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1-18 of 18
Keywords: Bax
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Cell death and survival
Journal:
Biochemical Journal
Biochem J (2024) 481 (14): 903–922.
Published: 10 July 2024
... on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis Bax Bcl-2 BH3-only proteins protein–protein interactions transmembrane domain When a eukaryotic cell is faced with overwhelming cellular stress that surpasses...
Articles
Journal:
Biochemical Journal
Biochem J (2015) 467 (3): 495–505.
Published: 17 April 2015
...Aisha Shamas-Din; Scott Bindner; Xiaoke Chi; Brian Leber; David W. Andrews; Cécile Fradin tBid (truncated Bid/p15) and Bim activate Bax to permeabilize mitochondria and induce apoptosis. Binding of tBid and Bim to membranes is facilitated by electrostatic interactions. Additionally, cardiolipin (CL...
Articles
Journal:
Biochemical Journal
Biochem J (2008) 412 (2): 347–357.
Published: 14 May 2008
...Anthony J. Valentijn; John-Paul Upton; Andrew P. Gilmore Bax, a pro-apoptotic Bcl-2 family protein, translocates to mitochondria during apoptosis, where it causes MOMP (mitochondrial outer membrane permeabilization). MOMP releases pro-apoptotic factors, such as cytochrome c and SMAC (second...
Articles
Journal:
Biochemical Journal
Biochem J (2008) 412 (2): e15–e16.
Published: 14 May 2008
...Vilmante Borutaite The question of how Bax is activated during apoptosis to perform its role in permeabilization of mitochondrial membranes is intriguing for investigators in the wide field of cell death research. In their paper published in the Biochemical Journal in 2006, Capano and Crompton...
Articles
Journal:
Biochemical Journal
Biochem J (2007) 405 (3): 407–415.
Published: 13 July 2007
... of myocardial cells during I/R (ischaemia/reperfusion). Bnip3 exerts its action at the mitochondria, but the mechanism by which Bnip3 mediates mitochondrial dysfunction is not clear. In the present study, we have identified Bax and Bak as downstream effectors of Bnip3-mediated mitochondrial dysfunction. Bnip3...
Articles
Journal:
Biochemical Journal
Biochem J (2006) 396 (1): 1–5.
Published: 26 April 2006
... of the increase in mitochondrial association of actin in early apoptosis. Using cell fractionation and Western blot analysis, we found that mitochondrial accumulation of β-actin occurred before the mitochondrial insertion of Bax and release of cytochrome c in apoptosis. The mitochondrial accumulation of β-actin...
Articles
Journal:
Biochemical Journal
Biochem J (2006) 395 (1): 57–64.
Published: 15 March 2006
...Michela Capano; Martin Crompton The cytosolic protein Bax plays a key role in apoptosis by migrating to mitochondria and releasing proapoptotic proteins from the mitochondrial intermembrane space. The present study investigates the movement of Bax in isolated rat neonatal cardiomyocytes subjected...
Articles
José Antonio MUÑOZ-GÁMEZ, David MARTÍN-OLIVA, Rocío AGUILAR-QUESADA, Ana CAÑUELO, M. Isabel NUÑEZ, M. Teresa VALENZUELA, J. M. RUIZ de ALMODÓVAR, Gilbert de MURCIA, F. Javier OLIVER
Journal:
Biochemical Journal
Biochem J (2005) 386 (1): 119–125.
Published: 08 February 2005
... release, association of Bax with the mitochondria and caspase 3 activation were also observed in the presence of ANI. Therefore PARP inhibition may represent a novel way of selectively targeting p53-deficient breast cancer cells. The underlying mechanism is probably a potentiation of unrepaired DNA damage...
Articles
Gerd HEIMLICH, Alastair D. McKINNON, Katussevani BERNARDO, Dieter BRDICZKA, John C. REED, Renate KAIN, Martin KRÖNKE, Juliane M. JÜRGENSMEIER
Journal:
Biochemical Journal
Biochem J (2004) 378 (1): 247–255.
Published: 15 February 2004
...Gerd HEIMLICH; Alastair D. McKINNON; Katussevani BERNARDO; Dieter BRDICZKA; John C. REED; Renate KAIN; Martin KRÖNKE; Juliane M. JÜRGENSMEIER The pro-apoptotic protein Bax plays a key role in the mitochondrial signalling pathway. Upon induction of apoptosis, Bax undergoes a conformational change...
Articles
Journal:
Biochemical Journal
Biochem J (2004) 377 (2): 509–516.
