Skip Nav Destination
Close Modal
Update search
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
NARROW
Format
Subjects
Article Type
Date
Availability
1-30 of 30
Keywords: Bcl-2
Close
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Sort by
Articles
In Collection
Cell death and survival
Journal:
Biochemical Journal
Biochem J (2024) 481 (14): 903–922.
Published: 10 July 2024
...Dang Nguyen; Elizabeth Osterlund; Justin Kale; David W. Andrews Programmed cell death via the both intrinsic and extrinsic pathways is regulated by interactions of the Bcl-2 family protein members that determine whether the cell commits to apoptosis via mitochondrial outer membrane permeabilization...
Articles
In Collection
Cell death and survival
Journal:
Biochemical Journal
Biochem J (2022) 479 (3): 357–384.
Published: 11 February 2022
... are engaged by their ligands (the extrinsic pathway) or when BCL-2-family pro-apoptotic proteins cause the permeabilization of the mitochondrial outer membrane (the intrinsic pathway). Both the intrinsic and extrinsic pathways of apoptosis lead to the activation of a family of proteases, the caspases, which...
Articles
Journal:
Biochemical Journal
Biochem J (2020) 477 (23): 4527–4541.
Published: 03 December 2020
... ORFV125 homologous to B-cell lymphoma 2 or Bcl-2 family proteins, which has been shown to inhibit host cell encoded pro-apoptotic Bcl-2 proteins. However, the structural basis of apoptosis inhibition by ORFV125 remains to be clarified. We show that ORFV125 is able to bind to a range of peptides spanning...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2020) 477 (17): 3287–3297.
Published: 10 September 2020
...Suresh Banjara; Jaison D Sa; Mark G. Hinds; Marc Kvansakul Apoptosis is regulated by evolutionarily conserved signaling pathways to remove damaged, diseased or unwanted cells. Proteins homologous to the B-cell lymphoma 2 (Bcl-2) family of proteins, the primary arbiters of mitochondrially mediated...
Articles
Journal:
Biochemical Journal
Biochem J (2017) 474 (21): 3643–3657.
Published: 23 October 2017
...Astrid Ruefli-Brasse; John C. Reed Members of the B-cell lymphoma 2 ( BCL-2 ) gene family are attractive targets for cancer therapy as they play a key role in promoting cell survival, a long-since established hallmark of cancer. Clinical utility for selective inhibition of specific anti-apoptotic...
Articles
Journal:
Biochemical Journal
Biochem J (2014) 459 (2): 397–404.
Published: 28 March 2014
... with that of channels in excitable membranes. These channels are highly co-operative consistent with the fundamental conducting unit being a triplet of channels interacting through voltage-sensor dipoles. apoptosis Bcl-2 dipole mitochondria planar membrane pore Voltage-gated membrane channels...
Includes: Supplementary data
Articles
Seiko Shimamoto, Mitsumasa Tsuchiya, Fuminori Yamaguchi, Yasuo Kubota, Hiroshi Tokumitsu, Ryoji Kobayashi
Journal:
Biochemical Journal
Biochem J (2014) 458 (1): 141–152.
Published: 20 January 2014
... proteins can interact with FKBP38 and regulate its function. In vitro binding studies demonstrated that S100A1, S100A2, S100A6, S100B and S100P specifically interact with FKBP38 and inhibit the interaction of FKBP38 with Bcl-2 and Hsp90. Overexpression of permanently active S100P in Huh-7 cells inhibited...
Articles
Journal:
Biochemical Journal
Biochem J (2012) 444 (3): 475–485.
Published: 29 May 2012
... of a second VDAC1 molecule. When the N-terminal region α-helix structure was perturbed, intra-molecular cross-linking was abolished and dimerization was enhanced. This mutant also displays reduced voltage-gating and reduced binding to hexokinase, but not to the anti-apoptotic proteins Bcl-2 and Bcl-xL...
Articles
Journal:
Biochemical Journal
Biochem J (2012) 444 (1): 69–78.
