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Keywords: COVID-19
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Articles
Biochem J (2021) 478 (13): 2533–2535.
Published: 02 July 2021
...John F.X. Diffley In response to the COVID-19 pandemic, we began a project in March 2020 to identify small molecule inhibitors of SARS-CoV-2 enzymes from a library of chemical compounds containing many established pharmaceuticals. Our hope was that inhibitors we found might slow the replication...
Articles
Biochem J (2021) 478 (13): 2405–2423.
Published: 02 July 2021
... The coronavirus disease 2019 (COVID-19) pandemic, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global public health challenge. While the efficacy of vaccines against emerging and future virus variants remains unclear, there is a need for therapeutics. Repurposing existing...
Includes: Supplementary data
Articles
Biochem J (2021) 478 (13): 2425–2443.
Published: 02 July 2021
...Agustina P. Bertolin; Florian Weissmann; Jingkun Zeng; Viktor Posse; Jennifer C. Milligan; Berta Canal; Rachel Ulferts; Mary Wu; Lucy S. Drury; Michael Howell; Rupert Beale; John F.X. Diffley The coronavirus disease 2019 (COVID-19) global pandemic has turned into the largest public health...
Includes: Supplementary data
Articles
Biochem J (2021) 478 (13): 2465–2479.
Published: 02 July 2021
...Berta Canal; Ryo Fujisawa; Allison W. McClure; Tom D. Deegan; Mary Wu; Rachel Ulferts; Florian Weissmann; Lucy S. Drury; Agustina P. Bertolin; Jingkun Zeng; Rupert Beale; Michael Howell; Karim Labib; John F.X. Diffley SARS-CoV-2 is responsible for COVID-19, a human disease that has caused over 2...
Includes: Supplementary data
Articles
Biochem J (2021) 478 (13): 2517–2531.
Published: 02 July 2021
.... Diffley The COVID-19 pandemic has emerged as the biggest life-threatening disease of this century. Whilst vaccination should provide a long-term solution, this is pitted against the constant threat of mutations in the virus rendering the current vaccines less effective. Consequently, small molecule...
Includes: Supplementary data
Articles
Biochem J (2021) 478 (13): 2499–2515.
Published: 02 July 2021
... Beale; Karim Labib; Nicola O'Reilly; John F.X. Diffley The coronavirus 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spread around the world with unprecedented health and socio-economic effects for the global population. While different vaccines...
Includes: Supplementary data
Articles
Biochem J (2021) 478 (13): 2481–2497.
Published: 02 July 2021
...; Karim Labib; John F.X. Diffley The COVID-19 pandemic has presented itself as one of the most critical public health challenges of the century, with SARS-CoV-2 being the third member of the Coronaviridae family to cause a fatal disease in humans. There is currently only one antiviral compound, remdesivir...
Includes: Supplementary data