 14 March 2012

...Amy R. Cameron; Katherine Wallace; Lisa Logie; Alan R. Prescott; Terry G. Unterman; Jean Harthill; Graham Rena Many diseases of aging including AD (Alzheimer's disease) and T2D (Type 2 diabetes) are strongly associated with common risk factors, suggesting that there may be shared aging mechanisms...

View article titled, The anti-neurodegenerative agent clioquinol regulates the transcription factor FOXO1a

Articles

Selective reduction of hydroperoxyeicosatetraenoic acids to their hydroxy derivatives by apolipoprotein D: implications for lipid antioxidant activity and Alzheimer's disease

Surabhi Bhatia, Bianca Knoch, Jenny Wong, Woojin S. Kim, Paul L. Else, Aaron J. Oakley, Brett Garner

Biochem J (2012) 442 (3): 713–721.

https://doi.org/10.1042/BJ20111166

Published: 24 February 2012

...Surabhi Bhatia; Bianca Knoch; Jenny Wong; Woojin S. Kim; Paul L. Else; Aaron J. Oakley; Brett Garner ApoD (apolipoprotein D) is up-regulated in AD (Alzheimer's disease) and upon oxidative stress. ApoD inhibits brain lipid peroxidation in vivo , but the mechanism is unknown. Specific methionine...

View article titled, Selective reduction of hydroperoxyeicosatetraenoic acids to their hydroxy derivatives by apolipoprotein D: implications for lipid antioxidant activity and Alzheimer's disease

Includes: Supplementary data

Articles

Visualization of co-localization in Aβ42-administered neuroblastoma cells reveals lysosome damage and autophagosome accumulation related to cell death

Violetta Soura, Maris Stewart-Parker, Thomas L. Williams, Arjuna Ratnayaka, Joe Atherton, Kirsti Gorringe, Jack Tuffin, Elisabeth Darwent, Roma Rambaran, William Klein, Pascale Lacor, Kevin Staras, Julian Thorpe, Louise C. Serpell

Biochem J (2012) 441 (2): 579–590.

https://doi.org/10.1042/BJ20110749

Published: 21 December 2011

... Biochemical Society 2012 Alzheimer's disease amyloid-β peptide-(1–42) (Aβ42) autophagosome lysosome oligomer AD (Alzheimer's disease) is characterized by deposition of assembled Aβ42 [Aβ (amyloid-β peptide)-(1–42)] peptides in extracellular amyloid plaques [ 1 ]. However, accumulating...

View article titled, Visualization of co-localization in Aβ42-administered neuroblastoma cells reveals lysosome damage and autophagosome accumulation related to cell death

Includes: Supplementary data

Articles

Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in disease

Rohan D. Teasdale, Brett M. Collins

Biochem J (2012) 441 (1): 39–59.

https://doi.org/10.1042/BJ20111226

Published: 14 December 2011

... invasion and amyloid production in Alzheimer's disease. 1 To whom correspondence should be addressed (email [email protected] ). 11 7 2011 26 7 2011 27 7 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 Alzheimer's disease endosome...

View article titled, Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in disease

Includes: Multimedia, Supplementary data

Articles

Aβ42 oligomers, but not fibrils, simultaneously bind to and cause damage to ganglioside-containing lipid membranes

Thomas L. Williams, Benjamin R. G. Johnson, Brigita Urbanc, A. Toby A. Jenkins, Simon D. A. Connell, Louise C. Serpell

Biochem J (2011) 439 (1): 67–77.

https://doi.org/10.1042/BJ20110750

Published: 14 September 2011

...Thomas L. Williams; Benjamin R. G. Johnson; Brigita Urbanc; A. Toby A. Jenkins; Simon D. A. Connell; Louise C. Serpell Aβ (amyloid-β peptide) assembles to form amyloid fibres that accumulate in senile plaques associated with AD (Alzheimer's disease). The major constituent, a 42-residue Aβ, has...

View article titled, Aβ42 oligomers, but not fibrils, simultaneously bind to and cause damage to ganglioside-containing lipid membranes

Includes: Supplementary data

Articles

Aggregation of amyloids in a cellular context: modelling and experiment

Ran Friedman

Biochem J (2011) 438 (3): 415–426.

https://doi.org/10.1042/BJ20110369

Published: 26 August 2011

... of fibril growth during disease progression has been revealed by AFM ( Figure 5 ). 1 email [email protected] 28 2 2011 28 4 2011 4 5 2011 26 8 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 Alzheimer's disease computer simulation...

