1-10 of 10
Keywords: COVID-19
Close
Sort by
Articles
Biochem J (2023) 480 (11): 791–813.
Published: 07 June 2023
... in the active and allosteric sites of 3CLpro that could be targeted with competitive and noncompetitive inhibitors as new therapeutics against COVID-19. Among the intradomain II interactions in pocket 1, the side chain of S147 forms a hydrogen bond with the main chain of S144 at 2.7 Å, and the side chain...
Includes: Supplementary data
Articles
Articles
Biochem J (2022) 479 (5): 609–628.
Published: 04 March 2022
...Stefanie M. Bader; James P. Cooney; Marc Pellegrini; Marcel Doerflinger Two years after the emergence of SARS-CoV-2, our understanding of COVID-19 disease pathogenesis is still incomplete. Despite unprecedented global collaborative scientific efforts and rapid vaccine development, an uneven vaccine...
Articles
Biochem J (2021) 478 (13): 2533–2535.
Published: 02 July 2021
...John F.X. Diffley In response to the COVID-19 pandemic, we began a project in March 2020 to identify small molecule inhibitors of SARS-CoV-2 enzymes from a library of chemical compounds containing many established pharmaceuticals. Our hope was that inhibitors we found might slow the replication...
Articles
Articles
Articles
Articles
Articles
Articles