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... acid; PLC, phospholipase C; PTH, parathyroid hormone; RyR, ryanodine receptor. Biochem. J. (2003) 375, 713 720 (Printed in Great Britain) 713 Co-incident signalling between µ-opioid and M3 muscarinic receptors at the level of Ca2+ release from intracellular stores: lack of evidence for Ins(1,4,5)P3...

..., the concentration response relationship was evaluated in large population measurements in suspension. Trout BK activated the # 2002 Biochemical Society 821Characterization and expression of zebrafish bradykinin B2-related receptor Figure 3 Ca2+ responses upon activation of zebrafish BK receptors in HEK-293-EBNA-1...

... also forms inhibitory complexes with the bradykinin (BK) B2, the angiotensin II AT1 and endothelin-1 ETB receptor, from which the enzyme is released in Abbreviations used: BK, bradykinin ; [Ca2+]i, intracellular free Ca 2+ concentration ; CaM, calmodulin ; eNOS, endothelial nitric oxide synthase; fura...

... conjugated to FITC. Cells were washed again and fixed with 0.37% paraformal- dehyde. The mean fluorescence intensity of 5000 cells was de- termined by flow cytometry (FACScan; Becton Dickinson, Mountain View, CA, U.S.A Measurement of changes in cytosolic Ca2+ concentration Cytosolic Ca#+ concentration...

.... The Hill coefficient and seed values for the non-linear curve fit were obtained directly from a linear regression of logit log plots of ln [(B max ®B)}B) against ln ([Zn f ) ; IC ZnI , the [Zn f for producing half inhibition, was calculated from the relationship IC ZnI ¯ (K d/ZnI h. Measurement of [Ca2+]f...

... pore and cell death and that have made the field a topical one. 1 Ca2+ CYCLING AND THE CONTROL OF MITOCHONDRIAL Ca2+ PT-induced mitochondrial dysfunction is a consequence of mitochondrial Ca#+ overload. It is appropriate, therefore, to define the conditions under which the overload takes place...

...) antibody (Santa Cruz Biotechnology) was used at 1:1000 dilution. Measurement of cytosolic concentration of Ca2+ MIN6 cells were grown on glass coverslips for 3 days before the experiments. The cells were loaded with 5 lM fura-2 acetoxy- methyl ester during a 60 min incubation at 37 °C in a Hepes- buffered...