View article titled, Aggregation of amyloids in a cellular context: modelling and experiment

Includes: Multimedia, Supplementary data

Articles

Mass and relative elution time profiling: two-dimensional analysis of sphingolipids in Alzheimer's disease brains

Leila Hejazi, Jason W.H. Wong, Danni Cheng, Nicholas Proschogo, Diako Ebrahimi, Brett Garner, Anthony S. Don

Biochem J (2011) 438 (1): 165–175.

https://doi.org/10.1042/BJ20110566

Published: 27 July 2011

...) analysis of sphingolipids based on both mass and hydrophobicity, and use this method to characterize the SM (sphingomyelin), ceramide and GalCer (galactosylceramide) content of hippocampus from AD (Alzheimer's disease) and control subjects. Using a mathematical relationship we exclude the influence...

View article titled, Mass and relative elution time profiling: two-dimensional analysis of sphingolipids in Alzheimer's disease brains

Includes: Supplementary data

Articles

Calcium homoeostasis modulator 1 (CALHM1) reduces the calcium content of the endoplasmic reticulum (ER) and triggers ER stress

Sonia Gallego-Sandín, María Teresa Alonso, Javier García-Sancho

Biochem J (2011) 437 (3): 469–475.

https://doi.org/10.1042/BJ20110479

Published: 13 July 2011

... to generate a plasma-membrane Ca 2+ conductance and has been proposed to influence Alzheimer's disease risk. In the present study we have investigated the effects of CALHM1 on intracellular Ca 2+ handling in HEK-293T [HEK (human embryonic kidney)-293 cells expressing the large T-antigen of SV40 (simian virus...

View article titled, Calcium homoeostasis modulator 1 (CALHM1) reduces the calcium content of the endoplasmic reticulum (ER) and triggers ER stress

Includes: Supplementary data

Articles

Glycogen synthase kinase-3β regulates Tyr 307 phosphorylation of protein phosphatase-2A via protein tyrosine phosphatase 1B but not Src

Xiu-Qing Yao, Xiao-Xue Zhang, Yang-Yang Yin, Bin Liu, Dan-Ju Luo, Dan Liu, Ning-Ning Chen, Zhong-Fei Ni, Xiong Wang, Qun Wang, Jian-Zhi Wang, Gong-Ping Liu

Biochem J (2011) 437 (2): 335–344.

https://doi.org/10.1042/BJ20110347

Published: 28 June 2011

... that is suppressed in the brain in AD (Alzheimer's disease). However, the molecular mechanism is not understood. In the present study we found that activation of GSK-3β stimulates the inhibitory phosphorylation of PP2A at Tyr 307 (pY307-PP2A), whereas inhibition of GSK-3β decreased the level of pY307-PP2A both...

View article titled, Glycogen synthase kinase-3β regulates Tyr 307 phosphorylation of protein phosphatase-2A via protein tyrosine phosphatase 1B but not Src

Articles

An anti-Aβ (amyloid β) single-chain variable fragment prevents amyloid fibril formation and cytotoxicity by withdrawing Aβ oligomers from the amyloid pathway

Marta Marín-Argany, Geovanny Rivera-Hernández, Joaquim Martí, Sandra Villegas

Biochem J (2011) 437 (1): 25–34.

https://doi.org/10.1042/BJ20101712

Published: 14 June 2011

...Marta Marín-Argany; Geovanny Rivera-Hernández; Joaquim Martí; Sandra Villegas Aβ (amyloid β) immunotherapy has been revealed as a possible tool in Alzheimer's disease treatment. In contrast with complete antibodies, the administration of scFvs (single-chain variable fragments) produces neither...

View article titled, An anti-Aβ (amyloid β) single-chain variable fragment prevents amyloid fibril formation and cytotoxicity by withdrawing Aβ oligomers from the amyloid pathway

Includes: Supplementary data

Articles

GULP1 is a novel APP-interacting protein that alters APP processing

Candy Yan Hao, Michael S. Perkinton, William Wai-Lun Chan, Ho Yin Edwin Chan, Christopher C. J. Miller, Kwok-Fai Lau

Biochem J (2011) 436 (3): 631–639.

https://doi.org/10.1042/BJ20110145

Published: 27 May 2011

... (Alzheimer's disease). Accumulating evidence reveals that APPc (APP C-terminal domain)-interacting proteins can influence APP processing. There is also evidence to suggest that APPc-interacting proteins work co-operatively and competitively to maintain normal APP functions and processing. Hence, identification...

View article titled, GULP1 is a novel APP-interacting protein that alters APP processing

Includes: Supplementary data

Articles

AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure

Claire Thornton, Nicola J. Bright, Magdalena Sastre, Phillip J. Muckett, David Carling

Biochem J (2011) 434 (3): 503–512.

https://doi.org/10.1042/BJ20101485

Published: 24 February 2011

...Claire Thornton; Nicola J. Bright; Magdalena Sastre; Phillip J. Muckett; David Carling Hyperphosphorylation of tau is a hallmark of Alzheimer's disease and other tauopathies. Although the mechanisms underlying hyperphosphorylation are not fully understood, cellular stresses such as impaired energy...

