...Juliette Bayot; Caroline Martin; Guillaume Chevreux; Jean-Michel Camadro; Françoise Auchère Candida albicans is an opportunist pathogen responsible for a large spectrum of infections, from superficial mycosis to systemic diseases known as candidiasis. During infection in vivo , Candida albicans...

...Archana Kumari Redhu; Nitesh Kumar Khandelwal; Atanu Banerjee; Alexis Moreno; Pierre Falson; Rajendra Prasad Multidrug resistance 1 (MDR1) is a member of the major facilitator superfamily that contributes to MDR of Candida albicans . This antiporter belongs to the drug/H + antiporter 1 family...

... resistance), the overexpression of drug-efflux pumps belonging to the ABC (ATP-binding cassette) superfamily is the most frequent cause of resistance to antifungal agents. The multidrug transporter proteins Cdr1p and Cdr2p of the ABCG subfamily are major players in the development of MDR in Candida albicans...

... as compared with wild-type Candida albicans cells. Furthermore, lipidomic analysis of QDR-deletion mutants suggests massive remodelling of lipids, which may affect cell signalling, leading to the defect in biofilm development and attenuation of virulence. In summary, the results of the present study show...

... their direct involvement in MDR in Candida albicans . The Mdr1 protein has two transmembrane domains, each comprising six transmembrane helices, interconnected with extracellular loops and ICLs (intracellular loops). The introduction of deletions and insertions through mutagenesis was used to address the role...

...Guiliana Soraya Victoria; Bhawna Yadav; Lalremruata Hauhnar; Priyanka Jain; Shilpi Bhatnagar; Sneha Sudha Komath A novel co-regulation exists between the first step of GPI (glycosylphosphatidylinositol) anchor biosynthesis and the rate-determining step of ergosterol biosynthesis in Candida albicans...

...Hao-Teng Chang; Pei-Wen Tsai; Hsin-Hui Huang; Yu-Shu Liu; Tzu-Shan Chien; Chung-Yu Lan The opportunistic fungus Candida albicans causes oral thrush and vaginal candidiasis, as well as candidaemia in immunocompromised patients including those undergoing cancer chemotherapy, organ transplant...

...Nobuyuki Shibata; Akifumi Suzuki; Hidemitsu Kobayashi; Yoshio Okawa The structure of the cell-wall mannan from the J-1012 (serotype A) strain of the polymorphic yeast Candida albicans was determined by acetolysis under mild conditions followed by HPLC and sequential NMR experiments. The serotype...

... of AFT1 in Candida albicans , we transformed a C. albicans genomic DNA library into aft1 Δ to isolate genes that could allow the mutant to grow under iron-limiting conditions. In the present paper, we describe the unexpected discovery in this screen of CaMNN5 . CaMnn5p is an α-1,2-mannosyltransferease...

...-organisms are relatively scarce. We compared the effects of histatin 5 and LL-37, two antimicrobial peptides present in human saliva, on the functional and morphological properties of the Candida albicans cell membrane. Fluorescence microscopy and immunogold transmission electron microscopy revealed that LL...

... activity [Bobek and Situ (2003) Antimicrob. Agents Chemother. 47 , 645–652]. The aims of the present study were to determine the minimum peptide chain length and its location within the 20-mer region that retains potent antifungal activity against Candida albicans and Cryptococcus neoformans and to examine...

... been identified, these are based on complex chemistry, which hampers iterative structure-based optimization. Here we report the details of chitinase inhibition by the natural product peptide CI-4 [ cyclo -( l -Arg- d -Pro)], which possesses activity against the human pathogenic fungus Candida albicans...