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1-4 of 4
Keywords: CFTR
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Articles
Journal:
Biochemical Journal
Biochem J (2021) 478 (10): 1891–1906.
Published: 24 May 2021
..., that is ablated by the β-blocker Propranolol and is absent from homozygous ΔF508-CFTR mice lacking functional CFTR. These data suggest that PDE4 acts within salivary glands to gate saliva secretion that is contingent upon the cAMP/PKA-dependent activation of CFTR. Indeed, PDE4 contributes the majority of total...
Includes: Supplementary data
Articles
João D. Santos, Francisco R. Pinto, João F. Ferreira, Margarida D. Amaral, Manuela Zaccolo, Carlos M. Farinha
Journal:
Biochemical Journal
Biochem J (2020) 477 (13): 2561–2580.
Published: 10 July 2020
... Regulator (CFTR) protein, a cAMP-regulated chloride channel expressed at the apical surface of epithelial cells. Cyclic AMP regulates both CFTR channel gating through a protein kinase A (PKA)-dependent process and plasma membane (PM) stability through activation of the exchange protein directly activated...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2002) 366 (3): 797–806.
Published: 15 September 2002
...Carlos M. FARINHA; Paulo NOGUEIRA; Filipa MENDES; Deborah PENQUE; Margarida D. AMARAL The CFTR (cystic fibrosis transmembrane conductance regulator) gene, defective in cystic fibrosis, codes for a polytopic apical membrane protein functioning as a chloride channel. Wild-type (wt) CFTR matures...
Articles
Journal:
Biochemical Journal
Biochem J (2002) 366 (2): 541–548.
Published: 01 September 2002
...Martina GENTZSCH; Andrei ALEKSANDROV; Luba ALEKSANDROV; John R. RIORDAN The cystic fibrosis transmembrane conductance regulator (CFTR) contains two nucleotide-binding domains (NBDs) or ATP-binding cassettes (ABCs) that characterize a large family of membrane transporters. Although the three...