View article titled, AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure

Includes: Supplementary data

Articles

Surprising toxicity and assembly behaviour of amyloid β-protein oxidized to sulfone

Panchanan Maiti, Roberto Piacentini, Cristian Ripoli, Claudio Grassi, Gal Bitan

Biochem J (2011) 433 (2): 323–332.

https://doi.org/10.1042/BJ20101391

Published: 22 December 2010

...Panchanan Maiti; Roberto Piacentini; Cristian Ripoli; Claudio Grassi; Gal Bitan Aβ (amyloid β-peptide) is believed to cause AD (Alzheimer's disease). Aβ42 (Aβ comprising 42 amino acids) is substantially more neurotoxic than Aβ40 (Aβ comprising 40 amino acids), and this increased toxicity correlates...

View article titled, Surprising toxicity and assembly behaviour of amyloid β-protein oxidized to sulfone

Includes: Supplementary data

Articles

Specific amino acids in the BAR domain allow homodimerization and prevent heterodimerization of sorting nexin 33

Bastian Dislich, Manuel E. Than, Stefan F. Lichtenthaler

Biochem J (2011) 433 (1): 75–83.

https://doi.org/10.1042/BJ20100709

Published: 15 December 2010

... interactions and suggests that SNX9 and SNX33 have distinct molecular functions. © The Authors Journal compilation © 2011 Biochemical Society 2011 Alzheimer's disease BAR domain endocytosis molecular modelling protein dimerization sorting nexin 1 To whom correspondence should...

View article titled, Specific amino acids in the BAR domain allow homodimerization and prevent heterodimerization of sorting nexin 33

Includes: Supplementary data

Articles

The consequences of mitochondrial amyloid β-peptide in Alzheimer's disease

Kirsty E. A. Muirhead, Eva Borger, Laura Aitken, Stuart J. Conway, Frank J. Gunn-Moore

Biochem J (2010) 426 (3): 255–270.

https://doi.org/10.1042/BJ20091941

Published: 24 February 2010

...Kirsty E. A. Muirhead; Eva Borger; Laura Aitken; Stuart J. Conway; Frank J. Gunn-Moore The Aβ (amyloid-β peptide) has long been associated with Alzheimer's disease, originally in the form of extracellular plaques. However, in the present paper we review the growing evidence for the role of soluble...

View article titled, The consequences of mitochondrial amyloid β-peptide in Alzheimer's disease

Articles

Antiparallel β-sheet: a signature structure of the oligomeric amyloid β-peptide

Emilie Cerf, Rabia Sarroukh, Shiori Tamamizu-Kato, Leonid Breydo, Sylvie Derclaye, Yves F. Dufrêne, Vasanthy Narayanaswami, Erik Goormaghtigh, Jean-Marie Ruysschaert, Vincent Raussens

Biochem J (2009) 421 (3): 415–423.

https://doi.org/10.1042/BJ20090379

Published: 15 July 2009

...Emilie Cerf; Rabia Sarroukh; Shiori Tamamizu-Kato; Leonid Breydo; Sylvie Derclaye; Yves F. Dufrêne; Vasanthy Narayanaswami; Erik Goormaghtigh; Jean-Marie Ruysschaert; Vincent Raussens AD (Alzheimer's disease) is linked to Aβ (amyloid β-peptide) misfolding. Studies demonstrate that the level...

View article titled, Antiparallel β-sheet: a signature structure of the oligomeric amyloid β-peptide

Articles

The tumour suppressor p53 regulates the expression of amyloid precursor protein (APP)

Ascensión Cuesta, Alberto Zambrano, María Royo, Angel Pascual

Biochem J (2009) 418 (3): 643–650.

https://doi.org/10.1042/BJ20081793

Published: 25 February 2009

...Ascensión Cuesta; Alberto Zambrano; María Royo; Angel Pascual The expression of the APP (amyloid precursor protein), which plays a key role in the development of AD (Alzheimer's disease), is regulated by a variety of cellular mediators in a cell-dependent manner. In this study, we present evidence...

View article titled, The tumour suppressor p53 regulates the expression of amyloid precursor protein (APP)

Articles

Accommodation of physostigmine and its analogues by acetylcholinesterase is dominated by hydrophobic interactions

Dov Barak, Arie Ordentlich, Dana Stein, Qian-sheng Yu, Nigel H. Greig, Avigdor Shafferman

Biochem J (2009) 417 (1): 213–222.

https://doi.org/10.1042/BJ20081276

Published: 12 December 2008

... used or considered for use as drugs for Alzheimer's disease, was analysed using over 20 mutants of residues that constitute the interaction subsites in the active centre. Both steps of the HuAChE carbamylation reaction, formation of the Michaelis complex as well as the nucleophilic process...