Published: 26 April 2012
...Colins O. Eno; Guoping Zhao; Kristen E. Olberding; Chi Li Because the detailed molecular mechanisms by which oxidative stress induces apoptosis are not completely known, we investigated how the complex Bcl-2 protein network might regulate oxidative stress-induced apoptosis. Using MEFs (mouse...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2012) 444 (1): 127–139.
Published: 26 April 2012
...Elena S. Dremina; Victor S. Sharov; Christian Schöneich We have demonstrated previously that Bcl-2 and Bcl-2Δ21, a C-terminally truncated Bcl-2 sequence, inactivate SERCA (sarcoplasmic/endoplasmic reticulum Ca 2+ -ATPase) 1 in isolated SR (sarcoplasmic reticulum), accompanied by a translocation...
Articles
Journal:
Biochemical Journal
Biochem J (2012) 441 (1): 407–416.
Published: 14 December 2011
...Sung Nyo Yoon; Kang Sik Kim; Ju Hwan Cho; Weina Ma; Hye-Jin Choi; Sung-Joon Kwon; Joong-Soo Han The purpose of the present study was to investigate the role of PLD (phospholipase D) in bFGF (basic fibroblast growth factor)-induced Bcl-2 expression and to examine whether overexpressed Bcl-2...
Articles
Journal:
Biochemical Journal
Biochem J (2008) 415 (3): 333–344.
Published: 15 October 2008
... attempts to explain the meaning behind the abbreviations. Abbreviation Meaning Comments (or synonyms) Bad B cl-2/Bcl-X L - a ssociated d eath domain protein BH3-only member of the Bcl-2 family Bak B cl-2 homologous a ntagonist- k iller protein Multi-BH domain pro-apoptosis...
Articles
Journal:
Biochemical Journal
Biochem J (2006) 395 (2): 267–276.
Published: 28 March 2006
... be responsible for the degeneration of muscle occurring in DMD. In the present study, we used subsarcolemmal- and mitochondrial-targeted aequorin to study the effect of the antiapoptotic Bcl-2 protein overexpression on carbachol-induced near-plasma membrane and mitochondrial calcium responses in myotubes derived...
Articles
Alexander GOONESINGHE, Elizabeth S. MUNDY, Melanie SMITH, Roya KHOSRAVI-FAR, Jean-Claude MARTINOU, Mauro D. ESPOSTI
Journal:
Biochemical Journal
Biochem J (2005) 387 (1): 109–118.
Published: 22 March 2005
...Alexander GOONESINGHE; Elizabeth S. MUNDY; Melanie SMITH; Roya KHOSRAVI-FAR; Jean-Claude MARTINOU; Mauro D. ESPOSTI Bid is a BH3-only member of the Bcl-2 family that regulates cell death at the level of mitochondrial membranes. Bid appears to link the mitochondrial pathway with the death receptor...
Articles
Elena S. DREMINA, Victor S. SHAROV, Keshava KUMAR, Asma ZAIDI, Elias K. MICHAELIS, Christian SCHÖNEICH
Journal:
Biochemical Journal
Biochem J (2004) 383 (2): 361–370.
Published: 08 October 2004
...Elena S. DREMINA; Victor S. SHAROV; Keshava KUMAR; Asma ZAIDI; Elias K. MICHAELIS; Christian SCHÖNEICH The anti-apoptotic effect of Bcl-2 is well established, but the detailed mechanisms are unknown. In the present study, we show in vitro a direct interaction of Bcl-2 with the rat skeletal muscle...
Articles
Journal:
Biochemical Journal
Biochem J (2004) 381 (1): 43–49.
Published: 22 June 2004
... by the DNA-damaging agent, etoposide, is associated with a fall in the levels of the anti-apoptotic Bcl-2 protein. This fall in Bcl-2 protein concentration can be attenuated by M 3 -muscarinic receptor stimulation. We conclude, therefore, that the M 3 -muscarinic receptor signals to the anti-apoptotic...
