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Keywords: Bax
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Biochem J (2024) 481 (14): 903–922.
Published: 10 July 2024
... on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis Bax Bcl-2 BH3-only proteins protein–protein interactions transmembrane domain When a eukaryotic cell is faced with overwhelming cellular stress that surpasses...
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Biochem J (2015) 467 (3): 495–505.
Published: 17 April 2015
...Aisha Shamas-Din; Scott Bindner; Xiaoke Chi; Brian Leber; David W. Andrews; Cécile Fradin tBid (truncated Bid/p15) and Bim activate Bax to permeabilize mitochondria and induce apoptosis. Binding of tBid and Bim to membranes is facilitated by electrostatic interactions. Additionally, cardiolipin (CL...
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Biochem J (2008) 412 (2): e15–e16.
Published: 14 May 2008
...Vilmante Borutaite The question of how Bax is activated during apoptosis to perform its role in permeabilization of mitochondrial membranes is intriguing for investigators in the wide field of cell death research. In their paper published in the Biochemical Journal in 2006, Capano and Crompton...
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Biochem J (2007) 405 (3): 407–415.
Published: 13 July 2007
... of myocardial cells during I/R (ischaemia/reperfusion). Bnip3 exerts its action at the mitochondria, but the mechanism by which Bnip3 mediates mitochondrial dysfunction is not clear. In the present study, we have identified Bax and Bak as downstream effectors of Bnip3-mediated mitochondrial dysfunction. Bnip3...
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Biochem J (2006) 396 (1): 1–5.
Published: 26 April 2006
... of the increase in mitochondrial association of actin in early apoptosis. Using cell fractionation and Western blot analysis, we found that mitochondrial accumulation of β-actin occurred before the mitochondrial insertion of Bax and release of cytochrome c in apoptosis. The mitochondrial accumulation of β-actin...
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Biochem J (2005) 386 (1): 119–125.
Published: 08 February 2005
... release, association of Bax with the mitochondria and caspase 3 activation were also observed in the presence of ANI. Therefore PARP inhibition may represent a novel way of selectively targeting p53-deficient breast cancer cells. The underlying mechanism is probably a potentiation of unrepaired DNA damage...
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Biochem J (2004) 378 (1): 247–255.
Published: 15 February 2004
...Gerd HEIMLICH; Alastair D. McKINNON; Katussevani BERNARDO; Dieter BRDICZKA; John C. REED; Renate KAIN; Martin KRÖNKE; Juliane M. JÜRGENSMEIER The pro-apoptotic protein Bax plays a key role in the mitochondrial signalling pathway. Upon induction of apoptosis, Bax undergoes a conformational change...
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Biochem J (2004) 377 (2): 509–516.
Published: 15 January 2004
...Raquel F. EPAND; Jean-Claude MARTINOU; Sylvie MONTESSUIT; Richard M. EPAND Fatty acids are known promoters of apoptosis. In the present study, the direct role of fatty acids with regard to their ability to cause membrane permeabilization by Bax was explored. Addition of fatty acids to liposomes...
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Biochem J (2003) 376 (1): 229–236.
Published: 15 November 2003
... transmembrane domain. Our previous results showed that Bcl-B binds Bax and suppresses apoptosis induced by over-expression of Bax; however, Bcl-B does not bind or suppress Bak. To explore the molecular basis for the differential binding and suppression of Bax and Bak, we studied the BH3 dimerization domains...
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Biochem J (2003) 374 (2): 393–402.
Published: 01 September 2003
... independently in yeast. Using this system, we have focused on the action of the anti-apoptotic family member Bcl-x L , and have defined the quantitative relationships that underlie the antagonistic action of this protein on the lethal consequences of expression of the pro-apoptotic family member Bax...
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Biochem J (2002) 363 (3): 547–552.
Published: 24 April 2002
...Xavier ROUCOU; Tatiana ROSTOVTSEVA; Sylvie MONTESSUIT; Jean-Claude MARTINOU; Bruno ANTONSSON Bax is a proapoptotic member of the Bcl-2 family of proteins. The Bax protein is dormant in the cytosol of normal cells and is activated upon induction of apoptosis. In apoptotic cells, Bax gets...
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Biochem J (1999) 340 (2): 371–375.
Published: 25 May 1999
...-mail [email protected]). 19 2 1999 1 4 1999 9 4 1999 The Biochemical Society, London © 1999 1999 antioxidants apoptosis bax bcl-x L Biochem. J. (1999) 340, 371 375 (Printed in Great Britain) 371 RESEARCH COMMUNICATION The 5-lipoxygenase-activating protein (FLAP...