View article titled, Accommodation of physostigmine and its analogues by acetylcholinesterase is dominated by hydrophobic interactions

Articles

Mechanisms of neuronal death in disease: defining the models and the players

Elena M. Ribe, Esther Serrano-Saiz, Nsikan Akpan, Carol M. Troy

Biochem J (2008) 415 (2): 165–182.

https://doi.org/10.1042/BJ20081118

Published: 25 September 2008

... players in the death pathways, the current tools for examining these players and the models for studying neurological disease. Alzheimer's disease, the most common neurodegenerative disorder, and cerebral ischaemia, the most common cause of neurological death, are used to illustrate our current...

View article titled, Mechanisms of neuronal death in disease: defining the models and the players

Articles

A reversible form of lysine acetylation in the ER and Golgi lumen controls the molecular stabilization of BACE1

Claudio Costantini, Mi Hee Ko, Mary Cabell Jonas, Luigi Puglielli

Biochem J (2007) 407 (3): 383–395.

https://doi.org/10.1042/BJ20070040

Published: 12 October 2007

...Claudio Costantini; Mi Hee Ko; Mary Cabell Jonas; Luigi Puglielli The lipid second messenger ceramide regulates the rate of β cleavage of the Alzheimer's disease APP (amyloid precursor protein) by affecting the molecular stability of the β secretase BACE1 (β-site APP cleaving enzyme 1...

View article titled, A reversible form of lysine acetylation in the ER and Golgi lumen controls the molecular stabilization of BACE1

Includes: Supplementary data

Articles

Differential modulation of Alzheimer's disease amyloid β-peptide accumulation by diverse classes of metal ligands

Aphrodite Caragounis, Tai Du, Gulay Filiz, Katrina M. Laughton, Irene Volitakis, Robyn A. Sharples, Robert A. Cherny, Colin L. Masters, Simon C. Drew, Andrew F. Hill, Qiao-Xin Li, Peter J. Crouch, Kevin J. Barnham, Anthony R. White

Biochem J (2007) 407 (3): 435–450.

https://doi.org/10.1042/BJ20070579

Published: 12 October 2007

...Aphrodite Caragounis; Tai Du; Gulay Filiz; Katrina M. Laughton; Irene Volitakis; Robyn A. Sharples; Robert A. Cherny; Colin L. Masters; Simon C. Drew; Andrew F. Hill; Qiao-Xin Li; Peter J. Crouch; Kevin J. Barnham; Anthony R. White Biometals have an important role in AD (Alzheimer's disease...

View article titled, Differential modulation of Alzheimer's disease amyloid β-peptide accumulation by diverse classes of metal ligands

Articles

Modulation of Aβ generation by small ubiquitin-like modifiers does not require conjugation to target proteins

Véronique Dorval, Matthew J. Mazzella, Paul M. Mathews, Ronald T. Hay, Paul E. Fraser

Biochem J (2007) 404 (2): 309–316.

https://doi.org/10.1042/BJ20061451

Published: 14 May 2007

...Véronique Dorval; Matthew J. Mazzella; Paul M. Mathews; Ronald T. Hay; Paul E. Fraser The sequential processing of the APP (amyloid precursor protein) by the β- and γ-secretase and generation of the Aβ (amyloid-β) peptide is a primary pathological factor in AD (Alzheimer's disease). Regulation...

View article titled, Modulation of Aβ generation by small ubiquitin-like modifiers does not require conjugation to target proteins

Includes: Supplementary data

Articles

Amide solvent protection analysis demonstrates that amyloid-β(1–40) and amyloid-β(1–42) form different fibrillar structures under identical conditions

Anders Olofsson, Malin Lindhagen-Persson, A. Elisabeth Sauer-Eriksson, Anders Öhman

Biochem J (2007) 404 (1): 63–70.

https://doi.org/10.1042/BJ20061561

Published: 26 April 2007

...Anders Olofsson; Malin Lindhagen-Persson; A. Elisabeth Sauer-Eriksson; Anders Öhman AD (Alzheimer's disease) is a neurodegenerative disorder characterized by self-assembly and amyloid formation of the 39–43 residue long Aβ (amyloid-β)-peptide. The most abundant species, Aβ(1–40) and Aβ(1–42...

View article titled, Amide solvent protection analysis demonstrates that amyloid-β(1–40) and amyloid-β(1–42) form different fibrillar structures under identical conditions

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