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Keywords: Bak
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Articles
Journal:
Biochemical Journal
Biochem J (2007) 405 (3): 407–415.
Published: 13 July 2007
... of myocardial cells during I/R (ischaemia/reperfusion). Bnip3 exerts its action at the mitochondria, but the mechanism by which Bnip3 mediates mitochondrial dysfunction is not clear. In the present study, we have identified Bax and Bak as downstream effectors of Bnip3-mediated mitochondrial dysfunction. Bnip3...
Articles
Dayong ZHAI, Ning KE, Haichao ZHANG, Uri LADROR, Mary JOSEPH, Andreas EICHINGER, Adam GODZIK, Shi-Chung NG, John C. REED
Journal:
Biochemical Journal
Biochem J (2003) 376 (1): 229–236.
Published: 15 November 2003
... transmembrane domain. Our previous results showed that Bcl-B binds Bax and suppresses apoptosis induced by over-expression of Bax; however, Bcl-B does not bind or suppress Bak. To explore the molecular basis for the differential binding and suppression of Bax and Bak, we studied the BH3 dimerization domains...