Articles
Gerd HEIMLICH, Alastair D. McKINNON, Katussevani BERNARDO, Dieter BRDICZKA, John C. REED, Renate KAIN, Martin KRÖNKE, Juliane M. JÜRGENSMEIER
Journal:
Biochemical Journal
Biochem J (2004) 378 (1): 247–255.
Published: 15 February 2004
... and expressed in Escherichia coli . The proteins were then purified in order to delineate the function of the transmembrane domain, the BH3 (Bcl-2 homology 3) domain and the putative pore-forming α-helices-5 and -6. These proteins were used to analyse the mechanism of Bax-induced cytochrome c release from...
Articles
Dayong ZHAI, Ning KE, Haichao ZHANG, Uri LADROR, Mary JOSEPH, Andreas EICHINGER, Adam GODZIK, Shi-Chung NG, John C. REED
Journal:
Biochemical Journal
Biochem J (2003) 376 (1): 229–236.
Published: 15 November 2003
...Dayong ZHAI; Ning KE; Haichao ZHANG; Uri LADROR; Mary JOSEPH; Andreas EICHINGER; Adam GODZIK; Shi-Chung NG; John C. REED Bcl-B protein is an anti-apoptotic member of the Bcl-2 family protein that contains all the four BH (Bcl-2 homology) domains (BH1, BH2, BH3 and BH4) and a predicted C-terminal...
Articles
Journal:
Biochemical Journal
Biochem J (2003) 375 (2): 263–274.
Published: 15 October 2003
...Elvira CRESCENZI; Giuseppe PALUMBO; Hugh J. M. BRADY The apoptosis regulator Bcl-2 has been shown to modulate cell-cycle progression, favouring a quiescent state over a proliferative state, in both normal and tumour cells. We show here that constitutive expression of Bcl-2 in human carcinoma cells...
Articles
Katia M. DESBIENS, Réna G. DESCHESNES, Mireille M. LABRIE, Yan DESFOSSÉS, Herman LAMBERT, Jacques LANDRY, Kerstin BELLMANN
Journal:
Biochemical Journal
Biochem J (2003) 372 (2): 631–641.
Published: 01 June 2003
... only in cells with deregulated expression of c-Myc, but, in contrast with all features of apoptosis, this activation was not affected by Bcl-2. Remarkably, overexpression of an interfering mutant of the p38α isoform, but not p38β, blocked cisplatin-induced Bax activation or cytochrome c release...
Articles
Hagen SCHROETER, Clinton S. BOYD, Ruhi AHMED, Jeremy P. E. SPENCER, Roger F. DUNCAN, Catherine RICE-EVANS, Enrique CADENAS
Journal:
Biochemical Journal
Biochem J (2003) 372 (2): 359–369.
Published: 01 June 2003
... the phosphorylation of mitochondrial Bcl-2 and Bcl-x L . Although the c-Jun N-terminal kinase (JNK) has been proposed to mediate the phosphorylation of Bcl-2/Bcl-x L the mechanisms linking the modification of these proteins and the release of cytochrome c remain to be elucidated. This study was aimed at establishing...
Articles
Journal:
Biochemical Journal
Biochem J (2003) 372 (1): 203–210.
Published: 15 May 2003
... of bcl-2 or bcl-x L in FL5.12 cells inhibited apoptosis induced by MK886 as well as the enhancement of apoptosis by WY14643. Thus 24p3 is an MK886-inducible gene and may play an important role in MK886-induced apoptosis. 1 To whom correspondence should be addressed (e-mail [email protected]...
Articles
Journal:
Biochemical Journal
Biochem J (2002) 368 (3): 915–921.
Published: 15 December 2002
...Xavier ROUCOU; Sylvie MONTESSUIT; Bruno ANTONSSON; Jean-Claude MARTINOU In response to various apoptotic stimuli, Bax, a pro-apoptotic member of the Bcl-2 family, is oligomerized and permeabilizes the mitochondrial outer membrane to apoptogenic factors, including cytochrome c . Bax oligomerization...