Published: 15 January 2004
...Raquel F. EPAND; Jean-Claude MARTINOU; Sylvie MONTESSUIT; Richard M. EPAND Fatty acids are known promoters of apoptosis. In the present study, the direct role of fatty acids with regard to their ability to cause membrane permeabilization by Bax was explored. Addition of fatty acids to liposomes...
Articles
Dayong ZHAI, Ning KE, Haichao ZHANG, Uri LADROR, Mary JOSEPH, Andreas EICHINGER, Adam GODZIK, Shi-Chung NG, John C. REED
Journal:
Biochemical Journal
Biochem J (2003) 376 (1): 229–236.
Published: 15 November 2003
... transmembrane domain. Our previous results showed that Bcl-B binds Bax and suppresses apoptosis induced by over-expression of Bax; however, Bcl-B does not bind or suppress Bak. To explore the molecular basis for the differential binding and suppression of Bax and Bak, we studied the BH3 dimerization domains...
Articles
Journal:
Biochemical Journal
Biochem J (2003) 374 (2): 393–402.
Published: 01 September 2003
... independently in yeast. Using this system, we have focused on the action of the anti-apoptotic family member Bcl-x L , and have defined the quantitative relationships that underlie the antagonistic action of this protein on the lethal consequences of expression of the pro-apoptotic family member Bax...
Articles
Katia M. DESBIENS, Réna G. DESCHESNES, Mireille M. LABRIE, Yan DESFOSSÉS, Herman LAMBERT, Jacques LANDRY, Kerstin BELLMANN
Journal:
Biochemical Journal
Biochem J (2003) 372 (2): 631–641.
Published: 01 June 2003
... with deregulated expression of c-Myc resulted in nuclear fragmentation that was accompanied in all cells by the activation of Bax and the translocation of cytochrome c from the mitochondria to the cytoplasm. None of these features of apoptosis was induced in control Rat-1 cells. p38 was also activated by cisplatin...
Articles
Hagen SCHROETER, Clinton S. BOYD, Ruhi AHMED, Jeremy P. E. SPENCER, Roger F. DUNCAN, Catherine RICE-EVANS, Enrique CADENAS
Journal:
Biochemical Journal
Biochem J (2003) 372 (2): 359–369.
Published: 01 June 2003
...-mail [email protected] ). 3 2 2003 24 2 2003 4 3 2003 4 3 2003 The Biochemical Society, London ©2003 2003 Bax Bcl-2 cytochrome c membrane potential phosphorylation proteome Abbreviations used: ANT, adenine nucleotide translocase; FCCP, carbonyl cyanide p...
Articles
Journal:
Biochemical Journal
Biochem J (2003) 370 (1): 129–140.
Published: 15 February 2003
...Rami AQEILAN; Rotem KEDAR; Ahmi BEN-YEHUDAH; Haya LORBERBOUM-GALSKI The chimaeric protein interleukin-2 (IL-2)—Bax was designed to target and kill specific cell populations expressing the IL-2 receptor. However, it is not well understood how IL-2—Bax causes target cells to die. In the present study...
Articles
Journal:
Biochemical Journal
Biochem J (2002) 363 (3): 547–552.
Published: 24 April 2002
...Xavier ROUCOU; Tatiana ROSTOVTSEVA; Sylvie MONTESSUIT; Jean-Claude MARTINOU; Bruno ANTONSSON Bax is a proapoptotic member of the Bcl-2 family of proteins. The Bax protein is dormant in the cytosol of normal cells and is activated upon induction of apoptosis. In apoptotic cells, Bax gets...
Articles
Journal:
Biochemical Journal
Biochem J (2000) 348 (2): 343–350.
Published: 23 May 2000
...Elena DORAN; Andrew P. HALESTRAP Percoll-purified rat liver mitochondria were shown to contain BAX dimer and rapidly (< 2 min) release 5-10% of their cytochrome c when incubated in a standard KCl incubation medium under energized conditions. This release was not accompanied by release...
Articles
Journal:
Biochemical Journal
Biochem J (1999) 340 (2): 371–375.
Published: 25 May 1999
...-mail [email protected]). 19 2 1999 1 4 1999 9 4 1999 The Biochemical Society, London © 1999 1999 antioxidants apoptosis bax bcl-x L Biochem. J. (1999) 340, 371 375 (Printed in Great Britain) 371 RESEARCH COMMUNICATION The 5-lipoxygenase-activating protein (FLAP...