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Keywords: CD74
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Articles
Substrate determinants of signal peptide peptidase-like 2a (SPPL2a)-mediated intramembrane proteolysis of the invariant chain CD74
Available to PurchaseSusann Hüttl, Felix Helfrich, Torben Mentrup, Sebastian Held, Akio Fukumori, Harald Steiner, Paul Saftig, Regina Fluhrer, Bernd Schröder
Journal:
Biochemical Journal
Biochem J (2016) 473 (10): 1405–1422.
Published: 11 May 2016
... proteins. We recently identified CD74, the invariant chain of the MHCII complex, as the first in vivo validated substrate of this protease. In endosomal compartments, CD74 undergoes sequential proteolysis leading to the generation of a membrane-bound N-terminal fragment (NTF) that requires cleavage...