Articles
Philippe LALLE, Abdel AOUACHERIA, Agnès DUMONT-MISCOPEIN, Martin JAMBON, Séverine VENET, Hélène BOBICHON, Pierre COLAS, Gilbert DELÉAGE, Christophe GEOURJON, Germain GILLET
Journal:
Biochemical Journal
Biochem J (2002) 368 (1): 213–221.
Published: 15 November 2002
...Philippe LALLE; Abdel AOUACHERIA; Agnès DUMONT-MISCOPEIN; Martin JAMBON; Séverine VENET; Hélène BOBICHON; Pierre COLAS; Gilbert DELÉAGE; Christophe GEOURJON; Germain GILLET Nr-13 is an anti-apoptotic member of the Bcl-2 family previously shown to interact with Bax. The biological significance...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2002) 365 (3): 825–832.
Published: 01 August 2002
... in the breast tumour cell lines MCF-7 and MDA-MB231. IFN-γ promoted TRAIL-mediated activation of caspase-8, Bcl-2 interacting domain death agonist (Bid) degradation, Bcl-2-associated X protein (Bax) translocation to mitochondria, cytochrome c release to the cytosol and activation of caspase-9 in these cell...
Articles
Xiao-Chun BAI, Fan DENG, An-Ling LIU, Zhi-Peng ZOU, Yu WANG, Zhi-Yong KE, Qun-Sheng JI, Shen-Qiu LUO
Journal:
Biochemical Journal
Biochem J (2002) 363 (2): 395–401.
Published: 08 April 2002
... cell lines treated with H 2 O 2 (1–5mM), but with low doses (50–200 μ M), PKC activation was considerably decreased in Plcg1 −/− cells. After treatment with H 2 O 2 , PKC-dependent phosphorylation of Bcl-2 and cell viability of Plcg1 −/− cells decreased dramatically and caspase-3-like activity...
Articles
Patrice Xavier PETIT, Marie-Claude GENDRON, Nicolas SCHRANTZ, Didier MÉTIVIER, Guido KROEMER, Zofia MACIOROWSKA, Franck SUREAU, Steven KOESTER
Journal:
Biochemical Journal
Biochem J (2001) 353 (2): 357–367.
Published: 08 January 2001
...-oncogene Bcl-2, which encodes an inhibitor of the mitochondrial permeability transition (PT) pore, delayed both the ∆Ψ m disruption and the depletion of NAD(P)H. Similar effects were observed with the pharmacological PT pore inhibitors, bongkrekic acid and cyclosporin A. Thus there appears to be a close...
Articles
Journal:
Biochemical Journal
Biochem J (2000) 349 (2): 547–557.
Published: 10 July 2000
...Jose M. LIZCANO; Nick MORRICE; Philip COHEN The interaction of BAD (Bcl-2/Bcl-X L -antagonist, causing cell death) with Bcl-2/Bcl-X L is thought to neutralize the anti-apoptotic effects of the latter proteins, and may represent one of the mechanisms by which BAD promotes apoptosis. A variety...
Articles
Journal:
Biochemical Journal
Biochem J (2000) 348 (2): 473–479.
Published: 23 May 2000
...Hua-Kang CHOU; Show-Li CHEN; Chung-Te HSU; You-Chen CHAO; Yeou-Ping TSAO The role of Bcl-2 as an anti-apoptotic protein has been well documented. In the present work, we present evidence that Bcl-2 may also be involved in cell growth regulation. SC-M1 is an unique cell line which responds...
Articles
Journal:
Biochemical Journal
Biochem J (1999) 340 (1): 33–40.
Published: 10 May 1999
... protease or proteasome activity. Moreover, trypanosomes expressing mouse Bcl-2 were not protected from ROS even though protection from mitochondrial dysfunction and ROS have been reported for mammalian cells. Overall, these results demonstrate that Ca 2+ pathways can induce pathology in trypanosomes...
